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Items: 38

1.

Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.

Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY.

Oncotarget. 2017 Feb 21;8(8):12675-12685. doi: 10.18632/oncotarget.9307.

2.

Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy.

Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY.

J Biol Chem. 2015 Jun 12;290(24):14884-92. doi: 10.1074/jbc.M114.630178. Epub 2015 Apr 30.

3.

Peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1) regulates pulmonary effects of endotoxin and tumor necrosis factor-α in mice.

Liu T, Schneider RA, Lee NY, Hoyt DG.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):468-72. doi: 10.1016/j.bbrc.2014.08.089. Epub 2014 Aug 23.

PMID:
25159840
4.

Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.

Pan CC, Kumar S, Shah N, Hoyt DG, Hawinkels LJ, Mythreye K, Lee NY.

J Biol Chem. 2014 Sep 12;289(37):25486-96. doi: 10.1074/jbc.M114.578609. Epub 2014 Jul 28.

5.

Antibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling.

Kumar S, Pan CC, Bloodworth JC, Nixon AB, Theuer C, Hoyt DG, Lee NY.

Oncogene. 2014 Jul 24;33(30):3970-9. doi: 10.1038/onc.2013.386. Epub 2013 Sep 30.

6.

Calpastatin is regulated by protein never in mitosis gene A interacting-1 (PIN1) in endothelial cells.

Liu T, Schneider RA, Hoyt DG.

Biochem Biophys Res Commun. 2011 Oct 28;414(3):581-6. doi: 10.1016/j.bbrc.2011.09.125. Epub 2011 Oct 1.

PMID:
21982763
7.

The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity.

Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM Jr, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE 3rd, Li PK, Lesinski GB.

Mol Cancer. 2010 Jun 25;9:165. doi: 10.1186/1476-4598-9-165.

8.

Protein Never in Mitosis Gene A Interacting-1 regulates calpain activity and the degradation of cyclooxygenase-2 in endothelial cells.

Liu T, Schneider RA, Shah V, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG.

J Inflamm (Lond). 2009 Jun 22;6:20. doi: 10.1186/1476-9255-6-20.

9.

Protein Never in Mitosis Gene A Interacting-1 (PIN1) regulates degradation of inducible nitric oxide synthase in endothelial cells.

Liu T, Huang Y, Likhotvorik RI, Keshvara L, Hoyt DG.

Am J Physiol Cell Physiol. 2008 Sep;295(3):C819-27. doi: 10.1152/ajpcell.00366.2007. Epub 2008 Jul 23.

10.

Sensitivity of mice to lipopolysaccharide is increased by a high saturated fat and cholesterol diet.

Huang H, Liu T, Rose JL, Stevens RL, Hoyt DG.

J Inflamm (Lond). 2007 Nov 12;4:22.

11.

Base excision repair proteins are required for integrin-mediated suppression of bleomycin-induced DNA breakage in murine lung endothelial cells.

Rose JL, Reeves KC, Likhotvorik RI, Hoyt DG.

J Pharmacol Exp Ther. 2007 Apr;321(1):318-26. Epub 2007 Jan 3.

PMID:
17202402
12.

Integrin engagement increases histone H3 acetylation and reduces histone H1 association with DNA in murine lung endothelial cells.

Rose JL, Huang H, Wray SF, Hoyt DG.

Mol Pharmacol. 2005 Aug;68(2):439-46. Epub 2005 May 18.

PMID:
15901851
13.

Vascular endothelial toxicity induced by HIV protease inhibitor: evidence of oxidant-related dysfunction and apoptosis.

Baliga RS, Liu C, Hoyt DG, Chaves AA, Bauer JA.

Cardiovasc Toxicol. 2004;4(2):199-206.

PMID:
15371635
15.
16.
17.

Effects of angiotensin II on vascular endothelial cells: formation of receptor-mediated reactive nitrogen species.

Mihm MJ, Wattanapitayakul SK, Piao SF, Hoyt DG, Bauer JA.

Biochem Pharmacol. 2003 Apr 1;65(7):1189-97.

PMID:
12663054
18.

Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.

Jagtap P, Soriano FG, Virág L, Liaudet L, Mabley J, Szabó E, Haskó G, Marton A, Lorigados CB, Gallyas F Jr, Sümegi B, Hoyt DG, Baloglu E, VanDuzer J, Salzman AL, Southan GJ, Szabó C.

Crit Care Med. 2002 May;30(5):1071-82.

PMID:
12006805
19.

Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation.

Garcia Soriano F, Virág L, Jagtap P, Szabó E, Mabley JG, Liaudet L, Marton A, Hoyt DG, Murthy KG, Salzman AL, Southan GJ, Szabó C.

Nat Med. 2001 Jan;7(1):108-13.

PMID:
11135624
20.
21.

The neutral cysteine protease bleomycin hydrolase is essential for epidermal integrity and bleomycin resistance.

Schwartz DR, Homanics GE, Hoyt DG, Klein E, Abernethy J, Lazo JS.

Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4680-5.

22.

Nitric oxide inhibits lipopolysaccharide-induced apoptosis in pulmonary artery endothelial cells.

Ceneviva GD, Tzeng E, Hoyt DG, Yee E, Gallagher A, Engelhardt JF, Kim YM, Billiar TR, Watkins SA, Pitt BR.

Am J Physiol. 1998 Oct;275(4):L717-28. doi: 10.1152/ajplung.1998.275.4.L717.

PMID:
9755104
23.

Integrin activation protects pulmonary endothelial cells from the genotoxic effects of bleomycin.

Hoyt DG, Rizzo M, Gerritsen ME, Pitt BR, Lazo JS.

Am J Physiol. 1997 Sep;273(3 Pt 1):L612-7.

PMID:
9316496
24.

Enhanced apoptosis in metallothionein null cells.

Kondo Y, Rusnak JM, Hoyt DG, Settineri CE, Pitt BR, Lazo JS.

Mol Pharmacol. 1997 Aug;52(2):195-201.

PMID:
9271341
25.

Integrin activation suppresses etoposide-induced DNA strand breakage in cultured murine tumor-derived endothelial cells.

Hoyt DG, Rusnak JM, Mannix RJ, Modzelewski RA, Johnson CS, Lazo JS.

Cancer Res. 1996 Sep 15;56(18):4146-9.

26.

Nucleophilic distribution of metallothionein in human tumor cells.

Woo ES, Kondo Y, Watkins SC, Hoyt DG, Lazo JS.

Exp Cell Res. 1996 May 1;224(2):365-71.

PMID:
8612713
27.

Integrins inhibit LPS-induced DNA strand breakage in cultured lung endothelial cells.

Hoyt DG, Mannix RJ, Gerritsen ME, Watkins SC, Lazo JS, Pitt BR.

Am J Physiol. 1996 Apr;270(4 Pt 1):L689-94.

PMID:
8928830
28.

Genesis of discrete higher order DNA fragments in apoptotic human prostatic carcinoma cells.

Rusnak JM, Calmels TP, Hoyt DG, Kondo Y, Yalowich JC, Lazo JS.

Mol Pharmacol. 1996 Feb;49(2):244-52.

PMID:
8632756
29.

Collagen is a survival factor against LPS-induced apoptosis in cultured sheep pulmonary artery endothelial cells.

Hoyt DG, Mannix RJ, Rusnak JM, Pitt BR, Lazo JS.

Am J Physiol. 1995 Aug;269(2 Pt 1):L171-7.

PMID:
7653577
31.

NAD depletion after in vitro exposure of murine lung slices to bleomycin.

Hoyt DG, Lazo JS.

Biochem Pharmacol. 1993 Nov 17;46(10):1819-24.

PMID:
7504488
33.

The molecular basis of interstitial pulmonary fibrosis caused by antineoplastic agents.

Lazo JS, Hoyt DG.

Cancer Treat Rev. 1990 Sep;17(2-3):165-7. Review. No abstract available.

PMID:
1703044
34.

Bleomycin and cyclophosphamide increase pulmonary type IV procollagen mRNA in mice.

Hoyt DG, Lazo JS.

Am J Physiol. 1990 Aug;259(2 Pt 1):L47-52.

PMID:
1696433
35.

Bleomycin: a pharmacologic tool in the study of the pathogenesis of interstitial pulmonary fibrosis.

Lazo JS, Hoyt DG, Sebti SM, Pitt BR.

Pharmacol Ther. 1990;47(3):347-58. Review.

PMID:
1705351
36.

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