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Items: 1 to 50 of 55

1.

Structure-activity relationships of polybiguanides with activity against human immunodeficiency virus type 1.

Passic SR, Ferguson ML, Catalone BJ, Kish-Catalone T, Kholodovych V, Zhu W, Welsh W, Rando R, Howett MK, Wigdahl B, Labib M, Krebs FC.

Biomed Pharmacother. 2010 Dec;64(10):723-32. doi: 10.1016/j.biopha.2010.10.001. Epub 2010 Nov 4.

2.

Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.

Fraietta JA, Mueller YM, Do DH, Holmes VM, Howett MK, Lewis MG, Boesteanu AC, Alkan SS, Katsikis PD.

Antimicrob Agents Chemother. 2010 Oct;54(10):4064-73. doi: 10.1128/AAC.00367-10. Epub 2010 Jul 12.

3.

Differentiation of xenografted human fetal lung parenchyma.

Pavlovic J, Floros J, Phelps DS, Wigdahl B, Welsh P, Weisz J, Shearer DA, Leure du Pree A, Myers R, Howett MK.

Early Hum Dev. 2008 Mar;84(3):181-93. Epub 2007 Jun 6.

4.

An inhibitor of the epidermal growth factor receptor function does not affect the ability of human papillomavirus 11 to form warts in the xenografted immunodeficient mouse model.

Parkinson T, Howett MK, Welsh PA, Patrick SD, Neely EB, Flanagan N, Pollack VA, Pustilnik LR, Moyer J, Perros M.

Antiviral Res. 2007 Apr;74(1):43-50. Epub 2007 Jan 9.

PMID:
17239450
5.

The human papillomavirus type 11 E1/\E4 protein is not essential for viral genome amplification.

Fang L, Budgeon LR, Doorbar J, Briggs ER, Howett MK.

Virology. 2006 Aug 1;351(2):271-9. Epub 2006 May 9.

6.
7.

Biochemical analysis of human milk treated with sodium dodecyl sulfate, an alkyl sulfate microbicide that inactivates human immunodeficiency virus type 1.

Hartmann SU, Wigdahl B, Neely EB, Berlin CM, Schengrund CL, Lin HM, Howett MK.

J Hum Lact. 2006 Feb;22(1):61-74.

PMID:
16467288
8.

Induction of productive human papillomavirus type 11 life cycle in epithelial cells grown in organotypic raft cultures.

Fang L, Meyers C, Budgeon LR, Howett MK.

Virology. 2006 Mar 30;347(1):28-35. Epub 2006 Feb 7.

9.

In vitro preclinical testing of nonoxynol-9 as potential anti-human immunodeficiency virus microbicide: a retrospective analysis of results from five laboratories.

Beer BE, Doncel GF, Krebs FC, Shattock RJ, Fletcher PS, Buckheit RW Jr, Watson K, Dezzutti CS, Cummins JE, Bromley E, Richardson-Harman N, Pallansch LA, Lackman-Smith C, Osterling C, Mankowski M, Miller SR, Catalone BJ, Welsh PA, Howett MK, Wigdahl B, Turpin JA, Reichelderfer P.

Antimicrob Agents Chemother. 2006 Feb;50(2):713-23.

10.

Chlamydia trachomatis enters a viable but non-cultivable (persistent) state within herpes simplex virus type 2 (HSV-2) co-infected host cells.

Deka S, Vanover J, Dessus-Babus S, Whittimore J, Howett MK, Wyrick PB, Schoborg RV.

Cell Microbiol. 2006 Jan;8(1):149-62.

PMID:
16367874
11.

Microbicides for prevention of transmission of sexually transmitted diseases.

Howett MK, Kuhl JP.

Curr Pharm Des. 2005;11(29):3731-46. Review.

PMID:
16305508
12.

Toxicity, inflammation, and anti-human immunodeficiency virus type 1 activity following exposure to chemical moieties of C31G.

Catalone BJ, Miller SR, Ferguson ML, Malamud D, Kish-Catalone T, Thakkar NJ, Krebs FC, Howett MK, Wigdahl B.

Biomed Pharmacother. 2005 Sep;59(8):430-7.

PMID:
16154721
13.

Prolonged exposure to the candidate microbicide C31G differentially reduces cellular sensitivity to agent re-exposure.

Catalone BJ, Ferguson ML, Miller SR, Malamud D, Kish-Catalone T, Thakkar NJ, Krebs FC, Howett MK, Wigdahl B.

Biomed Pharmacother. 2005 Sep;59(8):460-8.

PMID:
16154719
14.

Inactivation of HIV-1 in breast milk by treatment with the alkyl sulfate microbicide sodium dodecyl sulfate (SDS).

Urdaneta S, Wigdahl B, Neely EB, Berlin CM Jr, Schengrund CL, Lin HM, Howett MK.

Retrovirology. 2005 Apr 29;2:28.

15.

Comparative safety evaluation of the candidate vaginal microbicide C31G.

Catalone BJ, Kish-Catalone TM, Neely EB, Budgeon LR, Ferguson ML, Stiller C, Miller SR, Malamud D, Krebs FC, Howett MK, Wigdahl B.

Antimicrob Agents Chemother. 2005 Apr;49(4):1509-20.

16.

Efforts to prevent mother-to-child transmission of human immunodeficiency virus type 1 through human milk: past, present, and future.

Urdaneta S, Berlin CM, Howett MK.

Adv Exp Med Biol. 2004;554:475-80. Review. No abstract available.

PMID:
15384628
17.

Mouse model of cervicovaginal toxicity and inflammation for preclinical evaluation of topical vaginal microbicides.

Catalone BJ, Kish-Catalone TM, Budgeon LR, Neely EB, Ferguson M, Krebs FC, Howett MK, Labib M, Rando R, Wigdahl B.

Antimicrob Agents Chemother. 2004 May;48(5):1837-47.

18.

HIV-1 infection in a small animal human vaginal xenograft model.

Kish TM, Ward MG, Welsh PA, Budgeon LR, Wigdahl B, Howett MK.

J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):454-60.

PMID:
14657754
19.

Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection.

Fang L, Ward MG, Welsh PA, Budgeon LR, Neely EB, Howett MK.

Virology. 2003 Sep 15;314(1):147-60.

20.

Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome.

McGarrity TJ, Peiffer LP, Amos CI, Frazier ML, Ward MG, Howett MK.

Am J Gastroenterol. 2003 Mar;98(3):671-8.

PMID:
12650805
21.

Comparative in vitro sensitivities of human immune cell lines, vaginal and cervical epithelial cell lines, and primary cells to candidate microbicides nonoxynol 9, C31G, and sodium dodecyl sulfate.

Krebs FC, Miller SR, Catalone BJ, Fichorova R, Anderson D, Malamud D, Howett MK, Wigdahl B.

Antimicrob Agents Chemother. 2002 Jul;46(7):2292-8.

23.

Papillomavirus microbicidal activities of high-molecular-weight cellulose sulfate, dextran sulfate, and polystyrene sulfonate.

Christensen ND, Reed CA, Culp TD, Hermonat PL, Howett MK, Anderson RA, Zaneveld LJ.

Antimicrob Agents Chemother. 2001 Dec;45(12):3427-32.

24.

Screening for cervical cancer.

Wright TC, Goldie SJ, Cain JM, Howett MK.

Science. 2000 Dec 1;290(5497):1651. No abstract available.

25.

Preventing cervical cancer.

Cain JM, Howett MK.

Science. 2000 Jun 9;288(5472):1753-5.

PMID:
10877694
26.

Sodium dodecyl sulfate and C31G as microbicidal alternatives to nonoxynol 9: comparative sensitivity of primary human vaginal keratinocytes.

Krebs FC, Miller SR, Catalone BJ, Welsh PA, Malamud D, Howett MK, Wigdahl B.

Antimicrob Agents Chemother. 2000 Jul;44(7):1954-60.

27.

Transforming growth factor beta 1 (TGF beta 1) down-regulates expression and function of proliferation-inducing molecules in HPV-transformed cells.

Shier MK, Neely EB, Ward MG, Meyers C, Howett MK.

Anticancer Res. 1999 Nov-Dec;19(6B):4977-82.

PMID:
10697499
28.

Correlation of TGF beta 1 overexpression with down-regulation of proliferation-inducing molecules in HPV-11 transformed human tissue xenografts.

Shier MK, Neely EB, Ward MG, Richards ME, Manders EC, Meyers C, Howett MK.

Anticancer Res. 1999 Nov-Dec;19(6B):4969-76.

PMID:
10697498
29.

Inactivation of human immunodeficiency virus type 1 by nonoxynol-9, C31G, or an alkyl sulfate, sodium dodecyl sulfate.

Krebs FC, Miller SR, Malamud D, Howett MK, Wigdahl B.

Antiviral Res. 1999 Oct;43(3):157-73.

PMID:
10551374
30.

A broad-spectrum microbicide with virucidal activity against sexually transmitted viruses.

Howett MK, Neely EB, Christensen ND, Wigdahl B, Krebs FC, Malamud D, Patrick SD, Pickel MD, Welsh PA, Reed CA, Ward MG, Budgeon LR, Kreider JW.

Antimicrob Agents Chemother. 1999 Feb;43(2):314-21.

31.

Tissue xenografts as a model system for study of the pathogenesis of papillomaviruses.

Howett MK, Christensen ND, Kreider JW.

Clin Dermatol. 1997 Mar-Apr;15(2):229-36. Review. No abstract available.

PMID:
9167907
32.

Localization of protein kinase C alpha isoform expression in the human gastrointestinal tract.

McGarrity TJ, Peiffer LP, Neely EB, Palavarapu RG, Koltun WA, Parker P, Howett MK.

Cell Growth Differ. 1996 Jul;7(7):953-9.

33.
34.

Infectious cycle of human papillomavirus type 11 in human foreskin xenografts in nude mice.

Stoler MH, Whitbeck A, Wolinsky SM, Broker TR, Chow LT, Howett MK, Kreider JW.

J Virol. 1990 Jul;64(7):3310-8.

35.
36.

Human xenografts. A model system for human papillomavirus infection.

Howett MK, Kreider JW, Cockley KD.

Intervirology. 1990;31(2-4):109-15.

PMID:
2165039
37.

Phenotypic properties of herpesvirus-transformed cells with high tumorigenic and metastatic ability.

Marks G, Choudhury T, Howett MK.

Virus Res. 1990 Jan;15(1):27-44.

PMID:
2156388
38.

Administration of ethylnitrosourea to neonate hamsters increases growth and frequency of SV40-induced fibrosarcomas.

Choudhury S, Pegg AE, Kreider JW, Mayo DR, Howett MK.

Proc Soc Exp Biol Med. 1989 Oct;192(1):72-7.

PMID:
2552456
39.

Characterization of an HPV type 11 isolate propagated in human foreskin implants in nude mice.

Dollard SC, Chow LT, Kreider JW, Broker TR, Lill NL, Howett MK.

Virology. 1989 Jul;171(1):294-7.

PMID:
2545034
40.

Herpes simplex virus replication and protein synthesis in a human blood-derived cell line.

Soslau G, Pastorino MB, Morgan DA, Brodsky I, Howett MK.

J Gen Virol. 1987 Aug;68 ( Pt 8):2079-92.

PMID:
3039040
41.

Susceptibility of various human tissues to transformation in vivo with human papillomavirus type 11.

Kreider JW, Howett MK, Stoler MH, Zaino RJ, Welsh P.

Int J Cancer. 1987 Apr 15;39(4):459-65.

PMID:
3030939
42.

Human papillomavirus type 16 in bowenoid papulosis, intraoral papillomas, and squamous cell carcinoma of the tongue.

Lookingbill DP, Kreider JW, Howett MK, Olmstead PM, Conner GH.

Arch Dermatol. 1987 Mar;123(3):363-8.

PMID:
3028282
43.

Laboratory production in vivo of infectious human papillomavirus type 11.

Kreider JW, Howett MK, Leure-Dupree AE, Zaino RJ, Weber JA.

J Virol. 1987 Feb;61(2):590-3.

44.

In vivo transformation of human skin with human papillomavirus type 11 from condylomata acuminata.

Kreider JW, Howett MK, Lill NL, Bartlett GL, Zaino RJ, Sedlacek TV, Mortel R.

J Virol. 1986 Aug;59(2):369-76.

45.

Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata.

Kreider JW, Howett MK, Wolfe SA, Bartlett GL, Zaino RJ, Sedlacek T, Mortel R.

Nature. 1985 Oct 17-23;317(6038):639-41.

PMID:
2997616
46.
47.
48.
49.

Protease inhibitors suppress fibrinolytic activity of herpesvirus-transformed cells.

Adelman SF, Howett MK, Rapp F.

J Gen Virol. 1982 May;60(Pt 1):15-24.

PMID:
6178796
50.

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