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Improved detection of gene fusions by applying statistical methods reveals oncogenic RNA cancer drivers.

Dehghannasiri R, Freeman DE, Jordanski M, Hsieh GL, Damljanovic A, Lehnert E, Salzman J.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15524-15533. doi: 10.1073/pnas.1900391116. Epub 2019 Jul 15.


Exploring the Design and Role of Mobile Apps for Healthcare Providers to Find Teratogenic Information.

Lie L, Shetty V, Gupta K, Polifka JE, Markham G, Albee S, Collins C, Hsieh G.

AMIA Annu Symp Proc. 2018 Apr 16;2017:1100-1109. eCollection 2017.


Flipping Out: Does the Flipped Classroom Learning Model Work for GME?

Cooper AZ, Hsieh G, Kiss JE, Huang GC.

J Grad Med Educ. 2017 Jun;9(3):392-393. doi: 10.4300/JGME-D-16-00827.1. No abstract available.


Statistical algorithms improve accuracy of gene fusion detection.

Hsieh G, Bierman R, Szabo L, Lee AG, Freeman DE, Watson N, Sweet-Cordero EA, Salzman J.

Nucleic Acids Res. 2017 Jul 27;45(13):e126. doi: 10.1093/nar/gkx453.


Crumbs: Lightweight Daily Food Challenges to Promote Engagement and Mindfulness.

Epstein DA, Cordeiro F, Fogarty J, Hsieh G, Munson SA.

Proc SIGCHI Conf Hum Factor Comput Syst. 2016 May;2016:5632-5644. doi: 10.1145/2858036.2858044.


"How Did We Get Here?": Topic Drift in Online Health Discussions.

Park A, Hartzler AL, Huh J, Hsieh G, McDonald DW, Pratt W.

J Med Internet Res. 2016 Nov 2;18(11):e284.


Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.

Frost JM, DeGoey DA, Shi L, Gum RJ, Fricano MM, Lundgaard GL, El-Kouhen OF, Hsieh GC, Neelands T, Matulenko MA, Daanen JF, Pai M, Ghoreishi-Haack N, Zhan C, Zhang XF, Kort ME.

J Med Chem. 2016 Apr 14;59(7):3373-91. doi: 10.1021/acs.jmedchem.6b00063. Epub 2016 Apr 5.


An Effort to Increase Organ Donor Registration Through Intergroup Competition and Electronic Word of Mouth.

Smith SW, Hitt R, Park HS, Walther J, Liang YJ, Hsieh G.

J Health Commun. 2016;21(3):376-86. doi: 10.1080/10810730.2015.1095815. Epub 2016 Jan 6.


Treatment Compliance and Outcomes for Women With Locoregionally Advanced Cervical Cancer Treated in a Safety Net Health System.

Hsieh GL, Linesch S, Sajjad A, Macdonald A, Bonnen M, Anderson ML, Ludwig MS.

Int J Gynecol Cancer. 2015 Nov;25(9):1669-76. doi: 10.1097/IGC.0000000000000537.


Tools for teen moms to reduce infant obesity: a randomized clinical trial.

Horodynski MA, Silk K, Hsieh G, Hoffman A, Robson M.

BMC Public Health. 2015 Jan 21;15:22. doi: 10.1186/s12889-015-1345-x.


Zinc oxide nanowire-poly(methyl methacrylate) dielectric layers for polymer capacitive pressure sensors.

Chen YS, Hsieh GW, Chen SP, Tseng PY, Wang CW.

ACS Appl Mater Interfaces. 2015 Jan 14;7(1):45-50. doi: 10.1021/am505880f. Epub 2014 Dec 12.


Female tubal sterilization: the time has come to routinely consider removal.

Hsieh G, Anderson ML.

Obstet Gynecol. 2014 Nov;124(5):1033. doi: 10.1097/AOG.0000000000000531. No abstract available.


Intraoperative ear bleeding with bilateral otorrhagia during laparoscopic sacrocolpopexy.

Chan R, Cuthbertson D, Jeng Z, Hsieh G, Antosh D.

Female Pelvic Med Reconstr Surg. 2015 Jan-Feb;21(1):e6-7. doi: 10.1097/SPV.0000000000000088.


Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K.

Mol Cancer Ther. 2013 Dec;12(12):2651-62. doi: 10.1158/1535-7163.MCT-13-0103-T. Epub 2013 Oct 15.


Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer.

Cron KR, Zhu K, Kushwaha DS, Hsieh G, Merzon D, Rameseder J, Chen CC, D'Andrea AD, Kozono D.

PLoS One. 2013 Sep 5;8(9):e73710. doi: 10.1371/journal.pone.0073710. eCollection 2013.


Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.

Gong L, Han X, Silva T, Tan YC, Goyal B, Tivitmahaisoon P, Trejo A, Palmer W, Hogg H, Jahagir A, Alam M, Wagner P, Stein K, Filonova L, Loe B, Makra F, Rotstein D, Rapatova L, Dunn J, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Hermann J, Kuglstatter A, Goldstein D.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3565-9. doi: 10.1016/j.bmcl.2013.04.029. Epub 2013 Apr 21.


Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.

Palmer WS, Alam M, Arzeno HB, Chang KC, Dunn JP, Goldstein DM, Gong L, Goyal B, Hermann JC, Hogg JH, Hsieh G, Jahangir A, Janson C, Jin S, Ursula Kammlott R, Kuglstatter A, Lukacs C, Michoud C, Niu L, Reuter DC, Shao A, Silva T, Trejo-Martin TA, Stein K, Tan YC, Tivitmahaisoon P, Tran P, Wagner P, Weller P, Wu SY.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1486-92. doi: 10.1016/j.bmcl.2012.12.047. Epub 2012 Dec 22.


Discovery of a novel series of 4-quinolone JNK inhibitors.

Gong L, Tan YC, Boice G, Abbot S, McCaleb K, Iyer P, Zuo F, Dal Porto J, Wong B, Jin S, Chang A, Tran P, Hsieh G, Niu L, Shao A, Reuter D, Lukacs CM, Ursula Kammlott R, Kuglstatter A, Goldstein D.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7381-7. doi: 10.1016/j.bmcl.2012.10.066. Epub 2012 Oct 24.


Knowledge of sexually transmitted infections among adolescents in the Houston area presenting for reproductive healthcare at Texas Children's Hospital.

Kurkowski JP, Hsieh G, Sokkary N, Santos X, Bercaw-Pratt JL, Dietrich JE.

J Pediatr Adolesc Gynecol. 2012 Jun;25(3):213-7. doi: 10.1016/j.jpag.2012.02.005.


Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation.

Mills C, Leblond D, Joshi S, Zhu C, Hsieh G, Jacobson P, Meyer M, Decker M.

J Pain. 2012 Jun;13(6):519-23. doi: 10.1016/j.jpain.2012.02.009. Epub 2012 Apr 28.


Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Cowart M, Hsieh G, Black LA, Zhan C, Gomez EJ, Pai M, Strakhova M, Manelli A, Carr T, Wetter J, Lee A, Diaz G, Garrison T, Brioni JD.

Eur J Pharmacol. 2012 Jun 5;684(1-3):87-94. doi: 10.1016/j.ejphar.2012.03.048. Epub 2012 Apr 5.


Inkjet-printed graphene electronics.

Torrisi F, Hasan T, Wu W, Sun Z, Lombardo A, Kulmala TS, Hsieh GW, Jung S, Bonaccorso F, Paul PJ, Chu D, Ferrari AC.

ACS Nano. 2012 Apr 24;6(4):2992-3006. doi: 10.1021/nn2044609. Epub 2012 Mar 26.


Synthesis and evaluation of 2-amido-3-carboxamide thiophene CB₂ receptor agonists for pain management.

Nelson DW, Frost JM, Tietje KR, Florjancic AS, Ryther K, Carroll WA, Dart MJ, Daza AV, Hooker BA, Grayson GK, Fan Y, Garrison TR, El-Kouhen OF, Yao B, Pai M, Chandran P, Zhu C, Hsieh GC, Meyer MD.

Bioorg Med Chem Lett. 2012 Apr 1;22(7):2604-8. doi: 10.1016/j.bmcl.2012.01.121. Epub 2012 Feb 4.


Assessing carrageenan-induced locomotor activity impairment in rats: comparison with evoked endpoint of acute inflammatory pain.

Zhu CZ, Mills CD, Hsieh GC, Zhong C, Mikusa J, Lewis LG, Gauvin D, Lee CH, Decker MW, Bannon AW, Rueter LE, Joshi SK.

Eur J Pain. 2012 Jul;16(6):816-26. doi: 10.1002/j.1532-2149.2011.00099.x. Epub 2012 Jan 19.


Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.

Lee Y, Pai M, Brederson JD, Wilcox D, Hsieh G, Jarvis MF, Bitner RS.

Mol Pain. 2011 May 20;7:39. doi: 10.1186/1744-8069-7-39.


Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.

Altenbach RJ, Black LA, Strakhova MI, Manelli AM, Carr TL, Marsh KC, Wetter JM, Wensink EJ, Hsieh GC, Honore P, Garrison TR, Brioni JD, Cowart MD.

J Med Chem. 2010 Nov 11;53(21):7869-73. doi: 10.1021/jm100666w.


Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.

Hsieh GC, Pai M, Chandran P, Hooker BA, Zhu CZ, Salyers AK, Wensink EJ, Zhan C, Carroll WA, Dart MJ, Yao BB, Honore P, Meyer MD.

Br J Pharmacol. 2011 Jan;162(2):428-40. doi: 10.1111/j.1476-5381.2010.01046.x.


Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems.

Hsieh GC, Honore P, Pai M, Wensink EJ, Chandran P, Salyers AK, Wetter JM, Zhao C, Liu H, Decker MW, Esbenshade TA, Cowart MD, Brioni JD.

Brain Res. 2010 Oct 1;1354:74-84. doi: 10.1016/j.brainres.2010.07.083. Epub 2010 Aug 1.


Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle.

Hsieh JC, Slater SA, Whitfield GK, Dawson JL, Hsieh G, Sheedy C, Haussler CA, Haussler MR.

J Cell Biochem. 2010 Jun 1;110(3):671-86. doi: 10.1002/jcb.22578.


Characteristics of norovirus gastroenteritis outbreaks in a psychiatric centre.

Tseng CY, Chen CH, Su SC, Wu FT, Chen CC, Hsieh GY, Hung CH, Fung CP.

Epidemiol Infect. 2011 Feb;139(2):275-85. doi: 10.1017/S0950268810000634. Epub 2010 Mar 25.


Functional genomics to explore cancer cell vulnerabilities.

Kahle KT, Kozono D, Ng K, Hsieh G, Zinn PO, Nitta M, Chen CC.

Neurosurg Focus. 2010 Jan;28(1):E5. doi: 10.3171/2009.10.FOCUS09212.


H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats.

Hsieh GC, Chandran P, Salyers AK, Pai M, Zhu CZ, Wensink EJ, Witte DG, Miller TR, Mikusa JP, Baker SJ, Wetter JM, Marsh KC, Hancock AA, Cowart MD, Esbenshade TA, Brioni JD, Honore P.

Pharmacol Biochem Behav. 2010 Mar;95(1):41-50. doi: 10.1016/j.pbb.2009.12.004. Epub 2009 Dec 11.


Indol-3-ylcycloalkyl ketones: effects of N1 substituted indole side chain variations on CB(2) cannabinoid receptor activity.

Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD.

J Med Chem. 2010 Jan 14;53(1):295-315. doi: 10.1021/jm901214q.


Chemokine receptor blockade with a synthetic nonpeptide compound attenuates cardiac allograft vasculopathy.

Bastani S, Sherman W, Schnickel GT, Hsieh GR, Bhatia R, Fishbein MC, Ardehali A.

Transplantation. 2009 Oct 27;88(8):995-1001. doi: 10.1097/TP.0b013e3181b9ccd5.


Discovery and biological evaluation of novel cyanoguanidine P2X(7) antagonists with analgesic activity in a rat model of neuropathic pain.

Perez-Medrano A, Donnelly-Roberts DL, Honore P, Hsieh GC, Namovic MT, Peddi S, Shuai Q, Wang Y, Faltynek CR, Jarvis MF, Carroll WA.

J Med Chem. 2009 May 28;52(10):3366-76. doi: 10.1021/jm8015848.


Pharmacological modulation of movement-evoked pain in a rat model of osteoarthritis.

Chandran P, Pai M, Blomme EA, Hsieh GC, Decker MW, Honore P.

Eur J Pharmacol. 2009 Jun 24;613(1-3):39-45. doi: 10.1016/j.ejphar.2009.04.009. Epub 2009 Apr 16.


Peripheral and central sites of action for the non-selective cannabinoid agonist WIN 55,212-2 in a rat model of post-operative pain.

Zhu CZ, Mikusa JP, Fan Y, Hollingsworth PR, Pai M, Chandran P, Daza AV, Yao BB, Dart MJ, Meyer MD, Decker MW, Hsieh GC, Honore P.

Br J Pharmacol. 2009 Jun;157(4):645-55. doi: 10.1111/j.1476-5381.2009.00184.x. Epub 2009 Apr 3.


Localization of histamine H4 receptors in the central nervous system of human and rat.

Strakhova MI, Nikkel AL, Manelli AM, Hsieh GC, Esbenshade TA, Brioni JD, Bitner RS.

Brain Res. 2009 Jan 23;1250:41-8. doi: 10.1016/j.brainres.2008.11.018. Epub 2008 Nov 19.


cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Liu H, Altenbach RJ, Carr TL, Chandran P, Hsieh GC, Lewis LG, Manelli AM, Milicic I, Marsh KC, Miller TR, Strakhova MI, Vortherms TA, Wakefield BD, Wetter JM, Witte DG, Honore P, Esbenshade TA, Brioni JD, Cowart MD.

J Med Chem. 2008 Nov 27;51(22):7094-8. doi: 10.1021/jm8007618.


Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging.

Yao BB, Hsieh G, Daza AV, Fan Y, Grayson GK, Garrison TR, El Kouhen O, Hooker BA, Pai M, Wensink EJ, Salyers AK, Chandran P, Zhu CZ, Zhong C, Ryther K, Gallagher ME, Chin CL, Tovcimak AE, Hradil VP, Fox GB, Dart MJ, Honore P, Meyer MD.

J Pharmacol Exp Ther. 2009 Jan;328(1):141-51. doi: 10.1124/jpet.108.145011. Epub 2008 Oct 17.


Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

Cowart MD, Altenbach RJ, Liu H, Hsieh GC, Drizin I, Milicic I, Miller TR, Witte DG, Wishart N, Fix-Stenzel SR, McPherson MJ, Adair RM, Wetter JM, Bettencourt BM, Marsh KC, Sullivan JP, Honore P, Esbenshade TA, Brioni JD.

J Med Chem. 2008 Oct 23;51(20):6547-57. doi: 10.1021/jm800670r. Epub 2008 Sep 26.


Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.

Altenbach RJ, Adair RM, Bettencourt BM, Black LA, Fix-Stenzel SR, Gopalakrishnan SM, Hsieh GC, Liu H, Marsh KC, McPherson MJ, Milicic I, Miller TR, Vortherms TA, Warrior U, Wetter JM, Wishart N, Witte DG, Honore P, Esbenshade TA, Hancock AA, Brioni JD, Cowart MD.

J Med Chem. 2008 Oct 23;51(20):6571-80. doi: 10.1021/jm8005959. Epub 2008 Sep 24.


A healthcare integration system for disease assessment and safety monitoring of dementia patients.

Lin CC, Lin PY, Lu PK, Hsieh GY, Lee WL, Lee RG.

IEEE Trans Inf Technol Biomed. 2008 Sep;12(5):579-86. doi: 10.1109/TITB.2008.917914.


Increased risk of death with congenital anomalies in the offspring of male semiconductor workers.

Lin CC, Wang JD, Hsieh GY, Chang YY, Chen PC.

Int J Occup Environ Health. 2008 Apr-Jun;14(2):112-6.


Health risk in the offspring of female semiconductor workers.

Lin CC, Wang JD, Hsieh GY, Chang YY, Chen PC.

Occup Med (Lond). 2008 Sep;58(6):388-92. doi: 10.1093/occmed/kqn046. Epub 2008 May 7.


Combined CXCR3/CCR5 blockade attenuates acute and chronic rejection.

Schnickel GT, Bastani S, Hsieh GR, Shefizadeh A, Bhatia R, Fishbein MC, Belperio J, Ardehali A.

J Immunol. 2008 Apr 1;180(7):4714-21.


Indol-3-yl-tetramethylcyclopropyl ketones: effects of indole ring substitution on CB2 cannabinoid receptor activity.

Frost JM, Dart MJ, Tietje KR, Garrison TR, Grayson GK, Daza AV, El-Kouhen OF, Miller LN, Li L, Yao BB, Hsieh GC, Pai M, Zhu CZ, Chandran P, Meyer MD.

J Med Chem. 2008 Mar 27;51(6):1904-12. doi: 10.1021/jm7011613. Epub 2008 Feb 27.


In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models.

Yao BB, Hsieh GC, Frost JM, Fan Y, Garrison TR, Daza AV, Grayson GK, Zhu CZ, Pai M, Chandran P, Salyers AK, Wensink EJ, Honore P, Sullivan JP, Dart MJ, Meyer MD.

Br J Pharmacol. 2008 Jan;153(2):390-401. Epub 2007 Nov 12.


Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI.

Chin CL, Tovcimak AE, Hradil VP, Seifert TR, Hollingsworth PR, Chandran P, Zhu CZ, Gauvin D, Pai M, Wetter J, Hsieh GC, Honore P, Frost JM, Dart MJ, Meyer MD, Yao BB, Cox BF, Fox GB.

Br J Pharmacol. 2008 Jan;153(2):367-79. Epub 2007 Oct 29.


Design and implementation of a mobile-care system over wireless sensor network for home healthcare applications.

Lee RG, Lai CC, Chiang SS, Liu HS, Chen CC, Hsieh GY.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:6004-7.


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