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Identification of the kinase STK25 as an upstream activator of LATS signaling.

Lim S, Hermance N, Mudianto T, Mustaly HM, Mauricio IPM, Vittoria MA, Quinton RJ, Howell BW, Cornils H, Manning AL, Ganem NJ.

Nat Commun. 2019 Apr 4;10(1):1547. doi: 10.1038/s41467-019-09597-w.


Ethanol Exposure Transiently Elevates but Persistently Inhibits Tyrosine Kinase Activity and Impairs the Growth of the Nascent Apical Dendrite.

Wang D, Enck J, Howell BW, Olson EC.

Mol Neurobiol. 2019 Aug;56(8):5749-5762. doi: 10.1007/s12035-019-1473-x. Epub 2019 Jan 23.


Synaptic structural protein dysfunction leads to altered excitation inhibition ratios in models of autism spectrum disorder.

Howell BW, Smith KM.

Pharmacol Res. 2019 Jan;139:207-214. doi: 10.1016/j.phrs.2018.11.019. Epub 2018 Nov 19. Review.


Reelin Can Modulate Migration of Olfactory Ensheathing Cells and Gonadotropin Releasing Hormone Neurons via the Canonical Pathway.

Dairaghi L, Flannery E, Giacobini P, Saglam A, Saadi H, Constantin S, Casoni F, Howell BW, Wray S.

Front Cell Neurosci. 2018 Aug 3;12:228. doi: 10.3389/fncel.2018.00228. eCollection 2018.


STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia.

Cansby E, Magnusson E, Nuñez-Durán E, Amrutkar M, Pedrelli M, Parini P, Hoffmann J, Ståhlman M, Howell BW, Marschall HU, Borén J, Mahlapuu M.

Arterioscler Thromb Vasc Biol. 2018 Aug;38(8):1723-1737. doi: 10.1161/ATVBAHA.118.311241.


STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue.

Sütt S, Cansby E, Paul A, Amrutkar M, Nuñez-Durán E, Kulkarni NM, Ståhlman M, Borén J, Laurencikiene J, Howell BW, Enerbäck S, Mahlapuu M.

J Endocrinol. 2018 Sep;238(3):187-202. doi: 10.1530/JOE-18-0182. Epub 2018 May 24.


The de novo autism spectrum disorder RELN R2290C mutation reduces Reelin secretion and increases protein disulfide isomerase expression.

Lammert DB, Middleton FA, Pan J, Olson EC, Howell BW.

J Neurochem. 2017 Jul;142(1):89-102. doi: 10.1111/jnc.14045. Epub 2017 May 18.


RELN Mutations in Autism Spectrum Disorder.

Lammert DB, Howell BW.

Front Cell Neurosci. 2016 Mar 31;10:84. doi: 10.3389/fncel.2016.00084. eCollection 2016. Review.


Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model.

Amrutkar M, Cansby E, Chursa U, Nuñez-Durán E, Chanclón B, Ståhlman M, Fridén V, Mannerås-Holm L, Wickman A, Smith U, Bäckhed F, Borén J, Howell BW, Mahlapuu M.

Diabetes. 2015 Aug;64(8):2791-804. doi: 10.2337/db15-0060. Epub 2015 Apr 6.


Novel Disabled-1-expressing neurons identified in adult brain and spinal cord.

Abadesco AD, Cilluffo M, Yvone GM, Carpenter EM, Howell BW, Phelps PE.

Eur J Neurosci. 2014 Feb;39(4):579-92. doi: 10.1111/ejn.12416. Epub 2013 Nov 19.


Acute inactivation of the serine-threonine kinase Stk25 disrupts neuronal migration.

Matsuki T, Chen J, Howell BW.

Neural Dev. 2013 Nov 13;8:21. doi: 10.1186/1749-8104-8-21.


Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice.

Brunne B, Franco S, Bouché E, Herz J, Howell BW, Pahle J, Müller U, May P, Frotscher M, Bock HH.

Glia. 2013 Aug;61(8):1347-63. doi: 10.1002/glia.22519. Epub 2013 Jul 4.


Open surgical management of complications from indwelling radial artery catheters.

Garg K, Howell BW, Saltzberg SS, Berland TL, Mussa FF, Maldonado TS, Rockman CB.

J Vasc Surg. 2013 Nov;58(5):1325-30. doi: 10.1016/j.jvs.2013.05.011. Epub 2013 Jun 27.


Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus.

Teixeira CM, Kron MM, Masachs N, Zhang H, Lagace DC, Martinez A, Reillo I, Duan X, Bosch C, Pujadas L, Brunso L, Song H, Eisch AJ, Borrell V, Howell BW, Parent JM, Soriano E.

J Neurosci. 2012 Aug 29;32(35):12051-65.


Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice.

Matsuki T, Zaka M, Guerreiro R, van der Brug MP, Cooper JA, Cookson MR, Hardy JA, Howell BW.

PLoS One. 2012;7(2):e31152. doi: 10.1371/journal.pone.0031152. Epub 2012 Feb 15.


Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment.

Matsuki T, Matthews RT, Cooper JA, van der Brug MP, Cookson MR, Hardy JA, Olson EC, Howell BW.

Cell. 2010 Nov 24;143(5):826-36. doi: 10.1016/j.cell.2010.10.029.


Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines.

Lee KJ, Moussa CE, Lee Y, Sung Y, Howell BW, Turner RS, Pak DT, Hoe HS.

Neuroscience. 2010 Aug 11;169(1):344-56. doi: 10.1016/j.neuroscience.2010.04.078. Epub 2010 May 6.


Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.

Lai C, Xie C, Shim H, Chandran J, Howell BW, Cai H.

Mol Brain. 2009 Jul 24;2:23. doi: 10.1186/1756-6606-2-23.


Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.

Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW.

J Neurosci. 2009 Jun 10;29(23):7459-73. doi: 10.1523/JNEUROSCI.4872-08.2009.


A recommended protocol for the immediate postoperative care of lower extremity free-flap reconstructions.

Rohde C, Howell BW, Buncke GM, Gurtner GC, Levin LS, Pu LL, Levine JP.

J Reconstr Microsurg. 2009 Jan;25(1):15-9. doi: 10.1055/s-0028-1090600. Epub 2008 Oct 31.


Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis.

Matsuki T, Pramatarova A, Howell BW.

J Cell Sci. 2008 Jun 1;121(11):1869-75. doi: 10.1242/jcs.027334. Epub 2008 May 13.


A genetic interaction between the APP and Dab1 genes influences brain development.

Pramatarova A, Chen K, Howell BW.

Mol Cell Neurosci. 2008 Jan;37(1):178-86. Epub 2007 Sep 26.


Akt blocks ligand binding and protects against expanded polyglutamine androgen receptor toxicity.

Palazzolo I, Burnett BG, Young JE, Brenne PL, La Spada AR, Fischbeck KH, Howell BW, Pennuto M.

Hum Mol Genet. 2007 Jul 1;16(13):1593-603. Epub 2007 Apr 30.


DAB1 and Reelin effects on amyloid precursor protein and ApoE receptor 2 trafficking and processing.

Hoe HS, Tran TS, Matsuoka Y, Howell BW, Rebeck GW.

J Biol Chem. 2006 Nov 17;281(46):35176-85. Epub 2006 Sep 1.


Mouse disabled 1 regulates the nuclear position of neurons in a Drosophila eye model.

Pramatarova A, Ochalski PG, Lee CH, Howell BW.

Mol Cell Biol. 2006 Feb;26(4):1510-7.


CSK negatively regulates nerve growth factor induced neural differentiation and augments AKT kinase activity.

Dey N, Howell BW, De PK, Durden DL.

Exp Cell Res. 2005 Jul 1;307(1):1-14.


Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting.

Verbeek DS, Knight MA, Harmison GG, Fischbeck KH, Howell BW.

Brain. 2005 Feb;128(Pt 2):436-42. Epub 2004 Dec 23.


Interaction between Dab1 and CrkII is promoted by Reelin signaling.

Chen K, Ochalski PG, Tran TS, Sahir N, Schubert M, Pramatarova A, Howell BW.

J Cell Sci. 2004 Sep 1;117(Pt 19):4527-36. Epub 2004 Aug 17.


Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons.

Pramatarova A, Ochalski PG, Chen K, Gropman A, Myers S, Min KT, Howell BW.

Mol Cell Biol. 2003 Oct;23(20):7210-21.


Genetic modulation of tau phosphorylation in the mouse.

Brich J, Shie FS, Howell BW, Li R, Tus K, Wakeland EK, Jin LW, Mumby M, Churchill G, Herz J, Cooper JA.

J Neurosci. 2003 Jan 1;23(1):187-92.


Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1.

Lieberman AP, Friedlich DL, Harmison G, Howell BW, Jordan CL, Breedlove SM, Fischbeck KH.

Biochem Biophys Res Commun. 2001 Mar 30;282(2):499-506.


The LDL receptor gene family: signaling functions during development.

Howell BW, Herz J.

Curr Opin Neurobiol. 2001 Feb;11(1):74-81. Review.


Dab1 tyrosine phosphorylation sites relay positional signals during mouse brain development.

Howell BW, Herrick TM, Hildebrand JD, Zhang Y, Cooper JA.

Curr Biol. 2000 Jul 27-Aug 10;10(15):877-85.


Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.

Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA, Herz J.

Neuron. 1999 Oct;24(2):481-9.


Thyroid hormone regulates reelin and dab1 expression during brain development.

Alvarez-Dolado M, Ruiz M, Del Río JA, Alcántara S, Burgaya F, Sheldon M, Nakajima K, Bernal J, Howell BW, Curran T, Soriano E, Muñoz A.

J Neurosci. 1999 Aug 15;19(16):6979-93.


Lipoprotein receptors: signaling functions in the brain?

Cooper JA, Howell BW.

Cell. 1999 Jun 11;97(6):671-4. Review. No abstract available.


Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning.

Howell BW, Herrick TM, Cooper JA.

Genes Dev. 1999 Mar 15;13(6):643-8. Erratum in: Genes Dev. 1999 Jun 15;13(12):1642.


Cerebellar abnormalities in the disabled (mdab1-1) mouse.

Gallagher E, Howell BW, Soriano P, Cooper JA, Hawkes R.

J Comp Neurol. 1998 Dec 14;402(2):238-51.


Neuronal position in the developing brain is regulated by mouse disabled-1.

Howell BW, Hawkes R, Soriano P, Cooper JA.

Nature. 1997 Oct 16;389(6652):733-7.


Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice.

Sheldon M, Rice DS, D'Arcangelo G, Yoneshima H, Nakajima K, Mikoshiba K, Howell BW, Cooper JA, Goldowitz D, Curran T.

Nature. 1997 Oct 16;389(6652):730-3.


Mouse disabled (mDab1): a Src binding protein implicated in neuronal development.

Howell BW, Gertler FB, Cooper JA.

EMBO J. 1997 Jan 2;16(1):121-32.


Regulation of Btk by Src family tyrosine kinases.

Afar DE, Park H, Howell BW, Rawlings DJ, Cooper J, Witte ON.

Mol Cell Biol. 1996 Jul;16(7):3465-71.


Alternative splicing of STY, a nuclear dual specificity kinase.

Duncan PI, Howell BW, Marius RM, Drmanic S, Douville EM, Bell JC.

J Biol Chem. 1995 Sep 15;270(37):21524-31.


Csk suppression of Src involves movement of Csk to sites of Src activity.

Howell BW, Cooper JA.

Mol Cell Biol. 1994 Aug;14(8):5402-11.


Deletion of the SH3 domain of Src interferes with regulation by the phosphorylated carboxyl-terminal tyrosine.

Okada M, Howell BW, Broome MA, Cooper JA.

J Biol Chem. 1993 Aug 25;268(24):18070-5.


Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms.

Douville EM, Afar DE, Howell BW, Letwin K, Tannock L, Ben-David Y, Pawson T, Bell JC.

Mol Cell Biol. 1992 Jun;12(6):2681-9.


STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

Howell BW, Afar DE, Lew J, Douville EM, Icely PL, Gray DA, Bell JC.

Mol Cell Biol. 1991 Jan;11(1):568-72.


Rat carbamyl-phosphate synthetase I gene. Promoter sequence and tissue-specific transcriptional regulation in vitro.

Lagacé M, Howell BW, Burak R, Lusty CJ, Shore GC.

J Biol Chem. 1987 Aug 5;262(22):10415-8.

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