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Items: 1 to 50 of 93

1.

Metastasis-associated upregulation of ER-Golgi trafficking kinetics: regulation of cancer progression via the Golgi apparatus.

Howley BV, Howe PH.

Oncoscience. 2018 Jun 25;5(5-6):142-143. doi: 10.18632/oncoscience.426. eCollection 2018 May. No abstract available.

2.

Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1).

Noguchi K, Dincman TA, Dalton AC, Howley BV, McCall BJ, Mohanty BK, Howe PH.

J Biol Chem. 2018 Jul 20;293(29):11401-11414. doi: 10.1074/jbc.RA118.003616. Epub 2018 Jun 5.

3.

The Long (lncRNA) and Short (miRNA) of It: TGFβ-Mediated Control of RNA-Binding Proteins and Noncoding RNAs.

Janakiraman H, House RP, Gangaraju VK, Diehl JA, Howe PH, Palanisamy V.

Mol Cancer Res. 2018 Apr;16(4):567-579. doi: 10.1158/1541-7786.MCR-17-0547. Epub 2018 Mar 19. Review.

PMID:
29555893
4.

TGF-beta signaling in cancer: post-transcriptional regulation of EMT via hnRNP E1.

Howley BV, Howe PH.

Cytokine. 2018 Jan 27. pii: S1043-4666(17)30403-9. doi: 10.1016/j.cyto.2017.12.032. [Epub ahead of print]

PMID:
29396052
5.

Metabolic Labeling and Profiling of Transfer RNAs Using Macroarrays.

Emetu S, Troiano M, Goldmintz J, Tomberlin J, Grelet S, Howe PH, Korey C, Geslain R.

J Vis Exp. 2018 Jan 16;(131). doi: 10.3791/56898.

6.

EMT does not work regular shifts.

Grelet S, Geslain R, Howe PH.

Cell Cycle. 2018;17(2):141-142. doi: 10.1080/15384101.2017.1414684. Epub 2018 Jan 15. No abstract available.

PMID:
29334820
7.

A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer.

Howley BV, Link LA, Grelet S, El-Sabban M, Howe PH.

Oncogene. 2018 Mar;37(10):1308-1325. doi: 10.1038/s41388-017-0023-0. Epub 2017 Dec 18.

8.

Addendum: A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.

Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH.

Nat Cell Biol. 2017 Nov 29;19(12):1443. doi: 10.1038/ncb3647.

PMID:
29184176
9.

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma.

Qie S, Majumder M, Mackiewicz K, Howley BV, Peterson YK, Howe PH, Palanisamy V, Diehl JA.

Nat Commun. 2017 Nov 16;8(1):1534. doi: 10.1038/s41467-017-01199-8.

10.

TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.

Gencer S, Oleinik N, Kim J, Panneer Selvam S, De Palma R, Dany M, Nganga R, Thomas RJ, Senkal CE, Howe PH, Ogretmen B.

Sci Signal. 2017 Oct 24;10(502). pii: eaam7464. doi: 10.1126/scisignal.aam7464.

11.

A regulated PNUTS mRNA to lncRNA splice switch mediates EMT and tumour progression.

Grelet S, Link LA, Howley B, Obellianne C, Palanisamy V, Gangaraju VK, Diehl JA, Howe PH.

Nat Cell Biol. 2017 Sep;19(9):1105-1115. doi: 10.1038/ncb3595. Epub 2017 Aug 21. Erratum in: Nat Cell Biol. 2017 Nov 29;19(12 ):1443.

12.

Pleiotropic Roles of Non-Coding RNAs in TGF-β-Mediated Epithelial-Mesenchymal Transition and Their Functions in Tumor Progression.

Grelet S, McShane A, Geslain R, Howe PH.

Cancers (Basel). 2017 Jul 1;9(7). pii: E75. doi: 10.3390/cancers9070075. Review.

13.

SPOt: A novel and streamlined microarray platform for observing cellular tRNA levels.

Grelet S, McShane A, Hok E, Tomberlin J, Howe PH, Geslain R.

PLoS One. 2017 May 17;12(5):e0177939. doi: 10.1371/journal.pone.0177939. eCollection 2017.

14.

Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines.

Noguchi K, Dalton AC, Howley BV, McCall BJ, Yoshida A, Diehl JA, Howe PH.

PLoS One. 2017 May 17;12(5):e0177830. doi: 10.1371/journal.pone.0177830. eCollection 2017.

15.

Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.

Ansa-Addo EA, Zhang Y, Yang Y, Hussey GS, Howley BV, Salem M, Riesenberg B, Sun S, Rockey DC, Karvar S, Howe PH, Liu B, Li Z.

J Clin Invest. 2017 Apr 3;127(4):1321-1337. doi: 10.1172/JCI89281. Epub 2017 Mar 13.

16.

S. pombe Uba1-Ubc15 Structure Reveals a Novel Regulatory Mechanism of Ubiquitin E2 Activity.

Lv Z, Rickman KA, Yuan L, Williams K, Selvam SP, Woosley AN, Howe PH, Ogretmen B, Smogorzewska A, Olsen SK.

Mol Cell. 2017 Feb 16;65(4):699-714.e6. doi: 10.1016/j.molcel.2017.01.008. Epub 2017 Feb 2.

17.

Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma.

Janakiraman H, House RP, Talwar S, Courtney SM, Hazard ES, Hardiman G, Mehrotra S, Howe PH, Gangaraju V, Palanisamy V.

Oncogene. 2017 Jun 1;36(22):3137-3148. doi: 10.1038/onc.2016.451. Epub 2016 Dec 12.

18.

Surface Expression of TGFβ Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer.

Metelli A, Wu BX, Fugle CW, Rachidi S, Sun S, Zhang Y, Wu J, Tomlinson S, Howe PH, Yang Y, Garrett-Mayer E, Liu B, Li Z.

Cancer Res. 2016 Dec 15;76(24):7106-7117. Epub 2016 Oct 20.

19.

Disabled-2; an autophagic and apoptotic switch.

Jiang Y, Woosley AN, Howe PH.

Cell Cycle. 2016 Dec 16;15(24):3319-3320. doi: 10.1080/15384101.2016.1222747. Epub 2016 Aug 25. No abstract available.

20.

Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy.

Jiang Y, Woosley AN, Sivalingam N, Natarajan S, Howe PH.

Nat Cell Biol. 2016 Aug;18(8):851-63. doi: 10.1038/ncb3388. Epub 2016 Jul 11.

21.

The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.

Heise T, Kota V, Brock A, Morris AB, Rodriguez RM, Zierk AW, Howe PH, Sommer G.

Oncotarget. 2016 May 17;7(20):29664-76. doi: 10.18632/oncotarget.8819.

22.

PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27.

Link LA, Howley BV, Hussey GS, Howe PH.

Mol Cancer Res. 2016 Jul;14(7):634-46. doi: 10.1158/1541-7786.MCR-16-0018. Epub 2016 Apr 21.

23.

Identification and characterization of an hnRNP E1 translational silencing motif.

Brown AS, Mohanty BK, Howe PH.

Nucleic Acids Res. 2016 Jul 8;44(12):5892-907. doi: 10.1093/nar/gkw241. Epub 2016 Apr 11.

24.

Transforming Growth Factor-β Is an Upstream Regulator of Mammalian Target of Rapamycin Complex 2-Dependent Bladder Cancer Cell Migration and Invasion.

Gupta S, Hau AM, Al-Ahmadie HA, Harwalkar J, Shoskes AC, Elson P, Beach JR, Hussey GS, Schiemann WP, Egelhoff TT, Howe PH, Hansel DE.

Am J Pathol. 2016 May;186(5):1351-60. doi: 10.1016/j.ajpath.2016.01.008. Epub 2016 Mar 14.

25.

Post-transcriptional mapping reveals critical regulators of metastasis.

Hussey GS, Howley BV, Howe PH.

Oncoscience. 2015 Aug 20;2(10):831-2. eCollection 2015. No abstract available.

26.

Computational Identification of Post Translational Modification Regulated RNA Binding Protein Motifs.

Brown AS, Mohanty BK, Howe PH.

PLoS One. 2015 Sep 14;10(9):e0137696. doi: 10.1371/journal.pone.0137696. eCollection 2015.

27.

Translational regulation of inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells.

Howley BV, Hussey GS, Link LA, Howe PH.

Oncogene. 2016 Mar 31;35(13):1725-35. doi: 10.1038/onc.2015.238. Epub 2015 Jun 22.

28.

Neuropilin-2 Is upregulated in lung cancer cells during TGF-β1-induced epithelial-mesenchymal transition.

Nasarre P, Gemmill RM, Potiron VA, Roche J, Lu X, Barón AE, Korch C, Garrett-Mayer E, Lagana A, Howe PH, Drabkin HA.

Cancer Res. 2013 Dec 1;73(23):7111-21. doi: 10.1158/0008-5472.CAN-13-1755. Epub 2013 Oct 11. Erratum in: Cancer Res. 2014 Jan 15;74(2):637.

29.

Establishment of a TGFβ-induced post-transcriptional EMT gene signature.

Hussey GS, Link LA, Brown AS, Howley BV, Chaudhury A, Howe PH.

PLoS One. 2012;7(12):e52624. doi: 10.1371/journal.pone.0052624. Epub 2012 Dec 20.

30.

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin.

Jiang Y, He X, Howe PH.

EMBO J. 2012 May 16;31(10):2336-49. doi: 10.1038/emboj.2012.83. Epub 2012 Apr 10.

31.

Myosin II isoform switching mediates invasiveness after TGF-β-induced epithelial-mesenchymal transition.

Beach JR, Hussey GS, Miller TE, Chaudhury A, Patel P, Monslow J, Zheng Q, Keri RA, Reizes O, Bresnick AR, Howe PH, Egelhoff TT.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):17991-6. doi: 10.1073/pnas.1106499108. Epub 2011 Oct 24.

32.

Discovery of a metastatic pathway: implications for future cancer treatment.

Hussey G, Chaudhury A, Howe PH.

Future Oncol. 2011 Jun;7(6):703-5. doi: 10.2217/fon.11.47. No abstract available.

PMID:
21675832
33.

3'-UTR-mediated post-transcriptional regulation of cancer metastasis: beginning at the end.

Chaudhury A, Hussey GS, Howe PH.

RNA Biol. 2011 Jul-Aug;8(4):595-9. doi: 10.4161/rna.8.4.16018. Epub 2011 Jul 1.

34.

Identification of an mRNP complex regulating tumorigenesis at the translational elongation step.

Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, Merrick WC, Howe PH.

Mol Cell. 2011 Feb 18;41(4):419-31. doi: 10.1016/j.molcel.2011.02.003.

35.

Type II transforming growth factor-beta receptor recycling is dependent upon the clathrin adaptor protein Dab2.

Penheiter SG, Singh RD, Repellin CE, Wilkes MC, Edens M, Howe PH, Pagano RE, Leof EB.

Mol Biol Cell. 2010 Nov 15;21(22):4009-19. doi: 10.1091/mbc.E09-12-1019. Epub 2010 Sep 29.

36.

Central role for disabled-2 in mesenchymal stem cardiac protein expression and functional consequences after engraftment in acute myocardial infarction.

Mayorga ME, Dong F, Sundararaman S, Huang Y, Jiang Y, Howe PH, Penn MS.

Stem Cells Dev. 2011 Apr;20(4):681-93. doi: 10.1089/scd.2010.0151. Epub 2010 Sep 13.

PMID:
20666606
37.

Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles.

Chaudhury A, Chander P, Howe PH.

RNA. 2010 Aug;16(8):1449-62. doi: 10.1261/rna.2254110. Epub 2010 Jun 28. Review.

38.

TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI.

Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH.

Nat Cell Biol. 2010 Mar;12(3):286-93. doi: 10.1038/ncb2029. Epub 2010 Feb 14.

39.

The tale of transforming growth factor-beta (TGFbeta) signaling: a soigné enigma.

Chaudhury A, Howe PH.

IUBMB Life. 2009 Oct;61(10):929-39. doi: 10.1002/iub.239. Review.

40.

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions.

Jiang Y, Luo W, Howe PH.

Oncogene. 2009 Aug 20;28(33):2999-3007. doi: 10.1038/onc.2009.157. Epub 2009 Jul 6.

41.

Runx1 is a co-activator with FOXO3 to mediate transforming growth factor beta (TGFbeta)-induced Bim transcription in hepatic cells.

Wildey GM, Howe PH.

J Biol Chem. 2009 Jul 24;284(30):20227-39. doi: 10.1074/jbc.M109.027201. Epub 2009 Jun 3.

42.

Transforming growth factor beta (TGFbeta)-induced apoptosis: the rise & fall of Bim.

Ramesh S, Wildey GM, Howe PH.

Cell Cycle. 2009 Jan 1;8(1):11-7. Epub 2009 Jan 30. Review.

43.

TGF beta-mediated BIM expression and apoptosis are regulated through SMAD3-dependent expression of the MAPK phosphatase MKP2.

Ramesh S, Qi XJ, Wildey GM, Robinson J, Molkentin J, Letterio J, Howe PH.

EMBO Rep. 2008 Oct;9(10):990-7. doi: 10.1038/embor.2008.158. Epub 2008 Aug 15.

44.

The inhibitory effects of Disabled-2 (Dab2) on Wnt signaling are mediated through Axin.

Jiang Y, Prunier C, Howe PH.

Oncogene. 2008 Mar 20;27(13):1865-75. Epub 2007 Oct 8.

45.

Cell autonomous sorting and surface positioning in the formation of primitive endoderm in embryoid bodies.

Rula ME, Cai KQ, Moore R, Yang DH, Staub CM, Capo-Chichi CD, Jablonski SA, Howe PH, Smith ER, Xu XX.

Genesis. 2007 Jun;45(6):327-38.

PMID:
17506089
46.

HOXA9 participates in the transcriptional activation of E-selectin in endothelial cells.

Bandyopadhyay S, Ashraf MZ, Daher P, Howe PH, DiCorleto PE.

Mol Cell Biol. 2007 Jun;27(12):4207-16. Epub 2007 Apr 23.

47.

Tumor necrosis factor alpha (TNF-alpha) receptor-II is required for TNF-alpha-induced leukocyte-endothelial interaction in vivo.

Chandrasekharan UM, Siemionow M, Unsal M, Yang L, Poptic E, Bohn J, Ozer K, Zhou Z, Howe PH, Penn M, DiCorleto PE.

Blood. 2007 Mar 1;109(5):1938-44. Epub 2006 Oct 26.

48.

Evidence that Ser87 of BimEL is phosphorylated by Akt and regulates BimEL apoptotic function.

Qi XJ, Wildey GM, Howe PH.

J Biol Chem. 2006 Jan 13;281(2):813-23. Epub 2005 Nov 10.

50.

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