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Items: 1 to 50 of 170


Improving Resuscitation Outcomes With AEDs: Location, Location, Location.

Stecker EC, Reinier K, Howell SJ.

J Am Coll Cardiol. 2019 Sep 24;74(12):1568-1569. doi: 10.1016/j.jacc.2019.07.064. No abstract available.


Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study.

Evans DGR, Kallionpää RA, Clementi M, Trevisson E, Mautner VF, Howell SJ, Lewis L, Zehou O, Peltonen S, Brunello A, Harkness EF, Wolkenstein P, Peltonen J.

Genet Med. 2019 Sep 9. doi: 10.1038/s41436-019-0651-6. [Epub ahead of print]


Should unaffected female BRCA2 pathogenic variant carriers be told there is little or no advantage from risk reducing mastectomy?

Evans DG, Howell SJ, Howell A.

Fam Cancer. 2019 Aug 23. doi: 10.1007/s10689-019-00142-8. [Epub ahead of print] No abstract available.


LVAD with concomitant rapid deployment valve implantation - a case report.

Holloway DD, Jones LC, Howell SJ, Rich JD, Pham DT.

J Cardiothorac Surg. 2019 Jul 1;14(1):126. doi: 10.1186/s13019-019-0944-5.


PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer.

Santiago-Gómez A, Kedward T, Simões BM, Dragoni I, NicAmhlaoibh R, Trivier E, Sabin V, Gee JM, Sims AH, Howell SJ, Clarke RB.

Cancer Lett. 2019 Aug 28;458:66-75. doi: 10.1016/j.canlet.2019.05.014. Epub 2019 May 20.


Consensus statements and expert guidance: interpret with care.

Howell SJ.

Br J Anaesth. 2019 Jun;122(6):719-722. doi: 10.1016/j.bja.2019.03.013. Epub 2019 Apr 19. No abstract available.


Usefulness of Predischarge Cardiac Testing in Low Risk Women and Men for Safe, Rapid Discharge from a Chest Pain Unit.

Howell SJ, Prasad P, Vipparla NS, Venugopal S, Amsterdam EA.

Am J Cardiol. 2019 Jun 1;123(11):1772-1775. doi: 10.1016/j.amjcard.2019.02.039. Epub 2019 Mar 8.


Breast cancer pathology and stage are better predicted by risk stratification models that include mammographic density and common genetic variants.

Evans DGR, Harkness EF, Brentnall AR, van Veen EM, Astley SM, Byers H, Sampson S, Southworth J, Stavrinos P, Howell SJ, Maxwell AJ, Howell A, Newman WG, Cuzick J.

Breast Cancer Res Treat. 2019 Jul;176(1):141-148. doi: 10.1007/s10549-019-05210-2. Epub 2019 Apr 2.


Value of witness observations in the differential diagnosis of transient loss of consciousness.

Chen M, Jamnadas-Khoda J, Broadhurst M, Wall M, Grünewald R, Howell SJL, Koepp M, Parry SW, Sisodiya SM, Walker M, Hesdorffer D, Reuber M.

Neurology. 2019 Feb 26;92(9):e895-e904. doi: 10.1212/WNL.0000000000007017. Epub 2019 Jan 25.


Prospective observational cohort study of the association between antiplatelet therapy, bleeding and thrombosis in patients with coronary stents undergoing noncardiac surgery.

Howell SJ, Hoeks SE, West RM, Wheatcroft SB, Hoeft A; OBTAIN Investigators of European Society of Anaesthesiology (ESA) Clinical Trial Network.

Br J Anaesth. 2019 Feb;122(2):170-179. doi: 10.1016/j.bja.2018.09.029. Epub 2018 Dec 15.


Association Between Invasive Lobular Breast Cancer and Mutations in the Mismatch Repair Gene MSH6.

Evans DG, Howell SJ, Peltonen J.

JAMA Oncol. 2019 Jan 1;5(1):119-120. doi: 10.1001/jamaoncol.2018.6905. No abstract available.


Gene panel testing for breast cancer should not be used to confirm syndromic gene associations.

Evans DG, Howell SJ, Frayling IM, Peltonen J.

NPJ Genom Med. 2018 Nov 26;3:32. doi: 10.1038/s41525-018-0071-6. eCollection 2018. No abstract available.


Implementation of High-Sensitivity Cardiac Troponin: Challenges From the International Experience.

Howell SJ, Amsterdam EA, Mumma BE, López JE, Tran NK.

Crit Pathw Cardiol. 2018 Dec;17(4):173-178. doi: 10.1097/HPC.0000000000000156.


Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.

Simões BM, Kohler B, Clarke RB, Stringer J, Novak-Frazer L, Young K, Rautemaa-Richardson R, Zucchini G, Armstrong A, Howell SJ.

Ther Adv Med Oncol. 2018 Apr 2;10:1758835918766189. doi: 10.1177/1758835918766189. eCollection 2018.


Personalized prevention in high risk individuals: Managing hormones and beyond.

Evans DG, Howell SJ, Howell A.

Breast. 2018 Jun;39:139-147. doi: 10.1016/j.breast.2018.03.009. Epub 2018 Mar 30. Review.


The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

Alferez DG, Simões BM, Howell SJ, Clarke RB.

Curr Stem Cell Rep. 2018;4(1):81-94. doi: 10.1007/s40778-018-0114-z. Epub 2018 Mar 13. Review.


Preoperative Hypertension.

Howell SJ.

Curr Anesthesiol Rep. 2018;8(1):25-31. doi: 10.1007/s40140-018-0248-7. Epub 2018 Feb 8. Review.


Utility of Physician Selection of Cardiac Tests in a Chest Pain Unit to Exclude Acute Coronary Syndrome Among Patients Without a History of Coronary Artery Disease.

Howell SJ, Bui J, Thevakumar B, Amsterdam EA.

Am J Cardiol. 2018 Apr 1;121(7):825-829. doi: 10.1016/j.amjcard.2017.12.030. Epub 2018 Jan 10.


Phenytoin-related ataxia in patients with epilepsy: clinical and radiological characteristics.

Shanmugarajah PD, Hoggard N, Aeschlimann DP, Aeschlimann PC, Dennis GJ, Howell SJ, Reuber M, Grünewald RA, Hadjivassiliou M.

Seizure. 2018 Mar;56:26-30. doi: 10.1016/j.seizure.2018.01.019. Epub 2018 Feb 2.


Abdominal aortic aneurysm repair in the United Kingdom: an exemplar for the role of anaesthetists in perioperative medicine.

Howell SJ.

Br J Anaesth. 2017 Dec 1;119(suppl_1):i15-i22. doi: 10.1093/bja/aex360. Review.


The Goldilocks principle as it applies to perioperative blood pressure: what is too high, too low, or just right?

Sweitzer BJ, Howell SJ.

Br J Anaesth. 2017 Jul 1;119(1):7-10. doi: 10.1093/bja/aex159. No abstract available.


Increased risk of breast cancer in neurofibromatosis type 1: current insights.

Howell SJ, Hockenhull K, Salih Z, Evans DG.

Breast Cancer (Dove Med Press). 2017 Aug 21;9:531-536. doi: 10.2147/BCTT.S111397. eCollection 2017. Review.


Panic symptoms in transient loss of consciousness: Frequency and diagnostic value in psychogenic nonepileptic seizures, epilepsy and syncope.

Rawlings GH, Jamnadas-Khoda J, Broadhurst M, Grünewald RA, Howell SJ, Koepp M, Parry SW, Sisodiya SM, Walker MC, Reuber M.

Seizure. 2017 May;48:22-27. doi: 10.1016/j.seizure.2017.03.015. Epub 2017 Mar 27.


What's in a Mass?: Large Native Mitral Valve Mass.

Howell SJ, Datta Mitra A, Amsterdam EA.

Am J Med. 2017 May;130(5):e171-e175. doi: 10.1016/j.amjmed.2016.12.038. Epub 2017 Feb 2. No abstract available.


Recruitment to the "Breast-Activity and Healthy Eating After Diagnosis" (B-AHEAD) Randomized Controlled Trial.

Pegington M, Adams JE, Bundred NJ, Campbell AM, Howell A, Howell SJ, Speed S, Wolstenholme J, Harvie MN.

Integr Cancer Ther. 2018 Mar;17(1):131-137. doi: 10.1177/1534735416687850. Epub 2017 Jan 23.


MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.

Sundermeier TR, Sakami S, Sahu B, Howell SJ, Gao S, Dong Z, Golczak M, Maeda A, Palczewski K.

J Biol Chem. 2017 Feb 24;292(8):3366-3378. doi: 10.1074/jbc.M116.770024. Epub 2017 Jan 19.


Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

Eyre R, Alférez DG, Spence K, Kamal M, Shaw FL, Simões BM, Santiago-Gómez A, Sarmiento-Castro A, Bramley M, Absar M, Saad Z, Chatterjee S, Kirwan C, Gandhi A, Armstrong AC, Wardley AM, O'Brien CS, Farnie G, Howell SJ, Clarke RB.

J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):111. No abstract available.


Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

Eyre R, Alférez DG, Spence K, Kamal M, Shaw FL, Simões BM, Santiago-Gómez A, Sarmiento-Castro A, Bramley M, Absar M, Saad Z, Chatterjee S, Kirwan C, Gandhi A, Armstrong AC, Wardley AM, O'Brien CS, Farnie G, Howell SJ, Clarke RB.

J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):99-109. Epub 2016 Sep 28. Erratum in: J Mammary Gland Biol Neoplasia. 2016 Dec;21(3-4):111.


4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways.

Guo J, Linetsky M, Yu AO, Zhang L, Howell SJ, Folkwein HJ, Wang H, Salomon RG.

Chem Res Toxicol. 2016 Dec 19;29(12):2125-2135. Epub 2016 Nov 11.


Risk algorithms that include pathology adjustment for HER2 amplification need to make further downward adjustments in likelihood scores.

Evans DG, Woodward ER, Howell SJ, Verhoef S, Howell A, Lalloo F.

Fam Cancer. 2017 Apr;16(2):173-179. doi: 10.1007/s10689-016-9942-0.


Current challenges in vascular anaesthesia.

Howell SJ, Thompson JP, Irwin MG.

Br J Anaesth. 2016 Sep;117 Suppl 2:ii1-ii2. doi: 10.1093/bja/aew271. No abstract available.


Value of patient-reported symptoms in the diagnosis of transient loss of consciousness.

Reuber M, Chen M, Jamnadas-Khoda J, Broadhurst M, Wall M, Grünewald RA, Howell SJ, Koepp M, Parry S, Sisodiya S, Walker M, Hesdorffer D.

Neurology. 2016 Aug 9;87(6):625-33. doi: 10.1212/WNL.0000000000002948. Epub 2016 Jul 6. Erratum in: Neurology. 2016 Nov 15;87(20):2175.


PO-31 - Circulating tumour cells and hypercoagulability: a lethal relationship in metastatic breast cancer.

Kirwan CC, Clarke AC, Howell SJ, Castle J.

Thromb Res. 2016 Apr;140 Suppl 1:S188. doi: 10.1016/S0049-3848(16)30164-5. Epub 2016 Apr 8.


JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL-6/23-stimulated neutrophil, IL-17, elastase, and MMP9 activity.

Taylor PR, Roy S, Meszaros EC, Sun Y, Howell SJ, Malemud CJ, Pearlman E.

J Leukoc Biol. 2016 Jul;100(1):213-22. doi: 10.1189/jlb.4A1015-483R. Epub 2016 Mar 31.


A synthesis of meta-analytic evidence of behavioral interventions to reduce HIV/STIs.

Covey J, Rosenthal-Stott HE, Howell SJ.

J Behav Med. 2016 Jun;39(3):371-85. doi: 10.1007/s10865-016-9714-1. Epub 2016 Jan 30. Review.


A phase II trial of low-dose estradiol in postmenopausal women with advanced breast cancer and acquired resistance to aromatase inhibition.

Zucchini G, Armstrong AC, Wardley AM, Wilson G, Misra V, Seif M, Ryder WD, Cope J, Blowers E, Howell A, Palmieri C, Howell SJ.

Eur J Cancer. 2015 Dec;51(18):2725-31. doi: 10.1016/j.ejca.2015.08.028. Epub 2015 Nov 18.


Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.

Simões BM, O'Brien CS, Eyre R, Silva A, Yu L, Sarmiento-Castro A, Alférez DG, Spence K, Santiago-Gómez A, Chemi F, Acar A, Gandhi A, Howell A, Brennan K, Rydén L, Catalano S, Andó S, Gee J, Ucar A, Sims AH, Marangoni E, Farnie G, Landberg G, Howell SJ, Clarke RB.

Cell Rep. 2015 Sep 29;12(12):1968-77. doi: 10.1016/j.celrep.2015.08.050. Epub 2015 Sep 17.


The role of steroid hormones in breast cancer stem cells.

Simões BM, Alferez DG, Howell SJ, Clarke RB.

Endocr Relat Cancer. 2015 Dec;22(6):T177-86. doi: 10.1530/ERC-15-0350. Epub 2015 Sep 17. Review.


Neoadjuvant chemotherapy and trastuzumab versus neoadjuvant chemotherapy followed by post-operative trastuzumab for patients with HER2-positive breast cancer.

Palmieri C, Macpherson IR, Yan K, Ades F, Riddle P, Ahmed R, Owadally W, Stanley B, Shah D, Gojis O, Januszewski A, Lewanski C, Asher R, Lythgoe D, de Azambuja E, Beresford M, Howell SJ.

Oncotarget. 2016 Mar 15;7(11):13209-20. doi: 10.18632/oncotarget.4801.


Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy.

Lamb R, Fiorillo M, Chadwick A, Ozsvari B, Reeves KJ, Smith DL, Clarke RB, Howell SJ, Cappello AR, Martinez-Outschoorn UE, Peiris-Pagès M, Sotgia F, Lisanti MP.

Oncotarget. 2015 Jun 10;6(16):14005-25.


Cardiopulmonary exercise testing before abdominal aortic aneurysm surgery: a validated risk prediction tool?

Hollingsworth A, Danjoux G, Howell SJ.

Br J Anaesth. 2015 Oct;115(4):494-7. doi: 10.1093/bja/aev150. Epub 2015 Jun 17. No abstract available.


Predicting survival after surgery: a matter of life and death.

Howell SJ.

Anaesthesia. 2015 Jun;70(6):637-40. doi: 10.1111/anae.13104. No abstract available.


4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids.

Wang H, Linetsky M, Guo J, Choi J, Hong L, Chamberlain AS, Howell SJ, Howes AM, Salomon RG.

Chem Res Toxicol. 2015 May 18;28(5):967-77. doi: 10.1021/acs.chemrestox.5b00001. Epub 2015 Apr 2.


Project Post Intensive Care eXercise (PIX): A qualitative exploration of intensive care unit survivors' perceptions of quality of life post-discharge and experience of exercise rehabilitation.

Walker W, Wright J, Danjoux G, Howell SJ, Martin D, Bonner S.

J Intensive Care Soc. 2015 Feb;16(1):37-44. doi: 10.1177/1751143714554896. Epub 2014 Dec 9.


Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux.

Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, Camilli A, Kadioglu A, Dubyak GR, Pearlman E.

J Immunol. 2015 Feb 15;194(4):1763-75. doi: 10.4049/jimmunol.1401624. Epub 2015 Jan 21.


I. Advances in trauma care: a quiet revolution.

Howell SJ.

Br J Anaesth. 2014 Aug;113(2):201-2. doi: 10.1093/bja/aeu253. No abstract available.


Novel flexible suture fixation for the distal tibiofibular syndesmotic joint injury: a cadaveric biomechanical model.

Gough BE, Chong AC, Howell SJ, Galvin JW, Wooley PH.

J Foot Ankle Surg. 2014 Nov-Dec;53(6):706-11. doi: 10.1053/j.jfas.2014.04.022. Epub 2014 May 17.


All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.

Sawada O, Perusek L, Kohno H, Howell SJ, Maeda A, Matsuyama S, Maeda T.

Exp Eye Res. 2014 Jun;123:27-36. doi: 10.1016/j.exer.2014.04.003. Epub 2014 Apr 12.

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