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Items: 27


Using biomarkers to predict clinical outcomes in multiple sclerosis.

Castle D, Wynford-Thomas R, Loveless S, Bentley E, Howell OW, Tallantyre EC.

Pract Neurol. 2019 Aug;19(4):342-349. doi: 10.1136/practneurol-2018-002000. Epub 2019 Jun 26.


Calorie restriction activates new adult born olfactory-bulb neurones in a ghrelin-dependent manner but acyl-ghrelin does not enhance subventricular zone neurogenesis.

Ratcliff M, Rees D, McGrady S, Buntwal L, Hornsby AKE, Bayliss J, Kent BA, Bussey T, Saksida L, Beynon AL, Howell OW, Morgan AH, Sun Y, Andrews ZB, Wells T, Davies JS.

J Neuroendocrinol. 2019 Jul;31(7):e12755. doi: 10.1111/jne.12755. Epub 2019 Jun 24.


Meningeal inflammation and cortical demyelination in acute multiple sclerosis.

Bevan RJ, Evans R, Griffiths L, Watkins LM, Rees MI, Magliozzi R, Allen I, McDonnell G, Kee R, Naughton M, Fitzgerald DC, Reynolds R, Neal JW, Howell OW.

Ann Neurol. 2018 Dec;84(6):829-842. doi: 10.1002/ana.25365. Epub 2018 Nov 30.


Molecular pathology of Multiple Sclerosis lesions reveals a heterogeneous expression pattern of genes involved in oligodendrogliogenesis.

Zeis T, Howell OW, Reynolds R, Schaeren-Wiemers N.

Exp Neurol. 2018 Jul;305:76-88. doi: 10.1016/j.expneurol.2018.03.012. Epub 2018 Mar 27.


Inflammatory intrathecal profiles and cortical damage in multiple sclerosis.

Magliozzi R, Howell OW, Nicholas R, Cruciani C, Castellaro M, Romualdi C, Rossi S, Pitteri M, Benedetti MD, Gajofatto A, Pizzini FB, Montemezzi S, Rasia S, Capra R, Bertoldo A, Facchiano F, Monaco S, Reynolds R, Calabrese M.

Ann Neurol. 2018 Apr;83(4):739-755. doi: 10.1002/ana.25197.


Measurement of soluble CD59 in CSF in demyelinating disease: Evidence for an intrathecal source of soluble CD59.

Zelek WM, Watkins LM, Howell OW, Evans R, Loveless S, Robertson NP, Beenes M, Willems L, Brandwijk R, Morgan BP.

Mult Scler. 2019 Apr;25(4):523-531. doi: 10.1177/1352458518758927. Epub 2018 Feb 9.


Tissue microarray methodology identifies complement pathway activation and dysregulation in progressive multiple sclerosis.

Loveless S, Neal JW, Howell OW, Harding KE, Sarkies P, Evans R, Bevan RJ, Hakobyan S, Harris CL, Robertson NP, Morgan BP.

Brain Pathol. 2018 Jul;28(4):507-520. doi: 10.1111/bpa.12546. Epub 2017 Jul 30.


Complement is activated in progressive multiple sclerosis cortical grey matter lesions.

Watkins LM, Neal JW, Loveless S, Michailidou I, Ramaglia V, Rees MI, Reynolds R, Robertson NP, Morgan BP, Howell OW.

J Neuroinflammation. 2016 Jun 22;13(1):161. doi: 10.1186/s12974-016-0611-x.


Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space.

Howell OW, Schulz-Trieglaff EK, Carassiti D, Gentleman SM, Nicholas R, Roncaroli F, Reynolds R.

Neuropathol Appl Neurobiol. 2015 Oct;41(6):798-813. doi: 10.1111/nan.12199. Epub 2015 May 2.


Complement activation in multiple sclerosis plaques: an immunohistochemical analysis.

Ingram G, Loveless S, Howell OW, Hakobyan S, Dancey B, Harris CL, Robertson NP, Neal JW, Morgan BP.

Acta Neuropathol Commun. 2014 May 9;2:53. doi: 10.1186/2051-5960-2-53.


Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats.

Gardner C, Magliozzi R, Durrenberger PF, Howell OW, Rundle J, Reynolds R.

Brain. 2013 Dec;136(Pt 12):3596-608. doi: 10.1093/brain/awt279. Epub 2013 Oct 30.


New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.

Bode A, Wood SE, Mullins JG, Keramidas A, Cushion TD, Thomas RH, Pickrell WO, Drew CJ, Masri A, Jones EA, Vassallo G, Born AP, Alehan F, Aharoni S, Bannasch G, Bartsch M, Kara B, Krause A, Karam EG, Matta S, Jain V, Mandel H, Freilinger M, Graham GE, Hobson E, Chatfield S, Vincent-Delorme C, Rahme JE, Afawi Z, Berkovic SF, Howell OW, Vanbellinghen JF, Rees MI, Chung SK, Lynch JW.

J Biol Chem. 2013 Nov 22;288(47):33745-59. doi: 10.1074/jbc.M113.509240. Epub 2013 Oct 9.


GLRB is the third major gene of effect in hyperekplexia.

Chung SK, Bode A, Cushion TD, Thomas RH, Hunt C, Wood SE, Pickrell WO, Drew CJ, Yamashita S, Shiang R, Leiz S, Longardt AC, Raile V, Weschke B, Puri RD, Verma IC, Harvey RJ, Ratnasinghe DD, Parker M, Rittey C, Masri A, Lingappa L, Howell OW, Vanbellinghen JF, Mullins JG, Lynch JW, Rees MI.

Hum Mol Genet. 2013 Mar 1;22(5):927-40. doi: 10.1093/hmg/dds498. Epub 2012 Nov 25. Erratum in: Hum Mol Genet. 2013 Jun 15;22(12):2552. Longhardt, Ann-Carolyn [corrected to Longardt, Ann-Carolyn].


Polymorphisms in neuropsychiatric and neuroinflammatory disorders and the role of next generation sequencing in early diagnosis and treatment.

Donev RM, Howell OW.

Adv Protein Chem Struct Biol. 2012;89:85-116. doi: 10.1016/B978-0-12-394287-6.00004-5. Review.


Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.

Choi SR, Howell OW, Carassiti D, Magliozzi R, Gveric D, Muraro PA, Nicholas R, Roncaroli F, Reynolds R.

Brain. 2012 Oct;135(Pt 10):2925-37. doi: 10.1093/brain/aws189. Epub 2012 Aug 20.


Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.

Howell OW, Reeves CA, Nicholas R, Carassiti D, Radotra B, Gentleman SM, Serafini B, Aloisi F, Roncaroli F, Magliozzi R, Reynolds R.

Brain. 2011 Sep;134(Pt 9):2755-71. doi: 10.1093/brain/awr182. Epub 2011 Aug 11.


Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis.

Lovato L, Willis SN, Rodig SJ, Caron T, Almendinger SE, Howell OW, Reynolds R, O'Connor KC, Hafler DA.

Brain. 2011 Feb;134(Pt 2):534-41. doi: 10.1093/brain/awq350. Epub 2011 Jan 7.


A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis.

Magliozzi R, Howell OW, Reeves C, Roncaroli F, Nicholas R, Serafini B, Aloisi F, Reynolds R.

Ann Neurol. 2010 Oct;68(4):477-93. doi: 10.1002/ana.22230.


Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.

Howell OW, Rundle JL, Garg A, Komada M, Brophy PJ, Reynolds R.

J Neuropathol Exp Neurol. 2010 Oct;69(10):1017-1033. doi: 10.1097/NEN.0b013e3181f3a5b1.


Detection of Epstein-Barr virus and B-cell follicles in the multiple sclerosis brain: what you find depends on how and where you look.

Aloisi F, Serafini B, Magliozzi R, Howell OW, Reynolds R.

Brain. 2010 Dec;133(Pt 12):e157. doi: 10.1093/brain/awq223. Epub 2010 Aug 25. No abstract available.


Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation.

Owen DR, Howell OW, Tang SP, Wells LA, Bennacef I, Bergstrom M, Gunn RN, Rabiner EA, Wilkins MR, Reynolds R, Matthews PM, Parker CA.

J Cereb Blood Flow Metab. 2010 Sep;30(9):1608-18. doi: 10.1038/jcbfm.2010.63. Epub 2010 Apr 28.


NPY augments the proliferative effect of FGF2 and increases the expression of FGFR1 on nestin positive postnatal hippocampal precursor cells, via the Y1 receptor.

Rodrigo C, Zaben M, Lawrence T, Laskowski A, Howell OW, Gray WP.

J Neurochem. 2010 May;113(3):615-27. doi: 10.1111/j.1471-4159.2010.06633.x. Epub 2010 Feb 1.


NPY mediates basal and seizure-induced proliferation in the subcallosal zone.

Laskowski A, Howell OW, Sosunov AA, McKhann G, Gray WP.

Neuroreport. 2007 Jul 2;18(10):1005-8. Erratum in: Neuroreport. 2007 Aug 6;18(12):1303. Sosuov, Alexander A [corrected to Sosunov, Alexander A].


Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus.

Howell OW, Silva S, Scharfman HE, Sosunov AA, Zaben M, Shtaya A, McKhann G 2nd, Herzog H, Laskowski A, Gray WP.

Neurobiol Dis. 2007 Apr;26(1):174-88. Epub 2006 Dec 30. Erratum in: Neurobiol Dis. 2013 Jan;49:199. Shatya, Anan [corrected to Shtaya, Anan].


Disruption of neurofascin localization reveals early changes preceding demyelination and remyelination in multiple sclerosis.

Howell OW, Palser A, Polito A, Melrose S, Zonta B, Scheiermann C, Vora AJ, Brophy PJ, Reynolds R.

Brain. 2006 Dec;129(Pt 12):3173-85. Epub 2006 Oct 14.


Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus.

Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, Beck-Sickinger AG, Gray WP.

J Neurochem. 2005 May;93(3):560-70.


Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells.

Howell OW, Scharfman HE, Herzog H, Sundstrom LE, Beck-Sickinger A, Gray WP.

J Neurochem. 2003 Aug;86(3):646-59.

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