Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 57

1.

The Absolute Bioavailability and Effect of Food on the Pharmacokinetics of Odanacatib: A Stable-Label i.v./Oral Study in Healthy Postmenopausal Women.

Zajic S, Rossenu S, Hreniuk D, Kesisoglou F, McCrea J, Liu F, Sun L, Witter R, Gauthier D, Helmy R, Joss D, Ni T, Stoltz R, Stone J, Stoch SA.

Drug Metab Dispos. 2016 Sep;44(9):1450-8. doi: 10.1124/dmd.116.069906. Epub 2016 Jul 11.

PMID:
27402726
2.

Prednisone has no effect on the pharmacokinetics of CYP3A4 metabolized drugs - midazolam and odanacatib.

Marcantonio EE, Ballard J, Gibson CR, Kassahun K, Palamanda J, Tang C, Evers R, Liu C, Zajic S, Mahon C, Mostoller K, Hreniuk D, Mehta A, Morris D, Wagner JA, Stoch SA.

J Clin Pharmacol. 2014 Nov;54(11):1280-9. doi: 10.1002/jcph.338. Epub 2014 Jun 25.

PMID:
24895078
3.

Absence of clinically relevant drug-drug interaction between odanacatib and digoxin after concomitant administration.

Stoch SA, Witter R, Hreniuk D, Liu C, Zajic S, Mehta A, Brandquist C, Dempsey C, Degroot B, Stypinski D, Denker A, Wagner JA.

Int J Clin Pharmacol Ther. 2013 Aug;51(8):688-92. doi: 10.5414/CP201864.

PMID:
23782582
4.

Pharmacokinetics and tolerability of rizatriptan in pediatric migraineurs in a randomized study.

Fraser IP, Han L, Han TH, Li CC, Hreniuk D, Stoch SA, Wagner JA, Linder S, Winner P.

Headache. 2012 Apr;52(4):625-35. doi: 10.1111/j.1526-4610.2011.02069.x. Epub 2012 Jan 30.

PMID:
22289113
5.

Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.

Morriello GJ, Wendt HR, Bansal A, Di Salvo J, Feighner S, He J, Hurley AL, Hreniuk DL, Salituro GM, Reddy MV, Galloway SM, McGettigan KK, Laws G, McKnight C, Doss GA, Tsou NN, Black RM, Morris J, Ball RG, Sanfiz AT, Streckfuss E, Struthers M, Edmondson SD.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1865-70. doi: 10.1016/j.bmcl.2010.12.087. Epub 2010 Dec 25.

PMID:
21353541
6.

Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.

Goble SD, Wang L, Howell KL, Bansal A, Berger R, Brockunier L, DiSalvo J, Feighner S, Harper B, He J, Hurley A, Hreniuk D, Parmee E, Robbins M, Salituro G, Sanfiz A, Streckfuss E, Watkins E, Weber AE, Struthers M, Edmondson SD.

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1895-9. doi: 10.1016/j.bmcl.2010.01.130. Epub 2010 Feb 4.

PMID:
20181479
7.

Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.

Pasternak A, Goble SD, deJesus RK, Hreniuk DL, Chung CC, Tota MR, Mazur P, Feighner SD, Howard AD, Mills SG, Yang L.

Bioorg Med Chem Lett. 2009 Nov 1;19(21):6237-40. doi: 10.1016/j.bmcl.2009.08.076. Epub 2009 Aug 26.

PMID:
19767208
8.

A thorough QTc study to assess the effect of sitagliptin, a DPP4 inhibitor, on ventricular repolarization in healthy subjects.

Bloomfield DM, Krishna R, Hreniuk D, Hickey L, Ghosh K, Bergman AJ, Miller J, Gutierrez MJ, Stoltz R, Gottesdiener KM, Herman GA, Wagner JA.

J Clin Pharmacol. 2009 Aug;49(8):937-46. doi: 10.1177/0091270009337511.

PMID:
19602719
9.

Single-dose administration of MK-0657, an NR2B-selective NMDA antagonist, does not result in clinically meaningful improvement in motor function in patients with moderate Parkinson's disease.

Addy C, Assaid C, Hreniuk D, Stroh M, Xu Y, Herring WJ, Ellenbogen A, Jinnah HA, Kirby L, Leibowitz MT, Stewart RM, Tarsy D, Tetrud J, Stoch SA, Gottesdiener K, Wagner J.

J Clin Pharmacol. 2009 Jul;49(7):856-64. doi: 10.1177/0091270009336735. Epub 2009 Jun 2.

PMID:
19491335
10.

The effect of moxifloxacin on QTc and implications for the design of thorough QT studies.

Bloomfield DM, Kost JT, Ghosh K, Hreniuk D, Hickey LA, Guitierrez MJ, Gottesdiener K, Wagner JA.

Clin Pharmacol Ther. 2008 Oct;84(4):475-80.

PMID:
19238652
11.

Sitagliptin, an dipeptidyl peptidase-4 inhibitor, does not alter the pharmacokinetics of the sulphonylurea, glyburide, in healthy subjects.

Mistry GC, Bergman AJ, Zheng W, Hreniuk D, Zinny MA, Gottesdiener KM, Wagner JA, Herman GA, Ruddy M.

Br J Clin Pharmacol. 2008 Jul;66(1):36-42. doi: 10.1111/j.1365-2125.2008.03148.x. Epub 2008 May 22.

12.

Effects of etoricoxib and comparator nonsteroidal anti-inflammatory drugs on urinary sodium excretion, blood pressure, and other renal function indicators in elderly subjects consuming a controlled sodium diet.

Schwartz JI, Thach C, Lasseter KC, Miller J, Hreniuk D, Hilliard DA, Snyder KM, Gertz BJ, Gottesdiener KM.

J Clin Pharmacol. 2007 Dec;47(12):1521-31. Epub 2007 Oct 9.

PMID:
17925592
13.

Metabolism and disposition in humans of raltegravir (MK-0518), an anti-AIDS drug targeting the human immunodeficiency virus 1 integrase enzyme.

Kassahun K, McIntosh I, Cui D, Hreniuk D, Merschman S, Lasseter K, Azrolan N, Iwamoto M, Wagner JA, Wenning LA.

Drug Metab Dispos. 2007 Sep;35(9):1657-63. Epub 2007 Jun 25.

PMID:
17591678
14.

2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists.

Jiang J, Hoang M, Young JR, Chaung D, Eid R, Turner C, Lin P, Tong X, Wang J, Tan C, Feighner S, Palyha O, Hreniuk DL, Pan J, Sailer AW, MacNeil DJ, Howard A, Shearman L, Stribling S, Camacho R, Strack A, Van der Ploeg LH, Goulet MT, DeVita RJ.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5270-4. Epub 2006 Aug 17.

PMID:
16919456
15.

4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

Jiang J, Lin P, Hoang M, Chang L, Tan C, Feighner S, Palyha OC, Hreniuk DL, Pan J, Sailer AW, Morin NR, MacNeil DJ, Howard AD, Van der Ploeg LH, Goulet MT, DeVita RJ.

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5275-9. Epub 2006 Aug 17.

PMID:
16919453
16.

Bioequivalence of an ezetimibe/simvastatin combination tablet and coadministration of ezetimibe and simvastatin as separate tablets in healthy subjects.

Migoya EM, Bergman A, Hreniuk D, Matthews N, Yi B, Roadcap B, Valesky R, Liu L, Riffel K, Groff M, Zhao JJ, Musson DG, Gambale J, Kosoglou T, Statkevich P, Lasseter KC, Laurent A, Johnson-Levonas AO, Murphy G, Gottesdiener K, Paolini JF.

Int J Clin Pharmacol Ther. 2006 Feb;44(2):83-92.

PMID:
16502768
17.

Increased melanin concentrating hormone receptor type I in the human hypothalamic infundibular nucleus in cachexia.

Unmehopa UA, van Heerikhuize JJ, Spijkstra W, Woods JW, Howard AD, Zycband E, Feighner SD, Hreniuk DL, Palyha OC, Guan XM, Macneil DJ, Van der Ploeg LH, Swaab DF.

J Clin Endocrinol Metab. 2005 Apr;90(4):2412-9. Epub 2005 Jan 25.

PMID:
15671106
18.

Characterization of the bombesin-like peptide receptor family in primates.

Sano H, Feighner SD, Hreniuk DL, Iwaasa H, Sailer AW, Pan J, Reitman ML, Kanatani A, Howard AD, Tan CP.

Genomics. 2004 Jul;84(1):139-46.

PMID:
15203211
19.

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats.

Shearman LP, Camacho RE, Sloan Stribling D, Zhou D, Bednarek MA, Hreniuk DL, Feighner SD, Tan CP, Howard AD, Van der Ploeg LH, MacIntyre DE, Hickey GJ, Strack AM.

Eur J Pharmacol. 2003 Aug 15;475(1-3):37-47.

PMID:
12954357
20.

Gene therapy vector-mediated expression of insulin-like growth factors protects cardiomyocytes from apoptosis and enhances neovascularization.

Su EJ, Cioffi CL, Stefansson S, Mittereder N, Garay M, Hreniuk D, Liau G.

Am J Physiol Heart Circ Physiol. 2003 Apr;284(4):H1429-40. Epub 2002 Dec 27.

21.

Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.

Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Ito M, Guan XM, MacNeil DJ, Kanatani A, Van der Ploeg LH, Howard AD.

Genomics. 2002 Jun;79(6):785-92.

PMID:
12036292
22.

Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Hreniuk DL, Tan C, Palyha OC, MacNeil DJ, Van der Ploeg LH, Howard AD, Feighner SD.

Biochemistry. 2002 May 21;41(20):6383-90.

PMID:
12009900
23.

Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1.

Bednarek MA, Tan C, Hreniuk DL, Palyha OC, MacNeil DJ, Van Der Ploeg LH, Howard AD, Feighner SD.

J Biol Chem. 2002 Apr 19;277(16):13821-6. Epub 2002 Feb 11.

24.

Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2.

Bednarek MA, Feighner SD, Hreniuk DL, Palyha OC, Morin NR, Sadowski SJ, MacNeil DJ, Howard AD, Van der Ploeg LH.

Biochemistry. 2001 Aug 7;40(31):9379-86.

PMID:
11478907
25.

Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.

Palucki BL, Feighner SD, Pong S, McKee KK, Hreniuk DL, Tan C, Howard AD, Van der Ploeg LH, Patchett AA, Nargund RP.

Bioorg Med Chem Lett. 2001 Jul 23;11(14):1955-7.

PMID:
11459669
26.

Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.

Sailer AW, Sano H, Zeng Z, McDonald TP, Pan J, Pong SS, Feighner SD, Tan CP, Fukami T, Iwaasa H, Hreniuk DL, Morin NR, Sadowski SJ, Ito M, Ito M, Bansal A, Ky B, Figueroa DJ, Jiang Q, Austin CP, MacNeil DJ, Ishihara A, Ihara M, Kanatani A, Van der Ploeg LH, Howard AD, Liu Q.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. Epub 2001 Jun 12.

27.
28.

Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a.

Bednarek MA, Feighner SD, Pong SS, McKee KK, Hreniuk DL, Silva MV, Warren VA, Howard AD, Van Der Ploeg LH, Heck JV.

J Med Chem. 2000 Nov 16;43(23):4370-6.

PMID:
11087562
29.

Identification of receptors for neuromedin U and its role in feeding.

Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams DL Jr, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, McKee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LH, Liu Q.

Nature. 2000 Jul 6;406(6791):70-4.

PMID:
10894543
30.

Ligand activation domain of human orphan growth hormone (GH) secretagogue receptor (GHS-R) conserved from Pufferfish to humans.

Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Gao YD, Schleim KD, Yang L, Morriello GJ, Nargund R, Patchett AA, Howard AD, Smith RG.

Mol Endocrinol. 2000 Jan;14(1):160-9.

PMID:
10628755
31.

Growth hormone releasing substances: types and their receptors.

Smith RG, Palyha OC, Feighner SD, Tan CP, McKee KK, Hreniuk DL, Yang L, Morriello G, Nargund R, Patchett AA, Howard AD.

Horm Res. 1999;51 Suppl 3:1-8. Review.

PMID:
10592437
32.

Receptor for motilin identified in the human gastrointestinal system.

Feighner SD, Tan CP, McKee KK, Palyha OC, Hreniuk DL, Pong SS, Austin CP, Figueroa D, MacNeil D, Cascieri MA, Nargund R, Bakshi R, Abramovitz M, Stocco R, Kargman S, O'Neill G, Van Der Ploeg LH, Evans J, Patchett AA, Smith RG, Howard AD.

Science. 1999 Jun 25;284(5423):2184-8.

33.

Molecular analysis of a new splice variant of the human melanocortin-1 receptor.

Tan CP, McKee KK, Weinberg DH, MacNeil T, Palyha OC, Feighner SD, Hreniuk DL, Van Der Ploeg LH, MacNeil DJ, Howard AD.

FEBS Lett. 1999 May 21;451(2):137-41.

34.

Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3.

Kolakowski LF Jr, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF.

J Neurochem. 1998 Dec;71(6):2239-51.

35.

Cloning and characterization of a human and murine T-cell orphan G-protein-coupled receptor similar to the growth hormone secretagogue and neurotensin receptors.

Tan CP, McKee KK, Liu Q, Palyha OC, Feighner SD, Hreniuk DL, Smith RG, Howard AD.

Genomics. 1998 Sep 1;52(2):223-9.

PMID:
9782091
36.

Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.

McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH.

Genomics. 1997 Dec 15;46(3):426-34.

PMID:
9441746
37.

Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues.

Feighner SD, Howard AD, Prendergast K, Palyha OC, Hreniuk DL, Nargund R, Underwood D, Tata JR, Dean DC, Tan CP, McKee KK, Woods JW, Patchett AA, Smith RG, Van der Ploeg LH.

Mol Endocrinol. 1998 Jan;12(1):137-45.

PMID:
9440817
38.

Partial agonists and full antagonists at the human and murine bradykinin B1 receptors.

MacNeil T, Feighner S, Hreniuk DL, Hess JF, Van der Ploeg LH.

Can J Physiol Pharmacol. 1997 Jun;75(6):735-40.

PMID:
9276157
39.

Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.

McKee KK, Palyha OC, Feighner SD, Hreniuk DL, Tan CP, Phillips MS, Smith RG, Van der Ploeg LH, Howard AD.

Mol Endocrinol. 1997 Apr;11(4):415-23.

PMID:
9092793
40.
41.

A receptor in pituitary and hypothalamus that functions in growth hormone release.

Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH.

Science. 1996 Aug 16;273(5277):974-7.

PMID:
8688086
42.

Detection of intracellular calcium elevations in Xenopus laevis oocytes: aequorin luminescence versus electrophysiology.

Grygorczyk R, Feighner SD, Adam M, Liu KK, LeCouter JE, Dashkevicz MP, Hreniuk DL, Rydberg EH, Arena JP.

J Neurosci Methods. 1996 Jul;67(1):19-25.

PMID:
8844521
43.

Suppression of TCA cycle activity in the cardiac muscle cell by hydroperoxide-induced oxidant stress.

Janero DR, Hreniuk D.

Am J Physiol. 1996 Jun;270(6 Pt 1):C1735-42.

PMID:
8764157
44.

Cardiac adenylate deaminase: molecular, kinetic and regulatory properties under phosphate-free conditions.

Thakkar JK, Janero DR, Sharif HM, Hreniuk D, Yarwood C.

Biochem J. 1994 Jun 1;300 ( Pt 2):359-63.

45.

Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism.

Janero DR, Hreniuk D, Sharif HM.

Am J Physiol. 1994 Jan;266(1 Pt 1):C179-88.

PMID:
8304415
46.
47.

Radioiodination of transforming growth factor-beta (TGF-beta) in a modified Bolton-Hunter reaction system.

Ross J, Janero DR, Hreniuk D, Wennogle LP.

J Biochem Biophys Methods. 1993 Jul;26(4):343-50.

PMID:
8409206
49.

Hydroperoxide-induced oxidative stress alters pyridine nucleotide metabolism in neonatal heart muscle cells.

Janero DR, Hreniuk D, Sharif HM, Prout KC.

Am J Physiol. 1993 Jun;264(6 Pt 1):C1401-10.

PMID:
8392794
50.

Mutations in murine Mx1: effects on localization and antiviral activity.

Garber EA, Hreniuk DL, Scheidel LM, van der Ploeg LH.

Virology. 1993 Jun;194(2):715-23.

PMID:
8389079

Supplemental Content

Loading ...
Support Center