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There should always be a "tech" in team.

Howe JA.

J Am Vet Med Assoc. 2019 Nov 1;255(9):966. doi: 10.2460/javma.255.9.966. No abstract available.


AVMA-sponsored health insurance is back; advocacy to expand to more states continues.

Howe JA.

J Am Vet Med Assoc. 2019 Oct 1;255(7):754. doi: 10.2460/javma.255.7.754. No abstract available.


Continuing our path forward: Working for you, advancing animal health.

Howe JA.

J Am Vet Med Assoc. 2019 Sep 1;255(5):492. doi: 10.2460/javma.255.5.492. No abstract available.


Fitness coordinators' and fitness instructors' perspectives on implementing a task-oriented community exercise program within a healthcare-recreation partnership for people with balance and mobility limitations: a qualitative study.

Skrastins O, Tsotsos S, Aqeel H, Qiang A, Renton J, Howe JA, Tee A, Moller J, Salbach NM.

Disabil Rehabil. 2019 Feb 10:1-9. doi: 10.1080/09638288.2019.1570357. [Epub ahead of print]


Duration of Retinol Isotope Dilution Studies with Compartmental Modeling Affects Model Complexity, Kinetic Parameters, and Calculated Vitamin A Stores in US Women.

Gannon BM, Valentine AR, Davis CR, Howe JA, Tanumihardjo SA.

J Nutr. 2018 Aug 1;148(8):1387-1396. doi: 10.1093/jn/nxy095.


Validation and Development of an Escherichia coli Riboflavin Pathway Phenotypic Screen Hit as a Small-Molecule Ligand of the Flavin Mononucleotide Riboswitch.

Balibar CJ, Villafania A, Barbieri CM, Murgolo N, Roemer T, Wang H, Howe JA.

Methods Mol Biol. 2018;1787:19-40. doi: 10.1007/978-1-4939-7847-2_2.


Deposition of artificial radionuclides in sediments of Loch Etive, Scotland.

Al-Qasmi H, Law GTW, Fifield LK, Howe JA, Brand T, Cowie GL, Law KA, Livens FR.

J Environ Radioact. 2018 Jul;187:45-52. doi: 10.1016/j.jenvrad.2018.02.001. Epub 2018 Feb 21.


Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry.

Rizvi NF, Howe JA, Nahvi A, Klein DJ, Fischmann TO, Kim HY, McCoy MA, Walker SS, Hruza A, Richards MP, Chamberlin C, Saradjian P, Butko MT, Mercado G, Burchard J, Strickland C, Dandliker PJ, Smith GF, Nickbarg EB.

ACS Chem Biol. 2018 Mar 16;13(3):820-831. doi: 10.1021/acschembio.7b01013. Epub 2018 Feb 14.


Retention of Carotenoids in Biofortified Maize Flour and β-Cryptoxanthin-Enhanced Eggs after Household Cooking.

Sowa M, Yu J, Palacios-Rojas N, Goltz SR, Howe JA, Davis CR, Rocheford T, Tanumihardjo SA.

ACS Omega. 2017 Oct 27;2(10):7320-7328. doi: 10.1021/acsomega.7b01202. eCollection 2017 Oct 31.


Nuclear reprocessing-related radiocarbon (14C) uptake into UK marine mammals.

Tierney KM, Muir GKP, Cook GT, Heymans JJ, MacKinnon G, Howe JA, Xu S, Brownlow A, Davison NJ, Ten Doeschate M, Deaville R.

Mar Pollut Bull. 2017 Nov 15;124(1):43-50. doi: 10.1016/j.marpolbul.2017.07.002. Epub 2017 Jul 8.


Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.

Wang H, Mann PA, Xiao L, Gill C, Galgoci AM, Howe JA, Villafania A, Barbieri CM, Malinverni JC, Sher X, Mayhood T, McCurry MD, Murgolo N, Flattery A, Mack M, Roemer T.

Cell Chem Biol. 2017 May 18;24(5):576-588.e6. doi: 10.1016/j.chembiol.2017.03.014. Epub 2017 Apr 20.


Considerations for the Selection of Time-Limited Walk Tests Poststroke: A Systematic Review of Test Protocols and Measurement Properties.

Salbach NM, OʼBrien KK, Brooks D, Irvin E, Martino R, Takhar P, Chan S, Howe JA.

J Neurol Phys Ther. 2017 Jan;41(1):3-17.


Ecosystem uptake and transfer of Sellafield-derived radiocarbon (14C) part 2: The West of Scotland.

Tierney KM, Muir GKP, Cook GT, MacKinnon G, Howe JA, Heymans JJ, Hughes DJ, Xu S.

Mar Pollut Bull. 2017 Feb 15;115(1-2):57-66. doi: 10.1016/j.marpolbul.2016.11.014. Epub 2016 Nov 26.


Ecosystem uptake and transfer of Sellafield-derived radiocarbon (14C). Part 1. The Irish Sea.

Muir GK, Tierney KM, Cook GT, MacKinnon G, Howe JA, Heymans JJ, Hughes DJ, Xu S.

Mar Pollut Bull. 2017 Jan 30;114(2):792-804. doi: 10.1016/j.marpolbul.2016.10.072. Epub 2016 Nov 10.


Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch.

Howe JA, Xiao L, Fischmann TO, Wang H, Tang H, Villafania A, Zhang R, Barbieri CM, Roemer T.

RNA Biol. 2016 Oct 2;13(10):946-954. Epub 2016 Aug 2.


Latest Quaternary palaeoceanographic change in the eastern North Atlantic based upon a dinoflagellate cyst event ecostratigraphy.

Harland R, Polovodova Asteman I, Morley A, Morris A, Harris A, Howe JA.

Heliyon. 2016 May 30;2(5):e00114. doi: 10.1016/j.heliyon.2016.e00114. eCollection 2016 May.


Promoting Optimal Physical Exercise for Life: An Exercise and Self-Management Program to Encourage Participation in Physical Activity after Discharge from Stroke Rehabilitation-A Feasibility Study.

Mansfield A, Knorr S, Poon V, Inness EL, Middleton L, Biasin L, Brunton K, Howe JA, Brooks D.

Stroke Res Treat. 2016;2016:9476541. doi: 10.1155/2016/9476541. Epub 2016 May 30.


Accumulation of Sellafield-derived radiocarbon ((14)C) in Irish Sea and West of Scotland intertidal shells and sediments.

Tierney KM, Muir GKP, Cook GT, MacKinnon G, Howe JA, Heymans JJ, Xu S.

J Environ Radioact. 2016 Jan;151 Pt 1:321-327. doi: 10.1016/j.jenvrad.2015.10.029. Epub 2015 Nov 8.


Selective small-molecule inhibition of an RNA structural element.

Howe JA, Wang H, Fischmann TO, Balibar CJ, Xiao L, Galgoci AM, Malinverni JC, Mayhood T, Villafania A, Nahvi A, Murgolo N, Barbieri CM, Mann PA, Carr D, Xia E, Zuck P, Riley D, Painter RE, Walker SS, Sherborne B, de Jesus R, Pan W, Plotkin MA, Wu J, Rindgen D, Cummings J, Garlisi CG, Zhang R, Sheth PR, Gill CJ, Tang H, Roemer T.

Nature. 2015 Oct 29;526(7575):672-7. doi: 10.1038/nature15542. Epub 2015 Sep 30.


Ecological impacts of large-scale disposal of mining waste in the deep sea.

Hughes DJ, Shimmield TM, Black KD, Howe JA.

Sci Rep. 2015 May 5;5:9985. doi: 10.1038/srep09985.


Clinical Implications of Detectable Baseline Hepatitis C Virus-Genotype 1 NS3/4A-Protease Variants on the Efficacy of Boceprevir Combined With Peginterferon/Ribavirin.

Howe JA, Long J, Black S, Chase R, McMonagle P, Curry S, Thompson S, DiNubile MJ, Howe AY.

Open Forum Infect Dis. 2014 Sep 16;1(2):ofu078. doi: 10.1093/ofid/ofu078. eCollection 2014 Sep.


Reference values for standardized tests of walking speed and distance: a systematic review.

Salbach NM, O'Brien KK, Brooks D, Irvin E, Martino R, Takhar P, Chan S, Howe JA.

Gait Posture. 2015 Feb;41(2):341-60. doi: 10.1016/j.gaitpost.2014.10.002. Epub 2014 Oct 12. Review.


Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations.

Aloia AL, Eyre NS, Black S, Bent SJ, Gaeguta A, Guo Z, Narayana SK, Chase R, Locarnini S, Carr JM, Howe JA, Beard MR.

Antivir Ther. 2015;20(3):271-80. doi: 10.3851/IMP2850. Epub 2014 Sep 15.


Methiozolin sorption and mobility in sand-based root zones.

Flessner ML, Wehtje GR, McElroy JS, Howe JA.

Pest Manag Sci. 2015 Aug;71(8):1133-40. doi: 10.1002/ps.3896. Epub 2014 Oct 18.


Integrating aerobic training within subacute stroke rehabilitation: a feasibility study.

Biasin L, Sage MD, Brunton K, Fraser J, Howe JA, Bayley M, Brooks D, McIlroy WE, Mansfield A, Inness EL.

Phys Ther. 2014 Dec;94(12):1796-806. doi: 10.2522/ptj.20130404. Epub 2014 Jul 31.


Novel Quinoline-Based P2-P4 Macrocyclic Derivatives As Pan-Genotypic HCV NS3/4a Protease Inhibitors.

Shah U, Jayne C, Chackalamannil S, Velázquez F, Guo Z, Buevich A, Howe JA, Chase R, Soriano A, Agrawal S, Rudd MT, McCauley JA, Liverton NJ, Romano J, Bush K, Coleman PJ, Grisé-Bard C, Brochu MC, Charron S, Aulakh V, Bachand B, Beaulieu P, Zaghdane H, Bhat S, Han Y, Vacca JP, Davies IW, Weber AE, Venkatraman S.

ACS Med Chem Lett. 2014 Jan 9;5(3):264-9. doi: 10.1021/ml400466p. eCollection 2014 Mar 13.


Once upon a time, there was a fabulous funambulist…: what children learn about the "high-level" vocabulary they encounter while listening to stories.

Houston-Price C, Howe JA, Lintern NJ.

Front Psychol. 2014 Feb 7;5:75. doi: 10.3389/fpsyg.2014.00075. eCollection 2014.


Analysis of boceprevir resistance associated amino acid variants (RAVs) in two phase 3 boceprevir clinical studies.

Barnard RJ, Howe JA, Ogert RA, Zeuzem S, Poordad F, Gordon SC, Ralston R, Tong X, Sniukiene V, Strizki J, Ryan D, Long J, Qiu P, Brass CA, Albrecht J, Burroughs M, Vuocolo S, Hazuda DJ.

Virology. 2013 Sep;444(1-2):329-36. doi: 10.1016/j.virol.2013.06.029. Epub 2013 Jul 19.


Using wireless technology in clinical practice: does feedback of daily walking activity improve walking outcomes of individuals receiving rehabilitation post-stroke? Study protocol for a randomized controlled trial.

Mansfield A, Wong JS, Bayley M, Biasin L, Brooks D, Brunton K, Howe JA, Inness EL, Jones S, Lymburner J, Mileris R, McIlroy WE.

BMC Neurol. 2013 Jul 18;13:93. doi: 10.1186/1471-2377-13-93.


Speed and distance requirements for community ambulation: a systematic review.

Salbach NM, O'Brien K, Brooks D, Irvin E, Martino R, Takhar P, Chan S, Howe JA.

Arch Phys Med Rehabil. 2014 Jan;95(1):117-128.e11. doi: 10.1016/j.apmr.2013.06.017. Epub 2013 Jun 29. Review.


Partnering to increase access to community exercise programs for people with stroke, acquired brain injury, and multiple sclerosis.

Salbach NM, Howe JA, Brunton K, Salisbury K, Bodiam L.

J Phys Act Health. 2014 May;11(4):838-45. doi: 10.1123/jpah.2012-0183. Epub 2013 May 13.


Antiviral activity of boceprevir monotherapy in treatment-naive subjects with chronic hepatitis C genotype 2/3.

Silva MO, Treitel M, Graham DJ, Curry S, Frontera MJ, McMonagle P, Gupta S, Hughes E, Chase R, Lahser F, Barnard RJ, Howe AY, Howe JA.

J Hepatol. 2013 Jul;59(1):31-7. doi: 10.1016/j.jhep.2013.02.018. Epub 2013 Feb 27.


Resistance-associated amino acid variants associated with boceprevir plus pegylated interferon-α2b and ribavirin in patients with chronic hepatitis C in the SPRINT-1 trial.

Ogert RA, Howe JA, Vierling JM, Kwo PY, Lawitz EJ, McCone J, Schiff ER, Pound D, Davis MN, Gordon SC, Ravendhran N, Rossaro L, Jacobson IM, Ralston R, Chaudhri E, Qiu P, Pedicone LD, Brass CA, Albrecht JK, Barnard RJ, Hazuda DJ, Howe AY.

Antivir Ther. 2013;18(3):387-97. doi: 10.3851/IMP2549. Epub 2013 Feb 13.


Clinician's Commentary on Ploughman et al.(1).

Howe JA.

Physiother Can. 2012 Winter;64(1):18-9. doi: 10.3138/ptc.2010-42-cc. Epub 2012 Jan 31. No abstract available.


Boceprevir with peginterferon alfa-2a-ribavirin is effective for previously treated chronic hepatitis C genotype 1 infection.

Flamm SL, Lawitz E, Jacobson I, Bourlière M, Hezode C, Vierling JM, Bacon BR, Niederau C, Sherman M, Goteti V, Sings HL, Barnard RO, Howe JA, Pedicone LD, Burroughs MH, Brass CA, Albrecht JK, Poordad F.

Clin Gastroenterol Hepatol. 2013 Jan;11(1):81-87.e4; quiz e5. doi: 10.1016/j.cgh.2012.10.006. Epub 2012 Oct 10.


Measuring Balance and Mobility after Traumatic Brain Injury: Validation of the Community Balance and Mobility Scale (CB&M).

Inness EL, Howe JA, Niechwiej-Szwedo E, Jaglal SB, McIlroy WE, Verrier MC.

Physiother Can. 2011 Spring;63(2):199-208. doi: 10.3138/ptc.2009-45. Epub 2011 Apr 13.


Organizational model and process for clinical best practice in rehabilitation and complex continuing care.

McGlynn M, Solway S, Lowe M, Howe JA, Hebert D, Velji K.

Healthc Q. 2011;14(1):62-9.


Carotenoid profiles in provitamin A-containing fruits and vegetables affect the bioefficacy in Mongolian gerbils.

Arscott SA, Howe JA, Davis CR, Tanumihardjo SA.

Exp Biol Med (Maywood). 2010 Jul;235(7):839-48. doi: 10.1258/ebm.2010.009216.


Clinical resistance to vicriviroc through adaptive V3 loop mutations in HIV-1 subtype D gp120 that alter interactions with the N-terminus and ECL2 of CCR5.

Ogert RA, Hou Y, Ba L, Wojcik L, Qiu P, Murgolo N, Duca J, Dunkle LM, Ralston R, Howe JA.

Virology. 2010 Apr 25;400(1):145-55. doi: 10.1016/j.virol.2010.01.037. Epub 2010 Feb 21.


Quantifying the relationship between HIV-1 susceptibility to CCR5 antagonists and virus affinity for antagonist-occupied co-receptor.

Buontempo PJ, Wojcik L, Buontempo CA, Ogert RA, Strizki JM, Howe JA, Ralston R.

Virology. 2009 Dec 20;395(2):268-79. doi: 10.1016/j.virol.2009.09.029. Epub 2009 Oct 20.


Structure-function analysis of human immunodeficiency virus type 1 gp120 amino acid mutations associated with resistance to the CCR5 coreceptor antagonist vicriviroc.

Ogert RA, Ba L, Hou Y, Buontempo C, Qiu P, Duca J, Murgolo N, Buontempo P, Ralston R, Howe JA.

J Virol. 2009 Dec;83(23):12151-63. doi: 10.1128/JVI.01351-09. Epub 2009 Sep 23.


Mathematical modeling of serum 13C-retinol in captive rhesus monkeys provides new insights on hypervitaminosis A.

Escaron AL, Green MH, Howe JA, Tanumihardjo SA.

J Nutr. 2009 Oct;139(10):2000-6. doi: 10.3945/jn.109.111922. Epub 2009 Aug 26.


Cassava with enhanced beta-carotene maintains adequate vitamin A status in Mongolian gerbils (Meriones unguiculatus) despite substantial cis-isomer content.

Howe JA, Maziya-Dixon B, Tanumihardjo SA.

Br J Nutr. 2009 Aug;102(3):342-9. doi: 10.1017/S0007114508184720. Epub 2009 Jan 13.


13C natural abundance in serum retinol acts as a biomarker for increases in dietary provitamin A.

Howe JA, Valentine AR, Hull AK, Tanumihardjo SA.

Exp Biol Med (Maywood). 2009 Feb;234(2):140-7. doi: 10.3181/0806-RM-199. Epub 2008 Dec 30.


The xanthophyll composition of biofortified maize (Zea mays Sp.) does not influence the bioefficacy of provitamin a carotenoids in Mongolian gerbils (Meriones unguiculatus).

Davis CR, Howe JA, Rocheford TR, Tanumihardjo SA.

J Agric Food Chem. 2008 Aug 13;56(15):6745-50. doi: 10.1021/jf800816q. Epub 2008 Jul 11.


Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay.

Hou Y, McGuinness DE, Prongay AJ, Feld B, Ingravallo P, Ogert RA, Lunn CA, Howe JA.

J Biomol Screen. 2008 Jun;13(5):406-14. doi: 10.1177/1087057108317060. Epub 2008 May 14.


beta-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils ( Meriones unguiculatus) better than or equal to beta-carotene supplements.

Davis C, Jing H, Howe JA, Rocheford T, Tanumihardjo SA.

Br J Nutr. 2008 Oct;100(4):786-93. doi: 10.1017/S0007114508944123. Epub 2008 Mar 3.


Mapping resistance to the CCR5 co-receptor antagonist vicriviroc using heterologous chimeric HIV-1 envelope genes reveals key determinants in the C2-V5 domain of gp120.

Ogert RA, Wojcik L, Buontempo C, Ba L, Buontempo P, Ralston R, Strizki J, Howe JA.

Virology. 2008 Apr 10;373(2):387-99. doi: 10.1016/j.virol.2007.12.009. Epub 2008 Jan 10.


First insights into the biodiversity and biogeography of the Southern Ocean deep sea.

Brandt A, Gooday AJ, Brandão SN, Brix S, Brökeland W, Cedhagen T, Choudhury M, Cornelius N, Danis B, De Mesel I, Diaz RJ, Gillan DC, Ebbe B, Howe JA, Janussen D, Kaiser S, Linse K, Malyutina M, Pawlowski J, Raupach M, Vanreusel A.

Nature. 2007 May 17;447(7142):307-11.


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