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Kynurenine 3-monooxygenase is a critical regulator of renal ischemia-reperfusion injury.

Zheng X, Zhang A, Binnie M, McGuire K, Webster SP, Hughes J, Howie SEM, Mole DJ.

Exp Mol Med. 2019 Feb 13;51(2):15. doi: 10.1038/s12276-019-0210-x.


An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade.

Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SE, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pederson A, Gravelle L, Tantawi S, Schambye H, Sethi T, Mackinnon AC.

Cancer Res. 2019 Jan 23. pii: canres.2244.2018. doi: 10.1158/0008-5472.CAN-18-2244. [Epub ahead of print]


Purine metabolism controls innate lymphoid cell function and protects against intestinal injury.

Crittenden S, Cheyne A, Adams A, Forster T, Robb CT, Felton J, Ho GT, Ruckerl D, Rossi AG, Anderton SM, Ghazal P, Satsangi J, Howie SE, Yao C.

Immunol Cell Biol. 2018 Nov;96(10):1049-1059. doi: 10.1111/imcb.12167. Epub 2018 Jul 10.


Host chemokine signature as a biomarker for the detection of pre-cancerous cervical lesions.

Bhatia R, Kavanagh K, Stewart J, Moncur S, Serrano I, Cong D, Cubie HA, Haas JG, Busby-Earle C, Williams ARW, Howie SEM, Cuschieri K.

Oncotarget. 2018 Apr 6;9(26):18548-18558. doi: 10.18632/oncotarget.24946. eCollection 2018 Apr 6.


Facilitation of IL-22 production from innate lymphoid cells by prostaglandin E2 prevents experimental lung neutrophilic inflammation.

Felton JM, Duffin R, Robb CT, Crittenden S, Anderton SM, Howie SEM, Whyte MKB, Rossi AG, Yao C.

Thorax. 2018 Nov;73(11):1081-1084. doi: 10.1136/thoraxjnl-2017-211097. Epub 2018 Mar 24.


TCR-stimulated changes in cell surface CD46 expression generate type 1 regulatory T cells.

Ni Choileain S, Hay J, Thomas J, Williams A, Vermeren MM, Benezech C, Gomez-Salazar M, Hugues OR, Vermeren S, Howie SEM, Dransfield I, Astier AL.

Sci Signal. 2017 Oct 24;10(502). pii: eaah6163. doi: 10.1126/scisignal.aah6163.


An increased CD25-positive intestinal regulatory T lymphocyte population is dependent upon Cox-2 activity in the Apcmin/+ model.

Faluyi OO, Fitch P, Howie SEM.

Clin Exp Immunol. 2018 Jan;191(1):32-41. doi: 10.1111/cei.13055. Epub 2017 Oct 24.


NKT cells are important mediators of hepatic ischemia-reperfusion injury.

Richards JA, Wigmore SJ, Anderton SM, Howie SEM.

Transpl Immunol. 2017 Dec;45:15-21. doi: 10.1016/j.trim.2017.08.002. Epub 2017 Aug 7.


Nitric oxide induces human CLA+CD25+Foxp3+ regulatory T cells with skin-homing potential.

Yu C, Fitzpatrick A, Cong D, Yao C, Yoo J, Turnbull A, Schwarze J, Norval M, Howie SEM, Weller RB, Astier AL.

J Allergy Clin Immunol. 2017 Nov;140(5):1441-1444.e6. doi: 10.1016/j.jaci.2017.05.023. Epub 2017 Jun 7. No abstract available.


Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis.

Robb CT, McSorley HJ, Lee J, Aoki T, Yu C, Crittenden S, Astier A, Felton JM, Parkinson N, Ayele A, Breyer RM, Anderton SM, Narumiya S, Rossi AG, Howie SE, Guttman-Yassky E, Weller RB, Yao C.

J Allergy Clin Immunol. 2018 Jan;141(1):152-162. doi: 10.1016/j.jaci.2017.04.045. Epub 2017 Jun 3.


Chlamydia trachomatis infection of human endometrial stromal cells induces defective decidualisation and chemokine release.

Giakoumelou S, Wheelhouse N, Brown J, Wade J, Simitsidellis I, Gibson D, Saunders PTK, Horner P, Entrican G, Howie SEM, Horne AW.

Sci Rep. 2017 May 17;7(1):2001. doi: 10.1038/s41598-017-02223-z.


Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.

Duffin R, O'Connor RA, Crittenden S, Forster T, Yu C, Zheng X, Smyth D, Robb CT, Rossi F, Skouras C, Tang S, Richards J, Pellicoro A, Weller RB, Breyer RM, Mole DJ, Iredale JP, Anderton SM, Narumiya S, Maizels RM, Ghazal P, Howie SE, Rossi AG, Yao C.

Science. 2016 Mar 18;351(6279):1333-8. doi: 10.1126/science.aad9903.


Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells.

Leitch CS, Natafji E, Yu C, Abdul-Ghaffar S, Madarasingha N, Venables ZC, Chu R, Fitch PM, Muinonen-Martin AJ, Campbell LE, McLean WH, Schwarze J, Howie SE, Weller RB.

J Allergy Clin Immunol. 2016 Aug;138(2):482-490.e7. doi: 10.1016/j.jaci.2015.11.040. Epub 2016 Mar 2.


Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.

Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Bénéton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP.

Nat Med. 2016 Feb;22(2):202-9. doi: 10.1038/nm.4020. Epub 2016 Jan 11.


Acute Liver Injury Is Independent of B Cells or Immunoglobulin M.

Richards JA, Bucsaiova M, Hesketh EE, Ventre C, Henderson NC, Simpson K, Bellamy CO, Howie SE, Anderton SM, Hughes J, Wigmore SJ.

PLoS One. 2015 Sep 25;10(9):e0138688. doi: 10.1371/journal.pone.0138688. eCollection 2015.


The role of infection in miscarriage.

Giakoumelou S, Wheelhouse N, Cuschieri K, Entrican G, Howie SE, Horne AW.

Hum Reprod Update. 2016 Jan-Feb;22(1):116-33. doi: 10.1093/humupd/dmv041. Epub 2015 Sep 19. Review.


The use of hyperosmotic saline for chondroprotection: implications for orthopaedic surgery and cartilage repair.

Eltawil NM, Howie SE, Simpson AH, Amin AK, Hall AC.

Osteoarthritis Cartilage. 2015 Mar;23(3):469-77. doi: 10.1016/j.joca.2014.12.004. Epub 2014 Dec 11.


Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1β in delirium after hip fracture.

Cape E, Hall RJ, van Munster BC, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, MacLullich AM.

J Psychosom Res. 2014 Sep;77(3):219-25. doi: 10.1016/j.jpsychores.2014.06.014. Epub 2014 Jul 4.


Effector and central memory T helper 2 cells respond differently to peptide immunotherapy.

Mackenzie KJ, Nowakowska DJ, Leech MD, McFarlane AJ, Wilson C, Fitch PM, O'Connor RA, Howie SE, Schwarze J, Anderton SM.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):E784-93. doi: 10.1073/pnas.1316178111. Epub 2014 Feb 10.


Ischemic preconditioning in the liver is independent of regulatory T cell activity.

Devey LR, Richards JA, O'Connor RA, Borthwick G, Clay S, Howie AF, Wigmore SJ, Anderton SM, Howie SE.

PLoS One. 2012;7(11):e49647. doi: 10.1371/journal.pone.0049647. Epub 2012 Nov 21.


Combination peptide immunotherapy based on T-cell epitope mapping reduces allergen-specific IgE and eosinophilia in allergic airway inflammation.

Mackenzie KJ, Fitch PM, Leech MD, Ilchmann A, Wilson C, McFarlane AJ, Howie SE, Anderton SM, Schwarze J.

Immunology. 2013 Mar;138(3):258-68. doi: 10.1111/imm.12032.


Histologic assessment of tumor-associated CD45(+) cell numbers is an independent predictor of prognosis in small cell lung cancer.

Wang W, Hodkinson P, McLaren F, Mackean MJ, Williams L, Howie SEM, Wallace WAH, Sethi T.

Chest. 2013 Jan;143(1):146-151. doi: 10.1378/chest.12-0681.


Adjuvanticity and toxicity of cobalt oxide nanoparticles as an alternative vaccine adjuvant.

Cho WS, Dart K, Nowakowska DJ, Zheng X, Donaldson K, Howie SE.

Nanomedicine (Lond). 2012 Oct;7(10):1495-505. doi: 10.2217/nnm.12.35. Epub 2012 Jul 20.


The role of macrophages in healing the wounded lung.

Alber A, Howie SE, Wallace WA, Hirani N.

Int J Exp Pathol. 2012 Aug;93(4):243-51. doi: 10.1111/j.1365-2613.2012.00833.x. Epub 2012 Jul 7. Review.


Go girls! Efficient female innate immunity.

Howie SE.

Blood. 2011 Nov 24;118(22):5718-9. doi: 10.1182/blood-2011-09-381137. No abstract available.


Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes.

Cho WS, Duffin R, Howie SE, Scotton CJ, Wallace WA, Macnee W, Bradley M, Megson IL, Donaldson K.

Part Fibre Toxicol. 2011 Sep 6;8:27. doi: 10.1186/1743-8977-8-27.


NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis.

Cho WS, Duffin R, Bradley M, Megson IL, Macnee W, Howie SE, Donaldson K.

Eur Respir J. 2012 Mar;39(3):546-57. doi: 10.1183/09031936.00047111. Epub 2011 Aug 4.


Chlamydia trachomatis infection during pregnancy: known unknowns.

Howie SE, Horner PJ, Horne AW.

Discov Med. 2011 Jul;12(62):57-64. Review.


Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis.

Gibbons MA, MacKinnon AC, Ramachandran P, Dhaliwal K, Duffin R, Phythian-Adams AT, van Rooijen N, Haslett C, Howie SE, Simpson AJ, Hirani N, Gauldie J, Iredale JP, Sethi T, Forbes SJ.

Am J Respir Crit Care Med. 2011 Sep 1;184(5):569-81. doi: 10.1164/rccm.201010-1719OC.


Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls.

MacLullich AM, Edelshain BT, Hall RJ, de Vries A, Howie SE, Pearson A, Middleton SD, Gillies F, Armstrong IR, White TO, Cunningham C, de Rooij SE, van Munster BC.

J Am Geriatr Soc. 2011 Jun;59(6):1151-3. doi: 10.1111/j.1532-5415.2011.03428.x. No abstract available.


Immunity and vaccines against sexually transmitted Chlamydia trachomatis infection.

Howie SE, Horner PJ, Horne AW, Entrican G.

Curr Opin Infect Dis. 2011 Feb;24(1):56-61. doi: 10.1097/QCO.0b013e3283421081. Review.


Ectopic lymphoid tissue formation in the lungs of mice infected with Chlamydia pneumoniae is associated with epithelial macrophage inflammatory protein-2/CXCL2 expression.

Fitch PM, Wheelhouse NM, Bowles P, Paterson M, Longbottom D, Entrican G, Howie SE.

Clin Exp Immunol. 2010 Nov;162(2):372-8. doi: 10.1111/j.1365-2249.2010.04231.x. Epub 2010 Sep 14.


Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing.

Cho WS, Duffin R, Poland CA, Howie SE, MacNee W, Bradley M, Megson IL, Donaldson K.

Environ Health Perspect. 2010 Dec;118(12):1699-706. doi: 10.1289/ehp.1002201. Epub 2010 Aug 20.


Diet and asthma--can you change what you or your children are by changing what you eat?

de Vries A, Howie SE.

Pharmacol Ther. 2009 Apr;122(1):78-82. doi: 10.1016/j.pharmthera.2009.02.001. Epub 2009 Feb 24. Review.


Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells.

Dumitriu IE, Dunbar DR, Howie SE, Sethi T, Gregory CD.

J Immunol. 2009 Mar 1;182(5):2795-807. doi: 10.4049/jimmunol.0712671.


High-fat feeding redirects cytokine responses and decreases allergic airway eosinophilia.

de Vries A, Hazlewood L, Fitch PM, Seckl JR, Foster P, Howie SE.

Clin Exp Allergy. 2009 May;39(5):731-9. doi: 10.1111/j.1365-2222.2008.03179.x. Epub 2009 Jan 22.


Modified adenine (9-benzyl-2-butoxy-8-hydroxyadenine) redirects Th2-mediated murine lung inflammation by triggering TLR7.

Vultaggio A, Nencini F, Fitch PM, Filì L, Maggi L, Fanti P, deVries A, Beccastrini E, Palandri F, Manuelli C, Bani D, Giudizi MG, Guarna A, Annunziato F, Romagnani S, Maggi E, Howie SE, Parronchi P.

J Immunol. 2009 Jan 15;182(2):880-9.


Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways.

Lees CW, Zacharias WJ, Tremelling M, Noble CL, Nimmo ER, Tenesa A, Cornelius J, Torkvist L, Kao J, Farrington S, Drummond HE, Ho GT, Arnott ID, Appelman HD, Diehl L, Campbell H, Dunlop MG, Parkes M, Howie SE, Gumucio DL, Satsangi J.

PLoS Med. 2008 Dec 9;5(12):e239. doi: 10.1371/journal.pmed.0050239.


Commercially available recombinant sonic hedgehog up-regulates Ptc and modulates the cytokine and chemokine expression of human macrophages: an effect mediated by endotoxin contamination?

Wakelin SJ, Forsythe JL, Garden OJ, Howie SE.

Immunobiology. 2008;213(1):25-38. doi: 10.1016/j.imbio.2007.06.006. Epub 2007 Aug 27.


Resolution of Der p1-induced allergic airway inflammation is dependent on CD4+CD25+Foxp3+ regulatory cells.

Leech MD, Benson RA, De Vries A, Fitch PM, Howie SE.

J Immunol. 2007 Nov 15;179(10):7050-8.


IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease.

Perona-Wright G, Anderton SM, Howie SE, Gray D.

Int Immunol. 2007 Sep;19(9):1123-34. Epub 2007 Jul 28.


Inflammation-associated remodelling and fibrosis in the lung - a process and an end point.

Wallace WA, Fitch PM, Simpson AJ, Howie SE.

Int J Exp Pathol. 2007 Apr;88(2):103-10. Review.


Inflammatory lung secretions inhibit dendritic cell maturation and function via neutrophil elastase.

Roghanian A, Drost EM, MacNee W, Howie SE, Sallenave JM.

Am J Respir Crit Care Med. 2006 Dec 1;174(11):1189-98. Epub 2006 Sep 7.


The role of megalin (LRP-2/Gp330) during development.

Fisher CE, Howie SE.

Dev Biol. 2006 Aug 15;296(2):279-97. Epub 2006 Jun 8. Review.


"Dirty little secrets"--endotoxin contamination of recombinant proteins.

Wakelin SJ, Sabroe I, Gregory CD, Poxton IR, Forsythe JL, Garden OJ, Howie SE.

Immunol Lett. 2006 Jul 15;106(1):1-7. Epub 2006 May 11.


Human neutrophil elastase inhibitors in innate and adaptive immunity.

Fitch PM, Roghanian A, Howie SE, Sallenave JM.

Biochem Soc Trans. 2006 Apr;34(Pt 2):279-82. Review.


The antimicrobial/elastase inhibitor elafin regulates lung dendritic cells and adaptive immunity.

Roghanian A, Williams SE, Sheldrake TA, Brown TI, Oberheim K, Xing Z, Howie SE, Sallenave JM.

Am J Respir Cell Mol Biol. 2006 May;34(5):634-42. Epub 2006 Jan 19.


FITC-induced murine pulmonary inflammation: CC10 up-regulation and concurrent Shh expression.

Fisher CE, Ahmad SA, Fitch PM, Lamb JR, Howie SE.

Cell Biol Int. 2005 Oct;29(10):868-76.


Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production.

Benson RA, Adamson K, Corsin-Jimenez M, Marley JV, Wahl KA, Lamb JR, Howie SE.

Eur J Immunol. 2005 Mar;35(3):859-69.

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