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Associations of adverse childhood experiences with educational attainment and adolescent health and the role of family and socioeconomic factors: A prospective cohort study in the UK.

Houtepen LC, Heron J, Suderman MJ, Fraser A, Chittleborough CR, Howe LD.

PLoS Med. 2020 Mar 2;17(3):e1003031. doi: 10.1371/journal.pmed.1003031. eCollection 2020 Mar.


The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence.

Huang Z, Fonseca R, Sharman JE, Park C, Chaturvedi N, Howe LD, Hughes AD, Schultz MG.

Scand J Med Sci Sports. 2020 Feb 26. doi: 10.1111/sms.13645. [Epub ahead of print]


Age at period cessation and trajectories of cardiovascular risk factors across mid and later life.

O'Keeffe LM, Kuh D, Fraser A, Howe LD, Lawlor D, Hardy R.

Heart. 2020 Apr;106(7):499-505. doi: 10.1136/heartjnl-2019-315754. Epub 2020 Feb 25.


Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

Anderson EL, Howe LD, Wade KH, Ben-Shlomo Y, Hill WD, Deary IJ, Sanderson EC, Zheng J, Korologou-Linden R, Stergiakouli E, Davey Smith G, Davies NM, Hemani G.

Int J Epidemiol. 2020 Jan 31. pii: dyz280. doi: 10.1093/ije/dyz280. [Epub ahead of print]


Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children.

Korologou-Linden R, O'Keeffe L, Howe LD, Davey-Smith G, Jones HJ, Anderson EL, Stergiakouli E.

Wellcome Open Res. 2019 Aug 20;4:125. doi: 10.12688/wellcomeopenres.15359.1. eCollection 2019.


Epigenetic gestational age and trajectories of weight and height during childhood: a prospective cohort study.

Bright HD, Howe LD, Khouja JN, Simpkin AJ, Suderman M, O'Keeffe LM.

Clin Epigenetics. 2019 Dec 16;11(1):194. doi: 10.1186/s13148-019-0761-7.


Adiposity, depression and anxiety: interrelationship and possible mediators.

Gomes AP, Soares ALG, Menezes AMB, Assunção MC, Wehrmeister FC, Howe LD, Gonçalves H.

Rev Saude Publica. 2019 Dec 2;53:103. doi: 10.11606/S1518-8787.2019053001119. eCollection 2019.


Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank.

Howe LD, Kanayalal R, Harrison S, Beaumont RN, Davies AR, Frayling TM, Davies NM, Hughes A, Jones SE, Sassi F, Wood AR, Tyrrell J.

Int J Epidemiol. 2019 Dec 4. pii: dyz240. doi: 10.1093/ije/dyz240. [Epub ahead of print]


Cardiometabolic Risk Factors and Physical Activity Patterns Maximizing Fitness and Minimizing Fatness Variation in Malaysian Adolescents: A Novel Application of Reduced Rank Regression.

Toumpakari Z, Jago R, Howe LD, Majid HA, Papadaki A, Mohammadi S, Jalaludin MY, Dahlui M, Mohamed MNA, Su TT, Johnson L.

Int J Environ Res Public Health. 2019 Nov 22;16(23). pii: E4662. doi: 10.3390/ijerph16234662.


Eating Style and the Frequency, Size and Timing of Eating Occasions: A cross-sectional analysis using 7-day weighed dietary records.

Magklis E, Howe LD, Johnson L.

Sci Rep. 2019 Oct 22;9(1):15133. doi: 10.1038/s41598-019-51534-w.


Using Genetic Instruments to Estimate Interactions in Mendelian Randomization Studies.

North TL, Davies NM, Harrison S, Carter AR, Hemani G, Sanderson E, Tilling K, Howe LD.

Epidemiology. 2019 Nov;30(6):e33-e35. doi: 10.1097/EDE.0000000000001096. No abstract available.


Masked hypertension and submaximal exercise blood pressure among adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC).

Huang Z, Sharman JE, Fonseca R, Park C, Chaturvedi N, Davey Smith G, Howe LD, Lawlor DA, Hughes AD, Schultz MG.

Scand J Med Sci Sports. 2020 Jan;30(1):25-30. doi: 10.1111/sms.13525. Epub 2019 Aug 22.


Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.

Carter AR, Gill D, Davies NM, Taylor AE, Tillmann T, Vaucher J, Wootton RE, Munafò MR, Hemani G, Malik R, Seshadri S, Woo D, Burgess S, Davey Smith G, Holmes MV, Tzoulaki I, Howe LD, Dehghan A.

BMJ. 2019 May 22;365:l1855. doi: 10.1136/bmj.l1855.


Polygenic risk scores for Alzheimer's disease, and academic achievement, cognitive and behavioural measures in children from the general population.

Korologou-Linden R, Anderson EL, Jones HJ, Davey Smith G, Howe LD, Stergiakouli E.

Int J Epidemiol. 2019 Dec 1;48(6):1972-1980. doi: 10.1093/ije/dyz080.


Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC).

O'Keeffe LM, Simpkin AJ, Tilling K, Anderson EL, Hughes AD, Lawlor DA, Fraser A, Howe LD.

Data Brief. 2019 Jan 19;23:103687. doi: 10.1016/j.dib.2019.01.035. eCollection 2019 Apr.


Using SITAR (SuperImposition by Translation and Rotation) to estimate age at peak height velocity in Avon Longitudinal Study of Parents and Children.

Frysz M, Howe LD, Tobias JH, Paternoster L.

Version 2. Wellcome Open Res. 2018 Dec 14 [revised 2018 Jan 1];3:90. doi: 10.12688/wellcomeopenres.14708.2. eCollection 2018.


Adverse childhood experiences in the children of the Avon Longitudinal Study of Parents and Children (ALSPAC).

Houtepen LC, Heron J, Suderman MJ, Tilling K, Howe LD.

Wellcome Open Res. 2018 Aug 30;3:106. doi: 10.12688/wellcomeopenres.14716.1. eCollection 2018.


Associations of Body Mass and Fat Indexes With Cardiometabolic Traits.

Bell JA, Carslake D, O'Keeffe LM, Frysz M, Howe LD, Hamer M, Wade KH, Timpson NJ, Davey Smith G.

J Am Coll Cardiol. 2018 Dec 18;72(24):3142-3154. doi: 10.1016/j.jacc.2018.09.066.


Assessing the causal role of body mass index on cardiovascular health in young adults: Mendelian randomization and recall-by-genotype analyses.

Wade KH, Chiesa ST, Hughes AD, Chaturvedi N, Charakida M, Rapala A, Muthurangu V, Khan T, Finer N, Sattar N, Howe LD, Fraser A, Lawlor DA, Davey Smith G, Deanfield JE, Timpson NJ.

Circulation. 2018 Nov 13;138(20):2187-2201. doi: 10.1161/CIRCULATIONAHA.117.033278. Epub 2018 Jul 30.


Childhood adversity and DNA methylation in two population-based cohorts.

Houtepen LC, Hardy R, Maddock J, Kuh D, Anderson EL, Relton CL, Suderman MJ, Howe LD.

Transl Psychiatry. 2018 Dec 3;8(1):266. doi: 10.1038/s41398-018-0307-3.


Submaximal exercise blood pressure and cardiovascular structure in adolescence.

Schultz MG, Park C, Fraser A, Howe LD, Jones S, Rapala A, Davey Smith G, Sharman JE, Lawlor DA, Chaturvedi N, Deanfield J, Hughes AD.

Int J Cardiol. 2019 Jan 15;275:152-157. doi: 10.1016/j.ijcard.2018.10.060. Epub 2018 Oct 19.


Early-life adversity, later-life mental health, and resilience resources: a longitudinal population-based birth cohort analysis.

Cosco TD, Hardy R, Howe LD, Richards M.

Int Psychogeriatr. 2018 Nov 23:1-10. doi: 10.1017/S1041610218001795. [Epub ahead of print]


Elevated Blood Pressure in Adolescence Is Attributable to a Combination of Elevated Cardiac Output and Total Peripheral Resistance.

Park C, Fraser A, Howe LD, Jones S, Davey Smith G, Lawlor DA, Chaturvedi N, Hughes AD.

Hypertension. 2018 Nov;72(5):1103-1108. doi: 10.1161/HYPERTENSIONAHA.118.11925.


Independent and combined associations of maternal and own smoking with adult lung function and COPD.

Magnus MC, Henderson J, Tilling K, Howe LD, Fraser A.

Int J Epidemiol. 2018 Dec 1;47(6):1855-1864. doi: 10.1093/ije/dyy221.


Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: A prospective cohort study.

O'Keeffe LM, Simpkin AJ, Tilling K, Anderson EL, Hughes AD, Lawlor DA, Fraser A, Howe LD.

Atherosclerosis. 2018 Nov;278:190-196. doi: 10.1016/j.atherosclerosis.2018.09.030. Epub 2018 Sep 27.


Effect of fish oil supplementation in pregnancy on bone, lean, and fat mass at six years: randomised clinical trial.

Vinding RK, Stokholm J, Sevelsted A, Sejersen T, Chawes BL, Bønnelykke K, Thorsen J, Howe LD, Krakauer M, Bisgaard H.

BMJ. 2018 Sep 4;362:k3312. doi: 10.1136/bmj.k3312.


Frailty in older-age European migrants: Cross-sectional and longitudinal analyses of the Survey of Health, Aging and Retirement in Europe (SHARE).

Walkden GJ, Anderson EL, Vink MP, Tilling K, Howe LD, Ben-Shlomo Y.

Soc Sci Med. 2018 Sep;213:1-11. doi: 10.1016/j.socscimed.2018.07.033. Epub 2018 Jul 21.


Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics.

Khouja JN, Simpkin AJ, O'Keeffe LM, Wade KH, Houtepen LC, Relton CL, Suderman M, Howe LD.

Clin Epigenetics. 2018 Jun 27;10:86. doi: 10.1186/s13148-018-0520-1. eCollection 2018.


Associations of Y chromosomal haplogroups with cardiometabolic risk factors and subclinical vascular measures in males during childhood and adolescence.

O'Keeffe LM, Howe LD, Fraser A, Hughes AD, Wade KH, Anderson EL, Lawlor DA, Erzurumluoglu AM, Davey-Smith G, Rodriguez S, Stergiakouli E.

Atherosclerosis. 2018 Jul;274:94-103. doi: 10.1016/j.atherosclerosis.2018.04.027. Epub 2018 Apr 25.


Socioeconomic differences in childhood BMI trajectories in Belarus.

Patel R, Tilling K, Lawlor DA, Howe LD, Hughes RA, Bogdanovich N, Matush L, Nicoli E, Oken E, Kramer MS, Martin RM.

Int J Obes (Lond). 2018 Sep;42(9):1651-1660. doi: 10.1038/s41366-018-0042-0. Epub 2018 Feb 28.


Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies.

Lawn RB, Anderson EL, Suderman M, Simpkin AJ, Gaunt TR, Teschendorff AE, Widschwendter M, Hardy R, Kuh D, Relton CL, Howe LD.

Hum Mol Genet. 2018 Apr 1;27(7):1301-1308. doi: 10.1093/hmg/ddy036.


DNA methylation from birth to late adolescence and development of multiple-risk behaviours.

de Vocht F, Suderman M, Tilling K, Heron J, Howe LD, Campbell R, Hickman M, Relton C.

J Affect Disord. 2018 Feb;227:588-594. doi: 10.1016/j.jad.2017.11.055. Epub 2017 Nov 15.


Adverse Childhood Experiences (ACEs) and Adiposity in Adolescents: A Cross-Cohort Comparison.

Soares ALG, Matijasevich A, Menezes AMB, Assunção MC, Wehrmeister FC, Howe LD, Gonçalves H.

Obesity (Silver Spring). 2018 Jan;26(1):150-159. doi: 10.1002/oby.22035. Epub 2017 Nov 14.


Childhood psychosocial adversity and female reproductive timing: a cohort study of the ALSPAC mothers.

Magnus MC, Anderson EL, Howe LD, Joinson CJ, Penton-Voak IS, Fraser A.

J Epidemiol Community Health. 2018 Jan;72(1):34-40. doi: 10.1136/jech-2017-209488. Epub 2017 Nov 9.


Associations of adversity in childhood and risk factors for cardiovascular disease in mid-adulthood.

Anderson EL, Fraser A, Caleyachetty R, Hardy R, Lawlor DA, Howe LD.

Child Abuse Negl. 2018 Feb;76:138-148. doi: 10.1016/j.chiabu.2017.10.015. Epub 2017 Nov 2.


Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort.

Simpkin AJ, Cooper R, Howe LD, Relton CL, Davey Smith G, Teschendorff A, Widschwendter M, Wong A, Kuh D, Hardy R.

BMJ Open. 2017 Nov 1;7(10):e016708. doi: 10.1136/bmjopen-2017-016708.


Epigenetic clocks for gestational age: statistical and study design considerations.

Simpkin AJ, Suderman M, Howe LD.

Clin Epigenetics. 2017 Sep 15;9:100. doi: 10.1186/s13148-017-0402-y. eCollection 2017.


Adversity in childhood and measures of aging in midlife: Findings from a cohort of british women.

Anderson EL, Heron J, Ben-Shlomo Y, Kuh D, Cooper R, Lawlor DA, Fraser A, Howe LD.

Psychol Aging. 2017 Sep;32(6):521-530. doi: 10.1037/pag0000182.


Prospective associations of psychosocial adversity in childhood with risk factors for cardiovascular disease in adulthood: the MRC National Survey of Health and Development.

Anderson EL, Caleyachetty R, Stafford M, Kuh D, Hardy R, Lawlor DA, Fraser A, Howe LD.

Int J Equity Health. 2017 Sep 7;16(1):170. doi: 10.1186/s12939-017-0656-1.


Bayesian Piecewise Linear Mixed Models With a Random Change Point: An Application to BMI Rebound in Childhood.

Brilleman SL, Howe LD, Wolfe R, Tilling K.

Epidemiology. 2017 Nov;28(6):827-833. doi: 10.1097/EDE.0000000000000723.


Associations of anthropometry since birth with sagittal posture at age 7 in a prospective birth cohort: the Generation XXI Study.

Araújo FA, Lucas R, Simpkin AJ, Heron J, Alegrete N, Tilling K, Howe LD, Barros H.

BMJ Open. 2017 Jul 26;7(7):e013412. doi: 10.1136/bmjopen-2016-013412.


Modeling Exposure to Multiple Childhood Social Risk Factors and Physical Capability and Common Affective Symptoms in Later Life.

Caleyachetty R, Hardy R, Cooper R, Richards M, Howe LD, Anderson E, Kuh D, Stafford M.

J Aging Health. 2018 Mar;30(3):386-407. doi: 10.1177/0898264316680434. Epub 2016 Dec 22.


A shared biomechanical environment for bone and posture development in children.

Araújo FA, Martins A, Alegrete N, Howe LD, Lucas R.

Spine J. 2017 Oct;17(10):1426-1434. doi: 10.1016/j.spinee.2017.04.024. Epub 2017 May 4.


Parental Separation and Cardiometabolic Risk Factors in Late Adolescence: A Cross-Cohort Comparison.

Soares ALG, Gonçalves H, Matijasevich A, Sequeira M, Smith GD, Menezes AMB, Assunção MC, Wehrmeister FC, Fraser A, Howe LD.

Am J Epidemiol. 2017 May 15;185(10):898-906. doi: 10.1093/aje/kwx007.


Longitudinal study of the associations between change in sedentary behavior and change in adiposity during childhood and adolescence: Gateshead Millennium Study.

Mann KD, Howe LD, Basterfield L, Parkinson KN, Pearce MS, Reilly JK, Adamson AJ, Reilly JJ, Janssen X.

Int J Obes (Lond). 2017 Jul;41(7):1042-1047. doi: 10.1038/ijo.2017.69. Epub 2017 Mar 15.


Defining Patterns of Sagittal Standing Posture in Girls and Boys of School Age.

Araújo FA, Severo M, Alegrete N, Howe LD, Lucas R.

Phys Ther. 2017 Feb 1;97(2):258-267. doi: 10.2522/ptj.20150712. No abstract available.


Socioeconomic disparities in birth weight and body mass index during infancy through age 7 years: a study within the Danish National Birth Cohort.

Morgen CS, Andersen PK, Mortensen LH, Howe LD, Rasmussen M, Due P, Sørensen TI, Andersen AN.

BMJ Open. 2017 Jan 20;7(1):e011781. doi: 10.1136/bmjopen-2016-011781.


The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort.

Simpkin AJ, Howe LD, Tilling K, Gaunt TR, Lyttleton O, McArdle WL, Ring SM, Horvath S, Smith GD, Relton CL.

Int J Epidemiol. 2017 Apr 1;46(2):549-558. doi: 10.1093/ije/dyw307.


Long-term effects of the Active for Life Year 5 (AFLY5) school-based cluster-randomised controlled trial.

Anderson EL, Howe LD, Kipping RR, Campbell R, Jago R, Noble SM, Wells S, Chittleborough C, Peters TJ, Lawlor DA.

BMJ Open. 2016 Nov 24;6(11):e010957. doi: 10.1136/bmjopen-2015-010957.


Trajectories and Transitions in Childhood and Adolescent Obesity.

Howe LD, Firestone R, Tilling K, Lawlor DA.

In: Burton-Jeangros C, Cullati S, Sacker A, Blane D, editors. A Life Course Perspective on Health Trajectories and Transitions [Internet]. Cham (CH): Springer; 2015. Chapter 2.

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