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Ischemia and reperfusion injury following cardioplegic arrest is attenuated by age and testosterone deficiency in male but not female mice.

Ghimire A, Bisset ES, Howlett SE.

Biol Sex Differ. 2019 Aug 23;10(1):42. doi: 10.1186/s13293-019-0256-4.


Frailty Assessment in Animal Models.

Heinze-Milne SD, Banga S, Howlett SE.

Gerontology. 2019;65(6):610-619. doi: 10.1159/000501333. Epub 2019 Jul 22. Review.


Spelunking the biology of frailty.

Kane AE, Howlett SE.

Mech Ageing Dev. 2019 Sep;182:111123. doi: 10.1016/j.mad.2019.111123. Epub 2019 Jul 10. No abstract available.


The Symptoms Targeted for Monitoring in a Web-Based Tracking Tool by Caregivers of People With Dementia and Agitation: Cross-Sectional Study.

Rockwood K, Sanon Aigbogun M, Stanley J, Wong H, Dunn T, Chapman CAT, Howlett SE, Miguelez M, McGarrigle L, Baker RA.

J Med Internet Res. 2019 Jun 28;21(6):e13360. doi: 10.2196/13360.


Nutrition interventions for healthy ageing across the lifespan: a conference report.

Kalache A, de Hoogh AI, Howlett SE, Kennedy B, Eggersdorfer M, Marsman DS, Shao A, Griffiths JC.

Eur J Nutr. 2019 Jun;58(Suppl 1):1-11. doi: 10.1007/s00394-019-02027-z.


Proceedings of the Canadian Frailty Network Workshop: Identifying Biomarkers of Frailty to Support Frailty Risk Assessment, Diagnosis and Prognosis. Toronto, January 15, 2018.

Muscedere J, Kim PM, Afilalo J, Balion C, Baracos VE, Bowdish D, Cesari M, Erusalimsky JD, Fülöp T, Heckman G, Howlett SE, Khadaroo RG, Kirkland JL, Rodriguez Mañas L, Marzetti E, Paré G, Raina P, Rockwood K, Sinclair A, Skappak C, Verschoor C, Walter S.

J Frailty Aging. 2019;8(3):106-116. doi: 10.14283/jfa.2019.12.


Age-related deficit accumulation and the diseases of ageing.

Rockwood K, Howlett SE.

Mech Ageing Dev. 2019 Jun;180:107-116. doi: 10.1016/j.mad.2019.04.005. Epub 2019 Apr 16. Review.


Rodent models of frailty and their application in preclinical research.

Banga S, Heinze-Milne SD, Howlett SE.

Mech Ageing Dev. 2019 Apr;179:1-10. doi: 10.1016/j.mad.2019.01.008. Epub 2019 Jan 28. Review.


Characterizing the symptom of misplacing objects in people with dementia: findings from an online tracking tool.

McGarrigle L, Howlett SE, Wong H, Stanley J, Rockwood K.

Int Psychogeriatr. 2019 Nov;31(11):1635-1641. doi: 10.1017/S104161021800220X. Epub 2019 Jan 30.


Long-term testosterone deficiency modifies myofilament and calcium-handling proteins and promotes diastolic dysfunction in the aging mouse heart.

Ayaz O, Banga S, Heinze-Milne S, Rose RA, Pyle WG, Howlett SE.

Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H768-H780. doi: 10.1152/ajpheart.00471.2018. Epub 2019 Jan 18.


Fifteen years of progress in understanding frailty and health in aging.

Rockwood K, Howlett SE.

BMC Med. 2018 Nov 27;16(1):220. doi: 10.1186/s12916-018-1223-3.


Chronic Treatment With the ACE Inhibitor Enalapril Attenuates the Development of Frailty and Differentially Modifies Pro- and Anti-inflammatory Cytokines in Aging Male and Female C57BL/6 Mice.

Keller K, Kane A, Heinze-Milne S, Grandy SA, Howlett SE.

J Gerontol A Biol Sci Med Sci. 2019 Jul 12;74(8):1149-1157. doi: 10.1093/gerona/gly219.


Differences in Cardiovascular Aging in Men and Women.

Kane AE, Howlett SE.

Adv Exp Med Biol. 2018;1065:389-411. doi: 10.1007/978-3-319-77932-4_25. Review.


Sex Differences in Healthspan Predict Lifespan in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Kane AE, Shin S, Wong AA, Fertan E, Faustova NS, Howlett SE, Brown RE.

Front Aging Neurosci. 2018 Jun 12;10:172. doi: 10.3389/fnagi.2018.00172. eCollection 2018.


A Murine Frailty Index Based on Clinical and Laboratory Measurements: Links Between Frailty and Pro-inflammatory Cytokines Differ in a Sex-Specific Manner.

Kane AE, Keller KM, Heinze-Milne S, Grandy SA, Howlett SE.

J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):275-282. doi: 10.1093/gerona/gly117.


Coxsackievirus B3-Induced Myocarditis: New Insights Into a Female Advantage.

Howlett SE.

Can J Cardiol. 2018 Apr;34(4):354-355. doi: 10.1016/j.cjca.2018.01.086. Epub 2018 Feb 1. No abstract available.


A frailty index from common clinical and laboratory tests predicts increased risk of death across the life course.

Blodgett JM, Theou O, Howlett SE, Rockwood K.

Geroscience. 2017 Aug;39(4):447-455. doi: 10.1007/s11357-017-9993-7. Epub 2017 Sep 2.


The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms.

Parks RJ, Bogachev O, Mackasey M, Ray G, Rose RA, Howlett SE.

J Mol Cell Cardiol. 2017 Oct;111:51-60. doi: 10.1016/j.yjmcc.2017.07.118. Epub 2017 Aug 1.


A Comparison of Two Mouse Frailty Assessment Tools.

Kane AE, Huizer-Pajkos A, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Howlett SE, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):904-909. doi: 10.1093/gerona/glx009.


Advances in Preclinical Models of Frailty.

Kane AE, Howlett SE.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):867-869. doi: 10.1093/gerona/glx072. Review. No abstract available.


The impact of age and frailty on ventricular structure and function in C57BL/6J mice.

Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE.

J Physiol. 2017 Jun 15;595(12):3721-3742. doi: 10.1113/JP274134. Epub 2017 May 14.


Implementation of the mouse frailty index.

Kane AE, Ayaz O, Ghimire A, Feridooni HA, Howlett SE.

Can J Physiol Pharmacol. 2017 Oct;95(10):1149-1155. doi: 10.1139/cjpp-2017-0025. Epub 2017 May 2. Review.


Influence of age on intestinal bile acid transport in C57BL/6 mice.

Gao T, Feridooni HA, Howlett SE, Pelis RM.

Pharmacol Res Perspect. 2017 Feb 3;5(2):e00287. doi: 10.1002/prp2.287. eCollection 2017 Apr.


Clinical meaningfulness of Alzheimer's Disease Assessment Scale-Cognitive subscale change in relation to goal attainment in patients on cholinesterase inhibitors.

Rockwood K, Howlett SE, Hoffman D, Schindler R, Mitnitski A.

Alzheimers Dement. 2017 Oct;13(10):1098-1106. doi: 10.1016/j.jalz.2017.02.005. Epub 2017 Mar 21.


Atrial structure, function and arrhythmogenesis in aged and frail mice.

Jansen HJ, Moghtadaei M, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA.

Sci Rep. 2017 Mar 14;7:44336. doi: 10.1038/srep44336.


The association between frailty, the metabolic syndrome, and mortality over the lifespan.

Kane AE, Gregson E, Theou O, Rockwood K, Howlett SE.

Geroscience. 2017 Apr;39(2):221-229. doi: 10.1007/s11357-017-9967-9. Epub 2017 Mar 9.


A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice.

Rockwood K, Blodgett JM, Theou O, Sun MH, Feridooni HA, Mitnitski A, Rose RA, Godin J, Gregson E, Howlett SE.

Sci Rep. 2017 Feb 21;7:43068. doi: 10.1038/srep43068.


Development of a Rat Clinical Frailty Index.

Yorke A, Kane AE, Hancock Friesen CL, Howlett SE, O'Blenes S.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):897-903. doi: 10.1093/gerona/glw339.


Sex differences in frailty: A systematic review and meta-analysis.

Gordon EH, Peel NM, Samanta M, Theou O, Howlett SE, Hubbard RE.

Exp Gerontol. 2017 Mar;89:30-40. doi: 10.1016/j.exger.2016.12.021. Epub 2016 Dec 31. Review.


Animal models of frailty: current applications in clinical research.

Kane AE, Hilmer SN, Mach J, Mitchell SJ, de Cabo R, Howlett SE.

Clin Interv Aging. 2016 Oct 26;11:1519-1529. eCollection 2016. Review.


Acute exposure to progesterone attenuates cardiac contraction by modifying myofilament calcium sensitivity in the female mouse heart.

Feridooni HA, MacDonald JK, Ghimire A, Pyle WG, Howlett SE.

Am J Physiol Heart Circ Physiol. 2017 Jan 1;312(1):H46-H59. doi: 10.1152/ajpheart.00073.2016. Epub 2016 Oct 28.


Novel cardioprotection strategies for the aged heart: evidence from pre-clinical studies.

Kane AE, Howlett SE.

Clin Exp Pharmacol Physiol. 2016 Dec;43(12):1251-1260. doi: 10.1111/1440-1681.12668. Review.


The impacts of age and frailty on heart rate and sinoatrial node function.

Moghtadaei M, Jansen HJ, Mackasey M, Rafferty SA, Bogachev O, Sapp JL, Howlett SE, Rose RA.

J Physiol. 2016 Dec 1;594(23):7105-7126. doi: 10.1113/JP272979. Epub 2016 Oct 17.


Sex Differences in the Biology and Pathology of the Aging Heart.

Keller KM, Howlett SE.

Can J Cardiol. 2016 Sep;32(9):1065-73. doi: 10.1016/j.cjca.2016.03.017. Epub 2016 Apr 7. Review.


Dysnatremia in Relation to Frailty and Age in Community-dwelling Adults in the National Health and Nutrition Examination Survey.

Miller AJ, Theou O, McMillan M, Howlett SE, Tennankore KK, Rockwood K.

J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):376-381. doi: 10.1093/gerona/glw114.


Heterogeneity of Human Aging and Its Assessment.

Mitnitski A, Howlett SE, Rockwood K.

J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):877-884. doi: 10.1093/gerona/glw089.


A frailty index based on laboratory deficits in community-dwelling men predicted their risk of adverse health outcomes.

Blodgett JM, Theou O, Howlett SE, Wu FC, Rockwood K.

Age Ageing. 2016 Jul;45(4):463-8. doi: 10.1093/ageing/afw054. Epub 2016 Apr 13.


Report of the National Heart, Lung, and Blood Institute Working Group on Sex Differences Research in Cardiovascular Disease: Scientific Questions and Challenges.

Maric-Bilkan C, Arnold AP, Taylor DA, Dwinell M, Howlett SE, Wenger N, Reckelhoff JF, Sandberg K, Churchill G, Levin E, Lundberg MS.

Hypertension. 2016 May;67(5):802-7. doi: 10.1161/HYPERTENSIONAHA.115.06967. Epub 2016 Mar 14. Review. No abstract available.


Commentary: Age-related neurodegenerative disease research needs aging models.

Wallace LM, Howlett SE.

Front Aging Neurosci. 2016 Jan 29;8:9. doi: 10.3389/fnagi.2016.00009. eCollection 2016. No abstract available.


Assessment of Frailty in Animal Models.

Howlett SE.

Interdiscip Top Gerontol Geriatr. 2015;41:15-25. doi: 10.1159/000381131. Epub 2015 Jul 17. Review.


Frailty: Scaling from Cellular Deficit Accumulation?

Rockwood K, Mitnitski A, Howlett SE.

Interdiscip Top Gerontol Geriatr. 2015;41:1-14. doi: 10.1159/000381127. Epub 2015 Jul 17. Review.


A Frailty Index Based on Common Laboratory Tests in Comparison With a Clinical Frailty Index for Older Adults in Long-Term Care Facilities.

Rockwood K, McMillan M, Mitnitski A, Howlett SE.

J Am Med Dir Assoc. 2015 Oct 1;16(10):842-7. doi: 10.1016/j.jamda.2015.03.027. Epub 2015 May 5.


Adverse Geriatric Outcomes Secondary to Polypharmacy in a Mouse Model: The Influence of Aging.

Huizer-Pajkos A, Kane AE, Howlett SE, Mach J, Mitchell SJ, de Cabo R, Le Couteur DG, Hilmer SN.

J Gerontol A Biol Sci Med Sci. 2016 May;71(5):571-7. doi: 10.1093/gerona/glv046. Epub 2015 May 4.


Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms.

Ayaz O, Howlett SE.

Biol Sex Differ. 2015 Apr 29;6:9. doi: 10.1186/s13293-015-0027-9. eCollection 2015. Review.


Factors that influence reliability of the mouse clinical frailty index.

Howlett SE, Rockwood K.

J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):696. doi: 10.1093/gerona/glv045. Epub 2015 Apr 10. No abstract available.


Impact of Longevity Interventions on a Validated Mouse Clinical Frailty Index.

Kane AE, Hilmer SN, Boyer D, Gavin K, Nines D, Howlett SE, de Cabo R, Mitchell SJ.

J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):333-9. doi: 10.1093/gerona/glu315. Epub 2015 Feb 22.


Microbial shifts in the aging mouse gut.

Langille MG, Meehan CJ, Koenig JE, Dhanani AS, Rose RA, Howlett SE, Beiko RG.

Microbiome. 2014 Dec 5;2(1):50. doi: 10.1186/s40168-014-0050-9. eCollection 2014.


How cardiomyocyte excitation, calcium release and contraction become altered with age.

Feridooni HA, Dibb KM, Howlett SE.

J Mol Cell Cardiol. 2015 Jun;83:62-72. doi: 10.1016/j.yjmcc.2014.12.004. Epub 2014 Dec 10. Review.


Standard laboratory tests to identify older adults at increased risk of death.

Howlett SE, Rockwood MR, Mitnitski A, Rockwood K.

BMC Med. 2014 Oct 7;12:171. doi: 10.1186/s12916-014-0171-9.


Reliability of a Frailty Index Based on the Clinical Assessment of Health Deficits in Male C57BL/6J Mice.

Feridooni HA, Sun MH, Rockwood K, Howlett SE.

J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):686-93. doi: 10.1093/gerona/glu161. Epub 2014 Sep 9.

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