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A molecular mechanism underlying genotype-specific intrahepatic cholestasis resulting from MYO5B mutations.

Overeem AW, Li Q, Qiu YL, Carton-Garciá F, Leng C, Klappe K, Dronkers J, Hsiao NH, Wang JS, Arango D, van IJzendoorn SCD.

Hepatology. 2019 Nov 21. doi: 10.1002/hep.31002. [Epub ahead of print]


Use of an Indeterminate Range in HIV Early Infant Diagnosis: A Systematic Review and Meta-Analysis.

Luo R, Boeras D, Broyles LN, Fong Y, Hsiao NY, Kiyaga C, Mazanderani AH, Myer L, Shapiro R, Sherman G, Penazzato M, Doherty M, Vojnov L.

J Acquir Immune Defic Syndr. 2019 Nov 1;82(3):281-286. doi: 10.1097/QAI.0000000000002104.


Bias in the estimation of cumulative viremia in cohort studies of HIV-infected individuals.

Lesosky M, Glass T, Rambau B, Hsiao NY, Abrams EJ, Myer L.

Ann Epidemiol. 2019 Oct;38:22-27. doi: 10.1016/j.annepidem.2019.08.008. Epub 2019 Aug 23.


Reliability of plasma HIV viral load testing beyond 24 hours: Insights gained from a study in a routine diagnostic laboratory.

Hardie D, Korsman S, Ameer S, Vojnov L, Hsiao NY.

PLoS One. 2019 Jul 3;14(7):e0219381. doi: 10.1371/journal.pone.0219381. eCollection 2019.


Antiretroviral Adherence, Elevated Viral Load, and Drug Resistance Mutations in Human Immunodeficiency Virus-infected Women Initiating Treatment in Pregnancy: A Nested Case-control Study.

Myer L, Redd AD, Mukonda E, Lynch BA, Phillips TK, Eisenberg A, Hsiao NY, Capoferri A, Zerbe A, Clarke W, Lesosky M, Breaud A, McIntyre J, Bruno D, Martens C, Abrams EJ, Reynolds SJ.

Clin Infect Dis. 2020 Jan 16;70(3):501-508. doi: 10.1093/cid/ciz209.


Integration of postpartum healthcare services for HIV-infected women and their infants in South Africa: A randomised controlled trial.

Myer L, Phillips TK, Zerbe A, Brittain K, Lesosky M, Hsiao NY, Remien RH, Mellins CA, McIntyre JA, Abrams EJ.

PLoS Med. 2018 Mar 30;15(3):e1002547. doi: 10.1371/journal.pmed.1002547. eCollection 2018 Mar.


Field evaluation of HIV point-of-care testing for early infant diagnosis in Cape Town, South Africa.

Dunning L, Kroon M, Hsiao NY, Myer L.

PLoS One. 2017 Dec 20;12(12):e0189226. doi: 10.1371/journal.pone.0189226. eCollection 2017.


Optimal timing of viral load monitoring during pregnancy to predict viraemia at delivery in HIV-infected women initiating ART in South Africa: a simulation study.

Lesosky M, Glass T, Mukonda E, Hsiao NY, Abrams EJ, Myer L.

J Int AIDS Soc. 2017 Nov;20 Suppl 7. doi: 10.1002/jia2.25000.


Misdiagnosed HIV infection in pregnant women initiating universal ART in South Africa.

Hsiao NY, Zerbe A, Phillips TK, Myer L, Abrams EJ.

J Int AIDS Soc. 2017 Aug 29;20(Suppl 6):21758. doi: 10.7448/IAS.20.7.21758.


Contamination with HIV antibody may be responsible for false positive results in specimens tested on automated platforms running HIV 4th generation assays in a region of high HIV prevalence.

Hardie DR, Korsman SN, Hsiao NY, Morobadi MD, Vawda S, Goedhals D.

PLoS One. 2017 Jul 31;12(7):e0182167. doi: 10.1371/journal.pone.0182167. eCollection 2017.


Frequency of Viremic Episodes in HIV-Infected Women Initiating Antiretroviral Therapy During Pregnancy: A Cohort Study.

Myer L, Dunning L, Lesosky M, Hsiao NY, Phillips T, Petro G, Zerbe A, McIntyre JA, Abrams EJ.

Clin Infect Dis. 2017 Feb 15;64(4):422-427. doi: 10.1093/cid/ciw792.


Optimizing Antiretroviral Therapy (ART) for Maternal and Child Health (MCH): Rationale and Design of the MCH-ART Study.

Myer L, Phillips TK, Zerbe A, Ronan A, Hsiao NY, Mellins CA, Remien RH, Le Roux SM, Brittain K, Ciaranello A, Petro G, McIntyre JA, Abrams EJ.

J Acquir Immune Defic Syndr. 2016 Aug 1;72 Suppl 2:S189-96. doi: 10.1097/QAI.0000000000001056.


HIV viraemia and mother-to-child transmission risk after antiretroviral therapy initiation in pregnancy in Cape Town, South Africa.

Myer L, Phillips TK, McIntyre JA, Hsiao NY, Petro G, Zerbe A, Ramjith J, Bekker LG, Abrams EJ.

HIV Med. 2017 Feb;18(2):80-88. doi: 10.1111/hiv.12397. Epub 2016 Jun 28.


Discovery of a potent cyclooxygenase-2 inhibitor, S4, through docking-based pharmacophore screening, in vivo and in vitro estimations.

Tseng TS, Chuang SM, Hsiao NW, Chen YW, Lee YC, Lin CC, Huang C, Tsai KC.

Mol Biosyst. 2016 Jul 19;12(8):2541-51. doi: 10.1039/c6mb00229c.


Clinical characterisation and phylogeny of respiratory syncytial virus infection in hospitalised children at Red Cross War Memorial Children's Hospital, Cape Town.

Oladokun R, Muloiwa R, Hsiao NY, Valley-Omar Z, Nuttall J, Eley B.

BMC Infect Dis. 2016 May 31;16:236. doi: 10.1186/s12879-016-1572-5.


Recommendations for the management of indeterminate HIV PCR results within South Africa's early infant diagnosis programme.

Mazanderani AH, Technau KG, Hsiao NY, Maritz J, Carmona S, Sherman GG.

South Afr J HIV Med. 2016 May 13;17(1):451. doi: 10.4102/sajhivmed.v17i1.451. eCollection 2016. Review.


Laboratory Evaluation of the Alere q Point-of-Care System for Early Infant HIV Diagnosis.

Hsiao NY, Dunning L, Kroon M, Myer L.

PLoS One. 2016 Mar 31;11(3):e0152672. doi: 10.1371/journal.pone.0152672. eCollection 2016.


Comparative study between 3D-QSAR and Docking-Based Pharmacophore models for potent Plasomodium falciparum dihydroorotate dehydrogenase inhibitors.

Tseng TS, Lee YC, Hsiao NW, Liu YR, Tsai KC.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):265-271. doi: 10.1016/j.bmcl.2015.12.043. Epub 2015 Dec 12.


False-negative HIV-1 polymerase chain reaction in a 15-month-old boy with HIV-1 subtype C infection.

Oladokun R, Korsman S, Ndabambi N, Hsiao N, Hans L, Williamson C, Abrahams MR, Eley B.

S Afr Med J. 2015 Oct;105(10):877.


Point-of-care HIV early infant diagnosis: is test sensitivity everything?

Dunning L, Hsiao NY, Myer L.

J Int AIDS Soc. 2015 Sep 4;18:20235. doi: 10.7448/IAS.18.1.20235. eCollection 2015.


Surgical manifestations of gastrointestinal cytomegalovirus infection in children: Clinical audit and literature review.

Arnold M, Itzikowitz R, Young B, Machoki SM, Hsiao NY, Pillay K, Alexander A.

J Pediatr Surg. 2015 Nov;50(11):1874-9. doi: 10.1016/j.jpedsurg.2015.06.018. Epub 2015 Jun 30. Review.


Plasma viraemia in HIV-positive pregnant women entering antenatal care in South Africa.

Myer L, Phillips TK, Hsiao NY, Zerbe A, Petro G, Bekker LG, McIntyre JA, Abrams EJ.

J Int AIDS Soc. 2015 Jul 6;18:20045. doi: 10.7448/IAS.18.1.20045. eCollection 2015.


Discovery of Potent Cysteine-Containing Dipeptide Inhibitors against Tyrosinase: A Comprehensive Investigation of 20 × 20 Dipeptides in Inhibiting Dopachrome Formation.

Tseng TS, Tsai KC, Chen WC, Wang YT, Lee YC, Lu CK, Don MJ, Chang CY, Lee CH, Lin HH, Hsu HJ, Hsiao NW.

J Agric Food Chem. 2015 Jul 15;63(27):6181-8. doi: 10.1021/acs.jafc.5b01026. Epub 2015 Jun 26.


Discovery of highly potent tyrosinase inhibitor, T1, with significant anti-melanogenesis ability by zebrafish in vivo assay and computational molecular modeling.

Chen WC, Tseng TS, Hsiao NW, Lin YL, Wen ZH, Tsai CC, Lee YC, Lin HH, Tsai KC.

Sci Rep. 2015 Jan 23;5:7995. doi: 10.1038/srep07995.


Phage display-mediated discovery of novel tyrosinase-targeting tetrapeptide inhibitors reveals the significance of N-terminal preference of cysteine residues and their functional sulfur atom.

Lee YC, Hsiao NW, Tseng TS, Chen WC, Lin HH, Leu SJ, Yang EW, Tsai KC.

Mol Pharmacol. 2015 Feb;87(2):218-30. doi: 10.1124/mol.114.094185. Epub 2014 Nov 17.


Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors.

Hsiao NW, Tseng TS, Lee YC, Chen WC, Lin HH, Chen YR, Wang YT, Hsu HJ, Tsai KC.

J Chem Inf Model. 2014 Nov 24;54(11):3099-111. doi: 10.1021/ci500370x. Epub 2014 Oct 30.


The S100A4 D10V polymorphism is related to cell migration ability but not drug resistance in gastric cancer cells.

Yuan TM, Liang RY, Hsiao NW, Chuang SM.

Oncol Rep. 2014 Dec;32(6):2307-18. doi: 10.3892/or.2014.3540. Epub 2014 Oct 13.


Development of 3D-QSAR combination approach for discovering and analysing neuraminidase inhibitors in silico.

Lin CY, Chi HC, Shih KC, Zhou J, Hsiao NW, Tang CY.

Int J Data Min Bioinform. 2014;9(3):305-20.


Birth prevalence of congenital cytomegalovirus among infants of HIV-infected women on prenatal antiretroviral prophylaxis in South Africa.

Manicklal S, van Niekerk AM, Kroon SM, Hutto C, Novak Z, Pati SK, Chowdhury N, Hsiao NY, Boppana SB.

Clin Infect Dis. 2014 May;58(10):1467-72. doi: 10.1093/cid/ciu096. Epub 2014 Feb 23.


Myosin Vb and Rab11a regulate phosphorylation of ezrin in enterocytes.

Dhekne HS, Hsiao NH, Roelofs P, Kumari M, Slim CL, Rings EH, van Ijzendoorn SC.

J Cell Sci. 2014 Mar 1;127(Pt 5):1007-17. doi: 10.1242/jcs.137273. Epub 2014 Jan 10.


Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients.

Hsu YC, Lin JT, Ho HJ, Kao YH, Huang YT, Hsiao NW, Wu MS, Liu YY, Wu CY.

Hepatology. 2014 Apr;59(4):1293-302. doi: 10.1002/hep.26892. Epub 2014 Feb 18.


Cytomegalovirus load in whole blood is more reliable for predicting and assessing CMV disease than pp65 antigenaemia.

Hardie DR, Korsman SN, Hsiao NY.

J Virol Methods. 2013 Oct;193(1):166-8. doi: 10.1016/j.jviromet.2013.06.019. Epub 2013 Jun 20.


Novel respiratory syncytial virus subtype ON1 among children, Cape Town, South Africa, 2012.

Valley-Omar Z, Muloiwa R, Hu NC, Eley B, Hsiao NY.

Emerg Infect Dis. 2013 Apr;19(4):668-70. doi: 10.3201/eid1904.121465. No abstract available.


Cytomegalovirus viraemia in HIV exposed and infected infants: prevalence and clinical utility for diagnosing CMV pneumonia.

Hsiao NY, Zampoli M, Morrow B, Zar HJ, Hardie D.

J Clin Virol. 2013 Sep;58(1):74-8. doi: 10.1016/j.jcv.2013.05.002. Epub 2013 May 31.


CLMP is essential for intestinal development, but does not play a key role in cellular processes involved in intestinal epithelial development.

van der Werf CS, Hsiao NH, Conroy S, Paredes J, Ribeiro AS, Sribudiani Y, Seruca R, Hofstra RM, Westers H, van Ijzendoorn SC.

PLoS One. 2013;8(2):e54649. doi: 10.1371/journal.pone.0054649. Epub 2013 Feb 27.


Linkage of HIV-infected infants from diagnosis to antiretroviral therapy services across the Western Cape, South Africa.

Hsiao NY, Stinson K, Myer L.

PLoS One. 2013;8(2):e55308. doi: 10.1371/journal.pone.0055308. Epub 2013 Feb 6.


Impact of thyroid dysfunction on erythropoietin dosage in hemodialysis patients.

Ng YY, Lin HD, Wu SC, Yang CY, Yang WC, Liou HH, Hu FH, Hou CC, Tseng SS, Ku NY, Hsiao NY, Wu WC, Tu HM, Lien TJ, Lee CC, Tsang KK, Cheng CS, Hu J, Lin RP.

Thyroid. 2013 May;23(5):552-61. doi: 10.1089/thy.2011.0495. Epub 2013 Apr 18.


Dg-Dys-Syn1 signaling in Drosophila regulates the microRNA profile.

Marrone AK, Edeleva EV, Kucherenko MM, Hsiao NH, Shcherbata HR.

BMC Cell Biol. 2012 Oct 29;13:26. doi: 10.1186/1471-2121-13-26.


Characterization of glycine substitution mutations within the putative NAD+-binding site of Bacillus licheniformis aldehyde dehydrogenase.

Lee YC, Lin DT, Chen HL, Lo HF, Hu HY, Hsiao NW, Lin LL.

Protein Pept Lett. 2012 Nov;19(11):1183-93.


Fisetin and rutin as 3C protease inhibitors of enterovirus A71.

Lin YJ, Chang YC, Hsiao NW, Hsieh JL, Wang CY, Kung SH, Tsai FJ, Lan YC, Lin CW.

J Virol Methods. 2012 Jun;182(1-2):93-8. doi: 10.1016/j.jviromet.2012.03.020. Epub 2012 Mar 23.


CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome.

Van Der Werf CS, Wabbersen TD, Hsiao NH, Paredes J, Etchevers HC, Kroisel PM, Tibboel D, Babarit C, Schreiber RA, Hoffenberg EJ, Vekemans M, Zeder SL, Ceccherini I, Lyonnet S, Ribeiro AS, Seruca R, Te Meerman GJ, van Ijzendoorn SC, Shepherd IT, Verheij JB, Hofstra RM.

Gastroenterology. 2012 Mar;142(3):453-462.e3. doi: 10.1053/j.gastro.2011.11.038. Epub 2011 Dec 7.


Design of novel FLT-3 inhibitors based on dual-layer 3D-QSAR model and fragment-based compounds in silico.

Shih KC, Lin CY, Chi HC, Hwang CS, Chen TS, Tang CY, Hsiao NW.

J Chem Inf Model. 2012 Jan 23;52(1):146-55. doi: 10.1021/ci200434f. Epub 2011 Dec 16.


Improved detection of Pneumocystis jirovecii in upper and lower respiratory tract specimens from children with suspected pneumocystis pneumonia using real-time PCR: a prospective study.

Samuel CM, Whitelaw A, Corcoran C, Morrow B, Hsiao NY, Zampoli M, Zar HJ.

BMC Infect Dis. 2011 Nov 28;11:329. doi: 10.1186/1471-2334-11-329.


Production of Active Nonglycosylated Recombinant B-Chain of Type-2 Ribosome-Inactivating Protein from Viscum articulatum and Its Biological Effects on Peripheral Blood Mononuclear Cells.

Lu TL, Chuang JY, Yang JS, Chiu ST, Hsiao NW, Wu MC, Wu SH, Hsu CH.

Evid Based Complement Alternat Med. 2011;2011:283747. doi: 10.1155/2011/283747. Epub 2011 Mar 30.


Prevalence and outcome of cytomegalovirus-associated pneumonia in relation to human immunodeficiency virus infection.

Zampoli M, Morrow B, Hsiao NY, Whitelaw A, Zar HJ.

Pediatr Infect Dis J. 2011 May;30(5):413-7. doi: 10.1097/INF.0b013e3182065197.


Structural and functional comparisons and production of recombinant crustacean hyperglycemic hormone (CHH) and CHH-like peptides from the mud crab Scylla olivacea.

Chang CC, Tsai KW, Hsiao NW, Chang CY, Lin CL, Watson RD, Lee CY.

Gen Comp Endocrinol. 2010 May 15;167(1):68-76. doi: 10.1016/j.ygcen.2010.02.013. Epub 2010 Feb 18.


A comparison of different electrostatic potentials on prediction accuracy in CoMFA and CoMSIA studies.

Tsai KC, Chen YC, Hsiao NW, Wang CL, Lin CL, Lee YC, Li M, Wang B.

Eur J Med Chem. 2010 Apr;45(4):1544-51. doi: 10.1016/j.ejmech.2009.12.063. Epub 2010 Jan 13.


ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells.

Hsiao NW, Chen JW, Yang TC, Orloff GM, Wu YY, Lai CH, Lan YC, Lin CW.

Antiviral Res. 2010 Mar;85(3):504-11. doi: 10.1016/j.antiviral.2009.12.007. Epub 2009 Dec 24.


Predicting melting temperature directly from protein sequences.

Ku T, Lu P, Chan C, Wang T, Lai S, Lyu P, Hsiao N.

Comput Biol Chem. 2009 Dec;33(6):445-50. doi: 10.1016/j.compbiolchem.2009.10.002. Epub 2009 Oct 20.


Analysis of two additional signaling molecules in Streptomyces coelicolor and the development of a butyrolactone-specific reporter system.

Hsiao NH, Nakayama S, Merlo ME, de Vries M, Bunet R, Kitani S, Nihira T, Takano E.

Chem Biol. 2009 Sep 25;16(9):951-60. doi: 10.1016/j.chembiol.2009.08.010.

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