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Items: 13

1.

Screening and profiling assays for HDACs and sirtuins.

Howitz KT.

Drug Discov Today Technol. 2015 Nov;18:38-48. doi: 10.1016/j.ddtec.2015.10.008. Epub 2015 Nov 6. Review.

PMID:
26723891
2.

Development and Use of Assay Conditions Suited to Screening for and Profiling of SET-Domain-Targeted Inhibitors of the MLL/SET1 Family of Lysine Methyltransferases.

Ferry JJ, Smith RF, Denney N, Walsh CP, McCauley L, Qian J, Ma H, Horiuchi KY, Howitz KT.

Assay Drug Dev Technol. 2015 May;13(4):221-34. doi: 10.1089/adt.2015.646.

3.

Assay development for histone methyltransferases.

Horiuchi KY, Eason MM, Ferry JJ, Planck JL, Walsh CP, Smith RF, Howitz KT, Ma H.

Assay Drug Dev Technol. 2013 May;11(4):227-36. doi: 10.1089/adt.2012.480. Epub 2013 Apr 4.

4.

Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA.

Science. 2013 Mar 8;339(6124):1216-9. doi: 10.1126/science.1231097.

5.

Xenohormesis: sensing the chemical cues of other species.

Howitz KT, Sinclair DA.

Cell. 2008 May 2;133(3):387-91. doi: 10.1016/j.cell.2008.04.019.

6.

Design and synthesis of compounds that extend yeast replicative lifespan.

Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.

Aging Cell. 2007 Feb;6(1):35-43. Epub 2006 Dec 5. Erratum in: Aging Cell. 2007 Aug;6(4):593. Adams, Jeffrey K [added]; Kisielewski, Anne [added]; Howitz, Konrad T [added]; Zipkin, Robert E [added].

7.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.

Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.

Science. 2004 Jul 16;305(5682):390-2. Epub 2004 Jun 17.

8.

Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA.

Science. 2003 Dec 19;302(5653):2124-2126. doi: 10.1126/science.1088697. Epub 2003 Nov 6.

9.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
11.
13.

pH Dependence and Kinetics of Glycolate Uptake by Intact Pea Chloroplasts.

Howitz KT, McCarty RE.

Plant Physiol. 1982 Oct;70(4):949-52.

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