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Items: 25

1.

Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Scatena CD, Kumer JL, Arbitrario JP, Howlett AR, Hawtin RE, Fox JA, Silverman JA.

Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. doi: 10.1007/s00280-009-1234-z. Epub 2010 Jan 8.

2.

SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo.

Arbitrario JP, Belmont BJ, Evanchik MJ, Flanagan WM, Fucini RV, Hansen SK, Harris SO, Hashash A, Hoch U, Hogan JN, Howlett AR, Jacobs JW, Lam JW, Ritchie SC, Romanowski MJ, Silverman JA, Stockett DE, Teague JN, Zimmerman KM, Taverna P.

Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17. doi: 10.1007/s00280-009-1076-8. Epub 2009 Aug 1.

PMID:
19649632
3.

Adventitial microvessel formation after coronary stenting and the effects of SU11218, a tyrosine kinase inhibitor.

Cheema AN, Hong T, Nili N, Segev A, Moffat JG, Lipson KE, Howlett AR, Holdsworth DW, Cole MJ, Qiang B, Kolodgie F, Virmani R, Stewart DJ, Strauss BH.

J Am Coll Cardiol. 2006 Mar 7;47(5):1067-75. Epub 2006 Feb 9.

4.

The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.

Berthou S, Aebersold DM, Schmidt LS, Stroka D, Heigl C, Streit B, Stalder D, Gruber G, Liang C, Howlett AR, Candinas D, Greiner RH, Lipson KE, Zimmer Y.

Oncogene. 2004 Jul 8;23(31):5387-93.

PMID:
15064724
5.

Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth and invasion.

Wang X, Le P, Liang C, Chan J, Kiewlich D, Miller T, Harris D, Sun L, Rice A, Vasile S, Blake RA, Howlett AR, Patel N, McMahon G, Lipson KE.

Mol Cancer Ther. 2003 Nov;2(11):1085-92.

6.

SU5416 and SU6668 attenuate the angiogenic effects of radiation-induced tumor cell growth factor production and amplify the direct anti-endothelial action of radiation in vitro.

Abdollahi A, Lipson KE, Han X, Krempien R, Trinh T, Weber KJ, Hahnfeldt P, Hlatky L, Debus J, Howlett AR, Huber PE.

Cancer Res. 2003 Jul 1;63(13):3755-63.

7.
8.

The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion.

Wright JH, Wang X, Manning G, LaMere BJ, Le P, Zhu S, Khatry D, Flanagan PM, Buckley SD, Whyte DB, Howlett AR, Bischoff JR, Lipson KE, Jallal B.

Mol Cell Biol. 2003 Mar;23(6):2068-82.

9.

Suppression of Ras-mediated tumorigenicity and metastasis through inhibition of the Met receptor tyrosine kinase.

Furge KA, Kiewlich D, Le P, Vo MN, Faure M, Howlett AR, Lipson KE, Vande Woude GF, Webb CP.

Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10722-7. Epub 2001 Sep 4.

10.

A cell-based adhesion assay for the characterization of integrin alpha v beta 3 antagonists.

Wu JM, Rosser MP, Howlett AR, Feldman RI.

Methods Mol Biol. 1999;129:211-7. No abstract available.

PMID:
10494566
11.

Negative cooperativity between alpha 3 beta 1 and alpha 2 beta 1 integrins in human mammary carcinoma MDA MB 231 cells.

Lichtner RB, Howlett AR, Lerch M, Xuan JA, Brink J, Langton-Webster B, Schneider MR.

Exp Cell Res. 1998 May 1;240(2):368-76.

PMID:
9597010
12.

Lactoferrin expression in mammary epithelial cells is mediated by changes in cell shape and actin cytoskeleton.

Close MJ, Howlett AR, Roskelley CD, Desprez PY, Bailey N, Rowning B, Teng CT, Stampfer MR, Yaswen P.

J Cell Sci. 1997 Nov;110 ( Pt 22):2861-71.

13.

The development of a functionally relevant cell culture model of progressive human breast cancer.

Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ.

Semin Cancer Biol. 1995 Jun;6(3):175-84. Review.

PMID:
7495986
14.

Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma.

Howlett AR, Bailey N, Damsky C, Petersen OW, Bissell MJ.

J Cell Sci. 1995 May;108 ( Pt 5):1945-57.

15.
16.

Cell differentiation by extracellular matrix components.

Blaschke RJ, Howlett AR, Desprez PY, Petersen OW, Bissell MJ.

Methods Enzymol. 1994;245:535-56. No abstract available.

PMID:
7760750
17.
18.

Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.

Petersen OW, R√łnnov-Jessen L, Howlett AR, Bissell MJ.

Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9064-8. Erratum in: Proc Natl Acad Sci U S A 1993 Mar 15;90(6):2556.

19.

pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.

Howlett AR, Carter VC, Martin GS, Bissell MJ.

Proc Natl Acad Sci U S A. 1988 Oct;85(20):7587-91.

20.
21.

Tissue tropism and temporal expression of Rous sarcoma virus in embryonic avian limb in ovo.

Howlett AR, Cullen B, Hertle M, Bissell MJ.

Oncogene Res. 1987 Aug;1(3):255-63.

PMID:
2835735
23.
24.

An ultrastructural analysis of the physical organization of collagenous (type I) matrices: one determinant of urothelium maintenance in vitro.

Hodges GM, Rowlatt C, Howlett AR, Trejdosiewicz LK.

Scan Electron Microsc. 1985;(Pt 1):215-30.

PMID:
4001851
25.

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