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Items: 1 to 50 of 115


Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.

Carter AR, Gill D, Davies NM, Taylor AE, Tillmann T, Vaucher J, Wootton RE, Munafò MR, Hemani G, Malik R, Seshadri S, Woo D, Burgess S, Davey Smith G, Holmes MV, Tzoulaki I, Howe LD, Dehghan A.

BMJ. 2019 May 22;365:l1855. doi: 10.1136/bmj.l1855.


Polygenic risk scores for Alzheimer's disease, and academic achievement, cognitive and behavioural measures in children from the general population.

Korologou-Linden R, Anderson EL, Jones HJ, Davey Smith G, Howe LD, Stergiakouli E.

Int J Epidemiol. 2019 May 5. pii: dyz080. doi: 10.1093/ije/dyz080. [Epub ahead of print]


Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC).

O'Keeffe LM, Simpkin AJ, Tilling K, Anderson EL, Hughes AD, Lawlor DA, Fraser A, Howe LD.

Data Brief. 2019 Jan 19;23:103687. doi: 10.1016/j.dib.2019.01.035. eCollection 2019 Apr.


Using SITAR (SuperImposition by Translation and Rotation) to estimate age at peak height velocity in Avon Longitudinal Study of Parents and Children.

Frysz M, Howe LD, Tobias JH, Paternoster L.

Version 2. Wellcome Open Res. 2018 Dec 14 [revised 2018 Jan 1];3:90. doi: 10.12688/wellcomeopenres.14708.2. eCollection 2018.


Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC).

Houtepen LC, Heron J, Suderman MJ, Tilling K, Howe LD.

Wellcome Open Res. 2018 Aug 30;3:106. doi: 10.12688/wellcomeopenres.14716.1. eCollection 2018.


Associations of Body Mass and Fat Indexes With Cardiometabolic Traits.

Bell JA, Carslake D, O'Keeffe LM, Frysz M, Howe LD, Hamer M, Wade KH, Timpson NJ, Davey Smith G.

J Am Coll Cardiol. 2018 Dec 18;72(24):3142-3154. doi: 10.1016/j.jacc.2018.09.066.


Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses.

Wade KH, Chiesa ST, Hughes AD, Chaturvedi N, Charakida M, Rapala A, Muthurangu V, Khan T, Finer N, Sattar N, Howe LD, Fraser A, Lawlor DA, Davey Smith G, Deanfield JE, Timpson NJ.

Circulation. 2018 Nov 13;138(20):2187-2201. doi: 10.1161/CIRCULATIONAHA.117.033278. Epub 2018 Jul 30.


Childhood adversity and DNA methylation in two population-based cohorts.

Houtepen LC, Hardy R, Maddock J, Kuh D, Anderson EL, Relton CL, Suderman MJ, Howe LD.

Transl Psychiatry. 2018 Dec 3;8(1):266. doi: 10.1038/s41398-018-0307-3.


Submaximal exercise blood pressure and cardiovascular structure in adolescence.

Schultz MG, Park C, Fraser A, Howe LD, Jones S, Rapala A, Davey Smith G, Sharman JE, Lawlor DA, Chaturvedi N, Deanfield J, Hughes AD.

Int J Cardiol. 2019 Jan 15;275:152-157. doi: 10.1016/j.ijcard.2018.10.060. Epub 2018 Oct 19.


Early-life adversity, later-life mental health, and resilience resources: a longitudinal population-based birth cohort analysis.

Cosco TD, Hardy R, Howe LD, Richards M.

Int Psychogeriatr. 2018 Nov 23:1-10. doi: 10.1017/S1041610218001795. [Epub ahead of print]


Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.

Park C, Fraser A, Howe LD, Jones S, Davey Smith G, Lawlor DA, Chaturvedi N, Hughes AD.

Hypertension. 2018 Nov;72(5):1103-1108. doi: 10.1161/HYPERTENSIONAHA.118.11925.


Independent and combined associations of maternal and own smoking with adult lung function and COPD.

Magnus MC, Henderson J, Tilling K, Howe LD, Fraser A.

Int J Epidemiol. 2018 Dec 1;47(6):1855-1864. doi: 10.1093/ije/dyy221.


Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study.

O'Keeffe LM, Simpkin AJ, Tilling K, Anderson EL, Hughes AD, Lawlor DA, Fraser A, Howe LD.

Atherosclerosis. 2018 Nov;278:190-196. doi: 10.1016/j.atherosclerosis.2018.09.030. Epub 2018 Sep 27.


Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.

Vinding RK, Stokholm J, Sevelsted A, Sejersen T, Chawes BL, Bønnelykke K, Thorsen J, Howe LD, Krakauer M, Bisgaard H.

BMJ. 2018 Sep 4;362:k3312. doi: 10.1136/bmj.k3312.


Frailty in older-age European migrants: Cross-sectional and longitudinal analyses of the Survey of Health, Aging and Retirement in Europe (SHARE).

Walkden GJ, Anderson EL, Vink MP, Tilling K, Howe LD, Ben-Shlomo Y.

Soc Sci Med. 2018 Sep;213:1-11. doi: 10.1016/j.socscimed.2018.07.033. Epub 2018 Jul 21.


Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics.

Khouja JN, Simpkin AJ, O'Keeffe LM, Wade KH, Houtepen LC, Relton CL, Suderman M, Howe LD.

Clin Epigenetics. 2018 Jun 27;10:86. doi: 10.1186/s13148-018-0520-1. eCollection 2018.


Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.

O'Keeffe LM, Howe LD, Fraser A, Hughes AD, Wade KH, Anderson EL, Lawlor DA, Erzurumluoglu AM, Davey-Smith G, Rodriguez S, Stergiakouli E.

Atherosclerosis. 2018 Jul;274:94-103. doi: 10.1016/j.atherosclerosis.2018.04.027. Epub 2018 Apr 25.


Socioeconomic differences in childhood BMI trajectories in Belarus.

Patel R, Tilling K, Lawlor DA, Howe LD, Hughes RA, Bogdanovich N, Matush L, Nicoli E, Oken E, Kramer MS, Martin RM.

Int J Obes (Lond). 2018 Sep;42(9):1651-1660. doi: 10.1038/s41366-018-0042-0. Epub 2018 Feb 28.


Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.

Lawn RB, Anderson EL, Suderman M, Simpkin AJ, Gaunt TR, Teschendorff AE, Widschwendter M, Hardy R, Kuh D, Relton CL, Howe LD.

Hum Mol Genet. 2018 Apr 1;27(7):1301-1308. doi: 10.1093/hmg/ddy036.


DNA methylation from birth to late adolescence and development of multiple-risk behaviours.

de Vocht F, Suderman M, Tilling K, Heron J, Howe LD, Campbell R, Hickman M, Relton C.

J Affect Disord. 2018 Feb;227:588-594. doi: 10.1016/j.jad.2017.11.055. Epub 2017 Nov 15.


Adverse Childhood Experiences (ACEs) and Adiposity in Adolescents: A Cross-Cohort Comparison.

Soares ALG, Matijasevich A, Menezes AMB, Assunção MC, Wehrmeister FC, Howe LD, Gonçalves H.

Obesity (Silver Spring). 2018 Jan;26(1):150-159. doi: 10.1002/oby.22035. Epub 2017 Nov 14.


Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers.

Magnus MC, Anderson EL, Howe LD, Joinson CJ, Penton-Voak IS, Fraser A.

J Epidemiol Community Health. 2018 Jan;72(1):34-40. doi: 10.1136/jech-2017-209488. Epub 2017 Nov 9.


Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood.

Anderson EL, Fraser A, Caleyachetty R, Hardy R, Lawlor DA, Howe LD.

Child Abuse Negl. 2018 Feb;76:138-148. doi: 10.1016/j.chiabu.2017.10.015. Epub 2017 Nov 2.


Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort.

Simpkin AJ, Cooper R, Howe LD, Relton CL, Davey Smith G, Teschendorff A, Widschwendter M, Wong A, Kuh D, Hardy R.

BMJ Open. 2017 Nov 1;7(10):e016708. doi: 10.1136/bmjopen-2017-016708.


Epigenetic clocks for gestational age: statistical and study design considerations.

Simpkin AJ, Suderman M, Howe LD.

Clin Epigenetics. 2017 Sep 15;9:100. doi: 10.1186/s13148-017-0402-y. eCollection 2017.


Adversity in childhood and measures of aging in midlife: Findings from a cohort of british women.

Anderson EL, Heron J, Ben-Shlomo Y, Kuh D, Cooper R, Lawlor DA, Fraser A, Howe LD.

Psychol Aging. 2017 Sep;32(6):521-530. doi: 10.1037/pag0000182.


Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development.

Anderson EL, Caleyachetty R, Stafford M, Kuh D, Hardy R, Lawlor DA, Fraser A, Howe LD.

Int J Equity Health. 2017 Sep 7;16(1):170. doi: 10.1186/s12939-017-0656-1.


Bayesian Piecewise Linear Mixed Models With a Random Change Point: An Application to BMI Rebound in Childhood.

Brilleman SL, Howe LD, Wolfe R, Tilling K.

Epidemiology. 2017 Nov;28(6):827-833. doi: 10.1097/EDE.0000000000000723.


Associations of anthropometry since birth with sagittal posture at age 7 in a prospective birth cohort: the Generation XXI Study.

Araújo FA, Lucas R, Simpkin AJ, Heron J, Alegrete N, Tilling K, Howe LD, Barros H.

BMJ Open. 2017 Jul 26;7(7):e013412. doi: 10.1136/bmjopen-2016-013412.


Modeling Exposure to Multiple Childhood Social Risk Factors and Physical Capability and Common Affective Symptoms in Later Life.

Caleyachetty R, Hardy R, Cooper R, Richards M, Howe LD, Anderson E, Kuh D, Stafford M.

J Aging Health. 2018 Mar;30(3):386-407. doi: 10.1177/0898264316680434. Epub 2016 Dec 22.


A shared biomechanical environment for bone and posture development in children.

Araújo FA, Martins A, Alegrete N, Howe LD, Lucas R.

Spine J. 2017 Oct;17(10):1426-1434. doi: 10.1016/j.spinee.2017.04.024. Epub 2017 May 4.


Parental Separation and Cardiometabolic Risk Factors in Late Adolescence: A Cross-Cohort Comparison.

Soares ALG, Gonçalves H, Matijasevich A, Sequeira M, Smith GD, Menezes AMB, Assunção MC, Wehrmeister FC, Fraser A, Howe LD.

Am J Epidemiol. 2017 May 15;185(10):898-906. doi: 10.1093/aje/kwx007.


Longitudinal study of the associations between change in sedentary behavior and change in adiposity during childhood and adolescence: Gateshead Millennium Study.

Mann KD, Howe LD, Basterfield L, Parkinson KN, Pearce MS, Reilly JK, Adamson AJ, Reilly JJ, Janssen X.

Int J Obes (Lond). 2017 Jul;41(7):1042-1047. doi: 10.1038/ijo.2017.69. Epub 2017 Mar 15.


Defining Patterns of Sagittal Standing Posture in Girls and Boys of School Age.

Araújo FA, Severo M, Alegrete N, Howe LD, Lucas R.

Phys Ther. 2017 Feb 1;97(2):258-267. doi: 10.2522/ptj.20150712. No abstract available.


Socioeconomic disparities in birth weight and body mass index during infancy through age 7 years: a study within the Danish National Birth Cohort.

Morgen CS, Andersen PK, Mortensen LH, Howe LD, Rasmussen M, Due P, Sørensen TI, Andersen AN.

BMJ Open. 2017 Jan 20;7(1):e011781. doi: 10.1136/bmjopen-2016-011781.


The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.

Simpkin AJ, Howe LD, Tilling K, Gaunt TR, Lyttleton O, McArdle WL, Ring SM, Horvath S, Smith GD, Relton CL.

Int J Epidemiol. 2017 Apr 1;46(2):549-558. doi: 10.1093/ije/dyw307.


Long-term effects of the Active for Life Year 5 (AFLY5) school-based cluster-randomised controlled trial.

Anderson EL, Howe LD, Kipping RR, Campbell R, Jago R, Noble SM, Wells S, Chittleborough C, Peters TJ, Lawlor DA.

BMJ Open. 2016 Nov 24;6(11):e010957. doi: 10.1136/bmjopen-2015-010957.


Trajectories and Transitions in Childhood and Adolescent Obesity.

Howe LD, Firestone R, Tilling K, Lawlor DA.

In: Burton-Jeangros C, Cullati S, Sacker A, Blane D, editors. A Life Course Perspective on Health Trajectories and Transitions [Internet]. Cham (CH): Springer; 2015. Chapter 2.


Relationship between mediation analysis and the structured life course approach.

Howe LD, Smith AD, Macdonald-Wallis C, Anderson EL, Galobardes B, Lawlor DA, Ben-Shlomo Y, Hardy R, Cooper R, Tilling K, Fraser A.

Int J Epidemiol. 2016 Aug;45(4):1280-1294. Epub 2016 Sep 27.


Active for Life Year 5: a cluster randomised controlled trial of a primary school-based intervention to increase levels of physical activity, decrease sedentary behaviour and improve diet.

Lawlor DA, Kipping RR, Anderson EL, Howe LD, Chittleborough CR, Moure-Fernandez A, Noble SM, Rawlins E, Wells SL, Peters TJ, Jago R, Campell R.

Southampton (UK): NIHR Journals Library; 2016 Jun.


Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium.

Fan Q, Guo X, Tideman JW, Williams KM, Yazar S, Hosseini SM, Howe LD, Pourcain BS, Evans DM, Timpson NJ, McMahon G, Hysi PG, Krapohl E, Wang YX, Jonas JB, Baird PN, Wang JJ, Cheng CY, Teo YY, Wong TY, Ding X, Wojciechowski R, Young TL, Pärssinen O, Oexle K, Pfeiffer N, Bailey-Wilson JE, Paterson AD, Klaver CC, Plomin R, Hammond CJ, Mackey DA, He M, Saw SM, Williams C, Guggenheim JA; CREAM Consortium.

Sci Rep. 2016 May 13;6:25853. doi: 10.1038/srep25853.


The Relationship Between Socioeconomic Status and CV Risk Factors: The CRONICAS Cohort Study of Peruvian Adults.

Quispe R, Benziger CP, Bazo-Alvarez JC, Howe LD, Checkley W, Gilman RH, Smeeth L, Bernabé-Ortiz A, Miranda JJ; CRONICAS Cohort Study Group.

Glob Heart. 2016 Mar;11(1):121-130.e2. doi: 10.1016/j.gheart.2015.12.005.


Nonlinear Exposure-Outcome Associations and Public Health Policy.

Fraser A, Lawlor DA, Howe LD.

JAMA. 2016 Mar 22-29;315(12):1286-7. doi: 10.1001/jama.2015.18023. No abstract available.


International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.

Parmar PG, Taal HR, Timpson NJ, Thiering E, Lehtimäki T, Marinelli M, Lind PA, Howe LD, Verwoert G, Aalto V, Uitterlinden AG, Briollais L, Evans DM, Wright MJ, Newnham JP, Whitfield JB, Lyytikäinen LP, Rivadeneira F, Boomsma DI, Viikari J, Gillman MW, St Pourcain B, Hottenga JJ, Montgomery GW, Hofman A, Kähönen M, Martin NG, Tobin MD, Raitakari O, Vioque J, Jaddoe VWV, Jarvelin MR, Beilin LJ, Heinrich J, van Duijn CM, Pennell CE, Lawlor DA, Palmer LJ; Early Genetics and Lifecourse Epidemiology Consortium.

Circ Cardiovasc Genet. 2016 Jun;9(3):266-278. doi: 10.1161/CIRCGENETICS.115.001190. Epub 2016 Mar 11.


Body mass index trajectories from 2 to 18 years - exploring differences between European cohorts.

Graversen L, Howe LD, Sørensen TI, Sovio U, Hohwü L, Tilling K, Laitinen J, Taanila A, Pouta A, Järvelin MR, Obel C.

Pediatr Obes. 2017 Apr;12(2):102-109. doi: 10.1111/ijpo.12115. Epub 2016 Feb 26.


The Active for Life Year 5 (AFLY5) school-based cluster randomised controlled trial: effect on potential mediators.

Lawlor DA, Howe LD, Anderson EL, Kipping RR, Campbell R, Wells S, Chittleborough CR, Peters TJ, Jago R.

BMC Public Health. 2016 Jan 22;16:68. doi: 10.1186/s12889-016-2734-5.


Adverse childhood experiences: Prevalence and related factors in adolescents of a Brazilian birth cohort.

Soares AL, Howe LD, Matijasevich A, Wehrmeister FC, Menezes AM, Gonçalves H.

Child Abuse Negl. 2016 Jan;51:21-30. doi: 10.1016/j.chiabu.2015.11.017. Epub 2015 Dec 19.


Short Sleep Duration in the First Years of Life and Obesity/Overweight at Age 4 Years: A Birth Cohort Study.

Halal CS, Matijasevich A, Howe LD, Santos IS, Barros FC, Nunes ML.

J Pediatr. 2016 Jan;168:99-103.e3. doi: 10.1016/j.jpeds.2015.09.074. Epub 2015 Nov 2.


The Prevalence of Non-Alcoholic Fatty Liver Disease in Children and Adolescents: A Systematic Review and Meta-Analysis.

Anderson EL, Howe LD, Jones HE, Higgins JP, Lawlor DA, Fraser A.

PLoS One. 2015 Oct 29;10(10):e0140908. doi: 10.1371/journal.pone.0140908. eCollection 2015. Review.

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