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The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study.

D'Ambrosio E, Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Rogdaki M, Froudist-Walsh S, Walters JTR, Howes OD.

Psychiatry Res Neuroimaging. 2019 Jul 19;291:34-41. doi: 10.1016/j.pscychresns.2019.07.005. [Epub ahead of print]


Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.

Kaar SJ, Natesan S, McCutcheon R, Howes OD.

Neuropharmacology. 2019 Jul 9:107704. doi: 10.1016/j.neuropharm.2019.107704. [Epub ahead of print] Review.


Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory.

Nour MM, Dahoun T, McCutcheon RA, Adams RA, Wall MB, Howes OD.

Elife. 2019 Jul 10;8. pii: e45045. doi: 10.7554/eLife.45045.


Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study.

Borgan FR, Jauhar S, McCutcheon RA, Pepper FS, Rogdaki M, Lythgoe DJ, Howes OD.

Sci Rep. 2019 Jul 2;9(1):8685. doi: 10.1038/s41598-019-45018-0.


Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study.

Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD.

Genes Brain Behav. 2019 Jul 2:e12596. doi: 10.1111/gbb.12596. [Epub ahead of print]


Prevalence of treatment-resistant psychoses in the community: A naturalistic study.

Beck K, McCutcheon R, Stephenson L, Schilderman M, Patel N, Ramsay R, Howes OD.

J Psychopharmacol. 2019 Jun 26:269881119855995. doi: 10.1177/0269881119855995. [Epub ahead of print]


Correction: Regulation of dopaminergic function: An [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2019 Jun 11;9(1):168. doi: 10.1038/s41398-019-0501-y.


Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis - ADDENDUM.

Beck K, Lally J, Shergill SS, Bloomfield MAP, MacCabe JH, Gaughran F, Howes OD.

Br J Psychiatry. 2019 Aug;215(2):507. doi: 10.1192/bjp.2019.141. Epub 2019 Jun 10. No abstract available.


Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.

Pillinger T, Osimo EF, de Marvao A, Berry MA, Whitehurst T, Statton B, Quinlan M, Brugger S, Vazir A, Cook SA, O'Regan DP, Howes OD.

Transl Psychiatry. 2019 Jun 7;9(1):163. doi: 10.1038/s41398-019-0502-x.


The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species.

Borgan F, Beck K, Butler E, McCutcheon R, Veronese M, Vernon A, Howes OD.

Psychopharmacology (Berl). 2019 Jun 5. doi: 10.1007/s00213-019-05283-3. [Epub ahead of print]


The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study.

Dahoun T, Calcia MA, Veronese M, Bloomfield P, Reis Marques T, Turkheimer F, Howes OD.

Brain Behav Immun. 2019 Aug;80:742-750. doi: 10.1016/j.bbi.2019.05.023. Epub 2019 May 18.


Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.

Ashok AH, Mizuno Y, Howes OD.

Psychopharmacology (Berl). 2019 Apr;236(4):1119-1129. doi: 10.1007/s00213-019-05196-1. Epub 2019 Mar 18. Review.


Understanding and Predicting Variability in Response to Treatment in Psychotic Disorders: In Vivo Findings.

Jauhar S, Howes OD.

Clin Pharmacol Ther. 2019 May;105(5):1079-1081. doi: 10.1002/cpt.1357. Epub 2019 Mar 18. No abstract available.


Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications.

Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD.

Psychopharmacology (Berl). 2019 Jul;236(7):1985-1997. doi: 10.1007/s00213-019-5188-5. Epub 2019 Feb 28.


Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms.

McCutcheon RA, Abi-Dargham A, Howes OD.

Trends Neurosci. 2019 Mar;42(3):205-220. doi: 10.1016/j.tins.2018.12.004. Epub 2019 Jan 6. Review.


Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.

McCutcheon RA, Bloomfield MAP, Dahoun T, Mehta M, Howes OD.

Schizophr Res. 2018 Dec 17. pii: S0920-9964(18)30699-6. doi: 10.1016/j.schres.2018.12.011. [Epub ahead of print]


Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study.

Kim S, Jung WH, Howes OD, Veronese M, Turkheimer FE, Lee YS, Lee JS, Kim E, Kwon JS.

Psychol Med. 2018 Nov 21:1-10. doi: 10.1017/S0033291718003471. [Epub ahead of print]


Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis.

Bossong MG, Antoniades M, Azis M, Samson C, Quinn B, Bonoldi I, Modinos G, Perez J, Howes OD, Stone JM, Allen P, McGuire P.

JAMA Psychiatry. 2019 Feb 1;76(2):199-207. doi: 10.1001/jamapsychiatry.2018.3252.


A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis.

Pillinger T, Osimo EF, Brugger S, Mondelli V, McCutcheon RA, Howes OD.

Schizophr Bull. 2018 Nov 8. doi: 10.1093/schbul/sby160. [Epub ahead of print]


Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.

McCutcheon RA, Nour MM, Dahoun T, Jauhar S, Pepper F, Expert P, Veronese M, Adams RA, Turkheimer F, Mehta MA, Howes OD.

Biol Psychiatry. 2019 Mar 1;85(5):368-378. doi: 10.1016/j.biopsych.2018.09.010. Epub 2018 Sep 29.


Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies.

Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, Sommer IEC, Howes OD.

Psychol Med. 2018 Oct 25:1-11. doi: 10.1017/S0033291718003057. [Epub ahead of print]


Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".

McGinnity CJ, Årstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Riaño Barros DA, Singh N, Trigg W, Hammers A.

ACS Chem Neurosci. 2019 Jan 16;10(1):768-772. doi: 10.1021/acschemneuro.8b00246. Epub 2018 Oct 11.


Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia.

Nour MM, Dahoun T, Schwartenbeck P, Adams RA, FitzGerald THB, Coello C, Wall MB, Dolan RJ, Howes OD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10167-E10176. doi: 10.1073/pnas.1809298115. Epub 2018 Oct 8.


GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models.

Horder J, Andersson M, Mendez MA, Singh N, Tangen Ä, Lundberg J, Gee A, Halldin C, Veronese M, Bölte S, Farde L, Sementa T, Cash D, Higgins K, Spain D, Turkheimer F, Mick I, Selvaraj S, Nutt DJ, Lingford-Hughes A, Howes OD, Murphy DG, Borg J.

Sci Transl Med. 2018 Oct 3;10(461). pii: eaam8434. doi: 10.1126/scitranslmed.aam8434.


Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis.

Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, McGuire P.

Neuropsychopharmacology. 2018 Dec;43(13):2660. doi: 10.1038/s41386-018-0118-5.


The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study.

Jauhar S, McCutcheon R, Borgan F, Veronese M, Nour M, Pepper F, Rogdaki M, Stone J, Egerton A, Turkheimer F, McGuire P, Howes OD.

Lancet Psychiatry. 2018 Oct;5(10):816-823. doi: 10.1016/S2215-0366(18)30268-2. Epub 2018 Sep 17. Erratum in: Lancet Psychiatry. 2018 Dec;5(12):e28.


Correction: Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2018 Aug 31;8(1):171. doi: 10.1038/s41398-018-0187-6.


Correction: Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis.

Winton-Brown T, Schmidt A, Roiser JP, Howes OD, Egerton A, Fusar-Poli P, Bunzeck N, Grace AA, Duzel E, Kapur S, McGuire P.

Transl Psychiatry. 2018 Aug 31;8(1):170. doi: 10.1038/s41398-018-0189-4.


Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study.

Lally J, Ajnakina O, Singh N, Gardner-Sood P, Stubbs B, Stringer D, Di Forti M, David AS, Smith S, Murray RM, Howes OD, Gaughran F.

Schizophr Res. 2019 Feb;204:381-388. doi: 10.1016/j.schres.2018.08.011. Epub 2018 Aug 25.


The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Natesan S, Turkheimer F, Stone J, Egerton A, McGuire P, Kapur S, Howes OD.

Biol Psychiatry. 2019 Jan 1;85(1):79-87. doi: 10.1016/j.biopsych.2018.07.003. Epub 2018 Jul 11.


The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.

Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD.

Hum Mol Genet. 2018 Oct 15;27(20):3498-3506. doi: 10.1093/hmg/ddy242.


Phasic Stimulation of Midbrain Dopamine Neuron Activity Reduces Salt Consumption.

Sandhu EC, Fernando ABP, Irvine EE, Tossell K, Kokkinou M, Glegola J, Smith MA, Howes OD, Withers DJ, Ungless MA.

eNeuro. 2018 May 15;5(2). pii: ENEURO.0064-18.2018. doi: 10.1523/ENEURO.0064-18.2018. eCollection 2018 Mar-Apr.


Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models.

Pillinger T, D'Ambrosio E, McCutcheon R, Howes OD.

Mol Psychiatry. 2019 Jun;24(6):776-794. doi: 10.1038/s41380-018-0058-9. Epub 2018 May 9. Review. Erratum in: Mol Psychiatry. 2018 Oct 18;:.


The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [11C]-raclopride PET study with aripiprazole.

Shin S, Kim S, Seo S, Lee JS, Howes OD, Kim E, Kwon JS.

Transl Psychiatry. 2018 Apr 24;8(1):87. doi: 10.1038/s41398-018-0134-6.


Determinants of treatment response in first-episode psychosis: an 18F-DOPA PET study.

Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Turkheimer FE, Stone J, Egerton A, McGuire P, Kapur S, Howes OD.

Mol Psychiatry. 2018 Apr 20. doi: 10.1038/s41380-018-0042-4. [Epub ahead of print]


The Relationship Between Dopamine Synthesis Capacity and Release: Implications for Psychosis.

Nour MM, McCutcheon R, Howes OD.

Neuropsychopharmacology. 2018 May;43(6):1195-1196. doi: 10.1038/npp.2017.293. No abstract available.


Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data.

Plavén-Sigray P, Matheson GJ, Collste K, Ashok AH, Coughlin JM, Howes OD, Mizrahi R, Pomper MG, Rusjan P, Veronese M, Wang Y, Cervenka S.

Biol Psychiatry. 2018 Sep 15;84(6):433-442. doi: 10.1016/j.biopsych.2018.02.1171. Epub 2018 Mar 6.


Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.

Osimo EF, Beck K, Reis Marques T, Howes OD.

Mol Psychiatry. 2019 Apr;24(4):549-561. doi: 10.1038/s41380-018-0041-5. Epub 2018 Mar 6. Review.


Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis.

Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, McGuire P.

Neuropsychopharmacology. 2018 Dec;43(13):2652-2659. doi: 10.1038/s41386-017-0004-6. Epub 2018 Jan 30. Erratum in: Neuropsychopharmacology. 2018 Oct 2;:.


Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis.

McCutcheon R, Beck K, Jauhar S, Howes OD.

Schizophr Bull. 2018 Oct 17;44(6):1301-1311. doi: 10.1093/schbul/sbx180.


Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort.

Allen P, Azis M, Modinos G, Bossong MG, Bonoldi I, Samson C, Quinn B, Kempton MJ, Howes OD, Stone JM, Calem M, Perez J, Bhattacharayya S, Broome MR, Grace AA, Zelaya F, McGuire P.

Schizophr Bull. 2018 Oct 17;44(6):1323-1331. doi: 10.1093/schbul/sbx169.


Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology.

Howes OD, Rogdaki M, Findon JL, Wichers RH, Charman T, King BH, Loth E, McAlonan GM, McCracken JT, Parr JR, Povey C, Santosh P, Wallace S, Simonoff E, Murphy DG.

J Psychopharmacol. 2018 Jan;32(1):3-29. doi: 10.1177/0269881117741766. Epub 2017 Dec 14.


Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [11 C]DASB PET study.

Lee J, Kim BH, Kim E, Howes OD, Cho KIK, Yoon YB, Kwon JS.

Hum Psychopharmacol. 2018 Jan;33(1). doi: 10.1002/hup.2642. Epub 2017 Dec 6.


Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors.

Bhattacharyya S, Egerton A, Kim E, Rosso L, Riano Barros D, Hammers A, Brammer M, Turkheimer FE, Howes OD, McGuire P.

Sci Rep. 2017 Nov 3;7(1):15025. doi: 10.1038/s41598-017-14203-4.


Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia.

McCutcheon R, Beck K, D'Ambrosio E, Donocik J, Gobjila C, Jauhar S, Kaar S, Pillinger T, Reis Marques T, Rogdaki M, Howes OD.

Acta Psychiatr Scand. 2018 Jan;137(1):39-46. doi: 10.1111/acps.12825. Epub 2017 Oct 26.


A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia.

Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD.

JAMA Psychiatry. 2017 Dec 1;74(12):1206-1213. doi: 10.1001/jamapsychiatry.2017.2943.


Cortical GABA in Subjects at Ultra-High Risk of Psychosis: Relationship to Negative Prodromal Symptoms.

Modinos G, Simsek F, Horder J, Bossong M, Bonoldi I, Azis M, Perez J, Broome M, Lythgoe DJ, Stone JM, Howes OD, Murphy DG, Grace AA, Allen P, McGuire P.

Int J Neuropsychopharmacol. 2018 Feb 1;21(2):114-119. doi: 10.1093/ijnp/pyx076.


Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis.

Pillinger T, Beck K, Stubbs B, Howes OD.

Br J Psychiatry. 2017 Dec;211(6):339-349. doi: 10.1192/bjp.bp.117.200907. Epub 2017 Oct 5. Review.


Heterogeneity and Homogeneity of Regional Brain Structure in Schizophrenia: A Meta-analysis.

Brugger SP, Howes OD.

JAMA Psychiatry. 2017 Nov 1;74(11):1104-1111. doi: 10.1001/jamapsychiatry.2017.2663.

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