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Successful Infliximab Treatment is Associated With Reversal of Clotting Abnormalities in Inflammatory Bowel Disease Patients.

Detrez I, Thomas D, Van Steen K, Ballet V, Peeters M, Hoylaerts MF, Van Assche G, Vermeire S, Ferrante M, Gils A.

J Clin Gastroenterol. 2019 Nov 26. doi: 10.1097/MCG.0000000000001290. [Epub ahead of print]


Radiosafe micro-computed tomography for longitudinal evaluation of murine disease models.

Berghen N, Dekoster K, Marien E, Dabin J, Hillen A, Wouters J, Deferme J, Vosselman T, Tiest E, Lox M, Vanoirbeek J, De Langhe E, Bogaerts R, Hoylaerts M, Lories R, Vande Velde G.

Sci Rep. 2019 Nov 26;9(1):17598. doi: 10.1038/s41598-019-53876-x.


Von Willebrand Factor and ADAMTS13 impact on the outcome of Staphylococcus aureus sepsis.

Peetermans M, Meyers S, Liesenborghs L, Vanhoorelbeke K, De Meyer SF, Vandenbriele C, Lox M, Hoylaerts MF, Martinod K, Jacquemin M, Vanassche T, Verhamme P.

J Thromb Haemost. 2019 Nov 22. doi: 10.1111/jth.14686. [Epub ahead of print]


Variation of PEAR1 DNA methylation influences platelet and leukocyte function.

Izzi B, Gianfagna F, Yang WY, Cludts K, De Curtis A, Verhamme P, Di Castelnuovo A, Cerletti C, Donati MB, de Gaetano G, Staessen JA, Hoylaerts MF, Iacoviello L; Moli-family Investigators.

Clin Epigenetics. 2019 Oct 29;11(1):151. doi: 10.1186/s13148-019-0744-8.


ZBTB12 DNA methylation is associated with coagulation- and inflammation-related blood cell parameters: findings from the Moli-family cohort.

Noro F, Gianfagna F, Gialluisi A, De Curtis A, Di Castelnuovo A, Napoleone E, Cerletti C, Donati MB, de Gaetano G, Hoylaerts MF, Iacoviello L, Izzi B; Moli-family study Investigators.

Clin Epigenetics. 2019 May 10;11(1):74. doi: 10.1186/s13148-019-0665-6.


Staphylococcus aureus endocarditis: distinct mechanisms of bacterial adhesion to damaged and inflamed heart valves.

Liesenborghs L, Meyers S, Lox M, Criel M, Claes J, Peetermans M, Trenson S, Vande Velde G, Vanden Berghe P, Baatsen P, Missiakas D, Schneewind O, Peetermans WE, Hoylaerts MF, Vanassche T, Verhamme P.

Eur Heart J. 2019 Oct 14;40(39):3248-3259. doi: 10.1093/eurheartj/ehz175.


Synthetic glycopolymers and natural fucoidans cause human platelet aggregation via PEAR1 and GPIbα.

Kardeby C, Fälker K, Haining EJ, Criel M, Lindkvist M, Barroso R, Påhlsson P, Ljungberg LU, Tengdelius M, Rainger GE, Watson S, Eble JA, Hoylaerts MF, Emsley J, Konradsson P, Watson SP, Sun Y, Grenegård M.

Blood Adv. 2019 Feb 12;3(3):275-287. doi: 10.1182/bloodadvances.2018024950.


An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues.

Ditkowski B, Veloso TR, Bezulska-Ditkowska M, Lubig A, Jockenhoevel S, Mela P, Jashari R, Gewillig M, Meyns B, Hoylaerts MF, Heying R.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/58476.


Pure ultra-fine carbon particles do not exert pro-coagulation and inflammatory effects on microvascular endothelial cells.

Dinmohammadi H, Pirdel Z, Salarilak L, Hoylaerts M, Nejatbakhsh R, Biglari A, Jacquemin M, Shahani T.

Environ Sci Pollut Res Int. 2019 Jan;26(1):991-999. doi: 10.1007/s11356-018-3783-3. Epub 2018 Nov 19.


Are plasma proteins key players in the pathogenesis of infective endocarditis?

Veloso TR, Ditkowski B, Mela P, Hoylaerts MF, Heying R.

J Thorac Cardiovasc Surg. 2018 Aug;156(2):738-739. doi: 10.1016/j.jtcvs.2018.04.053. No abstract available.


Assessment of the Dual Role of Clumping Factor A in S. Aureus Adhesion to Endothelium in Absence and Presence of Plasma.

Claes J, Ditkowski B, Liesenborghs L, Veloso TR, Entenza JM, Moreillon P, Vanassche T, Verhamme P, Hoylaerts MF, Heying R.

Thromb Haemost. 2018 Jul;118(7):1230-1241. doi: 10.1055/s-0038-1660435. Epub 2018 Jun 17.


Targeting Coagulase Activity in Staphylococcus aureus Bacteraemia: A Randomized Controlled Single-Centre Trial of Staphylothrombin Inhibition.

Peetermans M, Liesenborghs L, Peerlinck K, Wijngaerden EV, Gheysens O, Goffin KE, Hoylaerts MF, Jacquemin M, Verhaegen J, Peetermans WE, Verhamme P, Vanassche T; Staphylothrombin Investigators.

Thromb Haemost. 2018 May;118(5):818-829. doi: 10.1055/s-0038-1639586. Epub 2018 Apr 3.


Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes.

Izzi B, Noro F, Cludts K, Freson K, Hoylaerts MF.

Int J Mol Sci. 2018 Apr 3;19(4). pii: E1069. doi: 10.3390/ijms19041069.


Bacterial killing by platelets: making sense of (H)IT.

Hoylaerts MF, Vanassche T, Verhamme P.

J Thromb Haemost. 2018 Jun;16(6):1182-1186. doi: 10.1111/jth.14012. Epub 2018 Apr 23. No abstract available.


Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.

Geys L, Roose E, Scroyen I, Rottensteiner H, Tersteeg C, Hoylaerts MF, Vanhoorelbeke K, Lijnen HR.

J Thromb Haemost. 2018 Jan;16(1):150-163. doi: 10.1111/jth.13901. Epub 2017 Nov 28.


Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation.

Grippi C, Izzi B, Gianfagna F, Noro F, Falcinelli E, Di Pardo A, Amico E, Donati MB, de Gaetano G, Iacoviello L, Hoylaerts MF, Cerletti C.

Thromb Res. 2017 Nov;159:100-108. doi: 10.1016/j.thromres.2017.09.027. Epub 2017 Sep 29.


Biophysical aspects of biomineralization.

Bolean M, Simão AMS, Barioni MB, Favarin BZ, Sebinelli HG, Veschi EA, Janku TAB, Bottini M, Hoylaerts MF, Itri R, Millán JL, Ciancaglini P.

Biophys Rev. 2017 Oct;9(5):747-760. doi: 10.1007/s12551-017-0315-1. Epub 2017 Aug 29. Review.


Bacterial adherence to graft tissues in static and flow conditions.

Veloso TR, Claes J, Van Kerckhoven S, Ditkowski B, Hurtado-Aguilar LG, Jockenhoevel S, Mela P, Jashari R, Gewillig M, Hoylaerts MF, Meyns B, Heying R.

J Thorac Cardiovasc Surg. 2018 Jan;155(1):325-332.e4. doi: 10.1016/j.jtcvs.2017.06.014. Epub 2017 Jun 16.


Topographic analysis by atomic force microscopy of proteoliposomes matrix vesicle mimetics harboring TNAP and AnxA5.

Bolean M, Borin IA, Simão AMS, Bottini M, Bagatolli LA, Hoylaerts MF, Millán JL, Ciancaglini P.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1911-1920. doi: 10.1016/j.bbamem.2017.05.010. Epub 2017 May 23.


Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization.

Favarin BZ, Andrade MAR, Bolean M, Simão AMS, Ramos AP, Hoylaerts MF, Millán JL, Ciancaglini P.

Colloids Surf B Biointerfaces. 2017 Jul 1;155:466-476. doi: 10.1016/j.colsurfb.2017.04.051. Epub 2017 Apr 26.


PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

Yang WY, Petit T, Cauwenberghs N, Zhang ZY, Sheng CS, Thijs L, Salvi E, Izzi B, Vandenbriele C, Wei FF, Gu YM, Jacobs L, Citterio L, Delli Carpini S, Barlassina C, Cusi D, Hoylaerts MF, Verhamme P, Kuznetsova T, Staessen JA.

BMC Med Genet. 2017 Apr 27;18(1):45. doi: 10.1186/s12881-017-0411-x.


Clumping factor A, von Willebrand factor-binding protein and von Willebrand factor anchor Staphylococcus aureus to the vessel wall.

Claes J, Liesenborghs L, Peetermans M, Veloso TR, Missiakas D, Schneewind O, Mancini S, Entenza JM, Hoylaerts MF, Heying R, Verhamme P, Vanassche T.

J Thromb Haemost. 2017 May;15(5):1009-1019. doi: 10.1111/jth.13653. Epub 2017 Mar 23.


A novel mechanism regulating human platelet activation by MMP-2-mediated PAR1 biased signaling.

Sebastiano M, Momi S, Falcinelli E, Bury L, Hoylaerts MF, Gresele P.

Blood. 2017 Feb 16;129(7):883-895. doi: 10.1182/blood-2016-06-724245. Epub 2016 Dec 29.


Absence of Pear1 does not affect murine platelet function in vivo.

Criel M, Izzi B, Vandenbriele C, Liesenborghs L, Van Kerckhoven S, Lox M, Cludts K, Jones EA, Vanassche T, Verhamme P, Hoylaerts M.

Thromb Res. 2016 Oct;146:76-83. doi: 10.1016/j.thromres.2016.08.026. Epub 2016 Aug 26.


ADAMTS13 deficiency promotes microthrombosis in a murine model of diet-induced liver steatosis.

Geys L, Bauters D, Roose E, Tersteeg C, Vanhoorelbeke K, Hoylaerts MF, Lijnen RH, Scroyen I.

Thromb Haemost. 2017 Jan 5;117(1):19-26. doi: 10.1160/TH16-03-0195. Epub 2016 Sep 8.


Allele-specific DNA methylation reinforces PEAR1 enhancer activity.

Izzi B, Pistoni M, Cludts K, Akkor P, Lambrechts D, Verfaillie C, Verhamme P, Freson K, Hoylaerts MF.

Blood. 2016 Aug 18;128(7):1003-12. doi: 10.1182/blood-2015-11-682153. Epub 2016 Jun 16.


Shear-Resistant Binding to von Willebrand Factor Allows Staphylococcus lugdunensis to Adhere to the Cardiac Valves and Initiate Endocarditis.

Liesenborghs L, Peetermans M, Claes J, Veloso TR, Vandenbriele C, Criel M, Lox M, Peetermans WE, Heilbronner S, de Groot PG, Vanassche T, Hoylaerts MF, Verhamme P.

J Infect Dis. 2016 Apr 1;213(7):1148-56. doi: 10.1093/infdis/jiv773. Epub 2016 Jan 6.


Dextran sulfate triggers platelet aggregation via direct activation of PEAR1.

Vandenbriele C, Sun Y, Criel M, Cludts K, Van Kerckhoven S, Izzi B, Vanassche T, Verhamme P, Hoylaerts MF.

Platelets. 2016 Jun;27(4):365-72. doi: 10.3109/09537104.2015.1111321. Epub 2015 Nov 30.


Thrombin Generation by Fetoscopic Trauma to the Fetal Membranes: An in vivo and in vitro Study.

Engels AC, Bauters D, Rynkevic R, Pranpanus S, Richter J, van Mieghem T, Hoylaerts MF, Deprest JA.

Fetal Diagn Ther. 2016;39(4):261-8. doi: 10.1159/000439304. Epub 2015 Oct 2.


Effects of GPI-anchored TNAP on the dynamic structure of model membranes.

Garcia AF, Simão AM, Bolean M, Hoylaerts MF, Millán JL, Ciancaglini P, Costa-Filho AJ.

Phys Chem Chem Phys. 2015 Oct 21;17(39):26295-301. doi: 10.1039/c5cp02377g.


Proteoliposomes with the ability to transport Ca(2+) into the vesicles and hydrolyze phosphosubstrates on their surface.

Bolean M, Simão AM, Kiffer-Moreira T, Hoylaerts MF, Millán JL, Itri R, Ciancaglini P.

Arch Biochem Biophys. 2015 Oct 15;584:79-89. doi: 10.1016/ Epub 2015 Aug 29.


Platelet endothelial aggregation receptor-1: a novel modifier of neoangiogenesis.

Vandenbriele C, Kauskot A, Vandersmissen I, Criel M, Geenens R, Craps S, Luttun A, Janssens S, Hoylaerts MF, Verhamme P.

Cardiovasc Res. 2015 Oct 1;108(1):124-38. doi: 10.1093/cvr/cvv193. Epub 2015 Jul 7.


Functional significance of calcium binding to tissue-nonspecific alkaline phosphatase.

Hoylaerts MF, Van Kerckhoven S, Kiffer-Moreira T, Sheen C, Narisawa S, Millán JL.

PLoS One. 2015 Mar 16;10(3):e0119874. doi: 10.1371/journal.pone.0119874. eCollection 2015.


A Human Platelet Receptor Protein Microarray Identifies the High Affinity Immunoglobulin E Receptor Subunit α (FcεR1α) as an Activating Platelet Endothelium Aggregation Receptor 1 (PEAR1) Ligand.

Sun Y, Vandenbriele C, Kauskot A, Verhamme P, Hoylaerts MF, Wright GJ.

Mol Cell Proteomics. 2015 May;14(5):1265-74. doi: 10.1074/mcp.M114.046946. Epub 2015 Feb 23.


Short-term effect of infliximab is reflected in the clot lysis profile of patients with inflammatory bowel disease: a prospective study.

Bollen L, Vande Casteele N, Peeters M, Bessonov K, Van Steen K, Rutgeerts P, Ferrante M, Hoylaerts MF, Vermeire S, Gils A.

Inflamm Bowel Dis. 2015 Mar;21(3):570-8. doi: 10.1097/MIB.0000000000000301.


Plasminogen activation by staphylokinase enhances local spreading of S. aureus in skin infections.

Peetermans M, Vanassche T, Liesenborghs L, Claes J, Vande Velde G, Kwiecinksi J, Jin T, De Geest B, Hoylaerts MF, Lijnen RH, Verhamme P.

BMC Microbiol. 2014 Dec 17;14:310. doi: 10.1186/s12866-014-0310-7.


Expert position paper on air pollution and cardiovascular disease.

Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, Forastiere F, Franchini M, Franco OH, Graham I, Hoek G, Hoffmann B, Hoylaerts MF, Künzli N, Mills N, Pekkanen J, Peters A, Piepoli MF, Rajagopalan S, Storey RF; ESC Working Group on Thrombosis, European Association for Cardiovascular Prevention and Rehabilitation; ESC Heart Failure Association.

Eur Heart J. 2015 Jan 7;36(2):83-93b. doi: 10.1093/eurheartj/ehu458. Epub 2014 Dec 9. No abstract available.


Pathophysiological role of vascular smooth muscle alkaline phosphatase in medial artery calcification.

Sheen CR, Kuss P, Narisawa S, Yadav MC, Nigro J, Wang W, Chhea TN, Sergienko EA, Kapoor K, Jackson MR, Hoylaerts MF, Pinkerton AB, O'Neill WC, Millán JL.

J Bone Miner Res. 2015 May;30(5):824-36. doi: 10.1002/jbmr.2420.


Pulmonary and hemostatic toxicity of multi-walled carbon nanotubes and zinc oxide nanoparticles after pulmonary exposure in Bmal1 knockout mice.

Luyts K, Smulders S, Napierska D, Van Kerckhoven S, Poels K, Scheers H, Hemmeryckx B, Nemery B, Hoylaerts MF, Hoet PH.

Part Fibre Toxicol. 2014 Nov 14;11:61. doi: 10.1186/s12989-014-0061-5.


Active PAI-1 as marker for venous thromboembolism: case-control study using a comprehensive panel of PAI-1 and TAFI assays.

Bollen L, Peetermans M, Peeters M, Van Steen K, Hoylaerts MF, Declerck PJ, Verhamme P, Gils A.

Thromb Res. 2014 Nov;134(5):1097-102. doi: 10.1016/j.thromres.2014.08.007. Epub 2014 Aug 20.


Adhesion of Staphylococcus aureus to the vessel wall under flow is mediated by von Willebrand factor-binding protein.

Claes J, Vanassche T, Peetermans M, Liesenborghs L, Vandenbriele C, Vanhoorelbeke K, Missiakas D, Schneewind O, Hoylaerts MF, Heying R, Verhamme P.

Blood. 2014 Sep 4;124(10):1669-76. doi: 10.1182/blood-2014-02-558890. Epub 2014 Jun 20.


Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.

Yadav MC, Huesa C, Narisawa S, Hoylaerts MF, Moreau A, Farquharson C, Millán JL.

J Bone Miner Res. 2014 Nov;29(11):2369-81. doi: 10.1002/jbmr.2281.


Whole blood thrombin generation in Bmal1-deficient mice.

Ninivaggi M, Kelchtermans H, Kuijpers MJ, Hemmeryckx B, Heemskerk JW, Lindhout T, Hoylaerts MF, de Laat B.

Thromb Haemost. 2014 Aug;112(2):271-5. doi: 10.1160/TH13-11-0910. Epub 2014 Apr 17.


Supporting roles of platelet thrombospondin-1 and CD36 in thrombus formation on collagen.

Kuijpers MJ, de Witt S, Nergiz-Unal R, van Kruchten R, Korporaal SJ, Verhamme P, Febbraio M, Tjwa M, Voshol PJ, Hoylaerts MF, Cosemans JM, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1187-92. doi: 10.1161/ATVBAHA.113.302917. Epub 2014 Mar 27.


Catalytic signature of a heat-stable, chimeric human alkaline phosphatase with therapeutic potential.

Kiffer-Moreira T, Sheen CR, Gasque KC, Bolean M, Ciancaglini P, van Elsas A, Hoylaerts MF, Millán JL.

PLoS One. 2014 Feb 24;9(2):e89374. doi: 10.1371/journal.pone.0089374. eCollection 2014.


Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

Ardecky RJ, Bobkova EV, Kiffer-Moreira T, Brown B, Ganji S, Zou J, Pass I, Narisawa S, Iano FG, Rosenstein C, Cheltsov A, Rascon J, Hedrick M, Gasior C, Forster A, Shi S, Dahl R, Vasile S, Su Y, Sergienko E, Chung TDY, Kaunitz J, Hoylaerts MF, Pinkerton AB, Millán JL.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):1000-1004. doi: 10.1016/j.bmcl.2013.12.043. Epub 2013 Dec 19.


Effects of pH on the production of phosphate and pyrophosphate by matrix vesicles' biomimetics.

Simão AM, Bolean M, Hoylaerts MF, Millán JL, Ciancaglini P.

Calcif Tissue Int. 2013 Sep;93(3):222-32. doi: 10.1007/s00223-013-9745-3. Epub 2013 May 31.


Age-associated pro-inflammatory adaptations of the mouse thoracic aorta.

Hemmeryckx B, Hoylaerts MF, Deloose E, Van Hove CE, Fransen P, Bult H, Lijnen HR.

Thromb Haemost. 2013 Oct;110(4):785-94. doi: 10.1160/TH13-01-0022. Epub 2013 Aug 8.


PEAR1 attenuates megakaryopoiesis via control of the PI3K/PTEN pathway.

Kauskot A, Vandenbriele C, Louwette S, Gijsbers R, Tousseyn T, Freson K, Verhamme P, Hoylaerts MF.

Blood. 2013 Jun 27;121(26):5208-17. doi: 10.1182/blood-2012-10-462887. Epub 2013 May 10.


The role of staphylothrombin-mediated fibrin deposition in catheter-related Staphylococcus aureus infections.

Vanassche T, Peetermans M, Van Aelst LN, Peetermans WE, Verhaegen J, Missiakas DM, Schneewind O, Hoylaerts MF, Verhamme P.

J Infect Dis. 2013 Jul;208(1):92-100. doi: 10.1093/infdis/jit130. Epub 2013 Mar 26.

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