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Items: 32


Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.

Myint NNM, Verma AM, Fernandez-Garcia D, Sarmah P, Tarpey PS, Al-Aqbi SS, Cai H, Trigg R, West K, Howells LM, Thomas A, Brown K, Guttery DS, Singh B, Pringle HJ, McDermott U, Shaw JA, Rufini A.

Cell Death Dis. 2018 Aug 30;9(9):894. doi: 10.1038/s41419-018-0934-x.


Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.

Alexandrou C, Al-Aqbi SS, Higgins JA, Boyle W, Karmokar A, Andreadi C, Luo JL, Moore DA, Viskaduraki M, Blades M, Murray GI, Howells LM, Thomas A, Brown K, Cheng PN, Rufini A.

Sci Rep. 2018 Aug 14;8(1):12096. doi: 10.1038/s41598-018-30591-7.


Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers.

Mahale J, Singh R, Howells LM, Britton RG, Khan SM, Brown K.

Mol Nutr Food Res. 2018 Aug;62(16):e1800267. doi: 10.1002/mnfr.201800267. Epub 2018 Jul 10.


An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications.

Mahale J, Howells LM, Singh R, Britton RG, Cai H, Brown K.

Biomed Chromatogr. 2018 May 9:e4280. doi: 10.1002/bmc.4280. [Epub ahead of print]


Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression.

Eltweri AM, Howells LM, Thomas AL, Dennison AR, Bowrey DJ.

Lipids Health Dis. 2018 Jan 30;17(1):19. doi: 10.1186/s12944-018-0664-1.


Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis.

Wood JP, Howells LM, Brown K, Thomas AL.

Eur J Cancer Prev. 2017 Jul;26(4):277-284. doi: 10.1097/CEJ.0000000000000256.


Targeting pancreatic cancer using a combination of gemcitabine with the omega-3 polyunsaturated fatty acid emulsion, Lipidem™.

Haqq J, Howells LM, Garcea G, Dennison AR.

Mol Nutr Food Res. 2016 Jun;60(6):1437-47. doi: 10.1002/mnfr.201500755. Epub 2015 Dec 18.


Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

Hill CU, Saad SE, Britton RG, Gescher AJ, Sale S, Brown K, Howells LM.

Cancer Chemother Pharmacol. 2015 Jul;76(1):179-85. doi: 10.1007/s00280-015-2771-2. Epub 2015 May 29.


Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.

James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K.

Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12.


Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial.

Irving GR, Iwuji CO, Morgan B, Berry DP, Steward WP, Thomas A, Brown K, Howells LM.

Trials. 2015 Mar 24;16:110. doi: 10.1186/s13063-015-0641-1.


Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.

James MI, Howells LM, Karmokar A, Higgins JA, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Brown K.

PLoS One. 2015 Feb 6;10(2):e0117776. doi: 10.1371/journal.pone.0117776. eCollection 2015.


The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention?

Mahale J, Smagurauskaite G, Brown K, Thomas A, Howells LM.

Int J Cancer. 2016 Jan 1;138(1):30-44. doi: 10.1002/ijc.29447. Epub 2015 Feb 6. Review.


Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.

Haqq J, Howells LM, Garcea G, Metcalfe MS, Steward WP, Dennison AR.

Eur J Cancer. 2014 Oct;50(15):2570-82. doi: 10.1016/j.ejca.2014.06.021. Epub 2014 Aug 1. Review.


Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies.

Howells LM, Mahale J, Sale S, McVeigh L, Steward WP, Thomas A, Brown K.

J Pharmacol Exp Ther. 2014 Sep;350(3):483-94. doi: 10.1124/jpet.114.216333. Epub 2014 Jun 17. Review.


Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP.

Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11.


Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2011 Sep;4(9):1419-25. doi: 10.1158/1940-6207.CAPR-11-0148. Epub 2011 Jun 16.


Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.

Howells LM, Sale S, Sriramareddy SN, Irving GR, Jones DJ, Ottley CJ, Pearson DG, Mann CD, Manson MM, Berry DP, Gescher A, Steward WP, Brown K.

Int J Cancer. 2011 Jul 15;129(2):476-86. doi: 10.1002/ijc.25670. Epub 2010 Nov 3.


Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, Brown K, Steward WP, Gescher AJ, Sale S.

Cancer Prev Res (Phila). 2010 Aug;3(8):929-39. doi: 10.1158/1940-6207.CAPR-09-0236. Epub 2010 Jul 13.


Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.

Howells LM, Neal CP, Brown MC, Berry DP, Manson MM.

Biochem Pharmacol. 2008 May 1;75(9):1774-82. doi: 10.1016/j.bcp.2008.02.012. Epub 2008 Feb 17.


Determining the efficacy of dietary phytochemicals in cancer prevention.

Manson MM, Foreman BE, Howells LM, Moiseeva EP.

Biochem Soc Trans. 2007 Nov;35(Pt 5):1358-63. Review.


Predicting the physiological relevance of in vitro cancer preventive activities of phytochemicals.

Howells LM, Moiseeva EP, Neal CP, Foreman BE, Andreadi CK, Sun YY, Hudson EA, Manson MM.

Acta Pharmacol Sin. 2007 Sep;28(9):1274-304. Review.


Comparison of oxaliplatin- and curcumin-mediated antiproliferative effects in colorectal cell lines.

Howells LM, Mitra A, Manson MM.

Int J Cancer. 2007 Jul 1;121(1):175-83.


Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.

Moiseeva EP, Fox LH, Howells LM, Temple LA, Manson MM.

Apoptosis. 2006 May;11(5):799-812.


Involvement of Nrf2, p38, B-Raf, and nuclear factor-kappaB, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols.

Andreadi CK, Howells LM, Atherfold PA, Manson MM.

Mol Pharmacol. 2006 Mar;69(3):1033-40. Epub 2005 Dec 14.


Prospects for plant-derived chemopreventive agents exhibiting multiple mechanisms of action.

Howells LM, Manson MM.

Curr Med Chem Anticancer Agents. 2005 May;5(3):201-13. Review.


Characterisation of metabolites of the putative cancer chemopreventive agent quercetin and their effect on cyclo-oxygenase activity.

Jones DJ, Lamb JH, Verschoyle RD, Howells LM, Butterworth M, Lim CK, Ferry D, Farmer PB, Gescher AJ.

Br J Cancer. 2004 Sep 13;91(6):1213-9.


Growth-inhibitory effects of the chemopreventive agent indole-3-carbinol are increased in combination with the polyamine putrescine in the SW480 colon tumour cell line.

Hudson EA, Howells LM, Gallacher-Horley B, Fox LH, Gescher A, Manson MM.

BMC Cancer. 2003 Jan 14;3:2. Epub 2003 Jan 14.


Differences between human breast cell lines in susceptibility towards growth inhibition by genistein.

Dampier K, Hudson EA, Howells LM, Manson MM, Walker RA, Gescher A.

Br J Cancer. 2001 Aug 17;85(4):618-24.


Modulation of signal-transduction pathways by chemopreventive agents.

Manson MM, Holloway KA, Howells LM, Hudson EA, Plummer SM, Squires MS, Prigent SA.

Biochem Soc Trans. 2000 Feb;28(2):7-12. Review.


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