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Items: 37


FANCD2 binding to H4K20me2 via a methyl-binding domain is essential for efficient DNA crosslink repair.

Paquin KL, Mamrak NE, Garzon JL, Cantres-Velez JA, Azzinaro PA, Vuono EA, Lima KE, Camberg JL, Howlett NG.

Mol Cell Biol. 2019 May 13. pii: MCB.00194-19. doi: 10.1128/MCB.00194-19. [Epub ahead of print]


Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

Higgs MR, Sato K, Reynolds JJ, Begum S, Bayley R, Goula A, Vernet A, Paquin KL, Skalnik DG, Kobayashi W, Takata M, Howlett NG, Kurumizaka H, Kimura H, Stewart GS.

Mol Cell. 2018 Jul 5;71(1):25-41.e6. doi: 10.1016/j.molcel.2018.05.018. Epub 2018 Jun 21.


Understanding the Histone DNA Repair Code: H4K20me2 Makes Its Mark.

Paquin KL, Howlett NG.

Mol Cancer Res. 2018 Sep;16(9):1335-1345. doi: 10.1158/1541-7786.MCR-17-0688. Epub 2018 Jun 1. Review.


Modulation of the Fanconi anemia pathway via chemically induced changes in chromatin structure.

Vierra DA, Garzon JL, Rego MA, Adroved MM, Mauro M, Howlett NG.

Oncotarget. 2017 Jul 22;8(44):76443-76457. doi: 10.18632/oncotarget.19470. eCollection 2017 Sep 29.


Tuning the Multifunctionality of Iron Oxide Nanoparticles Using Self-Assembled Mixed Lipid Layers.

Preiss MR, Cournoyer E, Paquin KL, Vuono EA, Belanger K, Walsh E, Howlett NG, Bothun GD.

Bioconjug Chem. 2017 Nov 15;28(11):2729-2736. doi: 10.1021/acs.bioconjchem.7b00483. Epub 2017 Oct 30.


Proteomic responses to elevated ocean temperature in ovaries of the ascidian Ciona intestinalis.

Lopez CE, Sheehan HC, Vierra DA, Azzinaro PA, Meedel TH, Howlett NG, Irvine SQ.

Biol Open. 2017 Jul 15;6(7):943-955. doi: 10.1242/bio.024786.


The PTEN phosphatase functions cooperatively with the Fanconi anemia proteins in DNA crosslink repair.

Vuono EA, Mukherjee A, Vierra DA, Adroved MM, Hodson C, Deans AJ, Howlett NG.

Sci Rep. 2016 Nov 7;6:36439. doi: 10.1038/srep36439.


Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.

Mamrak NE, Shimamura A, Howlett NG.

Blood Rev. 2017 May;31(3):93-99. doi: 10.1016/j.blre.2016.10.002. Epub 2016 Oct 13. Review.


FANCD2 Facilitates Replication through Common Fragile Sites.

Madireddy A, Kosiyatrakul ST, Boisvert RA, Herrera-Moyano E, García-Rubio ML, Gerhardt J, Vuono EA, Owen N, Yan Z, Olson S, Aguilera A, Howlett NG, Schildkraut CL.

Mol Cell. 2016 Oct 20;64(2):388-404. doi: 10.1016/j.molcel.2016.09.017.


A DUB-less step? Tighten up D-loop.

Paquin KL, Vierra DA, Howlett NG.

Cell Cycle. 2016 Dec;15(23):3163-3164. Epub 2016 Sep 14. No abstract available.


The Simple Chordate Ciona intestinalis Has a Reduced Complement of Genes Associated with Fanconi Anemia.

Stanley EC, Azzinaro PA, Vierra DA, Howlett NG, Irvine SQ.

Evol Bioinform Online. 2016 Jun 6;12:133-48. doi: 10.4137/EBO.S37920. eCollection 2016.


The Fanconi anemia ID2 complex: dueling saxes at the crossroads.

Boisvert RA, Howlett NG.

Cell Cycle. 2014;13(19):2999-3015. doi: 10.4161/15384101.2014.956475. Review.


Cyclic peptide-capped gold nanoparticles for enhanced siRNA delivery.

Shirazi AN, Paquin KL, Howlett NG, Mandal D, Parang K.

Molecules. 2014 Aug 28;19(9):13319-31. doi: 10.3390/molecules190913319.


Coordinate nuclear targeting of the FANCD2 and FANCI proteins via a FANCD2 nuclear localization signal.

Boisvert RA, Rego MA, Azzinaro PA, Mauro M, Howlett NG.

PLoS One. 2013 Nov 21;8(11):e81387. doi: 10.1371/journal.pone.0081387. eCollection 2013.


Multinucleation regulated by the Akt/PTEN signaling pathway is a survival strategy for HepG2 cells.

Mukherjee A, Misra S, Howlett NG, Karmakar P.

Mutat Res. 2013 Aug 15;755(2):135-40. doi: 10.1016/j.mrgentox.2013.06.009. Epub 2013 Jun 21.


Regulation of the Fanconi anemia pathway by a CUE ubiquitin-binding domain in the FANCD2 protein.

Rego MA, Kolling FW 4th, Vuono EA, Mauro M, Howlett NG.

Blood. 2012 Sep 6;120(10):2109-17. doi: 10.1182/blood-2012-02-410472. Epub 2012 Jul 31.


p21 promotes error-free replication-coupled DNA double-strand break repair.

Mauro M, Rego MA, Boisvert RA, Esashi F, Cavallo F, Jasin M, Howlett NG.

Nucleic Acids Res. 2012 Sep 1;40(17):8348-60. Epub 2012 Jun 26.


Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor.

Rego MA, Harney JA, Mauro M, Shen M, Howlett NG.

Oncogene. 2012 Jan 19;31(3):366-75. doi: 10.1038/onc.2011.237. Epub 2011 Jun 20.


FANCP/SLX4: a Swiss army knife of DNA interstrand crosslink repair.

Cybulski KE, Howlett NG.

Cell Cycle. 2011 Jun 1;10(11):1757-63. Epub 2011 Jun 1. Review.


Differential roles for DNA polymerases eta, zeta, and REV1 in lesion bypass of intrastrand versus interstrand DNA cross-links.

Hicks JK, Chute CL, Paulsen MT, Ragland RL, Howlett NG, Guéranger Q, Glover TW, Canman CE.

Mol Cell Biol. 2010 Mar;30(5):1217-30. doi: 10.1128/MCB.00993-09. Epub 2009 Dec 22.


Functional interaction between the Fanconi Anemia D2 protein and proliferating cell nuclear antigen (PCNA) via a conserved putative PCNA interaction motif.

Howlett NG, Harney JA, Rego MA, Kolling FW 4th, Glover TW.

J Biol Chem. 2009 Oct 16;284(42):28935-42. doi: 10.1074/jbc.M109.016352. Epub 2009 Aug 24.


The Fanconi anemia protein interaction network: casting a wide net.

Rego MA, Kolling FW 4th, Howlett NG.

Mutat Res. 2009 Jul 31;668(1-2):27-41. doi: 10.1016/j.mrfmmm.2008.11.018. Epub 2008 Dec 3. Review.


Fanconi anemia: Fanconi anemia, breast and embryonal cancer risk revisited.

Howlett NG.

Eur J Hum Genet. 2007 Jul;15(7):715-7. Epub 2007 May 16. No abstract available.


Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites.

Durkin SG, Arlt MF, Howlett NG, Glover TW.

Oncogene. 2006 Jul 27;25(32):4381-8. Epub 2006 May 29.


Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients.

Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH.

DNA Repair (Amst). 2006 Feb 3;5(2):251-7. Epub 2005 Nov 22.


The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stability.

Howlett NG, Taniguchi T, Durkin SG, D'Andrea AD, Glover TW.

Hum Mol Genet. 2005 Mar 1;14(5):693-701. Epub 2005 Jan 20.


Effect of Ku86 and DNA-PKcs deficiency on non-homologous end-joining and homologous recombination using a transient transfection assay.

Secretan MB, Scuric Z, Oshima J, Bishop AJ, Howlett NG, Yau D, Schiestl RH.

Mutat Res. 2004 Oct 4;554(1-2):351-64.


Mutagen X and chlorinated tap water are recombinagenic in yeast.

Egorov AI, Howlett NG, Schiestl RH.

Mutat Res. 2004 Oct 10;563(2):159-69.


Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis.

Liu TX, Howlett NG, Deng M, Langenau DM, Hsu K, Rhodes J, Kanki JP, D'Andrea AD, Look AT.

Dev Cell. 2003 Dec;5(6):903-14.


Detection of Arabidopsis thaliana AtRAD1 cDNA variants and assessment of function by expression in a yeast rad1 mutant.

Vonarx EJ, Howlett NG, Schiestl RH, Kunz BA.

Gene. 2002 Aug 21;296(1-2):1-9.


Biallelic inactivation of BRCA2 in Fanconi anemia.

Howlett NG, Taniguchi T, Olson S, Cox B, Waisfisz Q, De Die-Smulders C, Persky N, Grompe M, Joenje H, Pals G, Ikeda H, Fox EA, D'Andrea AD.

Science. 2002 Jul 26;297(5581):606-9. Epub 2002 Jun 13.


Copper toxicity towards Saccharomyces cerevisiae: dependence on plasma membrane fatty acid composition.

Avery SV, Howlett NG, Radice S.

Appl Environ Microbiol. 1996 Nov;62(11):3960-6.

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