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Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma.

Buchanan RA, Foley KE, Pepper KW, Reagan AM, Keezer KJ, Hewes AA, Diemler CA, Preuss C, Soto I, John SWM, Howell GR.

Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3283-3296. doi: 10.1167/iovs.18-26126.


Persistent organic pollutants (POPs) increase rage signaling to promote downstream cardiovascular remodeling.

Coole JB, Burr SS, Kay AM, Singh JA, Kondakala S, Yang EJ, Kaplan BLF, Howell GE 3rd, Stewart JA Jr.

Environ Toxicol. 2019 Jul 16. doi: 10.1002/tox.22817. [Epub ahead of print]


What are the earlier life contributions to reserve and resilience?

Walhovd KB, Howell GR, Ritchie SJ, Staff RT, Cotman CW.

Neurobiol Aging. 2019 Apr 30. pii: S0197-4580(19)30128-9. doi: 10.1016/j.neurobiolaging.2019.04.014. [Epub ahead of print]


Vascular Inflammation Risk Factors in Retinal Disease.

Soto I, Krebs MP, Reagan AM, Howell GR.

Annu Rev Vis Sci. 2019 Jun 21. doi: 10.1146/annurev-vision-091517-034416. [Epub ahead of print]


Exercise prevents obesity-induced cognitive decline and white matter damage in mice.

Graham LC, Grabowska WA, Chun Y, Risacher SL, Philip VM, Saykin AJ; Alzheimer's Disease Neuroimaging Initiative (ADNI), Sukoff Rizzo SJ, Howell GR.

Neurobiol Aging. 2019 Aug;80:154-172. doi: 10.1016/j.neurobiolaging.2019.03.018. Epub 2019 May 3.


Enhancing face validity of mouse models of Alzheimer's disease with natural genetic variation.

Onos KD, Uyar A, Keezer KJ, Jackson HM, Preuss C, Acklin CJ, O'Rourke R, Buchanan R, Cossette TL, Sukoff Rizzo SJ, Soto I, Carter GW, Howell GR.

PLoS Genet. 2019 May 31;15(5):e1008155. doi: 10.1371/journal.pgen.1008155. eCollection 2019 May.


The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation.

Svedberg FR, Brown SL, Krauss MZ, Campbell L, Sharpe C, Clausen M, Howell GJ, Clark H, Madsen J, Evans CM, Sutherland TE, Ivens AC, Thornton DJ, Grencis RK, Hussell T, Cunoosamy DM, Cook PC, MacDonald AS.

Nat Immunol. 2019 May;20(5):571-580. doi: 10.1038/s41590-019-0352-y. Epub 2019 Apr 1.


Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

Jarosz-Griffiths HH, Corbett NJ, Rowland HA, Fisher K, Jones AC, Baron J, Howell GJ, Cowley SA, Chintawar S, Cader MZ, Kellett KAB, Hooper NM.

J Biol Chem. 2019 Apr 26;294(17):7085-7097. doi: 10.1074/jbc.RA118.005364. Epub 2019 Mar 14.


Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.

Williams PA, Braine CE, Kizhatil K, Foxworth NE, Tolman NG, Harder JM, Scott RA, Sousa GL, Panitch A, Howell GR, John SWM.

Mol Neurodegener. 2019 Jan 22;14(1):6. doi: 10.1186/s13024-018-0303-3.


A comparison of methods for early prediction of anaerobic biogas potential on biologically treated municipal solid waste.

Howell G, Bennett C, Materić D.

J Environ Manage. 2019 Feb 15;232:887-894. doi: 10.1016/j.jenvman.2018.11.137. Epub 2018 Dec 6.


Liposomal Cytarabine-Daunorubicin (CPX-351) Extravasation: Case Report and Literature Review.

Howell G, Oliai C, Schiller G.

Anticancer Res. 2018 Dec;38(12):6927-6930. doi: 10.21873/anticanres.13070. Review.


Process Design and Optimization in the Pharmaceutical Industry: A Suzuki-Miyaura Procedure for the Synthesis of Savolitinib.

Adlington NK, Agnew LR, Campbell AD, Cox RJ, Dobson A, Barrat CF, Gall MAY, Hicks W, Howell GP, Jawor-Baczynska A, Miller-Potucka L, Pilling M, Shepherd K, Tassone R, Taylor BA, Williams A.

J Org Chem. 2019 Apr 19;84(8):4735-4747. doi: 10.1021/acs.joc.8b02351. Epub 2018 Oct 30.


Differences in Characteristics and Downstream Drug Use Among Opioid-Naïve and Prior Opioid Users with Low Back Pain.

DiMarco LA, Ramger BC, Howell GP, Serrani AM, Givens DL, Rhon DI, Cook CE.

Pain Pract. 2019 Feb;19(2):149-157. doi: 10.1111/papr.12728. Epub 2018 Dec 4.


Randomised clinical trial of community-based peer-led and psychologist-led group treatment for hoarding disorder.

Mathews CA, Mackin RS, Chou CY, Uhm SY, Bain LD, Stark SJ, Gause M, Vigil OR, Franklin J, Salazar M, Plumadore J, Smith LC, Komaiko K, Howell G, Vega E, Chan J, Eckfield MB, Tsoh JY, Delucchi K.

BJPsych Open. 2018 Jul 20;4(4):285-293. doi: 10.1192/bjo.2018.30. eCollection 2018 Jul.


Exploring breastfeeding support on social media.

Bridges N, Howell G, Schmied V.

Int Breastfeed J. 2018 Jun 15;13:22. doi: 10.1186/s13006-018-0166-9. eCollection 2018.


Alterations in cellular lipid metabolism produce neutral lipid accumulation following exposure to the organochlorine compound trans-nonachlor in rat primary hepatocytes.

Howell GE 3rd, McDevitt E, Henein L, Mulligan C, Young D.

Environ Toxicol. 2018 Sep;33(9):962-971. doi: 10.1002/tox.22583. Epub 2018 Jul 2.


Inhibition of cholinergic and non-cholinergic targets following subacute exposure to chlorpyrifos in normal and high fat fed male C57BL/6J mice.

Howell GE 3rd, Kondakala S, Holdridge J, Lee JH, Ross MK.

Food Chem Toxicol. 2018 Aug;118:821-829. doi: 10.1016/j.fct.2018.06.051. Epub 2018 Jun 21.


"Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells".

Howell GE 3rd, McDevitt E, Henein L, Mulligan C, Young D.

Toxicol In Vitro. 2018 Aug;50:285-292. doi: 10.1016/j.tiv.2018.04.003. Epub 2018 Apr 11.


A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

Wang X, Philip VM, Ananda G, White CC, Malhotra A, Michalski PJ, Karuturi KRM, Chintalapudi SR, Acklin C, Sasner M, Bennett DA, De Jager PL, Howell GR, Carter GW.

Genetics. 2018 May;209(1):51-64. doi: 10.1534/genetics.117.300673. Epub 2018 Mar 5.


Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model.

Tagge CA, Fisher AM, Minaeva OV, Gaudreau-Balderrama A, Moncaster JA, Zhang XL, Wojnarowicz MW, Casey N, Lu H, Kokiko-Cochran ON, Saman S, Ericsson M, Onos KD, Veksler R, Senatorov VV Jr, Kondo A, Zhou XZ, Miry O, Vose LR, Gopaul KR, Upreti C, Nowinski CJ, Cantu RC, Alvarez VE, Hildebrandt AM, Franz ES, Konrad J, Hamilton JA, Hua N, Tripodis Y, Anderson AT, Howell GR, Kaufer D, Hall GF, Lu KP, Ransohoff RM, Cleveland RO, Kowall NW, Stein TD, Lamb BT, Huber BR, Moss WC, Friedman A, Stanton PK, McKee AC, Goldstein LE.

Brain. 2018 Feb 1;141(2):422-458. doi: 10.1093/brain/awx350.


Generation of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.

Hughes DJ, Tiede C, Penswick N, Tang AA, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC, Whitehouse A.

Sci Signal. 2017 Nov 14;10(505). pii: eaaj2005. doi: 10.1126/scisignal.aaj2005.


Effects of acute exposure to chlorpyrifos on cholinergic and non-cholinergic targets in normal and high-fat fed male C57BL/6J mice.

Kondakala S, Lee JH, Ross MK, Howell GE 3rd.

Toxicol Appl Pharmacol. 2017 Dec 15;337:67-75. doi: 10.1016/j.taap.2017.10.019. Epub 2017 Oct 31.


Contributions of self-criticism and shame to hoarding.

Chou CY, Tsoh J, Vigil O, Bain D, Uhm SY, Howell G, Chan J, Eckfield M, Plumadore J, Chan E, Komaiko K, Smith L, Franklin J, Vega E, Delucchi K, Mathews CA.

Psychiatry Res. 2018 Apr;262:488-493. doi: 10.1016/j.psychres.2017.09.030. Epub 2017 Sep 13.


Sulfhaemoglobinaemia caused by ferrous sulfate.

Derbas L, Warsame M, Omar MA, Zafar Y, Howell G.

BMJ Case Rep. 2017 Jun 13;2017. pii: bcr-2017-220521. doi: 10.1136/bcr-2017-220521.


Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR, John SWM.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3839-E3848. doi: 10.1073/pnas.1608769114. Epub 2017 Apr 26.


Neuroinflammation in glaucoma: A new opportunity.

Williams PA, Marsh-Armstrong N, Howell GR; Lasker/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

Exp Eye Res. 2017 Apr;157:20-27. doi: 10.1016/j.exer.2017.02.014. Epub 2017 Feb 24. Review.


Strongyloides hyperinfection syndrome and VRE pneumonia.

Abu Omar M, Abu Ghanimeh M, Kim S, Howell G.

BMJ Case Rep. 2017 Jan 16;2017. pii: bcr2016216634. doi: 10.1136/bcr-2016-216634.


Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice.

Mulligan C, Kondakala S, Yang EJ, Stokes JV, Stewart JA, Kaplan BL, Howell GE 3rd.

Environ Toxicol. 2017 Apr;32(4):1399-1411. doi: 10.1002/tox.22334. Epub 2016 Aug 17.


Meox2 haploinsufficiency increases neuronal cell loss in a mouse model of Alzheimer's disease.

Soto I, Grabowska WA, Onos KD, Graham LC, Jackson HM, Simeone SN, Howell GR.

Neurobiol Aging. 2016 Jun;42:50-60. doi: 10.1016/j.neurobiolaging.2016.02.025. Epub 2016 Mar 2.


Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.

Williams PA, Tribble JR, Pepper KW, Cross SD, Morgan BP, Morgan JE, John SW, Howell GR.

Mol Neurodegener. 2016 Apr 6;11:26. doi: 10.1186/s13024-016-0091-6.


C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.

Silverman SM, Kim BJ, Howell GR, Miller J, John SW, Wordinger RJ, Clark AF.

Mol Neurodegener. 2016 Mar 24;11:24. doi: 10.1186/s13024-016-0089-0.


Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.

Smith GA, Howell GJ, Phillips C, Muench SP, Ponnambalam S, Harrison MA.

J Biol Chem. 2016 Apr 15;291(16):8500-15. doi: 10.1074/jbc.M116.723395. Epub 2016 Feb 24.


Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease.

Graham LC, Harder JM, Soto I, de Vries WN, John SW, Howell GR.

Sci Rep. 2016 Feb 18;6:21568. doi: 10.1038/srep21568.


Exposure to chlorpyrifos increases neutral lipid accumulation with accompanying increased de novo lipogenesis and decreased triglyceride secretion in McArdle-RH7777 hepatoma cells.

Howell GE 3rd, Mulligan C, Young D, Kondakala S.

Toxicol In Vitro. 2016 Apr;32:181-9. doi: 10.1016/j.tiv.2016.01.002. Epub 2016 Jan 7.


Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma.

Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, Burdon KP, Aschard H, Chasman DI, Igo RP Jr, Hysi PG, Glastonbury CA, Ashley-Koch A, Brilliant M, Brown AA, Budenz DL, Buil A, Cheng CY, Choi H, Christen WG, Curhan G, De Vivo I, Fingert JH, Foster PJ, Fuchs C, Gaasterland D, Gaasterland T, Hewitt AW, Hu F, Hunter DJ, Khawaja AP, Lee RK, Li Z, Lichter PR, Mackey DA, McGuffin P, Mitchell P, Moroi SE, Perera SA, Pepper KW, Qi Q, Realini T, Richards JE, Ridker PM, Rimm E, Ritch R, Ritchie M, Schuman JS, Scott WK, Singh K, Sit AJ, Song YE, Tamimi RM, Topouzis F, Viswanathan AC, Verma SS, Vollrath D, Wang JJ, Weisschuh N, Wissinger B, Wollstein G, Wong TY, Yaspan BL, Zack DJ, Zhang K, Study EN; ANZRAG Consortium, Weinreb RN, Pericak-Vance MA, Small K, Hammond CJ, Aung T, Liu Y, Vithana EN, MacGregor S, Craig JE, Kraft P, Howell G, Hauser MA, Pasquale LR, Haines JL, Wiggs JL.

Nat Genet. 2016 Feb;48(2):189-94. doi: 10.1038/ng.3482. Epub 2016 Jan 11.


Exposure to p,p'-DDE Alters Macrophage Reactivity and Increases Macrophage Numbers in Adipose Stromal Vascular Fraction.

Mangum LH, Crow JA, Stokes JV, Howell GE 3rd, Ross MK, Pruett SB, Chambers JE.

Toxicol Sci. 2016 Mar;150(1):169-77. doi: 10.1093/toxsci/kfv315. Epub 2016 Jan 8.


Toward more predictive genetic mouse models of Alzheimer's disease.

Onos KD, Sukoff Rizzo SJ, Howell GR, Sasner M.

Brain Res Bull. 2016 Apr;122:1-11. doi: 10.1016/j.brainresbull.2015.12.003. Epub 2015 Dec 17. Review.


Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.

Berry RH, Qu J, John SW, Howell GR, Jakobs TC.

PLoS One. 2015 Dec 4;10(12):e0144341. doi: 10.1371/journal.pone.0144341. eCollection 2015.


APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction.

Soto I, Graham LC, Richter HJ, Simeone SN, Radell JE, Grabowska W, Funkhouser WK, Howell MC, Howell GR.

PLoS Biol. 2015 Oct 29;13(10):e1002279. doi: 10.1371/journal.pbio.1002279. eCollection 2015 Oct.


Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells.

Martin HL, Alsaady I, Howell G, Prandovszky E, Peers C, Robinson P, McConkey GA.

Neuroscience. 2015 Oct 15;306:50-62. doi: 10.1016/j.neuroscience.2015.08.005. Epub 2015 Aug 20.


Exposure to p,p'-DDE enhances differentiation of 3T3-L1 preadipocytes in a model of sub-optimal differentiation.

Mangum LH, Howell GE 3rd, Chambers JE.

Toxicol Lett. 2015 Oct 14;238(2):65-71. doi: 10.1016/j.toxlet.2015.07.009. Epub 2015 Jul 19.


Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT.

Exp Eye Res. 2015 Dec;141:42-56. doi: 10.1016/j.exer.2015.06.019. Epub 2015 Jun 24. Review.


Adrenal Imaging Features Predict Malignancy Better than Tumor Size.

Yoo JY, McCoy KL, Carty SE, Stang MT, Armstrong MJ, Howell GM, Bartlett DL, Tublin ME, Yip L.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S721-7. doi: 10.1245/s10434-015-4684-z. Epub 2015 Jun 19.


Intensive care units with low versus high volume of myocardial infarction: clinical outcomes, resource utilization, and quality metrics.

Stolker JM, Badawi O, Spertus JA, Nasir A, Kennedy KF, Harris IH, Franey CS, Hsu VD, Ripple GR, Howell GH, Lem VM, Chan PS.

J Am Heart Assoc. 2015 Jun 11;4(6):e001225. doi: 10.1161/JAHA.114.001225.


Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Aung T, Ozaki M, Mizoguchi T, Allingham RR, Li Z, Haripriya A, Nakano S, Uebe S, Harder JM, Chan AS, Lee MC, Burdon KP, Astakhov YS, Abu-Amero KK, Zenteno JC, Nilgün Y, Zarnowski T, Pakravan M, Safieh LA, Jia L, Wang YX, Williams S, Paoli D, Schlottmann PG, Huang L, Sim KS, Foo JN, Nakano M, Ikeda Y, Kumar RS, Ueno M, Manabe S, Hayashi K, Kazama S, Ideta R, Mori Y, Miyata K, Sugiyama K, Higashide T, Chihara E, Inoue K, Ishiko S, Yoshida A, Yanagi M, Kiuchi Y, Aihara M, Ohashi T, Sakurai T, Sugimoto T, Chuman H, Matsuda F, Yamashiro K, Gotoh N, Miyake M, Astakhov SY, Osman EA, Al-Obeidan SA, Owaidhah O, Al-Jasim L, Shahwan SA, Fogarty RA, Leo P, Yetkin Y, Oğuz Ç, Kanavi MR, Beni AN, Yazdani S, Akopov EL, Toh KY, Howell GR, Orr AC, Goh Y, Meah WY, Peh SQ, Kosior-Jarecka E, Lukasik U, Krumbiegel M, Vithana EN, Wong TY, Liu Y, Koch AE, Challa P, Rautenbach RM, Mackey DA, Hewitt AW, Mitchell P, Wang JJ, Ziskind A, Carmichael T, Ramakrishnan R, Narendran K, Venkatesh R, Vijayan S, Zhao P, Chen X, Guadarrama-Vallejo D, Cheng CY, Perera SA, Husain R, Ho SL, Welge-Luessen UC, Mardin C, Schloetzer-Schrehardt U, Hillmer AM, Herms S, Moebus S, Nöthen MM, Weisschuh N, Shetty R, Ghosh A, Teo YY, Brown MA, Lischinsky I; Blue Mountains Eye Study GWAS Team; Wellcome Trust Case Control Consortium 2, Crowston JG, Coote M, Zhao B, Sang J, Zhang N, You Q, Vysochinskaya V, Founti P, Chatzikyriakidou A, Lambropoulos A, Anastasopoulos E, Coleman AL, Wilson MR, Rhee DJ, Kang JH, May-Bolchakova I, Heegaard S, Mori K, Alward WL, Jonas JB, Xu L, Liebmann JM, Chowbay B, Schaeffeler E, Schwab M, Lerner F, Wang N, Yang Z, Frezzotti P, Kinoshita S, Fingert JH, Inatani M, Tashiro K, Reis A, Edward DP, Pasquale LR, Kubota T, Wiggs JL, Pasutto F, Topouzis F, Dubina M, Craig JE, Yoshimura N, Sundaresan P, John SW, Ritch R, Hauser MA, Khor CC.

Nat Genet. 2015 Jun;47(6):689. doi: 10.1038/ng0615-689c. No abstract available.


Static, dynamic and inoculum augmented respiration based test assessment for determining in-vessel compost stability.

Aspray TJ, Dimambro ME, Wallace P, Howell G, Frederickson J.

Waste Manag. 2015 Aug;42:3-9. doi: 10.1016/j.wasman.2015.04.027. Epub 2015 May 16.


DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease.

Jackson HM, Onos KD, Pepper KW, Graham LC, Akeson EC, Byers C, Reinholdt LG, Frankel WN, Howell GR.

PLoS One. 2015 May 1;10(5):e0125897. doi: 10.1371/journal.pone.0125897. eCollection 2015.


I12: the Joint Engineering, Environment and Processing (JEEP) beamline at Diamond Light Source.

Drakopoulos M, Connolley T, Reinhard C, Atwood R, Magdysyuk O, Vo N, Hart M, Connor L, Humphreys B, Howell G, Davies S, Hill T, Wilkin G, Pedersen U, Foster A, De Maio N, Basham M, Yuan F, Wanelik K.

J Synchrotron Radiat. 2015 May;22(3):828-38. doi: 10.1107/S1600577515003513. Epub 2015 Apr 8.


Modular Synthesis of Constrained Ethyl (cEt) Purine and Pyrimidine Nucleosides.

Blade H, Bradley D, Diorazio L, Evans T, Hayter BR, Howell GP.

J Org Chem. 2015 May 15;80(10):5337-43. doi: 10.1021/acs.joc.5b00607. Epub 2015 Apr 28.


TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, Broihier ML, Xu G, Margevicius D, Karlo JC, Sousa GL, Cotleur AC, Butovsky O, Bekris L, Staugaitis SM, Leverenz JB, Pimplikar SW, Landreth GE, Howell GR, Ransohoff RM, Lamb BT.

J Exp Med. 2015 Mar 9;212(3):287-95. doi: 10.1084/jem.20142322. Epub 2015 Mar 2.

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