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Transcranial contrast-enhanced ultrasound in the rat brain reveals substantial hyperperfusion acutely post-stroke.

Premilovac D, Blackwood SJ, Ramsay CJ, Keske MA, Howells DW, Sutherland BA.

J Cereb Blood Flow Metab. 2020 Feb 17:271678X20905493. doi: 10.1177/0271678X20905493. [Epub ahead of print] No abstract available.


Applications of Nanotechnology in the Diagnosis and Therapy of Stroke.

Landowski LM, Niego B, Sutherland BA, Hagemeyer CE, Howells DW.

Semin Thromb Hemost. 2019 Dec 13. doi: 10.1055/s-0039-3399568. [Epub ahead of print]


Differential susceptibility of human neural progenitors and neurons to ischaemic injury.

Liu Y, Michalska AE, Dottori M, Eaton E, Courtney JM, Antonic A, Howells DW.

Brain Res Bull. 2020 Mar;156:25-32. doi: 10.1016/j.brainresbull.2019.12.005. Epub 2019 Dec 16.


Pericytes and Neurovascular Function in the Healthy and Diseased Brain.

Brown LS, Foster CG, Courtney JM, King NE, Howells DW, Sutherland BA.

Front Cell Neurosci. 2019 Jun 28;13:282. doi: 10.3389/fncel.2019.00282. eCollection 2019. Review.


Outcome heterogeneity and bias in acute experimental spinal cord injury: A meta-analysis.

Watzlawick R, Antonic A, Sena ES, Kopp MA, Rind J, Dirnagl U, Macleod M, Howells DW, Schwab JM.

Neurology. 2019 Jul 2;93(1):e40-e51. doi: 10.1212/WNL.0000000000007718. Epub 2019 Jun 7.


The effect of rapamycin treatment on cerebral ischemia: A systematic review and meta-analysis of animal model studies.

Beard DJ, Hadley G, Thurley N, Howells DW, Sutherland BA, Buchan AM.

Int J Stroke. 2019 Feb;14(2):137-145. doi: 10.1177/1747493018816503. Epub 2018 Nov 29.


Hyperacute changes in blood mRNA expression profiles of rats after middle cerebral artery occlusion: Towards a stroke time signature.

Dagonnier M, Wilson WJ, Favaloro JM, Rewell SSJ, Lockett LJ, Sastra SA, Jeffreys AL, Dewey HM, Donnan GA, Howells DW.

PLoS One. 2018 Nov 15;13(11):e0206321. doi: 10.1371/journal.pone.0206321. eCollection 2018.


Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods.

Liu Y, Antonic A, Yang X, Korte N, Lim K, Michalska AE, Dottori M, Howells DW.

J Neurosci Methods. 2018 Oct 1;308:286-293. doi: 10.1016/j.jneumeth.2018.07.005. Epub 2018 Jul 6.


NXY-059, a Failed Stroke Neuroprotectant, Offers No Protection to Stem Cell-Derived Human Neurons.

Antonic A, Dottori M, Macleod MR, Donnan GA, Howells DW.

J Stroke Cerebrovasc Dis. 2018 Aug;27(8):2158-2165. doi: 10.1016/j.jstrokecerebrovasdis.2018.03.015. Epub 2018 Apr 16.


Human Ischaemic Cascade Studies Using SH-SY5Y Cells: a Systematic Review and Meta-Analysis.

Liu Y, Eaton ED, Wills TE, McCann SK, Antonic A, Howells DW.

Transl Stroke Res. 2018 Dec;9(6):564-574. doi: 10.1007/s12975-018-0620-4. Epub 2018 Mar 23. Review.


Discovery and Longitudinal Evaluation of Candidate Biomarkers for Ischaemic Stroke by Mass Spectrometry-Based Proteomics.

Dagonnier M, Cooke IR, Faou P, Sidon TK, Dewey HM, Donnan GA, Howells DW.

Biomark Insights. 2017 Dec 20;12:1177271917749216. doi: 10.1177/1177271917749216. eCollection 2017.


Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.

Simonato M, Iyengar S, Brooks-Kayal A, Collins S, Depaulis A, Howells DW, Jensen F, Liao J, Macleod MR, Patel M, Potschka H, Walker M, Whittemore V, Sena ES.

Epilepsia. 2017 Nov;58 Suppl 4:68-77. doi: 10.1111/epi.13908.


Risk of bias reporting in the recent animal focal cerebral ischaemia literature.

Bahor Z, Liao J, Macleod MR, Bannach-Brown A, McCann SK, Wever KE, Thomas J, Ottavi T, Howells DW, Rice A, Ananiadou S, Sena E.

Clin Sci (Lond). 2017 Oct 12;131(20):2525-2532. doi: 10.1042/CS20160722. Print 2017 Oct 15. Review.


Standardized mean differences cause funnel plot distortion in publication bias assessments.

Zwetsloot PP, Van Der Naald M, Sena ES, Howells DW, IntHout J, De Groot JA, Chamuleau SA, MacLeod MR, Wever KE.

Elife. 2017 Sep 8;6. pii: e24260. doi: 10.7554/eLife.24260.


Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study.

Borschmann KN, Rewell SS, Iuliano S, Ghasem-Zadeh A, Davey RA, Ho H, Skeers PN, Bernhardt J, Howells DW.

PLoS One. 2017 Mar 9;12(3):e0172889. doi: 10.1371/journal.pone.0172889. eCollection 2017.


Evolution of ischemic damage and behavioural deficit over 6 months after MCAo in the rat: Selecting the optimal outcomes and statistical power for multi-centre preclinical trials.

Rewell SS, Churilov L, Sidon TK, Aleksoska E, Cox SF, Macleod MR, Howells DW.

PLoS One. 2017 Feb 9;12(2):e0171688. doi: 10.1371/journal.pone.0171688. eCollection 2017.


Hypothermia revisited: Impact of ischaemic duration and between experiment variability.

Rewell SS, Jeffreys AL, Sastra SA, Cox SF, Fernandez JA, Aleksoska E, van der Worp HB, Churilov L, Macleod MR, Howells DW.

J Cereb Blood Flow Metab. 2017 Oct;37(10):3380-3390. doi: 10.1177/0271678X16688704. Epub 2017 Jan 13.


A Pathway Proteomic Profile of Ischemic Stroke Survivors Reveals Innate Immune Dysfunction in Association with Mild Symptoms of Depression - A Pilot Study.

Nguyen VA, Carey LM, Giummarra L, Faou P, Cooke I, Howells DW, Tse T, Macaulay SL, Ma H, Davis SM, Donnan GA, Crewther SG.

Front Neurol. 2016 Jun 14;7:85. doi: 10.3389/fneur.2016.00085. eCollection 2016.


Olfactory Ensheathing Cell Transplantation in Experimental Spinal Cord Injury: Effect size and Reporting Bias of 62 Experimental Treatments: A Systematic Review and Meta-Analysis.

Watzlawick R, Rind J, Sena ES, Brommer B, Zhang T, Kopp MA, Dirnagl U, Macleod MR, Howells DW, Schwab JM.

PLoS Biol. 2016 May 31;14(5):e1002468. doi: 10.1371/journal.pbio.1002468. eCollection 2016 May.


Corrigendum to 'Meta-analysis of data from animal studies: A practical guide': [Journal of Neuroscience Methods 221 (2014) 92-102].

Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, Antonic A, Howells DW, Macleod MR.

J Neurosci Methods. 2016 Feb 1;259:156. doi: 10.1016/j.jneumeth.2015.11.021. Epub 2015 Dec 12. No abstract available.


Neuroprotection After Traumatic Brain Injury.

Watzlawick R, Howells DW, Schwab JM.

JAMA Neurol. 2016 Feb;73(2):149-50. doi: 10.1001/jamaneurol.2015.3627. Review. No abstract available.


Correction: Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Macleod MR, Lawson McLean A, Kyriakopoulou A, Serghiou S, de Wilde A, Sherratt N, Hirst T, Hemblade R, Bahor Z, Nunes-Fonseca C, Potluru A, Thomson A, Baginskaite J, Egan K, Vesterinen H, Currie GL, Churilov L, Howells DW, Sena ES.

PLoS Biol. 2015 Nov 10;13(11):e1002301. doi: 10.1371/journal.pbio.1002301. eCollection 2015 Nov.


Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Macleod MR, Lawson McLean A, Kyriakopoulou A, Serghiou S, de Wilde A, Sherratt N, Hirst T, Hemblade R, Bahor Z, Nunes-Fonseca C, Potluru A, Thomson A, Baginskaite J, Egan K, Vesterinen H, Currie GL, Churilov L, Howells DW, Sena ES.

PLoS Biol. 2015 Oct 13;13(10):e1002273. doi: 10.1371/journal.pbio.1002273. eCollection 2015 Oct. Erratum in: PLoS Biol. 2015 Nov;13(11):e1002301. Baginskitae, Julija [corrected to Baginskaite, Julija].


A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation.

Kleikers PW, Hooijmans C, Göb E, Langhauser F, Rewell SS, Radermacher K, Ritskes-Hoitinga M, Howells DW, Kleinschnitz C, Schmidt HH.

Sci Rep. 2015 Aug 27;5:13428. doi: 10.1038/srep13428.


Fish oil supplementation associated with decreased cellular degeneration and increased cellular proliferation 6 weeks after middle cerebral artery occlusion in the rat.

Pascoe MC, Howells DW, Crewther DP, Carey LM, Crewther SG.

Neuropsychiatr Dis Treat. 2015 Jan 14;11:153-64. doi: 10.2147/NDT.S72925. eCollection 2015.


Efficacy of antidepressants in animal models of ischemic stroke: a systematic review and meta-analysis.

McCann SK, Irvine C, Mead GE, Sena ES, Currie GL, Egan KE, Macleod MR, Howells DW.

Stroke. 2014 Oct;45(10):3055-63. doi: 10.1161/STROKEAHA.114.006304. Epub 2014 Sep 2. Review.


Recruitment to trials of late thrombolysis: lessons from the EXTEND study.

Dagonnier M, Howells DW, Donnan GA, Dewey HM.

J Clin Neurosci. 2014 Jul;21(7):1215-9. doi: 10.1016/j.jocn.2013.10.033. Epub 2014 Jan 29.


Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment.

Pascoe MC, Howells DW, Crewther DP, Constantinou N, Carey LM, Rewell SS, Turchini GM, Kaur G, Crewther SG.

Front Neurol. 2014 Feb 6;5:14. doi: 10.3389/fneur.2014.00014. eCollection 2014.


Exercise reduces infarct volume and facilitates neurobehavioral recovery: results from a systematic review and meta-analysis of exercise in experimental models of focal ischemia.

Egan KJ, Janssen H, Sena ES, Longley L, Speare S, Howells DW, Spratt NJ, Macleod MR, Mead GE, Bernhardt J.

Neurorehabil Neural Repair. 2014 Oct;28(8):800-12. doi: 10.1177/1545968314521694. Epub 2014 Feb 18. Review.


Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically.

Sena ES, Currie GL, McCann SK, Macleod MR, Howells DW.

J Cereb Blood Flow Metab. 2014 May;34(5):737-42. doi: 10.1038/jcbfm.2014.28. Epub 2014 Feb 19. Review.


Detection of activated platelets in a mouse model of carotid artery thrombosis with 18 F-labeled single-chain antibodies.

Ardipradja K, Yeoh SD, Alt K, O'Keefe G, Rigopoulos A, Howells DW, Scott AM, Peter K, Ackerman U, Hagemeyer CE.

Nucl Med Biol. 2014 Mar;41(3):229-37. doi: 10.1016/j.nucmedbio.2013.12.006. Epub 2013 Dec 18.


How to increase value and reduce waste when research priorities are set.

Chalmers I, Bracken MB, Djulbegovic B, Garattini S, Grant J, Gülmezoglu AM, Howells DW, Ioannidis JP, Oliver S.

Lancet. 2014 Jan 11;383(9912):156-65. doi: 10.1016/S0140-6736(13)62229-1. Epub 2014 Jan 8.


Hypothermia protects human neurons.

Antonic A, Dottori M, Leung J, Sidon K, Batchelor PE, Wilson W, Macleod MR, Howells DW.

Int J Stroke. 2014 Jul;9(5):544-52. doi: 10.1111/ijs.12224. Epub 2014 Jan 3.


Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies.

Antonic A, Sena ES, Lees JS, Wills TE, Skeers P, Batchelor PE, Macleod MR, Howells DW.

PLoS Biol. 2013 Dec;11(12):e1001738. doi: 10.1371/journal.pbio.1001738. Epub 2013 Dec 17. Review.


Effect and reporting bias of RhoA/ROCK-blockade intervention on locomotor recovery after spinal cord injury: a systematic review and meta-analysis.

Watzlawick R, Sena ES, Dirnagl U, Brommer B, Kopp MA, Macleod MR, Howells DW, Schwab JM.

JAMA Neurol. 2014 Jan;71(1):91-9. doi: 10.1001/jamaneurol.2013.4684. Review.


Bringing rigour to translational medicine.

Howells DW, Sena ES, Macleod MR.

Nat Rev Neurol. 2014 Jan;10(1):37-43. doi: 10.1038/nrneurol.2013.232. Epub 2013 Nov 19. Review.


STroke imAging pRevention and treatment (START): A longitudinal stroke cohort study: Clinical trials protocol.

Carey LM, Crewther S, Salvado O, Lindén T, Connelly A, Wilson W, Howells DW, Churilov L, Ma H, Tse T, Rose S, Palmer S, Bougeat P, Campbell BC, Christensen S, Macaulay SL, Favaloro J, O' Collins V, McBride S, Bates S, Cowley E, Dewey H, Wijeratne T, Gerraty R, Phan TG, Yan B, Parsons MW, Bladin C, Barber PA, Read S, Wong A, Lee A, Kleinig T, Hankey GJ, Blacker D, Markus R, Leyden J, Krause M, Grimley R, Mahant N, Jannes J, Sturm J, Davis SM, Donnan GA; START Research Team.

Int J Stroke. 2015 Jun;10(4):636-44. doi: 10.1111/ijs.12190. Epub 2013 Nov 10.


Meta-analysis of data from animal studies: a practical guide.

Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, Antonic A, Howells DW, Macleod MR.

J Neurosci Methods. 2014 Jan 15;221:92-102. doi: 10.1016/j.jneumeth.2013.09.010. Epub 2013 Oct 4. Erratum in: J Neurosci Methods. 2016 Feb 1;259:156.


Meta-analysis of pre-clinical studies of early decompression in acute spinal cord injury: a battle of time and pressure.

Batchelor PE, Wills TE, Skeers P, Battistuzzo CR, Macleod MR, Howells DW, Sena ES.

PLoS One. 2013 Aug 23;8(8):e72659. doi: 10.1371/journal.pone.0072659. eCollection 2013.


Systematic review and meta-analysis of therapeutic hypothermia in animal models of spinal cord injury.

Batchelor PE, Skeers P, Antonic A, Wills TE, Howells DW, Macleod MR, Sena ES.

PLoS One. 2013 Aug 9;8(8):e71317. doi: 10.1371/journal.pone.0071317. eCollection 2013. Review.


Evaluation of excess significance bias in animal studies of neurological diseases.

Tsilidis KK, Panagiotou OA, Sena ES, Aretouli E, Evangelou E, Howells DW, Al-Shahi Salman R, Macleod MR, Ioannidis JP.

PLoS Biol. 2013 Jul;11(7):e1001609. doi: 10.1371/journal.pbio.1001609. Epub 2013 Jul 16.


Hypertension and experimental stroke therapies.

O'Collins VE, Donnan GA, Macleod MR, Howells DW.

J Cereb Blood Flow Metab. 2013 Aug;33(8):1141-7. doi: 10.1038/jcbfm.2013.88. Epub 2013 Jun 5. Review.


Corticospinal tract sprouting in the injured rat spinal cord stimulated by Schwann cell preconditioning of the motor cortex.

Wills TE, Batchelor PE, Kerr NF, Sidon K, Katz M, Loy C, Howells DW.

Neurol Res. 2013 Sep;35(7):763-72. doi: 10.1179/1743132813Y.0000000199. Epub 2013 Apr 12.


Evidence-based translational medicine.

Howells DW, Macleod MR.

Stroke. 2013 May;44(5):1466-71. doi: 10.1161/STROKEAHA.113.000469. Epub 2013 Apr 4. No abstract available.


A call for transparent reporting to optimize the predictive value of preclinical research.

Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT 3rd, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD.

Nature. 2012 Oct 11;490(7419):187-91. doi: 10.1038/nature11556.


Human in vitro models of ischaemic stroke: a test bed for translation.

Antonic A, Sena ES, Donnan GA, Howells DW.

Transl Stroke Res. 2012 Sep;3(3):306-9. doi: 10.1007/s12975-012-0201-x. Epub 2012 Jul 21. No abstract available.


A novel population of α-smooth muscle actin-positive cells activated in a rat model of stroke: an analysis of the spatio-temporal distribution in response to ischemia.

Sharma V, Ling TW, Rewell SS, Hare DL, Howells DW, Kourakis A, Wookey PJ.

J Cereb Blood Flow Metab. 2012 Nov;32(11):2055-65. doi: 10.1038/jcbfm.2012.107. Epub 2012 Jul 18.


The benefit of hypothermia in experimental ischemic stroke is not affected by pethidine.

Sena ES, Jeffreys AL, Cox SF, Sastra SA, Churilov L, Rewell S, Batchelor PE, van der Worp HB, Macleod MR, Howells DW.

Int J Stroke. 2013 Apr;8(3):180-5. doi: 10.1111/j.1747-4949.2012.00834.x. Epub 2012 Jul 3.


The influence of stroke risk factors and comorbidities on assessment of stroke therapies in humans and animals.

Ankolekar S, Rewell S, Howells DW, Bath PM.

Int J Stroke. 2012 Jul;7(5):386-97. doi: 10.1111/j.1747-4949.2012.00802.x. Review.


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