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Items: 1 to 50 of 202

1.

Back to The Fusion: Mitofusin-2 in Alzheimer's Disease.

Sita G, Hrelia P, Graziosi A, Morroni F.

J Clin Med. 2020 Jan 2;9(1). pii: E126. doi: 10.3390/jcm9010126. Review.

2.

A Novel MYCN-Specific Antigene Oligonucleotide Deregulates Mitochondria and Inhibits Tumor Growth in MYCN-Amplified Neuroblastoma.

Montemurro L, Raieli S, Angelucci S, Bartolucci D, Amadesi C, Lampis S, Scardovi AL, Venturelli L, Nieddu G, Cerisoli L, Fischer M, Teti G, Falconi M, Pession A, Hrelia P, Tonelli R.

Cancer Res. 2019 Dec 15;79(24):6166-6177. doi: 10.1158/0008-5472.CAN-19-0008. Epub 2019 Oct 15.

PMID:
31615807
3.

Prognostic Role of miR-221 and miR-222 Expression in Cancer Patients: A Systematic Review and Meta-Analysis.

Ravegnini G, Cargnin S, Sammarini G, Zanotti F, Bermejo JL, Hrelia P, Terrazzino S, Angelini S.

Cancers (Basel). 2019 Jul 11;11(7). pii: E970. doi: 10.3390/cancers11070970. Review.

4.

Mechanisms of resistance to a PI3K inhibitor in gastrointestinal stromal tumors: an omic approach to identify novel druggable targets.

Ravegnini G, Sammarini G, Moran S, Calice G, Indio V, Urbini M, Astolfi A, Zanotti F, Pantaleo MA, Hrelia P, Angelini S.

Cancer Manag Res. 2019 Jul 5;11:6229-6244. doi: 10.2147/CMAR.S189661. eCollection 2019.

5.

Absence of mutations in the human interferon alpha-2b gene in workers chronically exposed to ionising radiation.

Botbayev D, Ravegnini G, Sammarini G, Kazymbet P, Cilli E, Serventi P, Khanseitova A, Alzhanuly B, Belkozhaev A, Aitkhozhina N, Bakhtin M, Lodi V, Hrelia P, Angelini S.

Arh Hig Rada Toksikol. 2019 Jun 1;70(2):104-108. doi: 10.2478/aiht-2019-70-3202.

PMID:
31246567
6.

PQM130, a Novel Feruloyl-Donepezil Hybrid Compound, Effectively Ameliorates the Cognitive Impairments and Pathology in a Mouse Model of Alzheimer's Disease.

Morroni F, Sita G, Graziosi A, Ravegnini G, Molteni R, Paladini MS, Dias KST, Dos Santos AF, Viegas C Jr, Camps I, Pruccoli L, Tarozzi A, Hrelia P.

Front Pharmacol. 2019 Jun 12;10:658. doi: 10.3389/fphar.2019.00658. eCollection 2019.

7.

A pro longevity role for cellular senescence.

Attaallah A, Lenzi M, Marchionni S, Bincoletto G, Cocchi V, Croco E, Hrelia P, Hrelia S, Sell C, Lorenzini A.

Geroscience. 2019 May 16. doi: 10.1007/s11357-019-00066-2. [Epub ahead of print]

PMID:
31098949
8.

Hemidesmus indicus induces apoptosis via proteasome inhibition and generation of reactive oxygen species.

Turrini E, Catanzaro E, Ferruzzi L, Guerrini A, Tacchini M, Sacchetti G, Paganetto G, Maffei F, Pellicioni V, Poli F, Hrelia P, Mandrone M, Sestili P, Brigotti M, Fimognari C.

Sci Rep. 2019 May 10;9(1):7199. doi: 10.1038/s41598-019-43609-5.

9.

The rs17084733 variant in the KIT 3' UTR disrupts a miR-221/222 binding site in gastrointestinal stromal tumour: a sponge-like mechanism conferring disease susceptibility.

Ravegnini G, Serrano C, Simeon V, Sammarini G, Nannini M, Roversi E, Urbini M, Ferrè F, Ricci R, Tarantino G, Pantaleo MA, Hrelia P, Angelini S.

Epigenetics. 2019 Jun;14(6):545-557. doi: 10.1080/15592294.2019.1595997. Epub 2019 Apr 13.

10.

Clinical relevance of circulating molecules in cancer: focus on gastrointestinal stromal tumors.

Ravegnini G, Sammarini G, Serrano C, Nannini M, Pantaleo MA, Hrelia P, Angelini S.

Ther Adv Med Oncol. 2019 Mar 1;11:1758835919831902. doi: 10.1177/1758835919831902. eCollection 2019. Review.

11.

Identification of a new tamoxifen-xanthene hybrid as pro-apoptotic anticancer agent.

Catanzaro E, Seghetti F, Calcabrini C, Rampa A, Gobbi S, Sestili P, Turrini E, Maffei F, Hrelia P, Bisi A, Belluti F, Fimognari C.

Bioorg Chem. 2019 May;86:538-549. doi: 10.1016/j.bioorg.2019.02.017. Epub 2019 Feb 10.

PMID:
30782572
12.

Isotopic Labeling Studies Reveal the Patulin Detoxification Pathway by the Biocontrol Yeast Rhodotorula kratochvilovae LS11.

Pinedo C, Wright SAI, Collado IG, Goss RJM, Castoria R, Hrelia P, Maffei F, Durán-Patrón R.

J Nat Prod. 2018 Dec 28;81(12):2692-2699. doi: 10.1021/acs.jnatprod.8b00539. Epub 2018 Nov 21.

PMID:
30460844
13.

Sulforaphane from Cruciferous Vegetables: Recent Advances to Improve Glioblastoma Treatment.

Sita G, Hrelia P, Graziosi A, Morroni F.

Nutrients. 2018 Nov 14;10(11). pii: E1755. doi: 10.3390/nu10111755. Review.

14.

Meripilus giganteus ethanolic extract exhibits pro-apoptotic and anti-proliferative effects in leukemic cell lines.

Lenzi M, Cocchi V, Novaković A, Karaman M, Sakač M, Mandić A, Pojić M, Barbalace MC, Angeloni C, Hrelia P, Malaguti M, Hrelia S.

BMC Complement Altern Med. 2018 Nov 12;18(1):300. doi: 10.1186/s12906-018-2366-7.

15.

An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor.

Ravegnini G, Urbini M, Simeon V, Genovese C, Astolfi A, Nannini M, Gatto L, Saponara M, Ianni M, Indio V, Brandi G, Trino S, Hrelia P, Biasco G, Angelini S, Pantaleo MA.

Pharmacogenomics J. 2019 Aug;19(4):390-400. doi: 10.1038/s41397-018-0050-4. Epub 2018 Sep 20.

PMID:
30237583
16.

A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels.

Rosticci M, Pervjakova N, Kaakinen M, Cicero AF, Feufer AP, Marullo L, Mägi R, Fischer K, Jiang L, D'Addato S, Rizzoli E, Massimo G, Giovannini M, Angelini S, Hrelia P, Scapoli C, Borghi C, Prokopenko I.

Biomark Med. 2019 Aug 1;13(11):931-940. doi: 10.2217/bmm-2017-0431. Epub 2018 Sep 7.

17.

Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer's Disease Involves Nrf2/HO-1 Pathway.

Morroni F, Sita G, Graziosi A, Turrini E, Fimognari C, Tarozzi A, Hrelia P.

Aging Dis. 2018 Aug 1;9(4):605-622. doi: 10.14336/AD.2017.0903. eCollection 2018 Aug.

18.

TRPM2 in the Brain: Role in Health and Disease.

Sita G, Hrelia P, Graziosi A, Ravegnini G, Morroni F.

Cells. 2018 Jul 22;7(7). pii: E82. doi: 10.3390/cells7070082. Review.

19.

Protective Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate on Aβ1-42-Induced Cognitive Deficit, Oxidative Stress, Inflammation, and Apoptosis in Mice.

Morroni F, Sita G, Graziosi A, Turrini E, Fimognari C, Tarozzi A, Hrelia P.

Int J Mol Sci. 2018 Jul 18;19(7). pii: E2083. doi: 10.3390/ijms19072083.

20.

Hemidesmus indicus induces immunogenic death in human colorectal cancer cells.

Turrini E, Catanzaro E, Muraro MG, Governa V, Trella E, Mele V, Calcabrini C, Morroni F, Sita G, Hrelia P, Tacchini M, Fimognari C.

Oncotarget. 2018 May 11;9(36):24443-24456. doi: 10.18632/oncotarget.25325. eCollection 2018 May 11.

21.

6-(Methylsulfonyl) hexyl isothiocyanate as potential chemopreventive agent: molecular and cellular profile in leukaemia cell lines.

Lenzi M, Cocchi V, Malaguti M, Barbalace MC, Marchionni S, Hrelia S, Hrelia P.

Oncotarget. 2017 Dec 4;8(67):111697-111714. doi: 10.18632/oncotarget.22902. eCollection 2017 Dec 19.

22.

P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease.

Sita G, Hrelia P, Tarozzi A, Morroni F.

Oxid Med Cell Longev. 2017;2017:7905486. doi: 10.1155/2017/7905486. Epub 2017 Nov 26. Review.

23.

Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson's Disease.

Morroni F, Sita G, Djemil A, D'Amico M, Pruccoli L, Cantelli-Forti G, Hrelia P, Tarozzi A.

J Agric Food Chem. 2018 Jan 31;66(4):856-865. doi: 10.1021/acs.jafc.7b04641. Epub 2018 Jan 22.

PMID:
29307179
24.

Relationship between Lipid Phenotypes, Overweight, Lipid Lowering Drug Response and KIF6 and HMG-CoA Genotypes in a Subset of the Brisighella Heart Study Population.

Angelini S, Rosticci M, Massimo G, Musti M, Ravegnini G, Consolini N, Sammarini G, D'Addato S, Rizzoli E, Botbayev D, Borghi C, Cantelli-Forti G, Cicero AF, Hrelia P.

Int J Mol Sci. 2017 Dec 24;19(1). pii: E49. doi: 10.3390/ijms19010049.

25.

Flow cytometry vs optical microscopy in the evaluation of the genotoxic potential of xenobiotic compounds.

Lenzi M, Cocchi V, Hrelia P.

Cytometry B Clin Cytom. 2018 Sep;94(5):696-706. doi: 10.1002/cyto.b.21546. Epub 2017 Aug 22.

26.

Italian intersociety consensus on prevention, diagnosis, and treatment of delirium in hospitalized older persons.

Bellelli G, Morandi A, Trabucchi M, Caironi G, Coen D, Fraticelli C, Paolillo C, Prevaldi C, Riccardi A, Cervellin G, Carabellese C, Putignano S, Maggi S, Cherubini A, Gnerre P, Fontanella A, Latronico N, Tommasino C, Corcione A, Ricevuti G, Ferrara N, De Filippi F, Ferrari A, Guarino M, Ruggieri MP, Modesti PA, Locatelli C, Hrelia P, Toscano MO, Bondi E, Tarasconi A, Ansaloni L, Perticone F.

Intern Emerg Med. 2018 Jan;13(1):113-121. doi: 10.1007/s11739-017-1705-x. Epub 2017 Jul 24.

PMID:
28741278
27.

Castanea sativa Mill. bark extract exhibits chemopreventive properties triggering extrinsic apoptotic pathway in Jurkat cells.

Lenzi M, Malaguti M, Cocchi V, Hrelia S, Hrelia P.

BMC Complement Altern Med. 2017 May 5;17(1):251. doi: 10.1186/s12906-017-1756-6.

28.

Gastrointestinal stromal tumors (GIST): Facing cell death between autophagy and apoptosis.

Ravegnini G, Sammarini G, Nannini M, Pantaleo MA, Biasco G, Hrelia P, Angelini S.

Autophagy. 2017 Mar 4;13(3):452-463. doi: 10.1080/15548627.2016.1256522. Epub 2017 Jan 5. Review.

29.

An exploratory association of polymorphisms in angiogenesis-related genes with susceptibility, clinical response and toxicity in gastrointestinal stromal tumors receiving sunitinib after imatinib failure.

Ravegnini G, Nannini M, Zenesini C, Simeon V, Sammarini G, Urbini M, Gatto L, Saponara M, Biasco G, Pantaleo MA, Venturoli N, Hrelia P, Angelini S.

Angiogenesis. 2017 Feb;20(1):139-148. doi: 10.1007/s10456-016-9534-5. Epub 2016 Nov 28.

PMID:
27896475
30.

Application of the lymphocyte Cytokinesis-Block Micronucleus Assay to populations exposed to petroleum and its derivatives: Results from a systematic review and meta-analysis.

Angelini S, Bermejo JL, Ravegnini G, Sammarini G, Hrelia P.

Mutat Res. 2016 Oct - Dec;770(Pt A):58-72. doi: 10.1016/j.mrrev.2016.03.001. Epub 2016 Mar 4. Review.

PMID:
27894691
31.

Electrocardiogram Alterations Associated With Psychotropic Drug Use and CACNA1C Gene Variants in Three Independent Samples.

Fabbri C, Boriani G, Diemberger I, Filippi MG, Ravegnini G, Hrelia P, Minarini A, Albani D, Forloni G, Angelini S, Serretti A.

Basic Clin Pharmacol Toxicol. 2017 May;120(5):482-490. doi: 10.1111/bcpt.12720. Epub 2017 Jan 5.

32.

Integrating miRNA and gene expression profiling analysis revealed regulatory networks in gastrointestinal stromal tumors.

Pantaleo MA, Ravegnini G, Astolfi A, Simeon V, Nannini M, Saponara M, Urbini M, Gatto L, Indio V, Sammarini G, Santini D, Ferracin M, Negrini M, Hrelia P, Biasco G, Angelini S.

Epigenomics. 2016 Oct;8(10):1347-1366. Epub 2016 Sep 14.

PMID:
27625077
33.

Isothiocyanates Are Promising Compounds against Oxidative Stress, Neuroinflammation and Cell Death that May Benefit Neurodegeneration in Parkinson's Disease.

Sita G, Hrelia P, Tarozzi A, Morroni F.

Int J Mol Sci. 2016 Sep 1;17(9). pii: E1454. doi: 10.3390/ijms17091454. Review.

34.

Early effects of Aβ1-42 oligomers injection in mice: Involvement of PI3K/Akt/GSK3 and MAPK/ERK1/2 pathways.

Morroni F, Sita G, Tarozzi A, Rimondini R, Hrelia P.

Behav Brain Res. 2016 Nov 1;314:106-15. doi: 10.1016/j.bbr.2016.08.002. Epub 2016 Aug 3.

PMID:
27498145
35.

Polymorphisms in DNA repair genes in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

Ravegnini G, Nannini M, Simeon V, Musti M, Sammarini G, Saponara M, Gatto L, Urbini M, Astolfi A, Biasco G, Pantaleo MA, Venturoli N, Hrelia P, Angelini S.

Tumour Biol. 2016 Oct;37(10):13413-13423. Epub 2016 Jul 27.

PMID:
27460091
36.

Withania somnifera Induces Cytotoxic and Cytostatic Effects on Human T Leukemia Cells.

Turrini E, Calcabrini C, Sestili P, Catanzaro E, de Gianni E, Diaz AR, Hrelia P, Tacchini M, Guerrini A, Canonico B, Papa S, Valdrè G, Fimognari C.

Toxins (Basel). 2016 May 12;8(5). pii: E147. doi: 10.3390/toxins8050147.

37.

Pharmacogenetics of tyrosine kinase inhibitors in gastrointestinal stromal tumor and chronic myeloid leukemia.

Ravegnini G, Sammarini G, Angelini S, Hrelia P.

Expert Opin Drug Metab Toxicol. 2016 Jul;12(7):733-42. doi: 10.1080/17425255.2016.1184649. Epub 2016 May 17. Review.

PMID:
27149004
38.

Simultaneous Analysis of SEPT9 Promoter Methylation Status, Micronuclei Frequency, and Folate-Related Gene Polymorphisms: The Potential for a Novel Blood-Based Colorectal Cancer Biomarker.

Ravegnini G, Zolezzi Moraga JM, Maffei F, Musti M, Zenesini C, Simeon V, Sammarini G, Festi D, Hrelia P, Angelini S.

Int J Mol Sci. 2015 Dec 1;16(12):28486-97. doi: 10.3390/ijms161226113.

39.

Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.

Ravegnini G, Sammarini G, Hrelia P, Angelini S.

Toxicol Sci. 2015 Nov;148(1):2-13. doi: 10.1093/toxsci/kfv165. Review.

PMID:
26500287
40.

Socio-Economic and Clinical Factors as Predictors of Disease Evolution and Acute Events in COPD Patients.

Pandolfi P, Zanasi A, Musti MA, Stivanello E, Pisani L, Angelini S, Maffei F, Hrelia S, Angeloni C, Zenesini C, Hrelia P.

PLoS One. 2015 Aug 7;10(8):e0135116. doi: 10.1371/journal.pone.0135116. eCollection 2015.

41.

Personalized Medicine in Gastrointestinal Stromal Tumor (GIST): Clinical Implications of the Somatic and Germline DNA Analysis.

Ravegnini G, Nannini M, Sammarini G, Astolfi A, Biasco G, Pantaleo MA, Hrelia P, Angelini S.

Int J Mol Sci. 2015 Jul 9;16(7):15592-608. doi: 10.3390/ijms160715592. Review.

42.

Polymorphisms in DNA repair genes: link with biomarkers of the CBMN cytome assay in hospital workers chronically exposed to low doses of ionising radiation.

Milić M, Rozgaj R, Kašuba V, Jazbec AM, Starčević B, Lyzbicki B, Ravegnini G, Zenesini C, Musti M, Hrelia P, Angelini S.

Arh Hig Rada Toksikol. 2015 Jun;66(2):109-20. doi: 10.1515/aiht-2015-66-2655.

PMID:
26110472
43.

In vitro anti-angiogenic effects of Hemidesmus indicus in hypoxic and normoxic conditions.

Turrini E, Ferruzzi L, Guerrini A, Gotti R, Tacchini M, Teti G, Falconi M, Hrelia P, Fimognari C.

J Ethnopharmacol. 2015 Mar 13;162:261-9. doi: 10.1016/j.jep.2014.12.010. Epub 2015 Jan 2.

PMID:
25560668
44.

Impact of personalized diet and probiotic supplementation on inflammation, nutritional parameters and intestinal microbiota - The "RISTOMED project": Randomized controlled trial in healthy older people.

Valentini L, Pinto A, Bourdel-Marchasson I, Ostan R, Brigidi P, Turroni S, Hrelia S, Hrelia P, Bereswill S, Fischer A, Leoncini E, Malaguti M, Blanc-Bisson C, Durrieu J, Spazzafumo L, Buccolini F, Pryen F, Donini LM, Franceschi C, Lochs H.

Clin Nutr. 2015 Aug;34(4):593-602. doi: 10.1016/j.clnu.2014.09.023. Epub 2014 Oct 8.

45.

Evaluation of chromosome aberration and micronucleus frequencies in blood lymphocytes of workers exposed to low concentrations of benzene.

Lovreglio P, Maffei F, Carrieri M, D'Errico MN, Drago I, Hrelia P, Bartolucci GB, Soleo L.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:55-60. doi: 10.1016/j.mrgentox.2014.04.022. Epub 2014 Jun 2.

PMID:
25344164
46.

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease.

Morroni F, Sita G, Tarozzi A, Cantelli-Forti G, Hrelia P.

Brain Res. 2014 Nov 17;1589:93-104. doi: 10.1016/j.brainres.2014.09.033. Epub 2014 Sep 23.

PMID:
25257035
47.

Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.

Angelini S, Ravegnini G, Nannini M, Bermejo JL, Musti M, Pantaleo MA, Fumagalli E, Venturoli N, Palassini E, Consolini N, Casali PG, Biasco G, Hrelia P.

Eur J Hum Genet. 2015 Jun;23(6):817-23. doi: 10.1038/ejhg.2014.198. Epub 2014 Sep 17.

48.

Antileukemic activity of sulforaphane in primary blasts from patients affected by myelo- and lympho-proliferative disorders and in hypoxic conditions.

Fimognari C, Turrini E, Sestili P, Calcabrini C, Carulli G, Fontanelli G, Rousseau M, Cantelli-Forti G, Hrelia P.

PLoS One. 2014 Jul 14;9(7):e101991. doi: 10.1371/journal.pone.0101991. eCollection 2014.

49.

Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.

Bergantin E, Quarta C, Nanni C, Fanti S, Pession A, Cantelli-Forti G, Tonelli R, Hrelia P.

Cancer Biol Ther. 2014 Sep;15(9):1219-25. doi: 10.4161/cbt.29684. Epub 2014 Jun 27.

50.

Micronucleus frequency in human peripheral blood lymphocytes as a biomarker for the early detection of colorectal cancer risk.

Maffei F, Zolezzi Moraga JM, Angelini S, Zenesini C, Musti M, Festi D, Cantelli-Forti G, Hrelia P.

Mutagenesis. 2014 May;29(3):221-5. doi: 10.1093/mutage/geu007. Epub 2014 Mar 25.

PMID:
24668056

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