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Items: 1 to 50 of 129


Effects of early life stress on cocaine self-administration in post-pubertal male and female rhesus macaques.

Wakeford AGP, Morin EL, Bramlett SN, Howell BR, McCormack KM, Meyer JS, Nader MA, Sanchez MM, Howell LL.

Psychopharmacology (Berl). 2019 Sep;236(9):2785-2796. doi: 10.1007/s00213-019-05254-8. Epub 2019 May 21.


Sensitization to the prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA).

Curry DW, Berro LF, Belkoff AR, Sulima A, Rice KC, Howell LL.

Neuropharmacology. 2019 Jun;151:13-20. doi: 10.1016/j.neuropharm.2019.03.017. Epub 2019 Mar 25.


Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys.

Maltbie EA, Gopinath KS, Howell LL.

Psychopharmacology (Berl). 2019 Jul;236(7):2105-2118. doi: 10.1007/s00213-019-05204-4. Epub 2019 Mar 16.


Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures.

Li CX, Kempf DJ, Tong FC, Yan Y, Xu Z, Connor-Stroud FR, Ford BD, Howell LL, Zhang X.

Comp Med. 2018 Dec 1;68(6):496-502. doi: 10.30802/AALAS-CM-18-000004. Epub 2018 Nov 28.


Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys.

Odabas-Geldiay M, Shields H, Berro LF, Rice KC, Howell LL.

Drug Alcohol Depend. 2019 Jan 1;194:252-256. doi: 10.1016/j.drugalcdep.2018.10.018. Epub 2018 Nov 13.


A review of nonhuman primate models of early life stress and adolescent drug abuse.

Wakeford AGP, Morin EL, Bramlett SN, Howell LL, Sanchez MM.

Neurobiol Stress. 2018 Sep 21;9:188-198. doi: 10.1016/j.ynstr.2018.09.005. eCollection 2018 Nov. Review.


Complex mechanical motion guided without external control.

Howell LL.

Nature. 2018 Sep;561(7724):470-471. doi: 10.1038/d41586-018-06787-2. No abstract available.


Effects of long-term high-fat food or methamphetamine intake and serotonin 2C receptors on reversal learning in female rhesus macaques.

Perez Diaz M, Wilson ME, Howell LL.

Neuropsychopharmacology. 2019 Feb;44(3):478-486. doi: 10.1038/s41386-018-0200-z. Epub 2018 Sep 6.


Creating Linkage Permutations to Prevent Self-Intersection and Enable Deployable Networks of Thick-Origami.

Yellowhorse A, Lang RJ, Tolman K, Howell LL.

Sci Rep. 2018 Aug 28;8(1):12936. doi: 10.1038/s41598-018-31180-4.


Acute effects of 3,4-methylenedioxymethamphetamine (MDMA) and R(-) MDMA on actigraphy-based daytime activity and sleep parameters in rhesus monkeys.

Berro LF, Shields H, Odabas-Geldiay M, Rothbaum BO, Andersen ML, Howell LL.

Exp Clin Psychopharmacol. 2018 Aug;26(4):410-420. doi: 10.1037/pha0000196. Epub 2018 Jun 25.


A peripheral immune response to remembering trauma contributes to the maintenance of fear memory in mice.

Young MB, Howell LL, Hopkins L, Moshfegh C, Yu Z, Clubb L, Seidenberg J, Park J, Swiercz AP, Marvar PJ.

Psychoneuroendocrinology. 2018 Aug;94:143-151. doi: 10.1016/j.psyneuen.2018.05.012. Epub 2018 May 21.


(±)-MDMA and its enantiomers: potential therapeutic advantages of R(-)-MDMA.

Pitts EG, Curry DW, Hampshire KN, Young MB, Howell LL.

Psychopharmacology (Berl). 2018 Feb;235(2):377-392. doi: 10.1007/s00213-017-4812-5. Epub 2017 Dec 16. Review.


Ketamine and pharmacological imaging: use of functional magnetic resonance imaging to evaluate mechanisms of action.

Maltbie EA, Kaundinya GS, Howell LL.

Behav Pharmacol. 2017 Dec;28(8):610-622. doi: 10.1097/FBP.0000000000000354. Review.


Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice.

Curry DW, Young MB, Tran AN, Daoud GE, Howell LL.

Neuropharmacology. 2018 Jan;128:196-206. doi: 10.1016/j.neuropharm.2017.10.003. Epub 2017 Oct 6.


Inhibition of serotonin transporters disrupts the enhancement of fear memory extinction by 3,4-methylenedioxymethamphetamine (MDMA).

Young MB, Norrholm SD, Khoury LM, Jovanovic T, Rauch SAM, Reiff CM, Dunlop BW, Rothbaum BO, Howell LL.

Psychopharmacology (Berl). 2017 Oct;234(19):2883-2895. doi: 10.1007/s00213-017-4684-8. Epub 2017 Jul 24.


Assessment of tolerance to the effects of methamphetamine on daytime and nighttime activity evaluated with actigraphy in rhesus monkeys.

Berro LF, Andersen ML, Howell LL.

Psychopharmacology (Berl). 2017 Aug;234(15):2277-2287. doi: 10.1007/s00213-017-4654-1. Epub 2017 Jun 7.


Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys.

Berro LF, Perez Diaz M, Maltbie E, Howell LL.

Psychopharmacology (Berl). 2017 Sep;234(17):2607-2617. doi: 10.1007/s00213-017-4653-2. Epub 2017 Jun 5.


GABAA receptor positive allosteric modulators modify the abuse-related behavioral and neurochemical effects of methamphetamine in rhesus monkeys.

Berro LF, Andersen ML, Tufik S, Howell LL.

Neuropharmacology. 2017 Sep 1;123:299-309. doi: 10.1016/j.neuropharm.2017.05.010. Epub 2017 May 8.


3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner.

Pitts EG, Minerva AR, Chandler EB, Kohn JN, Logun MT, Sulima A, Rice KC, Howell LL.

Neuropsychopharmacology. 2017 Sep;42(10):1962-1971. doi: 10.1038/npp.2017.80. Epub 2017 Apr 20.


Bistable Mechanisms for Space Applications.

Zirbel SA, Tolman KA, Trease BP, Howell LL.

PLoS One. 2016 Dec 28;11(12):e0168218. doi: 10.1371/journal.pone.0168218. eCollection 2016.


Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys.

Perez Diaz M, Andersen ML, Rice KC, Howell LL.

Neuropsychopharmacology. 2017 Jun;42(7):1531-1538. doi: 10.1038/npp.2016.280. Epub 2016 Dec 16.


Packing and deploying Soft Origami to and from cylindrical volumes with application to automotive airbags.

Bruton JT, Nelson TG, Zimmerman TK, Fernelius JD, Magleby SP, Howell LL.

R Soc Open Sci. 2016 Sep 28;3(9):160429. eCollection 2016 Sep.


Actigraphy-based sleep parameters during the reinstatement of methamphetamine self-administration in rhesus monkeys.

Berro LF, Andersen ML, Tufik S, Howell LL.

Exp Clin Psychopharmacol. 2016 Apr;24(2):142-6. doi: 10.1037/pha0000064. Epub 2016 Feb 15.


Rigidly foldable origami gadgets and tessellations.

Evans TA, Lang RJ, Magleby SP, Howell LL.

R Soc Open Sci. 2015 Sep 16;2(9):150067. doi: 10.1098/rsos.150067. eCollection 2015 Sep.


3,4-Methylenedioxymethamphetamine facilitates fear extinction learning.

Young MB, Andero R, Ressler KJ, Howell LL.

Transl Psychiatry. 2015 Sep 15;5:e634. doi: 10.1038/tp.2015.138.


Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder.

Howell LL, Cunningham KA.

Pharmacol Rev. 2015;67(1):176-97. doi: 10.1124/pr.114.009514. Review.


A standardized representation of spinal quality of motion.

Zirbel SA, Stolworthy DK, Howell LL, Bowden AE.

Proc Inst Mech Eng H. 2014 Nov;228(11):1168-75. doi: 10.1177/0954411914559079.


Functional connectivity in frontal-striatal brain networks and cocaine self-administration in female rhesus monkeys.

Murnane KS, Gopinath KS, Maltbie E, Daunais JB, Telesford QK, Howell LL.

Psychopharmacology (Berl). 2015 Feb;232(4):745-54. doi: 10.1007/s00213-014-3709-9. Epub 2014 Aug 21.


A thermostable bacterial cocaine esterase rapidly eliminates cocaine from brain in nonhuman primates.

Howell LL, Nye JA, Stehouwer JS, Voll RJ, Mun J, Narasimhan D, Nichols J, Sunahara R, Goodman MM, Carroll FI, Woods JH.

Transl Psychiatry. 2014 Jul 1;4:e407. doi: 10.1038/tp.2014.48.


A self-reconfiguring metamorphic nanoinjector for injection into mouse zygotes.

Aten QT, Jensen BD, Burnett SH, Howell LL.

Rev Sci Instrum. 2014 May;85(5):055005. doi: 10.1063/1.4872077.


Effects of pharmacologic dopamine β-hydroxylase inhibition on cocaine-induced reinstatement and dopamine neurochemistry in squirrel monkeys.

Cooper DA, Kimmel HL, Manvich DF, Schmidt KT, Weinshenker D, Howell LL.

J Pharmacol Exp Ther. 2014 Jul;350(1):144-52. doi: 10.1124/jpet.113.212357. Epub 2014 May 9.


Monoamine transporter inhibitors and substrates as treatments for stimulant abuse.

Howell LL, Negus SS.

Adv Pharmacol. 2014;69:129-76. doi: 10.1016/B978-0-12-420118-7.00004-4. Review.


Characterization and prediction of rate-dependent flexibility in lumbar spine biomechanics at room and body temperature.

Stolworthy DK, Zirbel SA, Howell LL, Samuels M, Bowden AE.

Spine J. 2014 May 1;14(5):789-98. doi: 10.1016/j.spinee.2013.08.043. Epub 2013 Oct 4.


Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates.

Murnane KS, Winschel J, Schmidt KT, Stewart LM, Rose SJ, Cheng K, Rice KC, Howell LL.

J Neurosci. 2013 Aug 14;33(33):13367-74. doi: 10.1523/JNEUROSCI.1437-13.2013.


Hypothalamic proteoglycan syndecan-3 is a novel cocaine addiction resilience factor.

Chen J, Repunte-Canonigo V, Kawamura T, Lefebvre C, Shin W, Howell LL, Hemby SE, Harvey BK, Califano A, Morales M, Koob GF, Sanna PP.

Nat Commun. 2013;4:1955. doi: 10.1038/ncomms2955.


Chronic interferon-α decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates.

Felger JC, Mun J, Kimmel HL, Nye JA, Drake DF, Hernandez CR, Freeman AA, Rye DB, Goodman MM, Howell LL, Miller AH.

Neuropsychopharmacology. 2013 Oct;38(11):2179-87. doi: 10.1038/npp.2013.115. Epub 2013 May 9.


Transgene delivery via intracellular electroporetic nanoinjection.

Wilson AM, Aten QT, Toone NC, Black JL, Jensen BD, Tamowski S, Howell LL, Burnett SH.

Transgenic Res. 2013 Oct;22(5):993-1002. doi: 10.1007/s11248-013-9706-7. Epub 2013 Mar 27.


Intervertebral disc degeneration alters lumbar spine segmental stiffness in all modes of loading under a compressive follower load.

Zirbel SA, Stolworthy DK, Howell LL, Bowden AE.

Spine J. 2013 Sep;13(9):1134-47. doi: 10.1016/j.spinee.2013.02.010. Epub 2013 Mar 15.


Effects of methamphetamine self-administration on actigraphy-based sleep parameters in rhesus monkeys.

Andersen ML, Diaz MP, Murnane KS, Howell LL.

Psychopharmacology (Berl). 2013 May;227(1):101-7. doi: 10.1007/s00213-012-2943-2. Epub 2012 Dec 22.


The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeys.

Manvich DF, Kimmel HL, Cooper DA, Howell LL.

J Pharmacol Exp Ther. 2012 Sep;342(3):761-9. doi: 10.1124/jpet.112.195156. Epub 2012 Jun 8.


Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use.

Sawyer EK, Mun J, Nye JA, Kimmel HL, Voll RJ, Stehouwer JS, Rice KC, Goodman MM, Howell LL.

Neuropsychopharmacology. 2012 Jul;37(8):1816-24. doi: 10.1038/npp.2012.29. Epub 2012 Mar 21.


Nanoinjection: pronuclear DNA delivery using a charged lance.

Aten QT, Jensen BD, Tamowski S, Wilson AM, Howell LL, Burnett SH.

Transgenic Res. 2012 Dec;21(6):1279-90. doi: 10.1007/s11248-012-9610-6. Epub 2012 Mar 14.


Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys.

Manvich DF, Kimmel HL, Howell LL.

J Pharmacol Exp Ther. 2012 May;341(2):424-34. doi: 10.1124/jpet.111.186981. Epub 2012 Feb 10.


The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys.

Bauzo RM, Kimmel HL, Howell LL.

Pharmacol Biochem Behav. 2012 Apr;101(2):288-96. doi: 10.1016/j.pbb.2011.12.018. Epub 2011 Dec 31.


Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys.

Kimmel HL, Nye JA, Voll R, Mun J, Stehouwer J, Goodman MM, Votaw JR, Carroll FI, Howell LL.

Synapse. 2012 Jun;66(6):501-8. doi: 10.1002/syn.21536. Epub 2012 Mar 16.


Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone.

Muly EC, Votaw JR, Ritchie J, Howell LL.

J Pharmacol Exp Ther. 2012 Apr;341(1):81-9. doi: 10.1124/jpet.111.189076. Epub 2012 Jan 3.


A compliant-mechanism approach to achieving specific quality of motion in a lumbar total disc replacement.

Halverson PA, Bowden AE, Howell LL.

Int J Spine Surg. 2012 Dec 1;6:78-86. doi: 10.1016/j.ijsp.2012.02.002. eCollection 2012.


The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine ("ecstasy"): a concurrent microdialysis and plasma analysis study.

Murnane KS, Kimmel HL, Rice KC, Howell LL.

Horm Behav. 2012 Feb;61(2):181-90. doi: 10.1016/j.yhbeh.2011.10.012. Epub 2011 Dec 14.


Influence of chronic dopamine transporter inhibition by RTI-336 on motor behavior, sleep, and hormone levels in rhesus monkeys.

Andersen ML, Sawyer EK, Carroll FI, Howell LL.

Exp Clin Psychopharmacol. 2012 Apr;20(2):77-83. doi: 10.1037/a0026034. Epub 2011 Oct 24.

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