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Development of a Canine Rigid Body Musculoskeletal Computer Model to Evaluate Gait.

Brown NP, Bertocci GE, States GJR, Levine GJ, Levine JM, Howland DR.

Front Bioeng Biotechnol. 2020 Mar 11;8:150. doi: 10.3389/fbioe.2020.00150. eCollection 2020.


Transcriptional Assessment of Striatal mRNAs as Valid Biomarkers of Disease Progression in Three Mouse Models of Huntington's Disease.

Ghavami A, Olsen M, Kwan M, Beltran J, Shea J, Ramboz S, Duan W, Lavery D, Howland D, Park LC.

J Huntingtons Dis. 2020;9(1):13-31. doi: 10.3233/JHD-190389.


Anatomical Plasticity of Rostrally Terminating Axons as a Possible Bridging Substrate across a Spinal Injury.

Doperalski AE, Montgomery LR, Mondello SE, Howland DR.

J Neurotrauma. 2020 Mar 15;37(6):877-888. doi: 10.1089/neu.2018.6193. Epub 2019 Dec 23.


Extensive Expression Analysis of Htt Transcripts in Brain Regions from the zQ175 HD Mouse Model Using a QuantiGene Multiplex Assay.

Papadopoulou AS, Gomez-Paredes C, Mason MA, Taxy BA, Howland D, Bates GP.

Sci Rep. 2019 Nov 6;9(1):16137. doi: 10.1038/s41598-019-52411-2.


Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene.

Franich NR, Hickey MA, Zhu C, Osborne GF, Ali N, Chu T, Bove NH, Lemesre V, Lerner RP, Zeitlin SO, Howland D, Neueder A, Landles C, Bates GP, Chesselet MF.

J Neurosci Res. 2019 Dec;97(12):1590-1605. doi: 10.1002/jnr.24493. Epub 2019 Jul 7.


The Role of the Cerebellum in Control of Swallow: Evidence of Inspiratory Activity During Swallow.

Reed MD, English M, English C, Huff A, Poliacek I, Musselwhite MN, Howland DR, Bolser DC, Pitts T.

Lung. 2019 Apr;197(2):235-240. doi: 10.1007/s00408-018-00192-2. Epub 2019 Jan 24.


A three dimensional multiplane kinematic model for bilateral hind limb gait analysis in cats.

Brown NP, Bertocci GE, Cheffer KA, Howland DR.

PLoS One. 2018 Aug 6;13(8):e0197837. doi: 10.1371/journal.pone.0197837. eCollection 2018.


Retraining walking adaptability following incomplete spinal cord injury.

Fox EJ, Tester NJ, Butera KA, Howland DR, Spiess MR, Castro-Chapman PL, Behrman AL.

Spinal Cord Ser Cases. 2017 Dec 14;3:17091. doi: 10.1038/s41394-017-0003-1. eCollection 2017.


Suppression of RGSz1 function optimizes the actions of opioid analgesics by mechanisms that involve the Wnt/β-catenin pathway.

Gaspari S, Purushothaman I, Cogliani V, Sakloth F, Neve RL, Howland D, Ring RH, Ross EM, Shen L, Zachariou V.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2085-E2094. doi: 10.1073/pnas.1707887115. Epub 2018 Feb 12.


MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice.

Langfelder P, Gao F, Wang N, Howland D, Kwak S, Vogt TF, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW.

PLoS One. 2018 Jan 11;13(1):e0190550. doi: 10.1371/journal.pone.0190550. eCollection 2018.


Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington's Disease.

Wang HB, Loh DH, Whittaker DS, Cutler T, Howland D, Colwell CS.

eNeuro. 2018 Jan 3;5(1). pii: ENEURO.0431-17.2017. doi: 10.1523/ENEURO.0431-17.2017. eCollection 2018 Jan-Feb.


Artificial miRNAs Reduce Human Mutant Huntingtin Throughout the Striatum in a Transgenic Sheep Model of Huntington's Disease.

Pfister EL, DiNardo N, Mondo E, Borel F, Conroy F, Fraser C, Gernoux G, Han X, Hu D, Johnson E, Kennington L, Liu P, Reid SJ, Sapp E, Vodicka P, Kuchel T, Morton AJ, Howland D, Moser R, Sena-Esteves M, Gao G, Mueller C, DiFiglia M, Aronin N.

Hum Gene Ther. 2018 Jun;29(6):663-673. doi: 10.1089/hum.2017.199. Epub 2018 Feb 23.


Myostatin inhibition prevents skeletal muscle pathophysiology in Huntington's disease mice.

Bondulich MK, Jolinon N, Osborne GF, Smith EJ, Rattray I, Neueder A, Sathasivam K, Ahmed M, Ali N, Benjamin AC, Chang X, Dick JRT, Ellis M, Franklin SA, Goodwin D, Inuabasi L, Lazell H, Lehar A, Richard-Londt A, Rosinski J, Smith DL, Wood T, Tabrizi SJ, Brandner S, Greensmith L, Howland D, Munoz-Sanjuan I, Lee SJ, Bates GP.

Sci Rep. 2017 Oct 27;7(1):14275. doi: 10.1038/s41598-017-14290-3.


Mitochondrial Metabolism in a Large-Animal Model of Huntington Disease: The Hunt for Biomarkers in the Spermatozoa of Presymptomatic Minipigs.

Krizova J, Stufkova H, Rodinova M, Macakova M, Bohuslavova B, Vidinska D, Klima J, Ellederova Z, Pavlok A, Howland DS, Zeman J, Motlik J, Hansikova H.

Neurodegener Dis. 2017;17(4-5):213-226. doi: 10.1159/000475467. Epub 2017 Jun 21.


The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients.

Neueder A, Landles C, Ghosh R, Howland D, Myers RH, Faull RLM, Tabrizi SJ, Bates GP.

Sci Rep. 2017 May 2;7(1):1307. doi: 10.1038/s41598-017-01510-z.


High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.

Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE.

Hum Mol Genet. 2017 Mar 1;26(5):913-922. doi: 10.1093/hmg/ddx006.


Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice.

Alexandrov V, Brunner D, Menalled LB, Kudwa A, Watson-Johnson J, Mazzella M, Russell I, Ruiz MC, Torello J, Sabath E, Sanchez A, Gomez M, Filipov I, Cox K, Kwan M, Ghavami A, Ramboz S, Lager B, Wheeler VC, Aaronson J, Rosinski J, Gusella JF, MacDonald ME, Howland D, Kwak S.

Nat Biotechnol. 2016 Aug;34(8):838-44. doi: 10.1038/nbt.3587. Epub 2016 Jul 4.


Enhancing Fluorogold-based neural tract tracing.

Mondello SE, Jefferson SC, O'Steen WA, Howland DR.

J Neurosci Methods. 2016 Sep 1;270:85-91. doi: 10.1016/j.jneumeth.2016.06.004. Epub 2016 Jun 7.


Feed-forward and reciprocal inhibition for gain and phase timing control in a computational model of repetitive cough.

Pitts T, Morris KF, Segers LS, Poliacek I, Rose MJ, Lindsey BG, Davenport PW, Howland DR, Bolser DC.

J Appl Physiol (1985). 2016 Jul 1;121(1):268-78. doi: 10.1152/japplphysiol.00790.2015. Epub 2016 Jun 9.


Sustaining organizational culture change in health systems.

Willis CD, Saul J, Bevan H, Scheirer MA, Best A, Greenhalgh T, Mannion R, Cornelissen E, Howland D, Jenkins E, Bitz J.

J Health Organ Manag. 2016;30(1):2-30. doi: 10.1108/JHOM-07-2014-0117. Review.


Mutated Huntingtin Causes Testicular Pathology in Transgenic Minipig Boars.

Macakova M, Bohuslavova B, Vochozkova P, Pavlok A, Sedlackova M, Vidinska D, Vochyanova K, Liskova I, Valekova I, Baxa M, Ellederova Z, Klima J, Juhas S, Juhasova J, Klouckova J, Haluzik M, Klempir J, Hansikova H, Spacilova J, Collins R, Blumenthal I, Talkowski M, Gusella JF, Howland DS, DiFiglia M, Motlik J.

Neurodegener Dis. 2016;16(3-4):245-59. doi: 10.1159/000443665. Epub 2016 Mar 10.


Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW.

Nat Neurosci. 2016 Apr;19(4):623-33. doi: 10.1038/nn.4256. Epub 2016 Feb 22.


Cognitive Training at a Young Age Attenuates Deficits in the zQ175 Mouse Model of HD.

Curtin PC, Farrar AM, Oakeshott S, Sutphen J, Berger J, Mazzella M, Cox K, He D, Alosio W, Park LC, Howland D, Brunner D.

Front Behav Neurosci. 2016 Jan 11;9:361. doi: 10.3389/fnbeh.2015.00361. eCollection 2015.


Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.

Mondello SE, Jefferson SC, Tester NJ, Howland DR.

Exp Neurol. 2015 May;267:64-77. doi: 10.1016/j.expneurol.2015.02.028. Epub 2015 Feb 26.


Mind the gap: models in multiple species needed for therapeutic development in Huntington's disease.

Howland DS, Munoz-Sanjuan I.

Mov Disord. 2014 Sep 15;29(11):1397-403. doi: 10.1002/mds.26008. Epub 2014 Aug 22. Review.


Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease.

Farrar AM, Murphy CA, Paterson NE, Oakeshott S, He D, Alosio W, McConnell K, Menalled LB, Ramboz S, Park LC, Howland D, Brunner D.

J Huntingtons Dis. 2014;3(2):145-58. doi: 10.3233/JHD-130061.


Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.

Menalled LB, Kudwa AE, Oakeshott S, Farrar A, Paterson N, Filippov I, Miller S, Kwan M, Olsen M, Beltran J, Torello J, Fitzpatrick J, Mushlin R, Cox K, McConnell K, Mazzella M, He D, Osborne GF, Al-Nackkash R, Bates GP, Tuunanen P, Lehtimaki K, Brunner D, Ghavami A, Ramboz S, Park L, Macdonald D, Munoz-Sanjuan I, Howland D.

PLoS One. 2014 Jun 23;9(6):e99520. doi: 10.1371/journal.pone.0099520. eCollection 2014.



Cheng G, Salehian H, Hwang MS, Howland D, Forder JR, Vemuri BC.

Proc IEEE Int Symp Biomed Imaging. 2012 Dec 31;2012:534-537.


Deficits in a Simple Visual Go/No-go Discrimination Task in Two Mouse Models of Huntington's Disease.

Oakeshott S, Farrar A, Port R, Cummins-Sutphen J, Berger J, Watson-Johnson J, Ramboz S, Howland D, Brunner D.

PLoS Curr. 2013 Nov 7;5. pii: ecurrents.hd.fe74c94bdd446a0470f6f905a30b5dd1. doi: 10.1371/currents.hd.fe74c94bdd446a0470f6f905a30b5dd1.


Increased Body Weight of the BAC HD Transgenic Mouse Model of Huntington's Disease Accounts for Some but Not All of the Observed HD-like Motor Deficits.

Kudwa AE, Menalled LB, Oakeshott S, Murphy C, Mushlin R, Fitzpatrick J, Miller SF, McConnell K, Port R, Torello J, Howland D, Ramboz S, Brunner D.

PLoS Curr. 2013 Jul 30;5. pii: ecurrents.hd.0ab4f3645aff523c56ecc8ccbe41a198. doi: 10.1371/currents.hd.0ab4f3645aff523c56ecc8ccbe41a198.


High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease.

Balci F, Oakeshott S, Shamy JL, El-Khodor BF, Filippov I, Mushlin R, Port R, Connor D, Paintdakhi A, Menalled L, Ramboz S, Howland D, Kwak S, Brunner D.

PLoS Curr. 2013 Jul 11;5. pii: ecurrents.hd.124aa0d16753f88215776fba102ceb29. doi: 10.1371/currents.hd.124aa0d16753f88215776fba102ceb29.


Modular control of varied locomotor tasks in children with incomplete spinal cord injuries.

Fox EJ, Tester NJ, Kautz SA, Howland DR, Clark DJ, Garvan C, Behrman AL.

J Neurophysiol. 2013 Sep;110(6):1415-25. doi: 10.1152/jn.00676.2012. Epub 2013 Jun 12.


Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22.


Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.

Heikkinen T, Lehtimäki K, Vartiainen N, Puoliväli J, Hendricks SJ, Glaser JR, Bradaia A, Wadel K, Touller C, Kontkanen O, Yrjänheikki JM, Buisson B, Howland D, Beaumont V, Munoz-Sanjuan I, Park LC.

PLoS One. 2012;7(12):e50717. doi: 10.1371/journal.pone.0050717. Epub 2012 Dec 20.


Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

Menalled LB, Kudwa AE, Miller S, Fitzpatrick J, Watson-Johnson J, Keating N, Ruiz M, Mushlin R, Alosio W, McConnell K, Connor D, Murphy C, Oakeshott S, Kwan M, Beltran J, Ghavami A, Brunner D, Park LC, Ramboz S, Howland D.

PLoS One. 2012;7(12):e49838. doi: 10.1371/journal.pone.0049838. Epub 2012 Dec 20.


A transgenic minipig model of Huntington's Disease.

Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M, Marsala S, Weiss A, Kubickova S, Musilova P, Vrtel R, Sontag EM, Thompson LM, Schier J, Hansikova H, Howland DS, Cattaneo E, DiFiglia M, Marsala M, Motlik J.

J Huntingtons Dis. 2013;2(1):47-68. doi: 10.3233/JHD-130001.


Large genetic animal models of Huntington's Disease.

Morton AJ, Howland DS.

J Huntingtons Dis. 2013;2(1):3-19. doi: 10.3233/JHD-130050. Review.


A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.

Yu-Taeger L, Petrasch-Parwez E, Osmand AP, Redensek A, Metzger S, Clemens LE, Park L, Howland D, Calaminus C, Gu X, Pichler B, Yang XW, Riess O, Nguyen HP.

J Neurosci. 2012 Oct 31;32(44):15426-38. doi: 10.1523/JNEUROSCI.1148-12.2012.


Translational spinal cord injury research: preclinical guidelines and challenges.

Reier PJ, Lane MA, Hall ED, Teng YD, Howland DR.

Handb Clin Neurol. 2012;109:411-33. doi: 10.1016/B978-0-444-52137-8.00026-7. Review.


Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease.

Landles C, Weiss A, Franklin S, Howland D, Bates G.

PLoS Curr. 2012 Jul 16;4:e4fd085bfc9973. doi: 10.1371/4fd085bfc9973. No abstract available.


Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.

Gafni J, Papanikolaou T, Degiacomo F, Holcomb J, Chen S, Menalled L, Kudwa A, Fitzpatrick J, Miller S, Ramboz S, Tuunanen PI, Lehtimäki KK, Yang XW, Park L, Kwak S, Howland D, Park H, Ellerby LM.

J Neurosci. 2012 May 30;32(22):7454-65. doi: 10.1523/JNEUROSCI.6379-11.2012.


Effect of the rd1 mutation on motor performance in R6/2 and wild type mice.

Menalled L, El-Khodor BF, Hornberger M, Park L, Howland D, Brunner D.

Version 2. PLoS Curr. 2012 Feb 13 [revised 2012 Jan 1];4:RRN1303.


Genetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's disease.

Moumné L, Campbell K, Howland D, Ouyang Y, Bates GP.

PLoS One. 2012;7(2):e31080. doi: 10.1371/journal.pone.0031080. Epub 2012 Feb 8.


Arm and leg coordination during treadmill walking in individuals with motor incomplete spinal cord injury: a preliminary study.

Tester NJ, Barbeau H, Howland DR, Cantrell A, Behrman AL.

Gait Posture. 2012 May;36(1):49-55. doi: 10.1016/j.gaitpost.2012.01.004. Epub 2012 Feb 14.


Pharmacokinetics of memantine in rats and mice.

Beconi MG, Howland D, Park L, Lyons K, Giuliano J, Dominguez C, Munoz-Sanjuan I, Pacifici R.

Version 2. PLoS Curr. 2011 Dec 15 [revised 2012 Jan 1];3:RRN1291.


Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.

Uribe V, Wong BK, Graham RK, Cusack CL, Skotte NH, Pouladi MA, Xie Y, Feinberg K, Ou Y, Ouyang Y, Deng Y, Franciosi S, Bissada N, Spreeuw A, Zhang W, Ehrnhoefer DE, Vaid K, Miller FD, Deshmukh M, Howland D, Hayden MR.

Hum Mol Genet. 2012 May 1;21(9):1954-67. doi: 10.1093/hmg/dds005. Epub 2012 Jan 18.


A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease.

Oakeshott S, Port R, Cummins-Sutphen J, Berger J, Watson-Johnson J, Ramboz S, Paterson N, Kwak S, Howland D, Brunner D.

Version 2. PLoS Curr. 2012 Apr 25 [revised 2012 Jan 1];4:e4f972cffe82c0. doi: 10.1371/4f972cffe82c0.


Target Validation for Huntington’s Disease.

Kwak SP, Wang JKT, Howland DS.

In: Lo DC, Hughes RE, editors. Neurobiology of Huntington's Disease: Applications to Drug Discovery. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 4.


Altered obstacle negotiation after low thoracic hemisection in the cat.

Doperalski AE, Tester NJ, Jefferson SC, Howland DR.

J Neurotrauma. 2011 Sep;28(9):1983-93. doi: 10.1089/neu.2010.1457. Epub 2011 Aug 31.



Cheng G, Vemuri BC, Hwang MS, Howland D, Forder JR.

Proc IEEE Int Symp Biomed Imaging. 2011 Jun 9;2011:549-552.

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