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Ageing, frailty and resilience in Botswana: rapid ageing, rapid change. Findings from a national working group meeting and literature review.

Onen BL, Harris C, Ignatowicz A, Davies J, Drouvelis M, Howes A, Nkomazana O, Onen CL, Sapey E, Tsima B, Lasserson D.

BMC Proc. 2019 Nov 19;13(Suppl 10):8. doi: 10.1186/s12919-019-0171-z. eCollection 2019.


What clinical practice strategies have been shown to decrease incidence rates of intraventricular haemorrhage in preterm infants?

Howes A, Hilditch C, Keir A.

J Paediatr Child Health. 2019 Oct;55(10):1269-1278. doi: 10.1111/jpc.14613.


Long-Term Studies Assessing Outcomes of Ibrutinib Therapy in Patients With Del(11q) Chronic Lymphocytic Leukemia.

Kipps TJ, Fraser G, Coutre SE, Brown JR, Barrientos JC, Barr PM, Byrd JC, O'Brien SM, Dilhuydy MS, Hillmen P, Jaeger U, Moreno C, Cramer P, Stilgenbauer S, Chanan-Khan AA, Mahler M, Salman M, Eckert K, Solman IG, Balasubramanian S, Cheng M, Londhe A, Ninomoto J, Howes A, James DF, Hallek M.

Clin Lymphoma Myeloma Leuk. 2019 Nov;19(11):715-722.e6. doi: 10.1016/j.clml.2019.07.004. Epub 2019 Jul 15.


Hematologic Abnormality in a Young Soldier.

Howes AB.

Am Fam Physician. 2019 Aug 1;100(3):176-178. No abstract available.


What evidence-based strategies have been shown to improve breastfeeding rates in preterm infants?

Hilditch C, Howes A, Dempster N, Keir A.

J Paediatr Child Health. 2019 Aug;55(8):907-914. doi: 10.1111/jpc.14551. Epub 2019 Jun 22. Review.


Parameter Inference for Computational Cognitive Models with Approximate Bayesian Computation.

Kangasrääsiö A, Jokinen JPP, Oulasvirta A, Howes A, Kaski S.

Cogn Sci. 2019 Jun;43(6):e12738. doi: 10.1111/cogs.12738.


Prognostic risk score for patients with relapsed or refractory chronic lymphocytic leukaemia treated with targeted therapies or chemoimmunotherapy: a retrospective, pooled cohort study with external validations.

Soumerai JD, Ni A, Darif M, Londhe A, Xing G, Mun Y, Kay NE, Shanafelt TD, Rabe KG, Byrd JC, Chanan-Khan AA, Furman RR, Hillmen P, Jones J, Seymour JF, Sharman JP, Ferrante L, Mobasher M, Stark T, Reddy V, Dreiling LK, Bhargava P, Howes A, James DF, Zelenetz AD.

Lancet Haematol. 2019 Jul;6(7):e366-e374. doi: 10.1016/S2352-3026(19)30085-7. Epub 2019 May 17. Erratum in: Lancet Haematol. 2019 Jul;6(7):e348.


Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial.

Lavezzi SM, de Jong J, Neyens M, Cramer P, Demirkan F, Fraser G, Bartlett N, Dilhuydy MS, Loscertales J, Avigdor A, Rule S, Samoilova O, Goy A, Ganguly S, Salman M, Howes A, Mahler M, De Nicolao G, Poggesi I.

Pharm Res. 2019 May 1;36(7):93. doi: 10.1007/s11095-019-2605-8.


The role of (bounded) optimization in theory testing and prediction.

Howes A, Lewis RL.

Behav Brain Sci. 2018 Jan;41:e232. doi: 10.1017/S0140525X18001486.


Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma.

Fraser G, Cramer P, Demirkan F, Silva RS, Grosicki S, Pristupa A, Janssens A, Mayer J, Bartlett NL, Dilhuydy MS, Pylypenko H, Loscertales J, Avigdor A, Rule S, Villa D, Samoilova O, Panagiotidis P, Goy A, Pavlovsky MA, Karlsson C, Hallek M, Mahler M, Salman M, Sun S, Phelps C, Balasubramanian S, Howes A, Chanan-Khan A.

Leukemia. 2019 Apr;33(4):969-980. doi: 10.1038/s41375-018-0276-9. Epub 2018 Oct 12.


Safety Analysis of Four Randomized Controlled Studies of Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or Mantle Cell Lymphoma.

O'Brien S, Hillmen P, Coutre S, Barr PM, Fraser G, Tedeschi A, Burger JA, Dilhuydy MS, Hess G, Moreno C, Cramer P, Liu E, Chang S, Vermeulen J, Styles L, Howes A, James DF, Patel K, Graef T, Valentino R.

Clin Lymphoma Myeloma Leuk. 2018 Oct;18(10):648-657.e15. doi: 10.1016/j.clml.2018.06.016. Epub 2018 Jun 28.


Quality improvement effort to reduce hypothermia among high-risk infants on a mother-infant unit.

Howes A, Keir A.

Acta Paediatr. 2018 Oct;107(10):1837. doi: 10.1111/apa.14413. Epub 2018 Jun 20. No abstract available.


4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.

Linetsky M, Bondelid KS, Losovskiy S, Gabyak V, Rullo MJ, Stiadle TI, Munjapara V, Saxena P, Ma D, Cheng YS, Howes AM, Udeigwe E, Salomon RG.

Chem Res Toxicol. 2018 Aug 20;31(8):666-679. doi: 10.1021/acs.chemrestox.8b00028. Epub 2018 Jul 9.


Real-Time Localization of Ventricular Tachycardia Origin From the 12-Lead Electrocardiogram.

Sapp JL, Bar-Tal M, Howes AJ, Toma JE, El-Damaty A, Warren JW, MacInnis PJ, Zhou S, Horáček BM.

JACC Clin Electrophysiol. 2017 Jul;3(7):687-699. doi: 10.1016/j.jacep.2017.02.024. Epub 2017 Jul 17.


Ibrutinib versus rituximab in relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma: a randomized, open-label phase 3 study.

Huang X, Qiu L, Jin J, Zhou D, Chen X, Hou M, Hu J, Hu Y, Ke X, Li J, Liang Y, Liu T, Lv Y, Ren H, Sun A, Wang J, Zhao C, Salman M, Sun S, Howes A, Wang J, Wu P, Li J.

Cancer Med. 2018 Apr;7(4):1043-1055. doi: 10.1002/cam4.1337. Epub 2018 Mar 13.


Ahr and Cyp1a2 genotypes both affect susceptibility to motor deficits following gestational and lactational exposure to polychlorinated biphenyls.

Colter BT, Garber HF, Fleming SM, Fowler JP, Harding GD, Hooven MK, Howes AA, Infante SK, Lang AL, MacDougall MC, Stegman M, Taylor KR, Curran CP.

Neurotoxicology. 2018 Mar;65:125-134. doi: 10.1016/j.neuro.2018.01.008.


Improvement of fatigue, physical functioning, and well-being among patients with severe impairment at baseline receiving ibrutinib in combination with bendamustine and rituximab for relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma in the HELIOS study.

Cramer P, Fraser G, Santucci-Silva R, Grosicki S, Dilhuydy MS, Janssens A, Loscertales J, Rule S, Goy A, Traina S, Chan EKH, Diels J, Sengupta N, Mahler M, Salman M, Howes A, Chanan-Khan A.

Leuk Lymphoma. 2018 Sep;59(9):2075-2084. doi: 10.1080/10428194.2017.1416364. Epub 2018 Jan 3.


The Effect of Expected Value on Attraction Effect Preference Reversals.

Farmer GD, Warren PA, El-Deredy W, Howes A.

J Behav Decis Mak. 2017 Oct;30(4):785-793. doi: 10.1002/bdm.2001. Epub 2016 Dec 19.


Characterization of atrial fibrillation adverse events reported in ibrutinib randomized controlled registration trials.

Brown JR, Moslehi J, O'Brien S, Ghia P, Hillmen P, Cymbalista F, Shanafelt TD, Fraser G, Rule S, Kipps TJ, Coutre S, Dilhuydy MS, Cramer P, Tedeschi A, Jaeger U, Dreyling M, Byrd JC, Howes A, Todd M, Vermeulen J, James DF, Clow F, Styles L, Valentino R, Wildgust M, Mahler M, Burger JA.

Haematologica. 2017 Oct;102(10):1796-1805. doi: 10.3324/haematol.2017.171041. Epub 2017 Jul 27.


Games for Psychological Science.

Howes A.

Top Cogn Sci. 2017 Apr;9(2):533-536. doi: 10.1111/tops.12266.


Workflows and individual differences during visually guided routine tasks in a road traffic management control room.

Starke SD, Baber C, Cooke NJ, Howes A.

Appl Ergon. 2017 May;61:79-89. doi: 10.1016/j.apergo.2017.01.006. Epub 2017 Jan 24.


Differential Production of Type I IFN Determines the Reciprocal Levels of IL-10 and Proinflammatory Cytokines Produced by C57BL/6 and BALB/c Macrophages.

Howes A, Taubert C, Blankley S, Spink N, Wu X, Graham CM, Zhao J, Saraiva M, Ricciardi-Castagnoli P, Bancroft GJ, O'Garra A.

J Immunol. 2016 Oct 1;197(7):2838-53. doi: 10.4049/jimmunol.1501923. Epub 2016 Aug 22.


Why contextual preference reversals maximize expected value.

Howes A, Warren PA, Farmer G, El-Deredy W, Lewis RL.

Psychol Rev. 2016 Jul;123(4):368-91. doi: 10.1037/a0039996.


Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

Howes A, O'Sullivan PA, Breyer F, Ghose A, Cao L, Krappmann D, Bowcock AM, Ley SC.

Biochem J. 2016 Jun 15;473(12):1759-68. doi: 10.1042/BCJ20160270. Epub 2016 Apr 12.


Long-Term Clinical Outcome of Arrhythmogenic Right Ventricular Cardiomyopathy in Individuals With a p.S358L Mutation in TMEM43 Following Implantable Cardioverter Defibrillator Therapy.

Hodgkinson KA, Howes AJ, Boland P, Shen XS, Stuckless S, Young TL, Curtis F, Collier A, Parfrey PS, Connors SP.

Circ Arrhythm Electrophysiol. 2016 Mar;9(3). pii: e003589. doi: 10.1161/CIRCEP.115.003589.


Analysis of Transcriptional Signatures in Response to Listeria monocytogenes Infection Reveals Temporal Changes That Result from Type I Interferon Signaling.

Pitt JM, Blankley S, Potempa K, Graham CM, Moreira-Teixeira L, McNab FW, Howes A, Stavropoulos E, Pascual V, Banchereau J, Chaussabel D, O'Garra A.

PLoS One. 2016 Feb 26;11(2):e0150251. doi: 10.1371/journal.pone.0150251. eCollection 2016.


Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.

Chanan-Khan A, Cramer P, Demirkan F, Fraser G, Silva RS, Grosicki S, Pristupa A, Janssens A, Mayer J, Bartlett NL, Dilhuydy MS, Pylypenko H, Loscertales J, Avigdor A, Rule S, Villa D, Samoilova O, Panagiotidis P, Goy A, Mato A, Pavlovsky MA, Karlsson C, Mahler M, Salman M, Sun S, Phelps C, Balasubramanian S, Howes A, Hallek M; HELIOS investigators.

Lancet Oncol. 2016 Feb;17(2):200-211. doi: 10.1016/S1470-2045(15)00465-9. Epub 2015 Dec 5.


Unilateral Shoulder Weakness and Visual Deformity in a Young Military Recruit.

Howes AB.

Am Fam Physician. 2015 Oct 15;92(8):725-6. No abstract available.


Multicentre analysis of incidental findings on low-resolution CT attenuation correction images: an extended study.

Coward J, Lawson R, Kane T, Elias M, Howes A, Birchall J, Hogg P.

Br J Radiol. 2015;88(1056):20150555. doi: 10.1259/bjr.20150555. Epub 2015 Oct 23.


Predicting Short-Term Remembering as Boundedly Optimal Strategy Choice.

Howes A, Duggan GB, Kalidindi K, Tseng YC, Lewis RL.

Cogn Sci. 2016 Jul;40(5):1192-223. doi: 10.1111/cogs.12271. Epub 2015 Aug 21.


4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids.

Wang H, Linetsky M, Guo J, Choi J, Hong L, Chamberlain AS, Howell SJ, Howes AM, Salomon RG.

Chem Res Toxicol. 2015 May 18;28(5):967-77. doi: 10.1021/acs.chemrestox.5b00001. Epub 2015 Apr 2.


Type I IFN induces IL-10 production in an IL-27-independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in Mycobacterium tuberculosis-infected macrophages.

McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N, Saraiva M, O'Garra A.

J Immunol. 2014 Oct 1;193(7):3600-12. doi: 10.4049/jimmunol.1401088. Epub 2014 Sep 3.


Multi-centre analysis of incidental findings on low-resolution CT attenuation correction images.

Coward J, Lawson R, Kane T, Elias M, Howes A, Birchall J, Hogg P.

Br J Radiol. 2014 Oct;87(1042):20130701. doi: 10.1259/bjr.20130701. Epub 2014 Aug 19.


The regulation of IL-10 expression.

Gabryšová L, Howes A, Saraiva M, O'Garra A.

Curr Top Microbiol Immunol. 2014;380:157-90. doi: 10.1007/978-3-662-43492-5_8. Review.


The HELIOS trial protocol: a phase III study of ibrutinib in combination with bendamustine and rituximab in relapsed/refractory chronic lymphocytic leukemia.

Hallek M, Kay NE, Osterborg A, Chanan-Khan AA, Mahler M, Salman M, Wan Y, Sun S, Zhuang SH, Howes A.

Future Oncol. 2015;11(1):51-9. doi: 10.2217/fon.14.119.


Identification of the key differential transcriptional responses of human whole blood following TLR2 or TLR4 ligation in-vitro.

Blankley S, Graham CM, Howes A, Bloom CI, Berry MP, Chaussabel D, Pascual V, Banchereau J, Lipman M, O'Garra A.

PLoS One. 2014 May 19;9(5):e97702. doi: 10.1371/journal.pone.0097702. eCollection 2014.


Computational rationality: linking mechanism and behavior through bounded utility maximization.

Lewis RL, Howes A, Singh S.

Top Cogn Sci. 2014 Apr;6(2):279-311. doi: 10.1111/tops.12086. Epub 2014 Mar 20.


Utility maximization and bounds on human information processing.

Howes A, Lewis RL, Singh S.

Top Cogn Sci. 2014 Apr;6(2):198-203. doi: 10.1111/tops.12089. Epub 2014 Mar 20.


Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages.

Teixeira-Coelho M, Guedes J, Ferreirinha P, Howes A, Pedrosa J, Rodrigues F, Lai WS, Blackshear PJ, O'Garra A, Castro AG, Saraiva M.

Eur J Immunol. 2014 Mar;44(3):856-66. doi: 10.1002/eji.201343734. Epub 2013 Dec 16.


Spectral assignments and NMR parameter-structure relationships in borates using high-resolution 11B NMR and density functional theory.

Alderman OL, Iuga D, Howes AP, Pike KJ, Holland D, Dupree R.

Phys Chem Chem Phys. 2013 Jun 7;15(21):8208-21. doi: 10.1039/c3cp50772f. Epub 2013 Apr 23.


The consequences of virtual embodiment for the mental representation of proximity.

Miles GE, Howes A.

Q J Exp Psychol (Hove). 2013;66(5):1035-50. doi: 10.1080/17470218.2012.726634. Epub 2012 Oct 12.


Despotic, high-impact species and the subcontinental scale control of avian assemblage structure.

MacNally R, Bowen M, Howes A, McAlpine CA, Maron M.

Ecology. 2012 Mar;93(3):668-78.


Useful theories make predictions.

Howes A.

Top Cogn Sci. 2012 Jan;4(1):84-6; discussion 94-102. doi: 10.1111/j.1756-8765.2011.01174.x.


A spectrometer designed for 6.7 and 14.1 T DNP-enhanced solid-state MAS NMR using quasi-optical microwave transmission.

Pike KJ, Kemp TF, Takahashi H, Day R, Howes AP, Kryukov EV, MacDonald JF, Collis AE, Bolton DR, Wylde RJ, Orwick M, Kosuga K, Clark AJ, Idehara T, Watts A, Smith GM, Newton ME, Dupree R, Smith ME.

J Magn Reson. 2012 Feb;215:1-9. doi: 10.1016/j.jmr.2011.12.006. Epub 2011 Dec 11.


Highlights of 10 years of immunology in Nature Reviews Immunology.

Medzhitov R, Shevach EM, Trinchieri G, Mellor AL, Munn DH, Gordon S, Libby P, Hansson GK, Shortman K, Dong C, Gabrilovich D, Gabryšová L, Howes A, O'Garra A.

Nat Rev Immunol. 2011 Sep 23;11(10):693-702. doi: 10.1038/nri3063. Review.


The post-illumination pupil response of melanopsin-expressing intrinsically photosensitive retinal ganglion cells in diabetes.

Feigl B, Zele AJ, Fader SM, Howes AN, Hughes CE, Jones KA, Jones R.

Acta Ophthalmol. 2012 May;90(3):e230-4. doi: 10.1111/j.1755-3768.2011.02226.x. Epub 2011 Aug 23.


Boron environments in Pyrex® glass--a high resolution, Double-Rotation NMR and thermodynamic modelling study.

Howes AP, Vedishcheva NM, Samoson A, Hanna JV, Smith ME, Holland D, Dupree R.

Phys Chem Chem Phys. 2011 Jul 7;13(25):11919-28. doi: 10.1039/c1cp20771g. Epub 2011 May 26.


Ultra-high resolution 17O solid-state NMR spectroscopy of biomolecules: a comprehensive spectral analysis of monosodium L-glutamate·monohydrate.

Wong A, Howes AP, Yates JR, Watts A, Anupõld T, Past J, Samoson A, Dupree R, Smith ME.

Phys Chem Chem Phys. 2011 Jul 14;13(26):12213-24. doi: 10.1039/c1cp20629j. Epub 2011 May 20.


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