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Items: 16

1.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G.

J Med Chem. 2018 Dec 13;61(23):10415-10439. doi: 10.1021/acs.jmedchem.8b00392. Epub 2018 Sep 9.

PMID:
30130103
2.

Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.

Miller AA, Bundy GL, Mott JE, Skepner JE, Boyle TP, Harris DW, Hromockyj AE, Marotti KR, Zurenko GE, Munzner JB, Sweeney MT, Bammert GF, Hamel JC, Ford CW, Zhong WZ, Graber DR, Martin GE, Han F, Dolak LA, Seest EP, Ruble JC, Kamilar GM, Palmer JR, Banitt LS, Hurd AR, Barbachyn MR.

Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12. doi: 10.1128/AAC.00247-08. Epub 2008 Jun 2.

3.

Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat.

Bolten CW, Payne MA, McDonald WG, Blanner PM, Chott RC, Ghosh S, Arhancet GB, Staten NR, Gulve EA, Sullivan PM, Hromockyj AE, Colca JR.

Diab Vasc Dis Res. 2007 Jun;4(2):117-23.

PMID:
17654445
4.

Insulin sensitizing pharmacology of thiazolidinediones correlates with mitochondrial gene expression rather than activation of PPAR gamma.

Bolten CW, Blanner PM, McDonald WG, Staten NR, Mazzarella RA, Arhancet GB, Meier MF, Weiss DJ, Sullivan PM, Hromockyj AE, Kletzien RF, Colca JR.

Gene Regul Syst Bio. 2007 Sep 17;1:73-82.

5.

The discovery of biaryl acids and amides exhibiting antibacterial activity against Gram-positive bacteria.

Look GC, Vacin C, Dias TM, Ho S, Tran TH, Lee LL, Wiesner C, Fang F, Marra A, Westmacott D, Hromockyj AE, Murphy MM, Schullek JR.

Bioorg Med Chem Lett. 2004 Mar 22;14(6):1423-6.

PMID:
15006375
6.

In vivo characterization of the psa genes from Streptococcus pneumoniae in multiple models of infection.

Marra A, Lawson S, Asundi JS, Brigham D, Hromockyj AE.

Microbiology. 2002 May;148(Pt 5):1483-91.

PMID:
11988523
7.

Differential fluorescence induction analysis of Streptococcus pneumoniae identifies genes involved in pathogenesis.

Marra A, Asundi J, Bartilson M, Lawson S, Fang F, Christine J, Wiesner C, Brigham D, Schneider WP, Hromockyj AE.

Infect Immun. 2002 Mar;70(3):1422-33.

8.
9.

Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide.

Bartilson M, Marra A, Christine J, Asundi JS, Schneider WP, Hromockyj AE.

Mol Microbiol. 2001 Jan;39(1):126-35.

10.

Salmonella typhimurium invasion induces apoptosis in infected macrophages.

Monack DM, Raupach B, Hromockyj AE, Falkow S.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9833-8.

11.

Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions.

Valdivia RH, Hromockyj AE, Monack D, Ramakrishnan L, Falkow S.

Gene. 1996;173(1 Spec No):47-52.

PMID:
8707055
13.

Environmental regulation of Shigella virulence.

Maurelli AT, Hromockyj AE, Bernardini ML.

Curr Top Microbiol Immunol. 1992;180:95-116. Review. No abstract available.

PMID:
1324135
14.

Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens.

Andrews GP, Hromockyj AE, Coker C, Maurelli AT.

Infect Immun. 1991 Jun;59(6):1997-2005.

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