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Items: 1 to 50 of 52

1.

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.

Knuepfer E, Wright KE, Kumar Prajapati S, Rawlinson TA, Mohring F, Koch M, Lyth OR, Howell SA, Villasis E, Snijders AP, Moon RW, Draper SJ, Rosanas-Urgell A, Higgins MK, Baum J, Holder AA.

PLoS Pathog. 2019 Jun 11;15(6):e1007809. doi: 10.1371/journal.ppat.1007809. eCollection 2019 Jun.

2.

Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.

3.

The Binding of Plasmodium falciparum Adhesins and Erythrocyte Invasion Proteins to Aldolase Is Enhanced by Phosphorylation.

Diaz SA, Martin SR, Howell SA, Grainger M, Moon RW, Green JL, Holder AA.

PLoS One. 2016 Sep 8;11(9):e0161850. doi: 10.1371/journal.pone.0161850. eCollection 2016.

4.

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.

Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA.

Antimicrob Agents Chemother. 2015 Dec 28;60(3):1464-75. doi: 10.1128/AAC.01748-15.

5.

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.

Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN.

PLoS Pathog. 2015 Oct 2;11(10):e1005194. doi: 10.1371/journal.ppat.1005194. eCollection 2015 Oct.

6.

The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA.

J Biol Chem. 2015 May 8;290(19):12147-64. doi: 10.1074/jbc.M115.637694. Epub 2015 Mar 23.

7.

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.

8.

Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization.

Diaz SA, Martin SR, Grainger M, Howell SA, Green JL, Holder AA.

Mol Biochem Parasitol. 2014 Oct;197(1-2):9-14. doi: 10.1016/j.molbiopara.2014.09.006. Epub 2014 Sep 27. Review.

9.

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].

10.

Structure of mammalian AMPK and its regulation by ADP.

Xiao B, Sanders MJ, Underwood E, Heath R, Mayer FV, Carmena D, Jing C, Walker PA, Eccleston JF, Haire LF, Saiu P, Howell SA, Aasland R, Martin SR, Carling D, Gamblin SJ.

Nature. 2011 Apr 14;472(7342):230-3. doi: 10.1038/nature09932. Epub 2011 Mar 13.

11.

Targeted disruption of py235ebp-1: invasion of erythrocytes by Plasmodium yoelii using an alternative Py235 erythrocyte binding protein.

Ogun SA, Tewari R, Otto TD, Howell SA, Knuepfer E, Cunningham DA, Xu Z, Pain A, Holder AA.

PLoS Pathog. 2011 Feb;7(2):e1001288. doi: 10.1371/journal.ppat.1001288. Epub 2011 Feb 17.

12.

Phosphorylation of the human papillomavirus type 16 E1--E4 protein at T57 by ERK triggers a structural change that enhances keratin binding and protein stability.

Wang Q, Kennedy A, Das P, McIntosh PB, Howell SA, Isaacson ER, Hinz SA, Davy C, Doorbar J.

J Virol. 2009 Apr;83(8):3668-83. doi: 10.1128/JVI.02063-08. Epub 2009 Feb 11.

13.

The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase.

Green JL, Rees-Channer RR, Howell SA, Martin SR, Knuepfer E, Taylor HM, Grainger M, Holder AA.

J Biol Chem. 2008 Nov 7;283(45):30980-9. doi: 10.1074/jbc.M803129200. Epub 2008 Sep 3.

14.

Malarial EBA-175 region VI crystallographic structure reveals a KIX-like binding interface.

Withers-Martinez C, Haire LF, Hackett F, Walker PA, Howell SA, Smerdon SJ, Dodson GG, Blackman MJ.

J Mol Biol. 2008 Jan 18;375(3):773-81. Epub 2007 Nov 1.

PMID:
18036613
15.

Intramembrane proteolysis mediates shedding of a key adhesin during erythrocyte invasion by the malaria parasite.

O'Donnell RA, Hackett F, Howell SA, Treeck M, Struck N, Krnajski Z, Withers-Martinez C, Gilberger TW, Blackman MJ.

J Cell Biol. 2006 Sep 25;174(7):1023-33.

16.

A member of the py235 gene family of Plasmodium yoelii encodes an erythrocyte binding protein recognised by a protective monoclonal antibody.

Ogun SA, Howell SA, Taylor HM, Holder AA.

Mol Biochem Parasitol. 2006 May;147(1):140-3. Epub 2006 Feb 21. No abstract available.

PMID:
16516987
17.
18.

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens.

Howell SA, Hackett F, Jongco AM, Withers-Martinez C, Kim K, Carruthers VB, Blackman MJ.

Mol Microbiol. 2005 Sep;57(5):1342-56.

19.

Sterol uptake in Candida glabrata: rescue of sterol auxotrophic strains.

Bard M, Sturm AM, Pierson CA, Brown S, Rogers KM, Nabinger S, Eckstein J, Barbuch R, Lees ND, Howell SA, Hazen KC.

Diagn Microbiol Infect Dis. 2005 Aug;52(4):285-93.

PMID:
15893902
20.

Isolation of cholesterol-dependent Candida glabrata from clinical specimens.

Hazen KC, Stei J, Darracott C, Breathnach A, May J, Howell SA.

Diagn Microbiol Infect Dis. 2005 May;52(1):35-7.

PMID:
15878440
21.

Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex.

Zhou XW, Blackman MJ, Howell SA, Carruthers VB.

Mol Cell Proteomics. 2004 Jun;3(6):565-76. Epub 2004 Feb 24.

22.

A single malaria merozoite serine protease mediates shedding of multiple surface proteins by juxtamembrane cleavage.

Howell SA, Well I, Fleck SL, Kettleborough C, Collins CR, Blackman MJ.

J Biol Chem. 2003 Jun 27;278(26):23890-8. Epub 2003 Apr 9.

23.

Crystal structure and functional analysis of the histone methyltransferase SET7/9.

Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B.

Cell. 2002 Oct 4;111(1):105-15.

24.

Investigation into the potential pathogenicity of Staphylococcus felis in a cat.

Patel A, Lloyd DH, Howell SA, Noble WC.

Vet Rec. 2002 May 25;150(21):668-9. No abstract available.

PMID:
12054137
25.

Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.

Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N.

EMBO J. 2001 Aug 1;20(15):4041-54.

26.

Proteolytic processing and primary structure of Plasmodium falciparum apical membrane antigen-1.

Howell SA, Withers-Martinez C, Kocken CH, Thomas AW, Blackman MJ.

J Biol Chem. 2001 Aug 17;276(33):31311-20. Epub 2001 Jun 8.

28.

Chronic urinary tract infection due to Candida utilis.

Hazen KC, Theisz GW, Howell SA.

J Clin Microbiol. 1999 Mar;37(3):824-7.

29.

Application of molecular typing methods to dermatophyte species that cause skin and nail infections.

Howell SA, Barnard RJ, Humphreys F.

J Med Microbiol. 1999 Jan;48(1):33-40.

PMID:
9920123
30.

Mechanism of inorganic phosphate interaction with phosphate binding protein from Escherichia coli.

Brune M, Hunter JL, Howell SA, Martin SR, Hazlett TL, Corrie JE, Webb MR.

Biochemistry. 1998 Jul 21;37(29):10370-80.

PMID:
9671505
31.
32.

Isolation of Malassezia sympodialis and Malassezia globosa from healthy pet cats.

Bond R, Howell SA, Haywood PJ, Lloyd DH.

Vet Rec. 1997 Aug 23;141(8):200-1. No abstract available.

PMID:
9292976
33.
34.

Typing methods for a study of gene transfer in enterococci.

Petts DN, Noble WC, Howell SA.

Adv Exp Med Biol. 1997;418:413-5. No abstract available.

PMID:
9331683
35.

Techniques for investigation of an apparent outbreak of infections with Candida glabrata.

Arif S, Barkham T, Power EG, Howell SA.

J Clin Microbiol. 1996 Sep;34(9):2205-9.

36.
37.

Application of RAPD and restriction enzyme analysis to the study of oral carriage of Candida albicans.

Howell SA, Anthony RM, Power E.

Lett Appl Microbiol. 1996 Feb;22(2):125-8.

PMID:
8936372
38.

Labile antibiotic resistance in Staphylococcus aureus.

Noble WC, Howell SA.

J Hosp Infect. 1995 Oct;31(2):135-41.

PMID:
8551019
39.

Expression and structural analysis of 14-3-3 proteins.

Jones DH, Martin H, Madrazo J, Robinson KA, Nielsen P, Roseboom PH, Patel Y, Howell SA, Aitken A.

J Mol Biol. 1995 Jan 27;245(4):375-84.

PMID:
7837270
40.

An in-vitro study of the sterol content and toxin production of Fusarium isolates from mycotic keratitis.

Raza SK, Mallet AI, Howell SA, Thomas PA.

J Med Microbiol. 1994 Sep;41(3):204-8.

PMID:
8064841
41.
42.

Karyotypes of oval cell forms of Malassezia furfur.

Howell SA, Quin C, Midgley G.

Mycoses. 1993 Jul-Aug;36(7-8):263-6.

PMID:
8114806
43.

Novel isoforms of CaBP 33/37 (annexin V) from mammalian brain: structural and phosphorylation differences that suggest distinct biological roles.

Learmonth MP, Howell SA, Harris AC, Amess B, Patel Y, Giambanco I, Bianchi R, Pula G, Ceccarelli P, Donato R, et al.

Biochim Biophys Acta. 1992 Nov 10;1160(1):76-83.

PMID:
1420335
44.
47.

A novel lanosterol isomer produced in response to azole antifungals.

Howell SA, Mallet AI.

J Steroid Biochem. 1990 Aug 14;36(5):505-6.

PMID:
2214765
48.

Typing tools for the investigation of epidemic fungal infection.

Howell SA, Noble WC.

Epidemiol Infect. 1990 Aug;105(1):1-9. Review. No abstract available.

49.

Sterols of fungi responsible for superficial skin and nail infection.

Howell SA, Moore MK, Mallet AI, Noble WC.

J Gen Microbiol. 1990 Feb;136(2):241-7.

PMID:
2324703
50.

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