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New Paradigms to Assess Consequences of Long-Term, Low-Dose Curcumin Exposure in Lung Cancer Cells.

Smagurauskaite G, Mahale J, Brown K, Thomas AL, Howells LM.

Molecules. 2020 Jan 16;25(2). pii: E366. doi: 10.3390/molecules25020366.


Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery.

Powley IR, Patel M, Miles G, Pringle H, Howells L, Thomas A, Kettleborough C, Bryans J, Hammonds T, MacFarlane M, Pritchard C.

Br J Cancer. 2020 Jan 2. doi: 10.1038/s41416-019-0672-6. [Epub ahead of print] Review.


Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

Howells L, Chalmers JR, Gran S, Ahmed A, Apfelbacher C, Burton T, Howie L, Lawton S, Ridd M, Rogers NK, Sears AV, Spuls P, von Kobyletzki L, Thomas KS.

Br J Dermatol. 2019 Dec 3. doi: 10.1111/bjd.18780. [Epub ahead of print]


Knowing the score - it's not quite enough anymore.

Howells L.

Br J Dermatol. 2019 Oct 23. doi: 10.1111/bjd.18544. [Epub ahead of print] No abstract available.


Evaluation of a non-diagnostic 'Psychology of Emotions' group intervention within a UK youth IAPT service: a mixed-methods approach.

Howells L, Rose A, Gee B, Clarke T, Carroll B, Harbrow S, Oliver C, Wilson J.

Behav Cogn Psychother. 2019 Jun 24:1-13. doi: 10.1017/S1352465819000407. [Epub ahead of print]


Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial.

Howells LM, Iwuji COO, Irving GRB, Barber S, Walter H, Sidat Z, Griffin-Teall N, Singh R, Foreman N, Patel SR, Morgan B, Steward WP, Gescher A, Thomas AL, Brown K.

J Nutr. 2019 Jul 1;149(7):1133-1139. doi: 10.1093/jn/nxz029.


New challenges in psycho-oncology: Using drug development methodology to improve survivorship and supportive care intervention trials.

Howells L, Hulbert-Williams NJ, Blagden SP.

Psychooncology. 2019 Jul;28(7):1362-1366. doi: 10.1002/pon.5100. Epub 2019 May 20. No abstract available.


Defining and measuring 'eczema control': an international qualitative study to explore the views of those living with and treating atopic eczema.

Howells L, Thomas KS, Sears AV, Nasr I, Wollenberg A, Schuttelaar MLA, Romeijn GLE, Paller AS, Mueller K, Doytcheva K, Kataoka Y, Daguze J, Barbarot S, von Kobyletzki LB, Beckman L, Ratib S, Cowdell F, Santer M, Chalmers JR; long-term control of eczema working group for the HOME initiative.

J Eur Acad Dermatol Venereol. 2019 Jun;33(6):1124-1132. doi: 10.1111/jdv.15475. Epub 2019 Apr 8.


Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.

Myint NNM, Verma AM, Fernandez-Garcia D, Sarmah P, Tarpey PS, Al-Aqbi SS, Cai H, Trigg R, West K, Howells LM, Thomas A, Brown K, Guttery DS, Singh B, Pringle HJ, McDermott U, Shaw JA, Rufini A.

Cell Death Dis. 2018 Aug 30;9(9):894. doi: 10.1038/s41419-018-0934-x.


Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes.

Alexandrou C, Al-Aqbi SS, Higgins JA, Boyle W, Karmokar A, Andreadi C, Luo JL, Moore DA, Viskaduraki M, Blades M, Murray GI, Howells LM, Thomas A, Brown K, Cheng PN, Rufini A.

Sci Rep. 2018 Aug 14;8(1):12096. doi: 10.1038/s41598-018-30591-7.


Detection of Plasma Curcuminoids from Dietary Intake of Turmeric-Containing Food in Human Volunteers.

Mahale J, Singh R, Howells LM, Britton RG, Khan SM, Brown K.

Mol Nutr Food Res. 2018 Aug;62(16):e1800267. doi: 10.1002/mnfr.201800267. Epub 2018 Jul 10.


An HPLC-UV method for the simultaneous quantification of curcumin and its metabolites in plasma and lung tissue: Potential for preclinical applications.

Mahale J, Howells LM, Singh R, Britton RG, Cai H, Brown K.

Biomed Chromatogr. 2018 May 9:e4280. doi: 10.1002/bmc.4280. [Epub ahead of print]


Report from the fifth international consensus meeting to harmonize core outcome measures for atopic eczema/dermatitis clinical trials (HOME initiative).

Chalmers JR, Thomas KS, Apfelbacher C, Williams HC, Prinsen CA, Spuls PI, Simpson E, Gerbens LAA, Boers M, Barbarot S, Stalder JF, Abuabara K, Aoki V, Ardeleanu M, Armstrong J, Bang B, Berents TL, Burton T, Butler L, Chubachi T, Cresswell-Melville A, DeLozier A, Eckert L, Eichenfield L, Flohr C, Futamura M, Gadkari A, Gjerde ES, van Halewijn KF, Hawkes C, Howells L, Howie L, Humphreys R, Ishii HA, Kataoka Y, Katayama I, Kouwenhoven W, Langan SM, Leshem YA, Merhand S, Mina-Osorio P, Murota H, Nakahara T, Nunes FP, Nygaard U, Nygårdas M, Ohya Y, Ono E, Rehbinder E, Rogers NK, Romeijn GLE, Schuttelaar MLA, Sears AV, Simpson MA, Singh JA, Srour J, Stuart B, Svensson Å, Talmo G, Talmo H, Teixeira HD, Thyssen JP, Todd G, Torchet F, Volke A, von Kobyletzki L, Weisshaar E, Wollenberg A, Zaniboni M.

Br J Dermatol. 2018 May;178(5):e332-e341. doi: 10.1111/bjd.16543. Epub 2018 Apr 19.


Effects of Omegaven®, EPA, DHA and oxaliplatin on oesophageal adenocarcinoma cell lines growth, cytokine and cell signal biomarkers expression.

Eltweri AM, Howells LM, Thomas AL, Dennison AR, Bowrey DJ.

Lipids Health Dis. 2018 Jan 30;17(1):19. doi: 10.1186/s12944-018-0664-1.


How should minimally important change scores for the Patient-Oriented Eczema Measure be interpreted? A validation using varied methods.

Howells L, Ratib S, Chalmers JR, Bradshaw L, Thomas KS; CLOTHES trial team.

Br J Dermatol. 2018 May;178(5):1135-1142. doi: 10.1111/bjd.16367. Epub 2018 Apr 17.


Impact of Disease Severity, Illness Beliefs, and Coping Strategies on Outcomes in Psoriatic Arthritis.

Howells L, Chisholm A, Cotterill S, Chinoy H, Warren RB, Bundy C.

Arthritis Care Res (Hoboken). 2018 Feb;70(2):295-302. doi: 10.1002/acr.23330. Epub 2017 Dec 29.


Cruel to Be Kind: Factors Underlying Altruistic Efforts to Worsen Another Person's Mood.

López-Pérez B, Howells L, Gummerum M.

Psychol Sci. 2017 Jul;28(7):862-871. doi: 10.1177/0956797617696312. Epub 2017 May 18.


Novel Solutions for Vaccines and Diagnostics To Combat Brucellosis.

Mandal SS, Duncombe L, Ganesh NV, Sarkar S, Howells L, Hogarth PJ, Bundle DR, McGiven J.

ACS Cent Sci. 2017 Mar 22;3(3):224-231. doi: 10.1021/acscentsci.7b00019. Epub 2017 Mar 3.


Management of a patient at high risk of type 2 diabetes.

Howells L, McKay AJ, Hussain S, Majeed A.

London J Prim Care (Abingdon). 2016 Jul 25;8(5):76-79. doi: 10.1080/17571472.2016.1203509. eCollection 2016.


Clinical impact of lifestyle interventions for the prevention of diabetes: an overview of systematic reviews.

Howells L, Musaddaq B, McKay AJ, Majeed A.

BMJ Open. 2016 Dec 21;6(12):e013806. doi: 10.1136/bmjopen-2016-013806. Review.


Assessing barriers to a rational chemoprevention trial design in young patients with familial adenomatous polyposis.

Wood JP, Howells LM, Brown K, Thomas AL.

Eur J Cancer Prev. 2017 Jul;26(4):277-284. doi: 10.1097/CEJ.0000000000000256.


Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-κB signalling pathway.

Ruiz de Porras V, Bystrup S, Martínez-Cardús A, Pluvinet R, Sumoy L, Howells L, James MI, Iwuji C, Manzano JL, Layos L, Bugés C, Abad A, Martínez-Balibrea E.

Sci Rep. 2016 Apr 19;6:24675. doi: 10.1038/srep24675.


Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

Khan S, Karmokar A, Howells L, Thomas AL, Bayliss R, Gescher A, Brown K.

Mol Nutr Food Res. 2016 Jun;60(6):1295-309. doi: 10.1002/mnfr.201500887. Epub 2016 May 11. Review.



Howells L.

Prim Dent J. 2015 Nov;4(4):20-1. No abstract available.


Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes.

Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS.

Sci Transl Med. 2015 Dec 23;7(319):319ra205. doi: 10.1126/scitranslmed.aac6336. Epub 2015 Dec 23.


Targeting pancreatic cancer using a combination of gemcitabine with the omega-3 polyunsaturated fatty acid emulsion, Lipidem™.

Haqq J, Howells LM, Garcea G, Dennison AR.

Mol Nutr Food Res. 2016 Jun;60(6):1437-47. doi: 10.1002/mnfr.201500755. Epub 2015 Dec 18.


Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.


Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

Hill CU, Saad SE, Britton RG, Gescher AJ, Sale S, Brown K, Howells LM.

Cancer Chemother Pharmacol. 2015 Jul;76(1):179-85. doi: 10.1007/s00280-015-2771-2. Epub 2015 May 29.


Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy.

James MI, Iwuji C, Irving G, Karmokar A, Higgins JA, Griffin-Teal N, Thomas A, Greaves P, Cai H, Patel SR, Morgan B, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Howells LM, Brown K.

Cancer Lett. 2015 Aug 10;364(2):135-41. doi: 10.1016/j.canlet.2015.05.005. Epub 2015 May 12.


A feasibility study of translating "Living Well with Dementia" groups into a Primary Care Improving Access to Psychological Therapy service (innovative practice).

Cheston R, Howells L.

Dementia (London). 2016 Mar;15(2):273-8. doi: 10.1177/1471301215582104. Epub 2015 Apr 17.


Combining curcumin (C3-complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial.

Irving GR, Iwuji CO, Morgan B, Berry DP, Steward WP, Thomas A, Brown K, Howells LM.

Trials. 2015 Mar 24;16:110. doi: 10.1186/s13063-015-0641-1.


Characterization and propagation of tumor initiating cells derived from colorectal liver metastases: trials, tribulations and a cautionary note.

James MI, Howells LM, Karmokar A, Higgins JA, Greaves P, Cai H, Dennison A, Metcalfe M, Garcea G, Lloyd DM, Berry DP, Steward WP, Brown K.

PLoS One. 2015 Feb 6;10(2):e0117776. doi: 10.1371/journal.pone.0117776. eCollection 2015.


Improved serodiagnosis of bovine brucellosis by novel synthetic oligosaccharide antigens representing the capping m epitope elements of Brucella O-polysaccharide.

McGiven J, Howells L, Duncombe L, Stack J, Ganesh NV, Guiard J, Bundle DR.

J Clin Microbiol. 2015 Apr;53(4):1204-10. doi: 10.1128/JCM.03185-14. Epub 2015 Feb 4.


Potential for proteomic approaches in determining efficacy biomarkers following administration of fish oils rich in omega-3 fatty acids: application in pancreatic cancers.

Runau F, Arshad A, Isherwood J, Norris L, Howells L, Metcalfe M, Dennison A.

Nutr Clin Pract. 2015 Jun;30(3):363-70. doi: 10.1177/0884533614567337. Epub 2015 Jan 23. Review.


The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention?

Mahale J, Smagurauskaite G, Brown K, Thomas A, Howells LM.

Int J Cancer. 2016 Jan 1;138(1):30-44. doi: 10.1002/ijc.29447. Epub 2015 Feb 6. Review.


A fully automated primary screening system for the discovery of therapeutic antibodies directly from B cells.

Tickle S, Howells L, O'Dowd V, Starkie D, Whale K, Saunders M, Lee D, Lightwood D.

J Biomol Screen. 2015 Apr;20(4):492-7. doi: 10.1177/1087057114564760. Epub 2014 Dec 29.


Molecular recognition of Brucella A and M antigens dissected by synthetic oligosaccharide glycoconjugates leads to a disaccharide diagnostic for brucellosis.

Ganesh NV, Sadowska JM, Sarkar S, Howells L, McGiven J, Bundle DR.

J Am Chem Soc. 2014 Nov 19;136(46):16260-9. doi: 10.1021/ja5081184. Epub 2014 Oct 9.


Cancer chemoprevention: factors influencing attitudes towards chemopreventive agents in high-risk populations.

Iwuji C, Howells L, Thomasset S, Brown K, Steward W, Barwell J, Thomas A.

Eur J Cancer Prev. 2014 Nov;23(6):594-601. doi: 10.1097/CEJ.0000000000000061.


Pancreatic stellate cells and pancreas cancer: current perspectives and future strategies.

Haqq J, Howells LM, Garcea G, Metcalfe MS, Steward WP, Dennison AR.

Eur J Cancer. 2014 Oct;50(15):2570-82. doi: 10.1016/j.ejca.2014.06.021. Epub 2014 Aug 1. Review.


Re: Irish patients knowledge and perception of anaesthesia.

Torlot G, Howells L, Comara J, Sayers R.

Ir Med J. 2014 Jun;107(6):189-90. No abstract available.


Translating curcumin to the clinic for lung cancer prevention: evaluation of the preclinical evidence for its utility in primary, secondary, and tertiary prevention strategies.

Howells LM, Mahale J, Sale S, McVeigh L, Steward WP, Thomas A, Brown K.

J Pharmacol Exp Ther. 2014 Sep;350(3):483-94. doi: 10.1124/jpet.114.216333. Epub 2014 Jun 17. Review.


Psoriasis: snapshots of the unspoken: using novel methods to explore patients' personal models of psoriasis and the impact on well-being.

Bundy C, Borthwick M, McAteer H, Cordingley L, Howells L, Bristow P, McBride S.

Br J Dermatol. 2014 Oct;171(4):825-31. doi: 10.1111/bjd.13101. Epub 2014 Sep 10.


Light scattering coupled with reversed phase chromatography to study protein self-association under separating conditions.

Onsberg M, Øgendal LH, Jensen ML, Howells LB, Andersen B, Bjerrum MJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 1;938:60-4. doi: 10.1016/j.jchromb.2013.08.031. Epub 2013 Aug 30.


The role of cancer stem cells in the anti-carcinogenicity of curcumin.

Norris L, Karmokar A, Howells L, Steward WP, Gescher A, Brown K.

Mol Nutr Food Res. 2013 Sep;57(9):1630-7. doi: 10.1002/mnfr.201300120. Epub 2013 Jul 31. Review.


MMC Reforms: have they put paid to the pluripotent medical student?

Howells L, Cook W.

J R Soc Med. 2013 Jul;106(7):252-3. doi: 10.1177/0141076813496405. No abstract available.


A camera in the surgery.

Howells L, Masters N.

Br J Gen Pract. 2013 Jan;63(606):42-3. doi: 10.3399/bjgp13X660896. No abstract available.


Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP.

Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11.


Increasingly divergent.

Howells L.

Br Dent J. 2011 Aug 12;211(3):103. doi: 10.1038/sj.bdj.2011.634. No abstract available.


Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2011 Sep;4(9):1419-25. doi: 10.1158/1940-6207.CAPR-11-0148. Epub 2011 Jun 16.

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