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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats.

Onwordi EC, Halff EF, Whitehurst T, Mansur A, Cotel MC, Wells L, Creeney H, Bonsall D, Rogdaki M, Shatalina E, Reis Marques T, Rabiner EA, Gunn RN, Natesan S, Vernon AC, Howes OD.

Nat Commun. 2020 Jan 14;11(1):246. doi: 10.1038/s41467-019-14122-0.


Dopamine and glutamate in schizophrenia: biology, symptoms and treatment.

McCutcheon RA, Krystal JH, Howes OD.

World Psychiatry. 2020 Feb;19(1):15-33. doi: 10.1002/wps.20693.


Cardiac structure and function in schizophrenia: cardiac magnetic resonance imaging study.

Osimo EF, Brugger SP, de Marvao A, Pillinger T, Whitehurst T, Statton B, Quinlan M, Berry A, Cook SA, O'Regan DP, Howes OD.

Br J Psychiatry. 2020 Jan 9:1-8. doi: 10.1192/bjp.2019.268. [Epub ahead of print]


The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research.

Potkin SG, Kane JM, Correll CU, Lindenmayer JP, Agid O, Marder SR, Olfson M, Howes OD.

NPJ Schizophr. 2020 Jan 7;6(1):1. doi: 10.1038/s41537-019-0090-z. Review.


Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis.

Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD.

Lancet Psychiatry. 2020 Jan;7(1):64-77. doi: 10.1016/S2215-0366(19)30416-X. Epub 2019 Dec 17.


Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology.

Barnes TR, Drake R, Paton C, Cooper SJ, Deakin B, Ferrier IN, Gregory CJ, Haddad PM, Howes OD, Jones I, Joyce EM, Lewis S, Lingford-Hughes A, MacCabe JH, Owens DC, Patel MX, Sinclair JM, Stone JM, Talbot PS, Upthegrove R, Wieck A, Yung AR.

J Psychopharmacol. 2020 Jan;34(1):3-78. doi: 10.1177/0269881119889296. Epub 2019 Dec 12.


Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis.

Mizuno Y, McCutcheon RA, Brugger SP, Howes OD.

Neuropsychopharmacology. 2019 Nov 25. doi: 10.1038/s41386-019-0577-3. [Epub ahead of print]


Serotonin release measured in the human brain: a PET study with [11C]CIMBI-36 and d-amphetamine challenge.

Erritzoe D, Ashok AH, Searle GE, Colasanti A, Turton S, Lewis Y, Huiban M, Moz S, Passchier J, Saleem A, Beaver J, Lingford-Hughes A, Nutt DJ, Howes OD, Gunn RN, Knudsen GM, Rabiner EA.

Neuropsychopharmacology. 2019 Nov 12. doi: 10.1038/s41386-019-0567-5. [Epub ahead of print]


The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [11C]-(+)-PHNO PET study.

Dahoun T, Nour MM, McCutcheon RA, Adams RA, Bloomfield MAP, Howes OD.

Transl Psychiatry. 2019 Nov 11;9(1):287. doi: 10.1038/s41398-019-0627-y.


The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal 18F-DOPA PET and voxel-based morphometry study.

D'Ambrosio E, Jauhar S, Kim S, Veronese M, Rogdaki M, Pepper F, Bonoldi I, Kotoula V, Kempton MJ, Turkheimer F, Kwon JS, Kim E, Howes OD.

Mol Psychiatry. 2019 Nov 5. doi: 10.1038/s41380-019-0570-6. [Epub ahead of print]


Schizophrenia-An Overview.

McCutcheon RA, Reis Marques T, Howes OD.

JAMA Psychiatry. 2019 Oct 30:1-10. doi: 10.1001/jamapsychiatry.2019.3360. [Epub ahead of print]


Treatment of First-Episode Schizophrenia in a Young Woman.

McCutcheon RA, Reis Marques T, Howes OD.

JAMA Psychiatry. 2019 Oct 30. doi: 10.1001/jamapsychiatry.2019.3369. [Epub ahead of print] No abstract available.


Making decisions about antipsychotics: a qualitative study of patient experience and the development of a decision aid.

Kaar SJ, Gobjila C, Butler E, Henderson C, Howes OD.

BMC Psychiatry. 2019 Oct 23;19(1):309. doi: 10.1186/s12888-019-2304-3.


Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study.

Howes OD, Bonoldi I, McCutcheon RA, Azis M, Antoniades M, Bossong M, Modinos G, Perez J, Stone JM, Santangelo B, Veronese M, Grace A, Allen P, McGuire PK.

Neuropsychopharmacology. 2019 Oct 16. doi: 10.1038/s41386-019-0541-2. [Epub ahead of print]


Reduced mu opioid receptor availability in schizophrenia revealed with [11C]-carfentanil positron emission tomographic Imaging.

Ashok AH, Myers J, Reis Marques T, Rabiner EA, Howes OD.

Nat Commun. 2019 Oct 3;10(1):4493. doi: 10.1038/s41467-019-12366-4.


Heterogeneity of Striatal Dopamine Function in Schizophrenia: Meta-analysis of Variance.

Brugger SP, Angelescu I, Abi-Dargham A, Mizrahi R, Shahrezaei V, Howes OD.

Biol Psychiatry. 2020 Feb 1;87(3):215-224. doi: 10.1016/j.biopsych.2019.07.008. Epub 2019 Jul 25. Erratum in: Biol Psychiatry. 2020 Feb 1;87(3):305.


Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies.

Kaar SJ, Angelescu I, Marques TR, Howes OD.

J Neural Transm (Vienna). 2019 Dec;126(12):1637-1651. doi: 10.1007/s00702-019-02080-2. Epub 2019 Sep 16.


The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis.

McCutcheon RA, Pillinger T, Mizuno Y, Montgomery A, Pandian H, Vano L, Marques TR, Howes OD.

Mol Psychiatry. 2019 Aug 30. doi: 10.1038/s41380-019-0502-5. [Epub ahead of print]


The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study.

D'Ambrosio E, Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Rogdaki M, Froudist-Walsh S, Walters JTR, Howes OD.

Psychiatry Res Neuroimaging. 2019 Sep 30;291:34-41. doi: 10.1016/j.pscychresns.2019.07.005. Epub 2019 Jul 19.


Antipsychotics: Mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology.

Kaar SJ, Natesan S, McCutcheon R, Howes OD.

Neuropharmacology. 2019 Jul 9:107704. doi: 10.1016/j.neuropharm.2019.107704. [Epub ahead of print] Review.


Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory.

Nour MM, Dahoun T, McCutcheon RA, Adams RA, Wall MB, Howes OD.

Elife. 2019 Jul 10;8. pii: e45045. doi: 10.7554/eLife.45045.


Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study.

Borgan FR, Jauhar S, McCutcheon RA, Pepper FS, Rogdaki M, Lythgoe DJ, Howes OD.

Sci Rep. 2019 Jul 2;9(1):8685. doi: 10.1038/s41598-019-45018-0.


Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study.

Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD.

Genes Brain Behav. 2019 Nov;18(8):e12596. doi: 10.1111/gbb.12596. Epub 2019 Jul 5.


Prevalence of treatment-resistant psychoses in the community: A naturalistic study.

Beck K, McCutcheon R, Stephenson L, Schilderman M, Patel N, Ramsay R, Howes OD.

J Psychopharmacol. 2019 Oct;33(10):1248-1253. doi: 10.1177/0269881119855995. Epub 2019 Jun 26.


Correction: Regulation of dopaminergic function: An [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2019 Jun 11;9(1):168. doi: 10.1038/s41398-019-0501-y.


Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis - ADDENDUM.

Beck K, Lally J, Shergill SS, Bloomfield MAP, MacCabe JH, Gaughran F, Howes OD.

Br J Psychiatry. 2019 Aug;215(2):507. doi: 10.1192/bjp.2019.141. Epub 2019 Jun 10. No abstract available.


Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.

Pillinger T, Osimo EF, de Marvao A, Berry MA, Whitehurst T, Statton B, Quinlan M, Brugger S, Vazir A, Cook SA, O'Regan DP, Howes OD.

Transl Psychiatry. 2019 Jun 7;9(1):163. doi: 10.1038/s41398-019-0502-x.


The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species.

Borgan F, Beck K, Butler E, McCutcheon R, Veronese M, Vernon A, Howes OD.

Psychopharmacology (Berl). 2019 Nov;236(11):3257-3270. doi: 10.1007/s00213-019-05283-3. Epub 2019 Jun 5.


The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study.

Dahoun T, Calcia MA, Veronese M, Bloomfield P, Reis Marques T, Turkheimer F, Howes OD.

Brain Behav Immun. 2019 Aug;80:742-750. doi: 10.1016/j.bbi.2019.05.023. Epub 2019 May 18.


Tobacco smoking and dopaminergic function in humans: a meta-analysis of molecular imaging studies.

Ashok AH, Mizuno Y, Howes OD.

Psychopharmacology (Berl). 2019 Apr;236(4):1119-1129. doi: 10.1007/s00213-019-05196-1. Epub 2019 Mar 18. Review.


Understanding and Predicting Variability in Response to Treatment in Psychotic Disorders: In Vivo Findings.

Jauhar S, Howes OD.

Clin Pharmacol Ther. 2019 May;105(5):1079-1081. doi: 10.1002/cpt.1357. Epub 2019 Mar 18. No abstract available.


Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications.

Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD.

Psychopharmacology (Berl). 2019 Jul;236(7):1985-1997. doi: 10.1007/s00213-019-5188-5. Epub 2019 Feb 28.


Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms.

McCutcheon RA, Abi-Dargham A, Howes OD.

Trends Neurosci. 2019 Mar;42(3):205-220. doi: 10.1016/j.tins.2018.12.004. Epub 2019 Jan 6. Review.


Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity.

McCutcheon RA, Bloomfield MAP, Dahoun T, Mehta M, Howes OD.

Schizophr Res. 2019 Nov;213:56-64. doi: 10.1016/j.schres.2018.12.011. Epub 2018 Dec 17.


Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study.

Kim S, Jung WH, Howes OD, Veronese M, Turkheimer FE, Lee YS, Lee JS, Kim E, Kwon JS.

Psychol Med. 2019 Nov;49(15):2533-2542. doi: 10.1017/S0033291718003471. Epub 2018 Nov 21.


Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis.

Bossong MG, Antoniades M, Azis M, Samson C, Quinn B, Bonoldi I, Modinos G, Perez J, Howes OD, Stone JM, Allen P, McGuire P.

JAMA Psychiatry. 2019 Feb 1;76(2):199-207. doi: 10.1001/jamapsychiatry.2018.3252.


A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis.

Pillinger T, Osimo EF, Brugger S, Mondelli V, McCutcheon RA, Howes OD.

Schizophr Bull. 2019 Sep 11;45(5):1120-1133. doi: 10.1093/schbul/sby160.


Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study.

McCutcheon RA, Nour MM, Dahoun T, Jauhar S, Pepper F, Expert P, Veronese M, Adams RA, Turkheimer F, Mehta MA, Howes OD.

Biol Psychiatry. 2019 Mar 1;85(5):368-378. doi: 10.1016/j.biopsych.2018.09.010. Epub 2018 Sep 29.


Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies.

Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, Sommer IEC, Howes OD.

Psychol Med. 2019 Oct;49(13):2186-2196. doi: 10.1017/S0033291718003057. Epub 2018 Oct 25.


Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".

McGinnity CJ, Årstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Riaño Barros DA, Singh N, Trigg W, Hammers A.

ACS Chem Neurosci. 2019 Jan 16;10(1):768-772. doi: 10.1021/acschemneuro.8b00246. Epub 2018 Oct 11.


Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia.

Nour MM, Dahoun T, Schwartenbeck P, Adams RA, FitzGerald THB, Coello C, Wall MB, Dolan RJ, Howes OD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10167-E10176. doi: 10.1073/pnas.1809298115. Epub 2018 Oct 8.


GABAA receptor availability is not altered in adults with autism spectrum disorder or in mouse models.

Horder J, Andersson M, Mendez MA, Singh N, Tangen Ä, Lundberg J, Gee A, Halldin C, Veronese M, Bölte S, Farde L, Sementa T, Cash D, Higgins K, Spain D, Turkheimer F, Mick I, Selvaraj S, Nutt DJ, Lingford-Hughes A, Howes OD, Murphy DG, Borg J.

Sci Transl Med. 2018 Oct 3;10(461). pii: eaam8434. doi: 10.1126/scitranslmed.aam8434.


Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis.

Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, McGuire P.

Neuropsychopharmacology. 2018 Dec;43(13):2660. doi: 10.1038/s41386-018-0118-5.


The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study.

Jauhar S, McCutcheon R, Borgan F, Veronese M, Nour M, Pepper F, Rogdaki M, Stone J, Egerton A, Turkheimer F, McGuire P, Howes OD.

Lancet Psychiatry. 2018 Oct;5(10):816-823. doi: 10.1016/S2215-0366(18)30268-2. Epub 2018 Sep 17. Erratum in: Lancet Psychiatry. 2018 Dec;5(12):e28.


Correction: Regulation of dopaminergic function: an [18F]-DOPA PET apomorphine challenge study in humans.

Jauhar S, Veronese M, Rogdaki M, Bloomfield M, Natesan S, Turkheimer F, Kapur S, Howes OD.

Transl Psychiatry. 2018 Aug 31;8(1):171. doi: 10.1038/s41398-018-0187-6.


Correction: Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis.

Winton-Brown T, Schmidt A, Roiser JP, Howes OD, Egerton A, Fusar-Poli P, Bunzeck N, Grace AA, Duzel E, Kapur S, McGuire P.

Transl Psychiatry. 2018 Aug 31;8(1):170. doi: 10.1038/s41398-018-0189-4.


Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study.

Lally J, Ajnakina O, Singh N, Gardner-Sood P, Stubbs B, Stringer D, Di Forti M, David AS, Smith S, Murray RM, Howes OD, Gaughran F.

Schizophr Res. 2019 Feb;204:381-388. doi: 10.1016/j.schres.2018.08.011. Epub 2018 Aug 25.


The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study.

Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Natesan S, Turkheimer F, Stone J, Egerton A, McGuire P, Kapur S, Howes OD.

Biol Psychiatry. 2019 Jan 1;85(1):79-87. doi: 10.1016/j.biopsych.2018.07.003. Epub 2018 Jul 11.


The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.

Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD.

Hum Mol Genet. 2018 Oct 15;27(20):3498-3506. doi: 10.1093/hmg/ddy242.

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