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Items: 1 to 50 of 359

1.

Exhaled volatile organic compounds in adult asthma: a systematic review.

Azim A, Barber C, Dennison P, Riley J, Howarth P.

Eur Respir J. 2019 Sep 29;54(3). pii: 1900056. doi: 10.1183/13993003.00056-2019. Print 2019 Sep.

PMID:
31273044
2.

Nocturnal temperature-controlled laminar airflow device for adults with severe allergic asthma: the LASER RCT.

Kapoor M, Storrar W, Balls L, Brown TP, Mansur A, Hedley E, Jones T, Roberts C, Shirkey B, Dutton S, Luengo-Fernandez R, Little M, Dewey A, Marshall S, Fogg C, Boughton K, Rahman N, Yu LM, Bradding P, Howarth P, Chauhan AJ.

Health Technol Assess. 2019 Jun;23(29):1-140. doi: 10.3310/hta23290.

3.

Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH): a pragmatic real-life longitudinal study of difficult asthma in the clinic.

Azim A, Mistry H, Freeman A, Barber C, Newell C, Gove K, Thirlwall Y, Harvey M, Bentley K, Knight D, Long K, Mitchell F, Cheng Y, Varkonyi-Sepp J, Grabau W, Dennison P, Haitchi HM, Arshad SH, Djukanovic R, Wilkinson T, Howarth P, Kurukulaaratchy RJ.

BMC Pulm Med. 2019 May 24;19(1):99. doi: 10.1186/s12890-019-0862-2.

4.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Perotin JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group; U-BIOPRED:.

Eur Respir J. 2019 Jun 27;53(6). pii: 1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. No abstract available.

PMID:
31023846
5.

IL-17-high asthma with features of a psoriasis immunophenotype.

Östling J, van Geest M, Schofield JPR, Jevnikar Z, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, Sousa AR, Guo Y, Adcock IM, Howarth P, Chung KF, Bigler J, Sterk PJ, Skipp PJ, Djukanović R, Vaarala O; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2019 Apr 15. pii: S0091-6749(19)30484-1. doi: 10.1016/j.jaci.2019.03.027. [Epub ahead of print]

PMID:
30998987
6.

Sputum proteomic signature of gastro-oesophageal reflux in patients with severe asthma.

Tariq K, Schofield JPR, Nicholas BL, Burg D, Brandsma J, Bansal AT, Wilson SJ, Lutter R, Fowler SJ, Bakke, Caruso M, Dahlen B, Horváth I, Krug N, Montuschi P, Sanak M, Sandström T, Geiser T, Pandis I, Sousa AR, Adcock IM, Shaw DE, Auffray C, Howarth PH, Sterk PJ, Chung KF, Skipp PJ, Dimitrov B, Djukanović R; U-BIOPRED Study Group.

Respir Med. 2019 Apr;150:66-73. doi: 10.1016/j.rmed.2019.02.008. Epub 2019 Feb 11.

PMID:
30961953
7.

Stratification of asthma phenotypes by airway proteomic signatures.

Schofield JPR, Burg D, Nicholas B, Strazzeri F, Brandsma J, Staykova D, Folisi C, Bansal AT, Xian Y, Guo Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Riley J, Auffray C, De Meulder B, Lefaudeux D, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Djukanović R; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2019 Jul;144(1):70-82. doi: 10.1016/j.jaci.2019.03.013. Epub 2019 Mar 28.

PMID:
30928653
8.

Contribution of airway eosinophils in airway wall remodeling in asthma: Role of MMP-10 and MET.

Kuo CS, Pavlidis S, Zhu J, Loza M, Baribaud F, Rowe A, Pandis I, Gibeon D, Hoda U, Sousa A, Wilson SJ, Howarth P, Shaw D, Fowler S, Dahlen B, Chanez P, Krug N, Sandstrom T, Fleming L, Corfield J, Auffray C, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team.

Allergy. 2019 Jun;74(6):1102-1112. doi: 10.1111/all.13727. Epub 2019 Feb 11.

PMID:
30667542
9.

"T2-high" in severe asthma related to blood eosinophil, exhaled nitric oxide and serum periostin.

Pavlidis S, Takahashi K, Ng Kee Kwong F, Xie J, Hoda U, Sun K, Elyasigomari V, Agapow P, Loza M, Baribaud F, Chanez P, Fowler SJ, Shaw DE, Fleming LJ, Howarth PH, Sousa AR, Corfield J, Auffray C, De Meulder B, Knowles R, Sterk PJ, Guo Y, Adcock IM, Djukanovic R, Fan Chung K; on behalf of the U-BIOPRED Study Group.

Eur Respir J. 2019 Jan 3;53(1). pii: 1800938. doi: 10.1183/13993003.00938-2018. Print 2019 Jan.

PMID:
30578390
10.

Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.

Shrine N, Portelli MA, John C, Soler Artigas M, Bennett N, Hall R, Lewis J, Henry AP, Billington CK, Ahmad A, Packer RJ, Shaw D, Pogson ZEK, Fogarty A, McKeever TM, Singapuri A, Heaney LG, Mansur AH, Chaudhuri R, Thomson NC, Holloway JW, Lockett GA, Howarth PH, Djukanovic R, Hankinson J, Niven R, Simpson A, Chung KF, Sterk PJ, Blakey JD, Adcock IM, Hu S, Guo Y, Obeidat M, Sin DD, van den Berge M, Nickle DC, Bossé Y, Tobin MD, Hall IP, Brightling CE, Wain LV, Sayers I.

Lancet Respir Med. 2019 Jan;7(1):20-34. doi: 10.1016/S2213-2600(18)30389-8. Epub 2018 Dec 11.

11.

Randomised controlled trials in severe asthma: selection by phenotype or stereotype.

Brown T, Jones T, Gove K, Barber C, Elliott S, Chauhan A, Howarth P; Wessex Severe Asthma Cohort (WSAC) team; Members of the Wessex Severe Asthma Cohort (WSAC) team:.

Eur Respir J. 2018 Dec 13;52(6). pii: 1801444. doi: 10.1183/13993003.01444-2018. Print 2018 Dec.

PMID:
30361247
12.

Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma.

Khatri S, Moore W, Gibson PG, Leigh R, Bourdin A, Maspero J, Barros M, Buhl R, Howarth P, Albers FC, Bradford ES, Gilson M, Price RG, Yancey SW, Ortega H.

J Allergy Clin Immunol. 2019 May;143(5):1742-1751.e7. doi: 10.1016/j.jaci.2018.09.033. Epub 2018 Oct 23.

13.

Enhanced oxidative stress in smoking and ex-smoking severe asthma in the U-BIOPRED cohort.

Emma R, Bansal AT, Kolmert J, Wheelock CE, Dahlen SE, Loza MJ, De Meulder B, Lefaudeux D, Auffray C, Dahlen B, Bakke PS, Chanez P, Fowler SJ, Horvath I, Montuschi P, Krug N, Sanak M, Sandstrom T, Shaw DE, Fleming LJ, Djukanovic R, Howarth PH, Singer F, Sousa AR, Sterk PJ, Corfield J, Pandis I, Chung KF, Adcock IM, Lutter R, Fabbella L, Caruso M; U-BIOPRED Study Group.

PLoS One. 2018 Sep 21;13(9):e0203874. doi: 10.1371/journal.pone.0203874. eCollection 2018.

14.

Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation.

Jevnikar Z, Östling J, Ax E, Calvén J, Thörn K, Israelsson E, Öberg L, Singhania A, Lau LCK, Wilson SJ, Ward JA, Chauhan A, Sousa AR, De Meulder B, Loza MJ, Baribaud F, Sterk PJ, Chung KF, Sun K, Guo Y, Adcock IM, Payne D, Dahlen B, Chanez P, Shaw DE, Krug N, Hohlfeld JM, Sandström T, Djukanovic R, James A, Hinks TSC, Howarth PH, Vaarala O, van Geest M, Olsson H; Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group.

J Allergy Clin Immunol. 2019 Feb;143(2):577-590. doi: 10.1016/j.jaci.2018.05.026. Epub 2018 Jun 11.

15.

Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.

Martinez-Nunez RT, Rupani H, Platé M, Niranjan M, Chambers RC, Howarth PH, Sanchez-Elsner T.

J Immunol. 2018 Jul 1;201(1):251-263. doi: 10.4049/jimmunol.1701798. Epub 2018 May 16.

16.

Large-Scale Label-Free Quantitative Mapping of the Sputum Proteome.

Burg D, Schofield JPR, Brandsma J, Staykova D, Folisi C, Bansal A, Nicholas B, Xian Y, Rowe A, Corfield J, Wilson S, Ward J, Lutter R, Fleming L, Shaw DE, Bakke PS, Caruso M, Dahlen SE, Fowler SJ, Hashimoto S, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Singer F, Sun K, Pandis I, Auffray C, Sousa AR, Adcock IM, Chung KF, Sterk PJ, Djukanović R, Skipp PJ, The U-Biopred Study Group.

J Proteome Res. 2018 Jun 1;17(6):2072-2091. doi: 10.1021/acs.jproteome.8b00018. Epub 2018 May 23.

17.

In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.

Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE.

Eur Respir J. 2018 May 24;51(5). pii: 1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May.

18.

Sputum proteomics and airway cell transcripts of current and ex-smokers with severe asthma in U-BIOPRED: an exploratory analysis.

Takahashi K, Pavlidis S, Ng Kee Kwong F, Hoda U, Rossios C, Sun K, Loza M, Baribaud F, Chanez P, Fowler SJ, Horvath I, Montuschi P, Singer F, Musial J, Dahlen B, Dahlen SE, Krug N, Sandstrom T, Shaw DE, Lutter R, Bakke P, Fleming LJ, Howarth PH, Caruso M, Sousa AR, Corfield J, Auffray C, De Meulder B, Lefaudeux D, Djukanovic R, Sterk PJ, Guo Y, Adcock IM, Chung KF; , on behalf of the U-BIOPRED study group.

Eur Respir J. 2018 May 3;51(5). pii: 1702173. doi: 10.1183/13993003.02173-2017. Print 2018 May.

PMID:
29650557
19.

Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma.

Ortega H, Yancey SW, Keene ON, Gunsoy NB, Albers FC, Howarth PH.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):980-986.e1. doi: 10.1016/j.jaip.2017.12.019. Epub 2018 Feb 15.

20.

Rigor Is Needed When Making Comparative Analyses of Biologics in Severe Asthma.

Prazma CM, Katial R, Howarth P, Bradford E, Martin N, Pizzichini E.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1508-1510. doi: 10.1164/rccm.201712-2455LE. No abstract available.

PMID:
29360390
21.

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, Howarth PH, Lordan J, Mansur AH, Menzies-Gow A, Mosesova S, Niven RM, Robinson DS, Shaw DE, Walker S, Woodcock A, Heaney LG; RASP-UK (Refractory Asthma Stratification Programme) Consortium.

Trials. 2018 Jan 4;19(1):5. doi: 10.1186/s13063-017-2384-7.

22.

Response to case report: Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy.

Pouliquen IJ, Howarth P, Austin D, Gunn G, Meyer E, Price RG, Bradford E.

Allergy Asthma Clin Immunol. 2017 Nov 3;13:45. doi: 10.1186/s13223-017-0217-6. eCollection 2017. No abstract available.

23.

Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma.

Hekking PP, Loza MJ, Pavlidis S, De Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P, Lutter R, Bansal AT, Sousa AR, Bates SA, Pandis I, Fleming LJ, Shaw DE, Fowler SJ, Guo Y, Meiser A, Sun K, Corfield J, Howarth P, Bel EH, Adcock IM, Chung KF, Djukanovic R, Sterk PJ; U-BIOPRED Study Group.

Eur Respir J. 2017 Sep 27;50(3). pii: 1602298. doi: 10.1183/13993003.02298-2016. Print 2017 Sep.

24.

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

Singhania A, Wallington JC, Smith CG, Horowitz D, Staples KJ, Howarth PH, Gadola SD, Djukanović R, Woelk CH, Hinks TSC.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):261-270. doi: 10.1165/rcmb.2017-0162OC.

25.

Pathway discovery using transcriptomic profiles in adult-onset severe asthma.

Hekking PP, Loza MJ, Pavlidis S, de Meulder B, Lefaudeux D, Baribaud F, Auffray C, Wagener AH, Brinkman P Ir, Lutter R Ir, Bansal AT, Sousa AR, Bates SA, Pandis Y, Fleming LJ, Shaw DE, Fowler SJ, Guo Y, Meiser A, Sun K, Corfield J, Howarth PH, Bel EH, Adcock IM, Chung KF, Djukanovic R, Sterk PJ; U-BIOPRED Study Group.

J Allergy Clin Immunol. 2018 Apr;141(4):1280-1290. doi: 10.1016/j.jaci.2017.06.037. Epub 2017 Jul 26.

26.

Allergenic proteases cleave the chemokine CX3CL1 directly from the surface of airway epithelium and augment the effect of rhinovirus.

Loxham M, Smart DE, Bedke NJ, Smithers NP, Filippi I, Blume C, Swindle EJ, Tariq K, Howarth PH, Holgate ST, Davies DE.

Mucosal Immunol. 2018 Mar;11(2):404-414. doi: 10.1038/mi.2017.63. Epub 2017 Jul 5.

PMID:
28677664
27.

Increased Expression of p22phox Mediates Airway Hyperresponsiveness in an Experimental Model of Asthma.

Nagaraj C, Haitchi HM, Heinemann A, Howarth PH, Olschewski A, Marsh LM.

Antioxid Redox Signal. 2017 Dec 20;27(18):1460-1472. doi: 10.1089/ars.2016.6863. Epub 2017 Jun 26.

PMID:
28510479
28.

A UK community-based survey on the prevalence of rhinosinusitis.

Sami AS, Scadding GK, Howarth P.

Clin Otolaryngol. 2018 Feb;43(1):76-89. doi: 10.1111/coa.12902. Epub 2017 Jun 13.

PMID:
28498627
29.

Susceptibility to influenza virus infection of bronchial biopsies in asthma.

Nicholas B, Dudley S, Tariq K, Howarth P, Lunn K, Pink S, Sterk PJ, Adcock IM, Monk P, Djukanović R; U-BIOPRED study group.

J Allergy Clin Immunol. 2017 Jul;140(1):309-312.e4. doi: 10.1016/j.jaci.2016.12.964. Epub 2017 Mar 1. No abstract available.

30.

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

Bousquet J, Farrell J, Crooks G, Hellings P, Bel EH, Bewick M, Chavannes NH, de Sousa JC, Cruz AA, Haahtela T, Joos G, Khaltaev N, Malva J, Muraro A, Nogues M, Palkonen S, Pedersen S, Robalo-Cordeiro C, Samolinski B, Strandberg T, Valiulis A, Yorgancioglu A, Zuberbier T, Bedbrook A, Aberer W, Adachi M, Agusti A, Akdis CA, Akdis M, Ankri J, Alonso A, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Bai C, Baiardini I, Bachert C, Baigenzhin AK, Barbara C, Bateman ED, Beghé B, Kheder AB, Bennoor KS, Benson M, Bergmann KC, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Blasi F, Boner AL, Bonini M, Bonini S, Bosnic-Anticevitch S, Boulet LP, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Caimmi D, Calderon MA, Calverley PM, Camargos PAM, Canonica GW, Camuzat T, Carlsen KH, Carr W, Carriazo A, Casale T, Cepeda Sarabia AM, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Chung KF, Ciprandi G, Cirule I, Cox L, Costa DJ, Custovic A, Dahl R, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, De Manuel Keenoy E, Demoly P, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Djukanovic R, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Fabbri LM, Fletcher M, Fiocchi A, Fink Wagner A, Fonseca J, Fokkens WJ, Forastiere F, Frith P, Gaga M, Gamkrelidze A, Garces J, Garcia-Aymerich J, Gemicioğlu B, Gereda JE, González Diaz S, Gotua M, Grisle I, Grouse L, Gutter Z, Guzmán MA, Heaney LG, Hellquist-Dahl B, Henderson D, Hendry A, Heinrich J, Heve D, Horak F, Hourihane JOB, Howarth P, Humbert M, Hyland ME, Illario M, Ivancevich JC, Jardim JR, Jares EJ, Jeandel C, Jenkins C, Johnston SL, Jonquet O, Julge K, Jung KS, Just J, Kaidashev I, Khaitov MR, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Klimek L, Koffi N'Goran B, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J, Lodrup Carlsen K, Louis R, MacNee W, Magard Y, Magnan A, Mahboub B, Mair A, Majer I, Makela MJ, Manning P, Mara S, Marshall GD, Masjedi MR, Matignon P, Maurer M, Mavale-Manuel S, Melén E, Melo-Gomes E, Meltzer EO, Menzies-Gow A, Merk H, Michel JP, Miculinic N, Mihaltan F, Milenkovic B, Mohammad GMY, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Morgan M, Mösges R, Mullol J, Nafti S, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Ninot G, Nyembue TD, O'Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schöll I, Panzner P, Papadopoulos N, Papi A, Park HS, Passalacqua G, Pavord I, Pawankar R, Pengelly R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Poethig D, Pohl W, Popov TA, Portejoie F, Potter P, Postma D, Price D, Rabe KF, Raciborski F, Radier Pontal F, Repka-Ramirez S, Reitamo S, Rennard S, Rodenas F, Roberts J, Roca J, Rodriguez Mañas L, Rolland C, Roman Rodriguez M, Romano A, Rosado-Pinto J, Rosario N, Rosenwasser L, Rottem M, Ryan D, Sanchez-Borges M, Scadding GK, Schunemann HJ, Serrano E, Schmid-Grendelmeier P, Schulz H, Sheikh A, Shields M, Siafakas N, Sibille Y, Similowski T, Simons FER, Sisul JC, Skrindo I, Smit HA, Solé D, Sooronbaev T, Spranger O, Stelmach R, Sterk PJ, Sunyer J, Thijs C, To T, Todo-Bom A, Triggiani M, Valenta R, Valero AL, Valia E, Valovirta E, Van Ganse E, van Hage M, Vandenplas O, Vasankari T, Vellas B, Vestbo J, Vezzani G, Vichyanond P, Viegi G, Vogelmeier C, Vontetsianos T, Wagenmann M, Wallaert B, Walker S, Wang DY, Wahn U, Wickman M, Williams DM, Williams S, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zaidi A, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J.

Clin Transl Allergy. 2017 Feb 20;7:5. doi: 10.1186/s13601-016-0135-6. eCollection 2017.

31.

Is fruit and vegetable intake associated with asthma or chronic rhino-sinusitis in European adults? Results from the Global Allergy and Asthma Network of Excellence (GA2LEN) Survey.

Garcia-Larsen V, Arthur R, Potts JF, Howarth PH, Ahlström M, Haahtela T, Loureiro C, Bom AT, Brożek G, Makowska J, Kowalski ML, Thilsing T, Keil T, Matricardi PM, Torén K, van Zele T, Bachert C, Rymarczyk B, Janson C, Forsberg B, Niżankowska-Mogilnicka E, Burney PGJ.

Clin Transl Allergy. 2017 Jan 27;7:3. doi: 10.1186/s13601-016-0140-9. eCollection 2017.

32.

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.

Singhania A, Rupani H, Jayasekera N, Lumb S, Hales P, Gozzard N, Davies DE, Woelk CH, Howarth PH.

PLoS One. 2017 Jan 3;12(1):e0168680. doi: 10.1371/journal.pone.0168680. eCollection 2017.

33.

CD48 on blood leukocytes and in serum of asthma patients varies with severity.

Gangwar RS, Minai-Fleminger Y, Seaf M, Gutgold A, Shikotra A, Barber C, Chauhan A, Holgate S, Bradding P, Howarth P, Eliashar R, Berkman N, Levi-Schaffer F.

Allergy. 2017 Jun;72(6):888-895. doi: 10.1111/all.13082. Epub 2016 Dec 1. Erratum in: Allergy. 2017 Oct;72 (10 ):1591.

PMID:
27859399
34.

Severe asthma exists despite suppressed tissue inflammation: findings of the U-BIOPRED study.

Wilson SJ, Ward JA, Sousa AR, Corfield J, Bansal AT, De Meulder B, Lefaudeux D, Auffray C, Loza MJ, Baribaud F, Fitch N, Sterk PJ, Chung KF, Gibeon D, Sun K, Guo YK, Adcock I, Djukanovic R, Dahlen B, Chanez P, Shaw D, Krug N, Hohlfeld J, Sandström T, Howarth PH; U-BIOPRED Study Group.

Eur Respir J. 2016 Nov;48(5):1307-1319. doi: 10.1183/13993003.01129-2016. Epub 2016 Oct 6.

35.

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients.

Portelli MA, Moseley C, Stewart CE, Postma DS, Howarth P, Warner JA, Holloway JW, Koppelman GH, Brightling C, Sayers I.

Allergy. 2017 Mar;72(3):473-482. doi: 10.1111/all.13046. Epub 2016 Oct 5.

PMID:
27624865
36.

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit.

Hill AR, Donaldson JE, Blume C, Smithers N, Tezera L, Tariq K, Dennison P, Rupani H, Edwards MJ, Howarth PH, Grainge C, Davies DE, Swindle EJ.

Tissue Barriers. 2016 Jun 28;4(3):e1206378. doi: 10.1080/21688370.2016.1206378. eCollection 2016 Jul-Sep.

37.

A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED.

Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, Krug N, Sandstrӧm T, De Meulder B, Lefaudeux D, Fowler S, Fleming L, Corfield J, Auffray C, Sterk PJ, Djukanovic R, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team ‡ .

Am J Respir Crit Care Med. 2017 Feb 15;195(4):443-455. doi: 10.1164/rccm.201512-2452OC.

38.

Response.

Mackay RM, Grainge CL, Lau LC, Barber C, Clark HW, Howarth PH.

Chest. 2016 Aug;150(2):474. doi: 10.1016/j.chest.2016.05.033. No abstract available.

PMID:
27502988
39.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM.

JCI Insight. 2016 Jul 21;1(11). pii: e87632.

40.

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5).

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Clin Transl Allergy. 2016 Jul 29;6:29. doi: 10.1186/s13601-016-0116-9. eCollection 2016. Review. Erratum in: Clin Transl Allergy. 2017 Feb 20;7:5.

41.

Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA2 LEN) survey.

Makowska JS, Burney P, Jarvis D, Keil T, Tomassen P, Bislimovska J, Brozek G, Bachert C, Baelum J, Bindslev-Jensen C, Bousquet J, Bousquet PJ, Kai-Håkon C, Dahlen SE, Dahlen B, Fokkens WJ, Forsberg B, Gjomarkaj M, Howarth P, Salagean E, Janson C, Kasper L, Kraemer U, Louiro C, Lundback B, Minov J, Nizankowska-Mogilnicka E, Papadopoulos N, Sakellariou AG, Todo-Bom A, Toskala E, Zejda JE, Zuberbier T, Kowalski ML.

Allergy. 2016 Nov;71(11):1603-1611. doi: 10.1111/all.12941. Epub 2016 Jul 11.

PMID:
27230252
42.

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

Manuyakorn W, Smart DE, Noto A, Bucchieri F, Haitchi HM, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2016 Apr 21;11(4):e0153926. doi: 10.1371/journal.pone.0153926. eCollection 2016.

43.

Microbes and asthma: Opportunities for intervention.

Smits HH, Hiemstra PS, Prazeres da Costa C, Ege M, Edwards M, Garn H, Howarth PH, Jartti T, de Jong EC, Maizels RM, Marsland BJ, McSorley HJ, Müller A, Pfefferle PI, Savelkoul H, Schwarze J, Unger WW, von Mutius E, Yazdanbakhsh M, Taube C.

J Allergy Clin Immunol. 2016 Mar;137(3):690-7. doi: 10.1016/j.jaci.2016.01.004. Review.

PMID:
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Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations.

Vries Md, Bedke N, Smithers NP, Loxham M, Howarth PH, Nawijn MC, Davies DE.

Eur Respir J. 2016 Mar;47(3):783-91. doi: 10.1183/13993003.00171-2015. Epub 2016 Feb 11.

45.

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

Hinks TSC, Brown T, Lau LCK, Rupani H, Barber C, Elliott S, Ward JA, Ono J, Ohta S, Izuhara K, Djukanović R, Kurukulaaratchy RJ, Chauhan A, Howarth PH.

J Allergy Clin Immunol. 2016 Jul;138(1):61-75. doi: 10.1016/j.jaci.2015.11.020. Epub 2016 Feb 3.

46.

Airway Surfactant Protein D Deficiency in Adults With Severe Asthma.

Mackay RM, Grainge CL, Lau LC, Barber C, Clark HW, Howarth PH.

Chest. 2016 May;149(5):1165-72. doi: 10.1016/j.chest.2015.11.012. Epub 2016 Jan 13.

47.

Toll-like Receptor 7 Is Reduced in Severe Asthma and Linked to an Altered MicroRNA Profile.

Rupani H, Martinez-Nunez RT, Dennison P, Lau LC, Jayasekera N, Havelock T, Francisco-Garcia AS, Grainge C, Howarth PH, Sanchez-Elsner T.

Am J Respir Crit Care Med. 2016 Jul 1;194(1):26-37. doi: 10.1164/rccm.201502-0280OC.

48.

Temperature-controlled laminar airflow in severe asthma for exacerbation reduction (The LASER Trial): study protocol for a randomised controlled trial.

Storrar W, Fogg C, Brown T, Dennison P, Yu LM, Dewey A, Luengo-Fernandez R, Dean T, Rahman N, Mansur A, Howarth PH, Bradding P, Chauhan AJ.

Trials. 2016 Jan 8;17:15. doi: 10.1186/s13063-015-1134-y.

49.

Regional assessment of lung function using thin-plate splines to align structural and functional imaging.

Bennett MJ, Havelock T, Bennett S, Conway J, Fleming J, Howarth P.

Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:2928-31. doi: 10.1109/EMBC.2015.7319005.

PMID:
26736905
50.

Common airborne fungi induce species-specific effects on upper airway inflammatory and remodelling responses.

Sproson EL, Thomas KM, Lau LC, Harries PG, Howarth PH, Salib RJ.

Rhinology. 2016 Mar;54(1):51-5. doi: 10.4193/Rhin14.278.

PMID:
26501134

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