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Items: 41


Genetic Diversity and Gene Family Expansions in Members of the Genus Entamoeba.

Wilson IW, Weedall GD, Lorenzi H, Howcroft T, Hon CC, Deloger M, Guillén N, Paterson S, Clark CG, Hall N.

Genome Biol Evol. 2019 Mar 1;11(3):688-705. doi: 10.1093/gbe/evz009.


Workshop Report: Modulation of Antitumor Immune Responses by Dietary and Microbial Metabolites.

Kumar A, Smith C, Jobin C, Trinchieri G, Howcroft TK, Seifried H, Espey MG, Flores R, Kim YS, Daschner PJ.

J Natl Cancer Inst. 2017 Jun 1;109(6). doi: 10.1093/jnci/djx040.


Understanding the tumor immune microenvironment (TIME) for effective therapy.

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF.

Nat Med. 2018 May;24(5):541-550. doi: 10.1038/s41591-018-0014-x. Epub 2018 Apr 23. Review.


Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop.

Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK.

JCI Insight. 2018 Apr 5;3(7). pii: 98942. doi: 10.1172/jci.insight.98942. eCollection 2018 Apr 5. Review.


Meeting Report: The Role of the Mobilome in Cancer.

Ardeljan D, Taylor MS, Burns KH, Boeke JD, Espey MG, Woodhouse EC, Howcroft TK.

Cancer Res. 2016 Aug 1;76(15):4316-9. doi: 10.1158/0008-5472.CAN-15-3421. Epub 2016 Jul 18.


The NIH Extracellular RNA Communication Consortium.

Ainsztein AM, Brooks PJ, Dugan VG, Ganguly A, Guo M, Howcroft TK, Kelley CA, Kuo LS, Labosky PA, Lenzi R, McKie GA, Mohla S, Procaccini D, Reilly M, Satterlee JS, Srinivas PR, Church ES, Sutherland M, Tagle DA, Tucker JM, Venkatachalam S.

J Extracell Vesicles. 2015 Aug 28;4:27493. doi: 10.3402/jev.v4.27493. eCollection 2015.


RNA editing, epitranscriptomics, and processing in cancer progression.

Witkin KL, Hanlon SE, Strasburger JA, Coffin JM, Jaffrey SR, Howcroft TK, Dedon PC, Steitz JA, Daschner PJ, Read-Connole E.

Cancer Biol Ther. 2015;16(1):21-7. doi: 10.4161/15384047.2014.987555.


Advances in geroscience: impact on healthspan and chronic disease.

Burch JB, Augustine AD, Frieden LA, Hadley E, Howcroft TK, Johnson R, Khalsa PS, Kohanski RA, Li XL, Macchiarini F, Niederehe G, Oh YS, Pawlyk AC, Rodriguez H, Rowland JH, Shen GL, Sierra F, Wise BC.

J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S1-3. doi: 10.1093/gerona/glu041. Review.


The role of inflammation in age-related disease.

Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, Augustine AD, McElhaney JE, Kohanski R, Sierra F.

Aging (Albany NY). 2013 Jan;5(1):84-93.


Metabolic reprogramming of the immune response in the tumor microenvironment.

McCarthy SA, Mufson RA, Pearce EJ, Rathmell JC, Howcroft TK.

Cancer Biol Ther. 2013 Apr;14(4):315-8. doi: 10.4161/cbt.23616. Epub 2013 Jan 28.


Vesicle transfer and cell fusion: Emerging concepts of cell-cell communication in the tumor microenvironment.

Howcroft TK, Zhang HG, Dhodapkar M, Mohla S.

Cancer Biol Ther. 2011 Aug 1;12(3):159-64. Epub 2011 Aug 1.


Three novel downstream promoter elements regulate MHC class I promoter activity in mammalian cells.

Lee N, Iyer SS, Mu J, Weissman JD, Ohali A, Howcroft TK, Lewis BA, Singer DS.

PLoS One. 2010 Dec 13;5(12):e15278. doi: 10.1371/journal.pone.0015278.


The NIH Human Microbiome Project.

NIH HMP Working Group, Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss JA, Bonazzi V, McEwen JE, Wetterstrand KA, Deal C, Baker CC, Di Francesco V, Howcroft TK, Karp RW, Lunsford RD, Wellington CR, Belachew T, Wright M, Giblin C, David H, Mills M, Salomon R, Mullins C, Akolkar B, Begg L, Davis C, Grandison L, Humble M, Khalsa J, Little AR, Peavy H, Pontzer C, Portnoy M, Sayre MH, Starke-Reed P, Zakhari S, Read J, Watson B, Guyer M.

Genome Res. 2009 Dec;19(12):2317-23. doi: 10.1101/gr.096651.109. Epub 2009 Oct 9.


Upstream stimulatory factor regulates constitutive expression and hormonal suppression of the 90K (Mac-2BP) protein.

Grassadonia A, Tinari N, Fiorentino B, Nakazato M, Chung HK, Giuliani C, Napolitano G, Iacobelli S, Howcroft TK, Singer DS, Kohn LD; Consorzio Interuniversitario Nazionale per la Bioncologia.

Endocrinology. 2007 Jul;148(7):3507-17. Epub 2007 Apr 19.


A T lymphocyte-specific transcription complex containing RUNX1 activates MHC class I expression.

Howcroft TK, Weissman JD, Gegonne A, Singer DS.

J Immunol. 2005 Feb 15;174(4):2106-15.


Distinct transcriptional pathways regulate basal and activated major histocompatibility complex class I expression.

Howcroft TK, Raval A, Weissman JD, Gegonne A, Singer DS.

Mol Cell Biol. 2003 May;23(10):3377-91.


Expression of nonclassical MHC class Ib genes: comparison of regulatory elements.

Howcroft T, Singer D.

Immunol Res. 2003;27(1):1-30. Review.


The GTP-binding domain of class II transactivator regulates its nuclear export.

Raval A, Weissman JD, Howcroft TK, Singer DS.

J Immunol. 2003 Jan 15;170(2):922-30.


Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250.

Raval A, Howcroft TK, Weissman JD, Kirshner S, Zhu XS, Yokoyama K, Ting J, Singer DS.

Mol Cell. 2001 Jan;7(1):105-15.


HIV-1: a molecular toolkit for analysis of major histocompatibility complex class I expression.

Howcroft TK.

Eur J Clin Invest. 2000 Aug;30(8):657-9. No abstract available.


Upstream stimulatory factor regulates major histocompatibility complex class I gene expression: the U2DeltaE4 splice variant abrogates E-box activity.

Howcroft TK, Murphy C, Weissman JD, Huber SJ, Sawadogo M, Singer DS.

Mol Cell Biol. 1999 Jul;19(7):4788-97.


HIV Tat represses transcription of the beta 2-microglobulin promoter.

Carroll IR, Wang J, Howcroft TK, Singer DS.

Mol Immunol. 1998 Dec;35(18):1171-8.


HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.

Weissman JD, Brown JA, Howcroft TK, Hwang J, Chawla A, Roche PA, Schiltz L, Nakatani Y, Singer DS.

Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11601-6.


Elf-1 regulates basal expression from the T cell antigen receptor zeta-chain gene promoter.

Rellahan BL, Jensen JP, Howcroft TK, Singer DS, Bonvini E, Weissman AM.

J Immunol. 1998 Mar 15;160(6):2794-801.


Characterization of two class I genes from the H2-M region: evidence for a new subfamily.

Arepalli SR, Jones EP, Howcroft TK, Carlo I, Wang C, Lindahl KF, Singer DS, Rudikoff S.

Immunogenetics. 1998;47(3):264-71.


HIV Tat protein requirements for transactivation and repression of transcription are separable.

Brown JA, Howcroft TK, Singer DS.

J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Jan 1;17(1):9-16.


A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development.

Wiest DL, Ashe JM, Howcroft TK, Lee HM, Kemper DM, Negishi I, Singer DS, Singer A, Abe R.

Immunity. 1997 Jun;6(6):663-71.


Measure of transient transfection efficiency using beta-galactosidase protein.

Howcroft TK, Kirshner SL, Singer DS.

Anal Biochem. 1997 Jan 1;244(1):22-7.


Repression of the nonclassical MHC class I gene H2-M1 by cis-acting silencer DNA elements.

Howcroft TK, Weissman JD, Rudikoff S, Frels WI, Singer DS.

Immunogenetics. 1996;44(4):268-74.


HIV Tat represses transcription through Sp1-like elements in the basal promoter.

Howcroft TK, Palmer LA, Brown J, Rellahan B, Kashanchi F, Brady JN, Singer DS.

Immunity. 1995 Jul;3(1):127-38.


MHC class I gene expression is negatively regulated by the proto-oncogene, c-jun.

Howcroft TK, Richardson JC, Singer DS.

EMBO J. 1993 Aug;12(8):3163-9.


Repression of MHC class I gene promoter activity by two-exon Tat of HIV.

Howcroft TK, Strebel K, Martin MA, Singer DS.

Science. 1993 May 28;260(5112):1320-2.


Membranolytic and nucleolytic activities of cytolytic T lymphocyte clones.

Cosgrove JM, Howcroft TK, Tatum SM, Lindquist RR.

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1562-7.


Cytolytic T lymphocyte (CTL) cytosolic alkalinization during CTL-mediated killing.

Lindquist RR, Howcroft TK.

J Leukoc Biol. 1991 May;49(5):525. No abstract available.


Protein kinase C (PKC) inhibitors inhibit primary (1-0) but not secondary (1-1) or cloned cytotoxic T lymphocytes.

Howcroft TK, Tatum SM, Cosgrove JM, Lindquist RR.

Biochem Biophys Res Commun. 1988 Aug 15;154(3):1280-6.


Primary integumentary allograft reactivity in the American cockroach, Periplaneta americana.

George JF, Howcroft TK, Karp RD.

Transplantation. 1987 Apr;43(4):514-9.


Variable number of coronary os in the aorta of the Zululand wildebeeste.

Wallach JD, Howcroft T.

Vet Med Small Anim Clin. 1967 Jan;62(1):21-2. No abstract available.


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