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Biophysical and Immunological Characterization and In Vivo Pharmacokinetics and Toxicology in Non-Human Primates of the Anti-PD-1 Antibody Pembrolizumab.

Hutchins B, Starling GC, McCoy MA, Herzyk D, Poulet FM, Dulos J, Liu L, Kang SP, Fayadat-Dilman L, Hsieh M, Andrews CL, Ayanoglu G, Cullen C, De Waal Malefyt R, Kastelein RA, Le Saux S, Lee J, Li S, Malashock D, Sadekova S, Soder G, van Eenennaam H, Willingham A, Yu Y, Streuli M, Carven GJ, van Elsas A.

Mol Cancer Ther. 2020 Mar 30. pii: molcanther.0774.2019. doi: 10.1158/1535-7163.MCT-19-0774. [Epub ahead of print]


The Impacts of Reassortant Avian Influenza H5N2 Virus NS1 Proteins on Viral Compatibility and Regulation of Immune Responses.

Wang WC, Kuan CY, Tseng YJ, Chang CH, Liu YC, Chang YC, Hsu YC, Hsieh MK, Ou SC, Hsu WL.

Front Microbiol. 2020 Mar 12;11:280. doi: 10.3389/fmicb.2020.00280. eCollection 2020.


Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.

Velmurugan BK, Lin JT, Mahalakshmi B, Chuang YC, Lin CC, Lo YS, Hsieh MJ, Chen MK.

Biomolecules. 2020 Mar 26;10(4). pii: E502. doi: 10.3390/biom10040502.


Comparison of 9-Month Angiographic Follow-Up and Long-Term Clinical Outcomes of Biodegradable Polymer Drug-Eluting Stents and Second-Generation Durable Polymer Drug-Eluting Stents in Patients Undergoing Single Coronary Artery Stenting.

Tsai ML, Hsieh MJ, Chen CC, Chang SH, Wang CY, Chen DY, Yang CH, Yeh JK, Ho MY, Hsieh IC.

Acta Cardiol Sin. 2020 Mar;36(2):97-104. doi: 10.6515/ACS.202003_36(2).20190729A.


Motivations and decision-making of adult sickle cell patients in high-risk clinical research.

Cho HL, Kim SY, Fitzhugh C, Hsieh M, Tisdale J, Grady C.

Biol Blood Marrow Transplant. 2020 Mar 18. pii: S1083-8791(20)30151-8. doi: 10.1016/j.bbmt.2020.03.014. [Epub ahead of print]


Novice training: The time course for developing competence in single port video-assisted thoracoscopic lobectomy.

Wu CF, Paradela M, Wu CY, Mercedes T, Fernandez R, Delgado M, Fieira E, Hsieh MJ, Chao YK, Yang LY, Pan YB, Gonzalez-Rivas D.

Medicine (Baltimore). 2020 Mar;99(12):e19459. doi: 10.1097/MD.0000000000019459.


Optimization of Three-Level Cervical Hybrid Surgery to Prevent Adjacent Segment Disease: A Finite Element Study.

Wong CE, Hu HT, Hsieh MP, Huang KY.

Front Bioeng Biotechnol. 2020 Mar 4;8:154. doi: 10.3389/fbioe.2020.00154. eCollection 2020.


Familial aggregation and heritability of primary Aldosteronism with Cardiovascular events: a population-based family cohort study.

Wu VC, Chueh JS, Hsieh MY, Hu YH, Huang KH, Lin YH, Yang SY, Chu TS, Kuo CF; TAIPAI study group.

J Clin Endocrinol Metab. 2020 Mar 20. pii: dgz257. doi: 10.1210/clinem/dgz257. [Epub ahead of print]


Multicenter Study of Azole-Resistant Aspergillus fumigatus Clinical Isolates, Taiwan1.

Wu CJ, Liu WL, Lai CC, Chao CM, Ko WC, Wang HC, Dai CT, Hsieh MI, Choi PC, Yang JL, Chen YC.

Emerg Infect Dis. 2020 Apr;26(4):804-806. doi: 10.3201/eid2604.190840.


A cross-sectional analysis of the urine microbiome of children with neuropathic bladders.

Forster CS, Panchapakesan K, Stroud C, Banerjee P, Gordish-Dressman H, Hsieh MH.

J Pediatr Urol. 2020 Feb 19. pii: S1477-5131(20)30027-9. doi: 10.1016/j.jpurol.2020.02.005. [Epub ahead of print]


Stratified risks of infection-related hospitalization in patients with chronic kidney disease - A prospective cohort study.

Yang WS, Chang YC, Hsieh ML, Wang JL, Wu LC, Chang CH.

Sci Rep. 2020 Mar 11;10(1):4475. doi: 10.1038/s41598-020-61144-6.


Fasting glucose-to-HbA1c ratio is a good indicator of G6PD deficiency, but not thalassemia, in patients with type 2 diabetes mellitus.

Chang YS, Hsiao LY, Lin CY, Shih MC, Hsieh MC, Chang JG.

Clin Chim Acta. 2020 Mar 7;506:9-15. doi: 10.1016/j.cca.2020.03.010. [Epub ahead of print]


Progress in Polymeric Nano-Medicines for Theranostic Cancer Treatment.

Ali I, Alsehli M, Scotti L, Tullius Scotti M, Tsai ST, Yu RS, Hsieh MF, Chen JC.

Polymers (Basel). 2020 Mar 6;12(3). pii: E598. doi: 10.3390/polym12030598. Review.


Goat Milk Consumption Enhances Innate and Adaptive Immunities and Alleviates Allergen-Induced Airway Inflammation in Offspring Mice.

Kao HF, Wang YC, Tseng HY, Wu LS, Tsai HJ, Hsieh MH, Chen PC, Kuo WS, Liu LF, Liu ZG, Wang JY.

Front Immunol. 2020 Feb 18;11:184. doi: 10.3389/fimmu.2020.00184. eCollection 2020.


Integral-based parallel algorithm for the fast generation of the Zernike polynomials.

Hsieh YH, Yu YT, Lai YH, Hsieh MX, Chen YF.

Opt Express. 2020 Jan 20;28(2):936-947. doi: 10.1364/OE.380567.


Teaching communication skills: Using Gagne's model as an illustration.

Lo WL, Hsieh MC.

Ci Ji Yi Xue Za Zhi. 2019 Sep 19;32(1):19-25. doi: 10.4103/tcmj.tcmj_59_19. eCollection 2020 Jan-Mar. Review.


Immune Response Following Quadrivalent Human Papillomavirus Vaccination in Women After Hematopoietic Allogeneic Stem Cell Transplant: A Nonrandomized Clinical Trial.

Stratton P, Battiwalla M, Tian X, Abdelazim S, Baird K, Barrett AJ, Cantilena CR, Childs RW, DeJesus J, Fitzhugh C, Fowler D, Gea-Banacloche J, Gress RE, Hickstein D, Hsieh M, Ito S, Kemp TJ, Khachikyan I, Merideth MA, Pavletic SZ, Quint W, Schiffman M, Scrivani C, Shanis D, Shenoy AG, Struijk L, Tisdale JF, Wagner S, Williams KM, Yu Q, Wood LV, Pinto LA.

JAMA Oncol. 2020 Feb 27. doi: 10.1001/jamaoncol.2019.6722. [Epub ahead of print]


Statin Use and the Risk of Subsequent Hospitalized Exacerbations in COPD Patients with Frequent Exacerbations.

Lin CM, Yang TM, Yang YH, Tsai YH, Lee CP, Chen PC, Chen WC, Hsieh MJ.

Int J Chron Obstruct Pulmon Dis. 2020 Feb 10;15:289-299. doi: 10.2147/COPD.S229047. eCollection 2020.


Author Correction: The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial.

Hsieh MC, Tsai WH, Jheng YP, Su SL, Wang SY, Lin CC, Chen YH, Chang WW.

Sci Rep. 2020 Feb 26;10(1):3872. doi: 10.1038/s41598-020-60957-9.


Chryseobacterium indologenes keratitis-A case report.

Hsieh MC, Yang SY, Liu YL, Lin CP.

Kaohsiung J Med Sci. 2020 Feb 24. doi: 10.1002/kjm2.12195. [Epub ahead of print] No abstract available.


Oral supplementation of fucoxanthin-rich brown algae extract ameliorates cisplatin-induced testicular damage in hamsters.

Wang PT, Sudirman S, Hsieh MC, Hu JY, Kong ZL.

Biomed Pharmacother. 2020 May;125:109992. doi: 10.1016/j.biopha.2020.109992. Epub 2020 Feb 25.


Biomechanical comparison of pedicle screw fixation strength in synthetic bones: Effects of screw shape, core/thread profile and cement augmentation.

Liu MY, Tsai TT, Lai PL, Hsieh MK, Chen LH, Tai CL.

PLoS One. 2020 Feb 21;15(2):e0229328. doi: 10.1371/journal.pone.0229328. eCollection 2020.


Caffeine Optimizes HIIT Benefits on Obesity-associated Metabolic Adversity in Women.

Alkhatib A, Hsieh MJ, Kuo CH, Hou CW.

Med Sci Sports Exerc. 2020 Feb 19. doi: 10.1249/MSS.0000000000002311. [Epub ahead of print]


Baseline TP53 mutations in Adults with SCD developing Myeloid Malignancy following Hematopoietic Cell Transplantation.

Ghannam JY, Xu X, Maric I, Dillon L, Li Y, Hsieh M, Hourigan CS, Fitzhugh CD.

Blood. 2020 Feb 14. pii: blood.2019004001. doi: 10.1182/blood.2019004001. [Epub ahead of print] No abstract available.


Hepatitis B-related outcomes following direct-acting antiviral therapy in Taiwanese patients with chronic HBV/HCV co-infection.

Yeh ML, Huang CF, Huang CI, Holmes JA, Hsieh MH, Tsai YS, Liang PC, Tsai PC, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Chung RT, Yu ML.

J Hepatol. 2020 Feb 13. pii: S0168-8278(20)30074-X. doi: 10.1016/j.jhep.2020.01.027. [Epub ahead of print]


Trend and survival benefit of Oncotype DX use among female hormone receptor-positive breast cancer patients in 17 SEER registries, 2004-2015.

Zhang L, Hsieh MC, Petkov V, Yu Q, Chiu YW, Wu XC.

Breast Cancer Res Treat. 2020 Apr;180(2):491-501. doi: 10.1007/s10549-020-05557-x. Epub 2020 Feb 14.


Extremely late recurrences (≥3 years) of atrioventricular nodal reentrant tachycardia: Electrophysiological characteristics of the index and repeat ablation procedures.

Chin CG, Chung FP, Lin YJ, Chang SL, Lo LW, Hu YF, Tuan TC, Chao TF, Liao JN, Lin CY, Chang TY, Vicera JJB, Chen CC, Chuang CM, Cheng WH, Liu SH, Hsieh MH, Chen SA.

Int J Cardiol. 2020 Apr 15;305:70-75. doi: 10.1016/j.ijcard.2020.02.007. Epub 2020 Feb 4.


Safe and efficient peripheral blood stem cell collection in patients with sickle cell disease using plerixafor.

Uchida N, Leonard A, Stroncek D, Panch SR, West K, Molloy E, Hughes TE, Hauffe S, Taylor T, Fitzhugh C, Hankins JS, Wilson M, Sharma A, Tsai SQ, Weiss MJ, Hsieh M, Tisdale JF.

Haematologica. 2020 Feb 13. pii: haematol.2019.236182. doi: 10.3324/haematol.2019.236182. [Epub ahead of print] No abstract available.


Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics.

Lin CH, Hsieh MJ, Lee HL, Yang SF, Su SC, Lee WJ, Chou YE.

J Cancer. 2020 Jan 14;11(6):1641-1647. doi: 10.7150/jca.38856. eCollection 2020.


A fitting machine learning prediction model for short-term mortality following percutaneous catheterization intervention: a nationwide population-based study.

Hsieh MH, Lin SY, Lin CL, Hsieh MJ, Hsu WH, Ju SW, Lin CC, Hsu CY, Kao CH.

Ann Transl Med. 2019 Dec;7(23):732. doi: 10.21037/atm.2019.12.21.


Post-Treatment with Erinacine A, a Derived Diterpenoid of H. erinaceus, Attenuates Neurotoxicity in MPTP Model of Parkinson's Disease.

Lee KF, Tung SY, Teng CC, Shen CH, Hsieh MC, Huang CY, Lee KC, Lee LY, Chen WP, Chen CC, Huang WS, Kuo HC.

Antioxidants (Basel). 2020 Feb 4;9(2). pii: E137. doi: 10.3390/antiox9020137.


Spontaneous bilateral haemothorax with haemopericardium secondary to rivaroxaban.

Yu JH, Liu HH, Hsieh MJ, Hsieh IC, Chu PH, Chen DY.

J Clin Pharm Ther. 2020 Feb 5. doi: 10.1111/jcpt.13116. [Epub ahead of print]


Effects of miR-34b/miR-892a Upregulation and Inhibition of ABCB1/ABCB4 on Melatonin-Induced Apoptosis in VCR-Resistant Oral Cancer Cells.

Hsieh MJ, Lin CW, Su SC, Reiter RJ, Chen AW, Chen MK, Yang SF.

Mol Ther Nucleic Acids. 2020 Mar 6;19:877-889. doi: 10.1016/j.omtn.2019.12.022. Epub 2020 Jan 9.


Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives.

Lee DY, Hou YC, Yang JS, Lin HY, Chang TY, Lee KH, Kuo SC, Hsieh MT.

Molecules. 2020 Jan 22;25(3). pii: E479. doi: 10.3390/molecules25030479.


Cysteine-Capped Hydrogels Incorporating Copper as Effective Antimicrobial Materials against Methicillin-Resistant Staphylococcus aureus.

Yang JJ, Huang YC, Chuang TH, Herr DR, Hsieh MF, Huang CJ, Huang CM.

Microorganisms. 2020 Jan 21;8(2). pii: E149. doi: 10.3390/microorganisms8020149.


A conductive cell-delivery construct as a bioengineered patch that can improve electrical propagation and synchronize cardiomyocyte contraction for heart repair.

Chen S, Hsieh MH, Li SH, Wu J, Weisel RD, Chang Y, Sung HW, Li RK.

J Control Release. 2020 Jan 17;320:73-82. doi: 10.1016/j.jconrel.2020.01.027. [Epub ahead of print]


Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase.

Chien YL, Hwu HG, Hwang TJ, Hsieh MH, Liu CC, Lin-Shiau SY, Liu CM.

Prog Neuropsychopharmacol Biol Psychiatry. 2020 Apr 20;99:109868. doi: 10.1016/j.pnpbp.2020.109868. Epub 2020 Jan 16.


Mismatch negativity to different deviant changes in autism spectrum disorders: A meta-analysis.

Chen TC, Hsieh MH, Lin YT, Chan PS, Cheng CH.

Clin Neurophysiol. 2020 Mar;131(3):766-777. doi: 10.1016/j.clinph.2019.10.031. Epub 2020 Jan 1.


Reconstruction for Defects of Total Nail Bed and Germinal Matrix Loss with Acellular Dermal Matrix Coverage and Subsequently Skin Graft.

Liu TH, Hsieh MC, Chou PR, Huang SH.

Medicina (Kaunas). 2020 Jan 3;56(1). pii: E17. doi: 10.3390/medicina56010017.


Tomatidine Represses Invasion and Migration of Human Osteosarcoma U2OS and HOS Cells by Suppression of Presenilin 1 and c-Raf-MEK-ERK Pathway.

Hsieh MH, Yang JS, Lin RC, Hsieh YH, Yang SF, Chang HR, Lu AK.

Molecules. 2020 Jan 13;25(2). pii: E326. doi: 10.3390/molecules25020326.


Impact of Matrix Metalloproteinases 11 Gene Variants on Urothelial Cell Carcinoma Development and Clinical Characteristics.

Li CC, Hsieh MJ, Wang SS, Hung SC, Lin CY, Kuo CW, Yang SF, Chou YE.

Int J Environ Res Public Health. 2020 Jan 11;17(2). pii: E475. doi: 10.3390/ijerph17020475.


Improved appropriateness of anti-tuberculosis prescription by the expert prescription review program in Taiwan.

Hsieh MJ, Huang YW, Tsai YH, Feng JY, Su WJ; Taiwan Society of Tuberculosis and Lung Disease.

J Formos Med Assoc. 2020 Jan 10. pii: S0929-6646(19)31154-4. doi: 10.1016/j.jfma.2019.12.011. [Epub ahead of print]


Breast and colorectal cancer recurrence and progression captured by five U.S. population-based registries: Findings from National Program of Cancer Registries patient-centered outcome research.

Thompson TD, Pollack LA, Johnson CJ, Wu XC, Rees JR, Hsieh MC, Rycroft R, Culp M, Wilson R, Wu M, Zhang K, Benard V.

Cancer Epidemiol. 2020 Feb;64:101653. doi: 10.1016/j.canep.2019.101653. Epub 2020 Jan 6.


Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression.

Hsieh MJ, Huang C, Lin CC, Tang CH, Lin CY, Lee IN, Huang HC, Chen JC.

Mol Carcinog. 2020 Mar;59(3):293-303. doi: 10.1002/mc.23153. Epub 2020 Jan 8.


Erianin Induces Apoptosis and Autophagy in Oral Squamous Cell Carcinoma Cells.

Chen YT, Hsieh MJ, Chen PN, Weng CJ, Yang SF, Lin CW.

Am J Chin Med. 2020;48(1):183-200. doi: 10.1142/S0192415X2050010X. Epub 2020 Jan 6.


Measurement challenge: protocol for international case-control comparison of mammographic measures that predict breast cancer risk.

Dench E, Bond-Smith D, Darcey E, Lee G, Aung YK, Chan A, Cuzick J, Ding ZY, Evans CF, Harvey J, Highnam R, Hsieh MK, Kontos D, Li S, Mariapun S, Nickson C, Nguyen TL, Pertuz S, Procopio P, Rajaram N, Repich K, Tan M, Teo SH, Trinh NH, Ursin G, Wang C, Dos-Santos-Silva I, McCormack V, Nielsen M, Shepherd J, Hopper JL, Stone J.

BMJ Open. 2019 Dec 31;9(12):e031041. doi: 10.1136/bmjopen-2019-031041.

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