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Items: 1 to 50 of 178


Targeting the Janus Kinase Family in Autoimmune Skin Diseases.

Howell MD, Kuo FI, Smith PA.

Front Immunol. 2019 Oct 9;10:2342. doi: 10.3389/fimmu.2019.02342. eCollection 2019. Review.


Treatment of atopic dermatitis with ruxolitinib cream (JAK1/JAK2 inhibitor) or triamcinolone cream.

Kim BS, Howell MD, Sun K, Papp K, Nasir A, Kuligowski ME; INCB 18424-206 Study Investigators.

J Allergy Clin Immunol. 2019 Oct 17. pii: S0091-6749(19)31326-0. doi: 10.1016/j.jaci.2019.08.042. [Epub ahead of print]


Atopic Dermatitis Endotypes Based on Allergen Sensitization, Reactivity to Staphylococcus aureus Antigens, and Underlying Systemic Inflammation.

Leonard A, Wang J, Yu L, Liu H, Estrada Y, Greenlees L, McPhee R, Ruzin A, Guttman-Yassky E, Howell MD.

J Allergy Clin Immunol Pract. 2019 Aug 17. pii: S2213-2198(19)30719-6. doi: 10.1016/j.jaip.2019.08.013. [Epub ahead of print]


Measuring the quality of inpatient specialist consultation in the intensive care unit: Nursing and family experiences of communication.

Roche SD, Reichheld AM, Demosthenes N, Johansson AC, Howell MD, Cocchi MN, Landon BE, Stevens JP.

PLoS One. 2019 Apr 11;14(4):e0214918. doi: 10.1371/journal.pone.0214918. eCollection 2019.


Ensuring Fairness in Machine Learning to Advance Health Equity.

Rajkomar A, Hardt M, Howell MD, Corrado G, Chin MH.

Ann Intern Med. 2018 Dec 18;169(12):866-872. doi: 10.7326/M18-1990. Epub 2018 Dec 4.


Bridging the Gap: Interdepartmental Quality Improvement and Patient Safety Curriculum Created by Hospital Leaders, Faculty, and Trainees.

Miller ME, Patel A, Schindler N, Hirsch K, Ming M, Weber S, Turner P, Howell MD, Arora VM, Oyler JL.

J Grad Med Educ. 2018 Oct;10(5):566-572. doi: 10.4300/JGME-D-18-00060.1.


Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature.

Hoffman LK, Tomalin LE, Schultz G, Howell MD, Anandasabapathy N, Alavi A, Suárez-Fariñas M, Lowes MA.

PLoS One. 2018 Sep 28;13(9):e0203672. doi: 10.1371/journal.pone.0203672. eCollection 2018.


Failures in the Respectful Care of Critically Ill Patients.

Law AC, Roche S, Reichheld A, Folcarelli P, Cocchi MN, Howell MD, Sands K, Stevens JP.

Jt Comm J Qual Patient Saf. 2019 Apr;45(4):276-284. doi: 10.1016/j.jcjq.2018.05.008. Epub 2018 Aug 28.


Building communities of respect in the intensive care unit.

Brown SM, Talmor D, Howell MD.

Intensive Care Med. 2018 Aug;44(8):1339-1341. doi: 10.1007/s00134-018-5259-9. Epub 2018 Jun 30. No abstract available.


Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb.

Wollenberg A, Howell MD, Guttman-Yassky E, Silverberg JI, Kell C, Ranade K, Moate R, van der Merwe R.

J Allergy Clin Immunol. 2019 Jan;143(1):135-141. doi: 10.1016/j.jaci.2018.05.029. Epub 2018 Jun 12.


Resolving the Productivity Paradox of Health Information Technology: A Time for Optimism.

Wachter RM, Howell MD.

JAMA. 2018 Jul 3;320(1):25-26. doi: 10.1001/jama.2018.5605. No abstract available.


Implications of Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Early Management Bundle and Initial Lactate Measurement on the Management of Sepsis.

Han X, Edelson DP, Snyder A, Pettit N, Sokol S, Barc C, Howell MD, Churpek MM.

Chest. 2018 Aug;154(2):302-308. doi: 10.1016/j.chest.2018.03.025. Epub 2018 May 24.


Predicting Intensive Care Unit Readmission with Machine Learning Using Electronic Health Record Data.

Rojas JC, Carey KA, Edelson DP, Venable LR, Howell MD, Churpek MM.

Ann Am Thorac Soc. 2018 Jul;15(7):846-853. doi: 10.1513/AnnalsATS.201710-787OC.


Scalable and accurate deep learning with electronic health records.

Rajkomar A, Oren E, Chen K, Dai AM, Hajaj N, Hardt M, Liu PJ, Liu X, Marcus J, Sun M, Sundberg P, Yee H, Zhang K, Zhang Y, Flores G, Duggan GE, Irvine J, Le Q, Litsch K, Mossin A, Tansuwan J, Wang, Wexler J, Wilson J, Ludwig D, Volchenboum SL, Chou K, Pearson M, Madabushi S, Shah NH, Butte AJ, Howell MD, Cui C, Corrado GS, Dean J.

NPJ Digit Med. 2018 May 8;1:18. doi: 10.1038/s41746-018-0029-1. eCollection 2018.


Less Is More: Learning from Variation in Pulmonary Embolism Care.

Howell MD.

Ann Am Thorac Soc. 2018 May;15(5):554-555. doi: 10.1513/AnnalsATS.201802-113ED. No abstract available.


Prevalence of Dyspnea Among Hospitalized Patients at the Time of Admission.

Stevens JP, Dechen T, Schwartzstein R, O'Donnell C, Baker K, Howell MD, Banzett RB.

J Pain Symptom Manage. 2018 Jul;56(1):15-22.e2. doi: 10.1016/j.jpainsymman.2018.02.013. Epub 2018 Feb 22.


Management of ARDS in Adults.

Howell MD, Davis AM.

JAMA. 2018 Feb 20;319(7):711-712. doi: 10.1001/jama.2018.0307. No abstract available.


JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease.

Howell MD, Fitzsimons C, Smith PA.

Ann Allergy Asthma Immunol. 2018 Apr;120(4):367-375. doi: 10.1016/j.anai.2018.02.012. Epub 2018 Feb 14. Review.


The Practice of Respect in the ICU.

Brown SM, Azoulay E, Benoit D, Butler TP, Folcarelli P, Geller G, Rozenblum R, Sands K, Sokol-Hessner L, Talmor D, Turner K, Howell MD.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1389-1395. doi: 10.1164/rccm.201708-1676CP.


Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists.

Stevens JP, Nyweide DJ, Maresh S, Hatfield LA, Howell MD, Landon BE.

JAMA Intern Med. 2017 Dec 1;177(12):1781-1787. doi: 10.1001/jamainternmed.2017.5824.


Activation of a cryptic 5' splice site reverses the impact of pathogenic splice site mutations in the spinal muscular atrophy gene.

Singh NN, Del Rio-Malewski JB, Luo D, Ottesen EW, Howell MD, Singh RN.

Nucleic Acids Res. 2017 Dec 1;45(21):12214-12240. doi: 10.1093/nar/gkx824.


The Critical Care Crisis of Opioid Overdoses in the United States.

Stevens JP, Wall MJ, Novack L, Marshall J, Hsu DJ, Howell MD.

Ann Am Thorac Soc. 2017 Dec;14(12):1803-1809. doi: 10.1513/AnnalsATS.201701-022OC.


TIA1 is a gender-specific disease modifier of a mild mouse model of spinal muscular atrophy.

Howell MD, Ottesen EW, Singh NN, Anderson RL, Seo J, Sivanesan S, Whitley EM, Singh RN.

Sci Rep. 2017 Aug 3;7(1):7183. doi: 10.1038/s41598-017-07468-2.


Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies.

Ganesan R, Raymond EL, Mennerich D, Woska JR Jr, Caviness G, Grimaldi C, Ahlberg J, Perez R, Roberts S, Yang D, Jerath K, Truncali K, Frego L, Sepulveda E, Gupta P, Brown SE, Howell MD, Canada KA, Kroe-Barrett R, Fine JS, Singh S, Mbow ML.

MAbs. 2017 Oct;9(7):1143-1154. doi: 10.1080/19420862.2017.1353853. Epub 2017 Jul 20.


Identification of unique proteomic signatures in allergic and non-allergic skin disease.

Wang J, Suárez-Fariñas M, Estrada Y, Parker ML, Greenlees L, Stephens G, Krueger J, Guttman-Yassky E, Howell MD.

Clin Exp Allergy. 2017 Nov;47(11):1456-1467. doi: 10.1111/cea.12979. Epub 2017 Aug 11.


Improving Value by Reducing Unnecessary Telemetry and Urinary Catheter Utilization in Hospitalized Patients.

Wray CM, Fahrenbach J, Bassi N, Bhattacharjee P, Modes M, Howell MD, Arora VM.

Am J Med. 2017 Sep;130(9):1037-1041. doi: 10.1016/j.amjmed.2017.04.030. Epub 2017 May 19. No abstract available.


How the discovery of ISS-N1 led to the first medical therapy for spinal muscular atrophy.

Singh NN, Howell MD, Androphy EJ, Singh RN.

Gene Ther. 2017 Sep;24(9):520-526. doi: 10.1038/gt.2017.34. Epub 2017 May 9. Review.


Gender-Specific Amelioration of SMA Phenotype upon Disruption of a Deep Intronic Structure by an Oligonucleotide.

Howell MD, Ottesen EW, Singh NN, Anderson RL, Singh RN.

Mol Ther. 2017 Jun 7;25(6):1328-1341. doi: 10.1016/j.ymthe.2017.03.036. Epub 2017 Apr 13.


Detecting Sepsis: Are Two Opinions Better Than One?

Bhattacharjee P, Churpek MM, Snyder A, Howell MD, Edelson DP.

J Hosp Med. 2017 Apr;12(4):256-258. doi: 10.12788/jhm.2721.


Quantifying the Mortality Impact of Do-Not-Resuscitate Orders in the ICU.

Fuchs L, Anstey M, Feng M, Toledano R, Kogan S, Howell MD, Clardy P, Celi L, Talmor D, Novack V.

Crit Care Med. 2017 Jun;45(6):1019-1027. doi: 10.1097/CCM.0000000000002312.


An Emergency Department Validation of the SEP-3 Sepsis and Septic Shock Definitions and Comparison With 1992 Consensus Definitions.

Henning DJ, Puskarich MA, Self WH, Howell MD, Donnino MW, Yealy DM, Jones AE, Shapiro NI.

Ann Emerg Med. 2017 Oct;70(4):544-552.e5. doi: 10.1016/j.annemergmed.2017.01.008. Epub 2017 Mar 3.


Lean: Targeted Therapy for Care Delivery.

Nabhan C, Horner G, Howell MD.

J Natl Compr Canc Netw. 2017 Feb;15(2):271-274. No abstract available.


Management of Sepsis and Septic Shock.

Howell MD, Davis AM.

JAMA. 2017 Feb 28;317(8):847-848. doi: 10.1001/jama.2017.0131. No abstract available.


Diverse role of survival motor neuron protein.

Singh RN, Howell MD, Ottesen EW, Singh NN.

Biochim Biophys Acta Gene Regul Mech. 2017 Mar;1860(3):299-315. doi: 10.1016/j.bbagrm.2016.12.008. Epub 2017 Jan 15. Review.


Association Between In-Hospital Critical Illness Events and Outcomes in Patients on the Same Ward.

Volchenboum SL, Mayampurath A, Göksu-Gürsoy G, Edelson DP, Howell MD, Churpek MM.

JAMA. 2016 Dec 27;316(24):2674-2675. doi: 10.1001/jama.2016.15505. No abstract available.


Targeting the T Helper 2 Inflammatory Axis in Atopic Dermatitis.

Moreno AS, McPhee R, Arruda LK, Howell MD.

Int Arch Allergy Immunol. 2016;171(2):71-80. doi: 10.1159/000451083. Epub 2016 Nov 16. Review.


Improving Pain Relief in Elder Patients (I-PREP): An Emergency Department Education and Quality Intervention.

Hogan TM, Howell MD, Cursio JF, Wong A, Dale W.

J Am Geriatr Soc. 2016 Dec;64(12):2566-2571. doi: 10.1111/jgs.14377. Epub 2016 Nov 2.


Quick Sepsis-related Organ Failure Assessment, Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit.

Churpek MM, Snyder A, Han X, Sokol S, Pettit N, Howell MD, Edelson DP.

Am J Respir Crit Care Med. 2017 Apr 1;195(7):906-911. doi: 10.1164/rccm.201604-0854OC.


No Exit: Identifying Avoidable Terminal Oncology Intensive Care Unit Hospitalizations.

Daly B, Hantel A, Wroblewski K, Balachandran JS, Chow S, DeBoer R, Fleming GF, Hahn OM, Kline J, Liu H, Patel BK, Verma A, Witt LJ, Fukui M, Kumar A, Howell MD, Polite BN.

J Oncol Pract. 2016 Oct;12(10):e901-e911.


Extremes of shock index predicts death in trauma patients.

Odom SR, Howell MD, Gupta A, Silva G, Cook CH, Talmor D.

J Emerg Trauma Shock. 2016 Jul-Sep;9(3):103-6. doi: 10.4103/0974-2700.185272.


The Ask Me to Explain Campaign: A 90-Day Intervention to Promote Patient and Family Involvement in Care in a Pediatric Emergency Department.

Tothy AS, Limper HM, Driscoll J, Bittick N, Howell MD.

Jt Comm J Qual Patient Saf. 2016 Jun;42(6):281-5.


Transcatheter Therapy for a Large Mobile Right Atrial Thrombus and Massive Pulmonary Embolism.

Narang A, Mediratta A, Estrada JR, Rosenberg J, DeCara JM, Howell MD, Lang RM, Paul JD, Nathan S, Shah AP, Blair JE.

J Invasive Cardiol. 2016 May;28(5):E49-51.


Prevalence and Predictive Value of Dyspnea Ratings in Hospitalized Patients: Pilot Studies.

Stevens JP, Baker K, Howell MD, Banzett RB.

PLoS One. 2016 Apr 12;11(4):e0152601. doi: 10.1371/journal.pone.0152601. eCollection 2016.


Standard work for room entry: Linking lean, hand hygiene, and patient-centeredness.

O'Reilly K, Ruokis S, Russell K, Teves T, DiLibero J, Yassa D, Berry H, Howell MD.

Healthc (Amst). 2016 Mar;4(1):45-51. doi: 10.1016/j.hjdsi.2015.12.008. Epub 2016 Jan 11.


Severe impairment of male reproductive organ development in a low SMN expressing mouse model of spinal muscular atrophy.

Ottesen EW, Howell MD, Singh NN, Seo J, Whitley EM, Singh RN.

Sci Rep. 2016 Feb 2;6:20193. doi: 10.1038/srep20193.


Antipsychotic utilization in the intensive care unit and in transitions of care.

Marshall J, Herzig SJ, Howell MD, Le SH, Mathew C, Kats JS, Stevens JP.

J Crit Care. 2016 Jun;33:119-24. doi: 10.1016/j.jcrc.2015.12.017. Epub 2015 Dec 30.


Variation and Cost-effectiveness of Quality Measurement Programs. The Case of Sepsis Bundles.

Wall MJ, Howell MD.

Ann Am Thorac Soc. 2015 Nov;12(11):1597-9. doi: 10.1513/AnnalsATS.201509-625ED. No abstract available.


Opportunities and Challenges for Reducing Hospital Revisits.

Graham KL, Howell MD, Marcantonio ER.

Ann Intern Med. 2015 Nov 3;163(9):727. doi: 10.7326/L15-5154. No abstract available.


Vitamin D in clinically isolated syndrome: evidence for possible neuroprotection.

Mowry EM, Pelletier D, Gao Z, Howell MD, Zamvil SS, Waubant E.

Eur J Neurol. 2016 Feb;23(2):327-32. doi: 10.1111/ene.12844. Epub 2015 Oct 31.


Estimating duration of central venous catheter at time of insertion: Clinician judgment and clinical predictors.

Holmberg MJ, Andersen LW, Graver A, Wright SB, Yassa D, Howell MD, Donnino MW, Cocchi MN.

J Crit Care. 2015 Dec;30(6):1299-302. doi: 10.1016/j.jcrc.2015.08.013. Epub 2015 Aug 22.


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