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Items: 31

1.

UK phenomics platform for developing and validating electronic health record phenotypes: CALIBER.

Denaxas S, Gonzalez-Izquierdo A, Direk K, Fitzpatrick NK, Fatemifar G, Banerjee A, Dobson RJB, Howe LJ, Kuan V, Lumbers RT, Pasea L, Patel RS, Shah AD, Hingorani AD, Sudlow C, Hemingway H.

J Am Med Inform Assoc. 2019 Jul 22. pii: ocz105. doi: 10.1093/jamia/ocz105. [Epub ahead of print]

PMID:
31329239
2.

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events.

Patel RS, Schmidt AF, Tragante V, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Dubé MP, Allayee H, Almgren P, Alver M, Baranova EV, Behlouli H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dufresne L, Eriksson N, Foco L, Gijsberts CM, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Fitzpatrick N, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Bogaty P, de Borst GJ, Brenner H, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Johnson JA, de Jong PA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Pepinski W, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Scholz M, Siegbahn A, Sinisalo J, Smith JG, Spertus JA, Stewart AFR, Szczeklik W, Szpakowicz A, Ten Berg JM, Thanassoulis G, Thiery J, van der Graaf Y, Visseren FLJ, Waltenberger J; CARDIoGRAMPlusC4D Consortium, Van der Harst P, Tardif JC, Sattar N, Lang CC, Pare G, Brophy JM, Anderson JL, März W, Wallentin L, Cameron VA, Horne BD, Samani NJ, Hingorani AD, Asselbergs FW.

Circ Genom Precis Med. 2019 Apr;12(4):e002471. doi: 10.1161/CIRCGEN.119.002471. Epub 2019 Mar 21.

PMID:
30897348
3.

Subsequent Event Risk in Individuals With Established Coronary Heart Disease.

Patel RS, Tragante V, Schmidt AF, McCubrey RO, Holmes MV, Howe LJ, Direk K, Åkerblom A, Leander K, Virani SS, Kaminski KA, Muehlschlegel JD, Allayee H, Almgren P, Alver M, Baranova EV, Behloui H, Boeckx B, Braund PS, Breitling LP, Delgado G, Duarte NE, Dubé MP, Dufresne L, Eriksson N, Foco L, Scholz M, Gijsberts CM, Glinge C, Gong Y, Hartiala J, Heydarpour M, Hubacek JA, Kleber M, Kofink D, Kotti S, Kuukasjärvi P, Lee VV, Leiherer A, Lenzini PA, Levin D, Lyytikäinen LP, Martinelli N, Mons U, Nelson CP, Nikus K, Pilbrow AP, Ploski R, Sun YV, Tanck MWT, Tang WHW, Trompet S, van der Laan SW, Van Setten J, Vilmundarson RO, Viviani Anselmi C, Vlachopoulou E, Al Ali L, Boerwinkle E, Briguori C, Carlquist JF, Carruthers KF, Casu G, Deanfield J, Deloukas P, Dudbridge F, Engstrøm T, Fitzpatrick N, Fox K, Gigante B, James S, Lokki ML, Lotufo PA, Marziliano N, Mordi IR, Muhlestein JB, Newton-Cheh C, Pitha J, Saely CH, Samman-Tahhan A, Sandesara PB, Teren A, Timmis A, Van de Werf F, Wauters E, Wilde AAM, Ford I, Stott DJ, Algra A, Andreassi MG, Ardissino D, Arsenault BJ, Ballantyne CM, Bergmeijer TO, Bezzina CR, Body SC, Boersma EH, Bogaty P, Bots ML, Brenner H, Brugts JJ, Burkhardt R, Carpeggiani C, Condorelli G, Cooper-DeHoff RM, Cresci S, Danchin N, de Faire U, Doughty RN, Drexel H, Engert JC, Fox KAA, Girelli D, Grobbee DE, Hagström E, Hazen SL, Held C, Hemingway H, Hoefer IE, Hovingh GK, Jabbari R, Johnson JA, Jukema JW, Kaczor MP, Kähönen M, Kettner J, Kiliszek M, Klungel OH, Lagerqvist B, Lambrechts D, Laurikka JO, Lehtimäki T, Lindholm D, Mahmoodi BK, Maitland-van der Zee AH, McPherson R, Melander O, Metspalu A, Niemcunowicz-Janica A, Olivieri O, Opolski G, Palmer CN, Pasterkamp G, Pepine CJ, Pereira AC, Pilote L, Quyyumi AA, Richards AM, Sanak M, Siegbahn A, Simon T, Sinisalo J, Smith JG, Spertus JA, Stender S, Stewart AFR, Szczeklik W, Szpakowicz A, Tardif JC, Ten Berg JM, Tfelt-Hansen J, Thanassoulis G, Thiery J, Torp-Pedersen C, van der Graaf Y, Visseren FLJ, Waltenberger J, Weeke PE, Van der Harst P, Lang CC, Sattar N, Cameron VA, Anderson JL, Brophy JM, Pare G, Horne BD, März W, Wallentin L, Samani NJ, Hingorani AD, Asselbergs FW.

Circ Genom Precis Med. 2019 Apr;12(4):e002470. doi: 10.1161/CIRCGEN.119.002470. Epub 2019 Mar 21.

PMID:
30896328
4.

Prenatal alcohol exposure and facial morphology in a UK cohort.

Howe LJ, Sharp GC, Hemani G, Zuccolo L, Richmond S, Lewis SJ.

Drug Alcohol Depend. 2019 Apr 1;197:42-47. doi: 10.1016/j.drugalcdep.2018.11.031. Epub 2019 Feb 5.

PMID:
30772781
5.

Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip/palate.

Howe LJ, Richardson TG, Arathimos R, Alvizi L, Passos-Bueno MR, Stanier P, Nohr E, Ludwig KU, Mangold E, Knapp M, Stergiakouli E, Pourcain BS, Smith GD, Sandy J, Relton CL, Lewis SJ, Hemani G, Sharp GC.

Epigenomics. 2019 Feb;11(2):133-145. doi: 10.2217/epi-2018-0091. Epub 2019 Jan 14.

6.

Facial Genetics: A Brief Overview.

Richmond S, Howe LJ, Lewis S, Stergiakouli E, Zhurov A.

Front Genet. 2018 Oct 16;9:462. doi: 10.3389/fgene.2018.00462. eCollection 2018. Review.

7.

Transcription Promotes the Interaction of the FAcilitates Chromatin Transactions (FACT) Complex with Nucleosomes in Saccharomyces cerevisiae.

Martin BJE, Chruscicki AT, Howe LJ.

Genetics. 2018 Nov;210(3):869-881. doi: 10.1534/genetics.118.301349. Epub 2018 Sep 20.

PMID:
30237209
8.

Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology.

Howe LJ, Lee MK, Sharp GC, Davey Smith G, St Pourcain B, Shaffer JR, Ludwig KU, Mangold E, Marazita ML, Feingold E, Zhurov A, Stergiakouli E, Sandy J, Richmond S, Weinberg SM, Hemani G, Lewis SJ.

PLoS Genet. 2018 Aug 1;14(8):e1007501. doi: 10.1371/journal.pgen.1007501. eCollection 2018 Aug.

9.

Viral proteins as a potential driver of histone depletion in dinoflagellates.

Irwin NAT, Martin BJE, Young BP, Browne MJG, Flaus A, Loewen CJR, Keeling PJ, Howe LJ.

Nat Commun. 2018 Apr 18;9(1):1535. doi: 10.1038/s41467-018-03993-4.

10.

Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits.

Howe LJ, Erzurumluoglu AM, Davey Smith G, Rodriguez S, Stergiakouli E.

Sci Rep. 2017 Sep 14;7(1):11655. doi: 10.1038/s41598-017-10871-4.

11.

Histone Acetylation, Not Stoichiometry, Regulates Linker Histone Binding in Saccharomyces cerevisiae.

Lawrence MBD, Coutin N, Choi JK, Martin BJE, Irwin NAT, Young B, Loewen C, Howe LJ.

Genetics. 2017 Sep;207(1):347-355. doi: 10.1534/genetics.117.1132. Epub 2017 Jul 24.

12.

Body mass index, body dissatisfaction and adolescent smoking initiation.

Howe LJ, Trela-Larsen L, Taylor M, Heron J, Munafò MR, Taylor AE.

Drug Alcohol Depend. 2017 Sep 1;178:143-149. doi: 10.1016/j.drugalcdep.2017.04.008. Epub 2017 Jun 8.

13.

Histone H3K4 and H3K36 Methylation Independently Recruit the NuA3 Histone Acetyltransferase in Saccharomyces cerevisiae.

Martin BJ, McBurney KL, Maltby VE, Jensen KN, Brind'Amour J, Howe LJ.

Genetics. 2017 Mar;205(3):1113-1123. doi: 10.1534/genetics.116.199422. Epub 2017 Jan 20.

14.

Divergent Residues Within Histone H3 Dictate a Unique Chromatin Structure in Saccharomyces cerevisiae.

McBurney KL, Leung A, Choi JK, Martin BJ, Irwin NA, Bartke T, Nelson CJ, Howe LJ.

Genetics. 2016 Jan;202(1):341-9. doi: 10.1534/genetics.115.180810. Epub 2015 Nov 3.

15.

Investigating the usefulness of a metacognitive training group programme for schizophrenia.

Howe LJ, Brown ID.

BJPsych Bull. 2015 Jun;39(3):114-8. doi: 10.1192/pb.bp.113.046037.

16.

Polarization of the endoplasmic reticulum by ER-septin tethering.

Chao JT, Wong AK, Tavassoli S, Young BP, Chruscicki A, Fang NN, Howe LJ, Mayor T, Foster LJ, Loewen CJ.

Cell. 2014 Jul 31;158(3):620-32. doi: 10.1016/j.cell.2014.06.033.

17.

Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae.

Maltby VE, Martin BJ, Brind'Amour J, Chruscicki AT, McBurney KL, Schulze JM, Johnson IJ, Hills M, Hentrich T, Kobor MS, Lorincz MC, Howe LJ.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18505-10. doi: 10.1073/pnas.1202070109. Epub 2012 Oct 22.

18.

Critical determinants for chromatin binding by Saccharomyces cerevisiae Yng1 exist outside of the plant homeodomain finger.

Chruscicki A, Macdonald VE, Young BP, Loewen CJ, Howe LJ.

Genetics. 2010 Jun;185(2):469-77. doi: 10.1534/genetics.110.116285. Epub 2010 Mar 29.

19.

Histone acetylation: where to go and how to get there.

MacDonald VE, Howe LJ.

Epigenetics. 2009 Apr 1;4(3):139-43. Epub 2009 Apr 18. Review.

PMID:
19430203
20.

Histone acetylation: truth of consequences?

Choi JK, Howe LJ.

Biochem Cell Biol. 2009 Feb;87(1):139-50. doi: 10.1139/O08-112. Review.

PMID:
19234530
21.

Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation.

Choi JK, Grimes DE, Rowe KM, Howe LJ.

Mol Cell Biol. 2008 Dec;28(23):6967-72. doi: 10.1128/MCB.00570-08. Epub 2008 Sep 22.

22.

Genetic immunization with codon-optimized equine infectious anemia virus (EIAV) surface unit (SU) envelope protein gene sequences stimulates immune responses in ponies.

Cook RF, Cook SJ, Bolin PS, Howe LJ, Zhou W, Montelaro RC, Issel CJ.

Vet Microbiol. 2005 Jun 15;108(1-2):23-37.

PMID:
15885929
23.

ICG angiography and uveitis.

Howe LJ, Tufail A.

Ocul Immunol Inflamm. 2004 Mar;12(1):1-5. No abstract available.

PMID:
15209458
24.

Management of age related macular degeneration: still room for improvement.

Howe LJ.

Br J Ophthalmol. 2003 Mar;87(3):375. No abstract available.

25.

Factors affecting the success rate of the Quickert and Wies procedures for lower lid entropion.

O'Sullivan EP, Howe LJ, Barnes E, Barnes J, Olver JM.

Orbit. 1999 Mar;18(1):59-60. No abstract available.

PMID:
12048700
26.

Delayed suprachoroidal haemorrhage following trabeculectomy bleb needling.

Howe LJ, Bloom P.

Br J Ophthalmol. 1999 Jun;83(6):757. No abstract available.

27.

Choroidal abnormalities in birdshot chorioretinopathy: an indocyanine green angiography study.

Howe LJ, Stanford MR, Graham EM, Marshall J.

Eye (Lond). 1997;11 ( Pt 4):554-9.

PMID:
9425423
28.

Angiographic abnormalities of experimental autoimmune uveoretinitis.

Howe LJ, Stanford MR, Whiston R, Dewhirst R, Marshall J.

Curr Eye Res. 1996 Dec;15(12):1149-55.

PMID:
9018428
29.

Choroidal hypoperfusion in acute posterior multifocal placoid pigment epitheliopathy. An indocyanine green angiography study.

Howe LJ, Woon H, Graham EM, Fitzke F, Bhandari A, Marshall J.

Ophthalmology. 1995 May;102(5):790-8.

PMID:
7777278
30.
31.

The efficacy of systemic corticosteroids in sight-threatening retinal vasculitis.

Howe LJ, Stanford MR, Edelsten C, Graham EM.

Eye (Lond). 1994;8 ( Pt 4):443-7.

PMID:
7821470

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