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The Feasibility of a Randomized Controlled Trial for Open Tibial Fractures at a Regional Hospital in Uganda.

Kisitu DK, Stockton DJ, O'Hara NN, Slobogean GP, Howe AL, Marinos D, Peck C, Blachut PA, O'Brien PJ.

J Bone Joint Surg Am. 2019 May 15;101(10):e44. doi: 10.2106/JBJS.18.01079.


'We're passengers sailing in the same ship, but we have our own berths to sleep in': Evaluating patient and public involvement within a regional research programme: An action research project informed by Normalisation Process Theory.

Keenan J, Poland F, Boote J, Howe A, Wythe H, Varley A, Vicary P, Irvine L, Wellings A.

PLoS One. 2019 May 14;14(5):e0215953. doi: 10.1371/journal.pone.0215953. eCollection 2019.


Tracking Conformational Changes in Calmodulin in Vitro, in Cell Extract, and in Cells by Electron Paramagnetic Resonance Distance Measurements.

Dalaloyan A, Martorana A, Barak Y, Gataulin D, Reuveny E, Howe A, Elbaum M, Albeck S, Unger T, Frydman V, Abdelkader EH, Otting G, Goldfarb D.

Chemphyschem. 2019 May 4. doi: 10.1002/cphc.201900341. [Epub ahead of print]


Complexities in understanding antimicrobial resistance across domesticated animal, human, and environmental systems.

Graham DW, Bergeron G, Bourassa MW, Dickson J, Gomes F, Howe A, Kahn LH, Morley PS, Scott HM, Simjee S, Singer RS, Smith TC, Storrs C, Wittum TE.

Ann N Y Acad Sci. 2019 Apr;1441(1):17-30. doi: 10.1111/nyas.14036. Review.


Valuing health-related quality of life in heart failure: a systematic review of methods to derive quality-adjusted life years (QALYs) in trial-based cost-utility analyses.

Rankin J, Rowen D, Howe A, Cleland JGF, Whitty JA.

Heart Fail Rev. 2019 Jul;24(4):549-563. doi: 10.1007/s10741-019-09780-7. Review.


RefSoil+: a Reference Database for Genes and Traits of Soil Plasmids.

Dunivin TK, Choi J, Howe A, Shade A.

mSystems. 2019 Feb 26;4(1). pii: e00349-18. doi: 10.1128/mSystems.00349-18. eCollection 2019 Jan-Feb.


Research reported in the AJA: Who does it and where do they do it?

Howe A, Jeon YH.

Australas J Ageing. 2019 Jun;38(2):e37-e42. doi: 10.1111/ajag.12617. Epub 2019 Feb 1.


Tackling multimorbidity in primary care: is relational continuity the missing ingredient?

Engamba SA, Steel N, Howe A, Bachman M.

Br J Gen Pract. 2019 Feb;69(679):92-93. doi: 10.3399/bjgp19X701201. No abstract available.


Drug Treatment Value in a Changing Oncology Landscape: A Literature and Provider Perspective.

Frois C, Howe A, Jarvis J, Grice K, Wong K, Zacker C, Sasane R.

J Manag Care Spec Pharm. 2019 Feb;25(2):246-259. doi: 10.18553/jmcp.2019.25.2.246. Review.


The principles of tomorrow's university.

Katz DS, Allen G, Barba LA, Berg DR, Bik H, Boettiger C, Borgman CL, Brown CT, Buck S, Burd R, de Waard A, Eve MP, Granger BE, Greenberg J, Howe A, Howe B, Khanna M, Killeen TL, Mayernik M, McKiernan E, Mentzel C, Merchant N, Niemeyer KE, Noren L, Nusser SM, Reed DA, Seidel E, Smith M, Spies JR, Turk M, Van Horn JD, Walsh J.

F1000Res. 2018 Dec 11;7:1926. doi: 10.12688/f1000research.17425.1. eCollection 2018.


Primary Care Research Priorities in Low-and Middle-Income Countries.

Goodyear-Smith F, Bazemore A, Coffman M, Fortier R, Howe A, Kidd M, Phillips RL, Rouleau K, van Weel C.

Ann Fam Med. 2019 Jan;17(1):31-35. doi: 10.1370/afm.2329.


A systematic, deep sequencing-based methodology for identification of mixed-genotype hepatitis C virus infections.

Olmstead AD, Montoya V, Chui CK, Dong W, Joy JB, Tai V, Poon AFY, Nguyen T, Brumme CJ, Martinello M, Matthews GV, Richard Harrigan P, Dore GJ, Applegate TL, Grebely J, Howe AYM.

Infect Genet Evol. 2019 Apr;69:76-84. doi: 10.1016/j.meegid.2019.01.016. Epub 2019 Jan 14.


Temporal Dynamics of Bacterial Communities in Soil and Leachate Water After Swine Manure Application.

Rieke EL, Soupir ML, Moorman TB, Yang F, Howe AC.

Front Microbiol. 2018 Dec 21;9:3197. doi: 10.3389/fmicb.2018.03197. eCollection 2018.


Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation.

Howe A, Kiffer F, Alexander TC, Sridharan V, Wang J, Ntagwabira F, Rodriguez A, Boerma M, Allen AR.

Int J Mol Sci. 2019 Jan 7;20(1). pii: E188. doi: 10.3390/ijms20010188.


Association Between 6-Week Postdischarge Risk Classification and 12-Month Outcomes After Orthopedic Trauma.

Castillo RC, Huang Y, Scharfstein D, Frey K, Bosse MJ, Pollak AN, Vallier HA, Archer KR, Hymes RA, Newcomb AB, MacKenzie EJ, Wegener S; and the Major Extremity Trauma Research Consortium (METRC), Hsu JR, Karunakar MA, Seymour RB, Sims SH, Flores E, Churchill C, Hak DJ, Henderson CE, Mir HR, Chan DS, Shah AR, Steverson B, Westberg J, Gary JL, Achor TS, Choo A, Munz JW, Porrey M, Hendrickson S, Breslin MA, McKinley TO, Gaski GE, Kempton LB, Sorkin AT, Virkus WW, Hill LC, Jones CB, Sietsema DL, O'Toole RV, Ordonio K, Howe AL, Zerhusen TJ Jr, Obremskey W, Boyce RH, Jahangir AA, Molina CS, Sethi MK, Vanston SW, Carroll EA, Drye DY, Holden MB, Collins SC, Wysocki E.

JAMA Surg. 2018 Dec 19:e184824. doi: 10.1001/jamasurg.2018.4824. [Epub ahead of print]


Large variations in the practice patterns of surgical antiseptic preparation solutions in patients with open and closed extremity fractures: a cross-sectional survey.

Jurado-Ruiz M, Slobogean GP, Bzovsky S, Garibaldi A, O'Hara NN, Howe A, Petrisor B, Sprague S.

Antimicrob Resist Infect Control. 2018 Nov 29;7:148. doi: 10.1186/s13756-018-0440-z. eCollection 2018.


Association of Long-term Child Growth and Developmental Outcomes With Metformin vs Insulin Treatment for Gestational Diabetes.

Landi SN, Radke S, Engel SM, Boggess K, Stürmer T, Howe AS, Funk MJ.

JAMA Pediatr. 2019 Feb 1;173(2):160-168. doi: 10.1001/jamapediatrics.2018.4214. Erratum in: JAMA Pediatr. 2019 Jan 7;:.


Core Principles to Improve Primary Care Quality Management.

Mutter JB, Liaw W, Moore MA, Etz RS, Howe A, Bazemore A.

J Am Board Fam Med. 2018 Nov-Dec;31(6):931-940. doi: 10.3122/jabfm.2018.06.170172.


Suboptimal performance of rotavirus testing in a vaccinated community population should prompt laboratories to review their rotavirus testing algorithms in response to changes in disease prevalence.

McAuliffe GN, Taylor SL, Moore S, Hewitt J, Upton A, Howe AS, Best EJ.

Diagn Microbiol Infect Dis. 2019 Mar;93(3):203-207. doi: 10.1016/j.diagmicrobio.2018.10.003. Epub 2018 Oct 11.


Assessing Pathogen Presence in an Intensively Tile Drained, Agricultural Watershed.

Rieke EL, Moorman TB, Soupir ML, Yang F, Howe A.

J Environ Qual. 2018 Sep;47(5):1033-1042. doi: 10.2134/jeq2017.12.0500.


Metagenomic Insights into the Degradation of Resistant Starch by Human Gut Microbiota.

Vital M, Howe A, Bergeron N, Krauss RM, Jansson JK, Tiedje JM.

Appl Environ Microbiol. 2018 Nov 15;84(23). pii: e01562-18. doi: 10.1128/AEM.01562-18. Print 2018 Dec 1.


Emerging role of family medicine in South Africa.

Moosa S, Peersman W, Derese A, Kidd M, Pettigrew LM, Howe A, Martinez-Bianchi V, De Maeseneer J.

BMJ Glob Health. 2018 Sep 6;3(Suppl 3):e000736. doi: 10.1136/bmjgh-2018-000736. eCollection 2018. No abstract available.


Designing a trapping strategy to aid Giant African Snail (Lissachatina fulica) eradication programs.

Roda A, Yong Cong M, Donner B, Dickens K, Howe A, Sharma S, Smith T.

PLoS One. 2018 Sep 7;13(9):e0203572. doi: 10.1371/journal.pone.0203572. eCollection 2018.


Risk Factors for Knee Stiffness Surgery After Tibial Plateau Fracture Fixation.

Reahl GB, Marinos D, OʼHara NN, Howe A, Degani Y, Wise B, Maceroli M, OʼToole RV.

J Orthop Trauma. 2018 Sep;32(9):e339-e343. doi: 10.1097/BOT.0000000000001237.


Characterization of hepatitis C virus resistance to grazoprevir reveals complex patterns of mutations following on-treatment breakthrough that are not observed at relapse.

Bonsall D, Black S, Howe AY, Chase R, Ingravallo P, Pak I, Brown A, Smith DA, Bowden R, Barnes E.

Infect Drug Resist. 2018 Aug 8;11:1119-1135. doi: 10.2147/IDR.S156581. eCollection 2018.


Evolutionary pathways to NS5A inhibitor resistance in genotype 1 hepatitis C virus.

Zhou S, Williford SE, McGivern DR, Burch CL, Hu F, Benzine T, Ingravallo P, Asante-Appiah E, Howe AYM, Swanstrom R, Lemon SM.

Antiviral Res. 2018 Oct;158:45-51. doi: 10.1016/j.antiviral.2018.07.024. Epub 2018 Aug 3.


Primer set 2.0 for highly parallel qPCR array targeting antibiotic resistance genes and mobile genetic elements.

Stedtfeld RD, Guo X, Stedtfeld TM, Sheng H, Williams MR, Hauschild K, Gunturu S, Tift L, Wang F, Howe A, Chai B, Yin D, Cole JR, Tiedje JM, Hashsham SA.

FEMS Microbiol Ecol. 2018 Sep 1;94(9). doi: 10.1093/femsec/fiy130.


Pneumococcal Conjugate Vaccines Turning the Tide on Inequity: A Retrospective Cohort Study of New Zealand Children Born 2006-2015.

Petousis-Harris H, Howe AS, Paynter J, Turner N, Griffin J.

Clin Infect Dis. 2019 Feb 15;68(5):818-826. doi: 10.1093/cid/ciy570.


Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A retrospective cohort study of safety outcomes in pregnant women vaccinated with Tdap vaccine.

Griffin JB, Yu L, Watson D, Turner N, Walls T, Howe AS, Jiang Y, Petousis-Harris H.

Vaccine. 2018 Aug 16;36(34):5173-5179. doi: 10.1016/j.vaccine.2018.07.011. Epub 2018 Jul 18.


Platinum Nanoparticle Inclusion into a Carbonized Polymer of Intrinsic Microporosity: Electrochemical Characteristics of a Catalyst for Electroless Hydrogen Peroxide Production.

Adamik RK, Hernández-Ibáñez N, Iniesta J, Edwards JK, Howe AGR, Armstrong RD, Taylor SH, Roldan A, Rong Y, Malpass-Evans R, Carta M, McKeown NB, He D, Marken F.

Nanomaterials (Basel). 2018 Jul 18;8(7). pii: E542. doi: 10.3390/nano8070542.


Tβ4 Increases Neovascularization and Cardiac Function in Chronic Myocardial Ischemia of Normo- and Hypercholesterolemic Pigs.

Ziegler T, Bähr A, Howe A, Klett K, Husada W, Weber C, Laugwitz KL, Kupatt C, Hinkel R.

Mol Ther. 2018 Jul 5;26(7):1706-1714. doi: 10.1016/j.ymthe.2018.06.004. Epub 2018 Jun 19.


One pot microwave synthesis of highly stable AuPd@Pd supported core-shell nanoparticles.

Howe AGR, Miedziak PJ, Morgan DJ, He Q, Strasser P, Edwards JK.

Faraday Discuss. 2018 Sep 3;208(0):409-425. doi: 10.1039/c8fd00004b.


A needs analysis and guide for interpretation of voiding cystourethrogram for trainees.

Howe AS, Maizels M, Palmer LS.

J Pediatr Urol. 2018 Apr;14(2):116-119. doi: 10.1016/j.jpurol.2018.02.023. Epub 2018 Mar 29. No abstract available.


Challenges for family medicine research: a global perspective.

Howe A, Kidd M.

Fam Pract. 2019 Mar 20;36(2):99-101. doi: 10.1093/fampra/cmy044. No abstract available.


Reflections on family medicine and primary healthcare in sub-Saharan Africa.

Mash R, Howe A, Olayemi O, Makwero M, Ray S, Zerihun M, Gyuse A, Goodyear-Smith F.

BMJ Glob Health. 2018 May 12;3(Suppl 3):e000662. doi: 10.1136/bmjgh-2017-000662. eCollection 2018. No abstract available.


Late effects of 1H irradiation on hippocampal physiology.

Kiffer F, Howe AK, Carr H, Wang J, Alexander T, Anderson JE, Groves T, Seawright JW, Sridharan V, Carter G, Boerma M, Allen AR.

Life Sci Space Res (Amst). 2018 May;17:51-62. doi: 10.1016/j.lssr.2018.03.004. Epub 2018 Mar 15.


The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation.

McKenzie AJ, Hicks SR, Svec KV, Naughton H, Edmunds ZL, Howe AK.

Sci Rep. 2018 May 8;8(1):7228. doi: 10.1038/s41598-018-25589-0.


Methods and quality of disease models incorporating more than two sexually transmitted infections: a protocol for a systematic review of the evidence.

Sailer F, Rait G, Howe A, Saunders J, Hunter R.

BMJ Open. 2018 May 5;8(5):e020246. doi: 10.1136/bmjopen-2017-020246.


Does practice analysis agree with the ambulatory care sensitive conditions' list of avoidable unplanned admissions?: a cross-sectional study in the East of England.

Fleetcroft R, Hardcastle A, Steel N, Price GM, Purdy S, Lipp A, Myint PK, Howe A.

BMJ Open. 2018 Apr 28;8(4):e020756. doi: 10.1136/bmjopen-2017-020756.


Young people's experiences of managing Type 1 diabetes at university: a national study of UK university students.

Kellett J, Sampson M, Swords F, Murphy HR, Clark A, Howe A, Price C, Datta V, Myint KS.

Diabet Med. 2018 Aug;35(8):1063-1071. doi: 10.1111/dme.13656. Epub 2018 Jul 5.


Corrigendum to "Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018" [Drug Resist. Updates 37 (March) (2018) 17-39].

Sorbo MC, Cento V, Di Maio VC, Howe AYM, Garcia F, Perno CF, Ceccherini-Silberstein F.

Drug Resist Updat. 2018 Sep;40:40-41. doi: 10.1016/j.drup.2018.04.001. Epub 2018 Apr 19. No abstract available.


Discordance in glycemic categories and regression to normality at baseline in 10,000 people in a Type 2 diabetes prevention trial.

Sampson M, Elwell-Sutton T, Bachmann MO, Clark A, Dhatariya KK, Ferns C, Howe A, John WG, Rayman G, Swafe L, Turner J, Pascale M.

Sci Rep. 2018 Apr 19;8(1):6240. doi: 10.1038/s41598-018-24662-y.


How embedded is public involvement in mainstream health research in England a decade after policy implementation? A realist evaluation.

Wilson P, Mathie E, Poland F, Keenan J, Howe A, Munday D, Kendall S, Cowe M, Staniszewska S, Goodman C.

J Health Serv Res Policy. 2018 Apr;23(2):98-106. doi: 10.1177/1355819617750688.


Analysis and dissociation of anti-HIV effects of shRNA to CCR5 and the fusion inhibitor C46.

Ledger S, Howe A, Turville S, Aggarwal A, Savkovic B, Ong A, Wolstein O, Boyd M, Millington M, Gorry PR, Murray JM, Symonds G.

J Gene Med. 2018 Feb;20(2-3):e3006. doi: 10.1002/jgm.3006.


Hepatitis C virus drug resistance associated substitutions and their clinical relevance: Update 2018.

Sorbo MC, Cento V, Di Maio VC, Howe AYM, Garcia F, Perno CF, Ceccherini-Silberstein F.

Drug Resist Updat. 2018 Mar;37:17-39. doi: 10.1016/j.drup.2018.01.004. Epub 2018 Feb 21. Review. Erratum in: Drug Resist Updat. 2018 Apr 18;:.


Management of Patients With High Baseline Hip Fracture Risk by FRAX Reduces Hip Fractures-A Post Hoc Analysis of the SCOOP Study.

McCloskey E, Johansson H, Harvey NC, Shepstone L, Lenaghan E, Fordham R, Harvey I, Howe A, Cooper C, Clarke S, Gittoes N, Heawood A, Holland R, Marshall T, O'Neill TW, Peters TJ, Redmond N, Torgerson D, Kanis JA; SCOOP Study Team.

J Bone Miner Res. 2018 Jun;33(6):1020-1026. doi: 10.1002/jbmr.3411. Epub 2018 Mar 23.


The Cost-Effectiveness of Screening in the Community to Reduce Osteoporotic Fractures in Older Women in the UK: Economic Evaluation of the SCOOP Study.

Turner DA, Khioe RFS, Shepstone L, Lenaghan E, Cooper C, Gittoes N, Harvey NC, Holland R, Howe A, McCloskey E, O'Neill TW, Torgerson D, Fordham R; SCOOP Study Team.

J Bone Miner Res. 2018 May;33(5):845-851. doi: 10.1002/jbmr.3381. Epub 2018 Feb 22.


Sequencing of hepatitis C virus for detection of resistance to direct-acting antiviral therapy: A systematic review.

Bartlett SR, Grebely J, Eltahla AA, Reeves JD, Howe AYM, Miller V, Ceccherini-Silberstein F, Bull RA, Douglas MW, Dore GJ, Harrington P, Lloyd AR, Jacka B, Matthews GV, Wang GP, Pawlotsky JM, Feld JJ, Schinkel J, Garcia F, Lennerstrand J, Applegate TL.

Hepatol Commun. 2017 May 22;1(5):379-390. doi: 10.1002/hep4.1050. eCollection 2017 Jul. Review.


The global origins of resistance-associated variants in the non-structural proteins 5A and 5B of the hepatitis C virus.

Jones BR, Howe AYM, Harrigan PR, Joy JB.

Virus Evol. 2018 Jan 16;4(1):vex041. doi: 10.1093/ve/vex041. eCollection 2018 Jan.

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