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Sharing Data from Molecular Simulations.

Abraham M, Apostolov R, Barnoud J, Bauer P, Blau C, Bonvin AMJJ, Chavent M, Chodera J, Čondić-Jurkić K, Delemotte L, Grubmüller H, Howard RJ, Jordan EJ, Lindahl E, Ollila OHS, Selent J, Smith DGA, Stansfeld PJ, Tiemann JKS, Trellet M, Woods C, Zhmurov A.

J Chem Inf Model. 2019 Oct 28;59(10):4093-4099. doi: 10.1021/acs.jcim.9b00665. Epub 2019 Oct 11.


Agonist Selectivity and Ion Permeation in the α3β4 Ganglionic Nicotinic Receptor.

Gharpure A, Teng J, Zhuang Y, Noviello CM, Walsh RM Jr, Cabuco R, Howard RJ, Zaveri NT, Lindahl E, Hibbs RE.

Neuron. 2019 Nov 6;104(3):501-511.e6. doi: 10.1016/j.neuron.2019.07.030. Epub 2019 Sep 2.


Metacognition in functional cognitive disorder- a potential mechanism and treatment target.

Bhome R, McWilliams A, Huntley JD, Fleming SM, Howard RJ.

Cogn Neuropsychiatry. 2019 Sep;24(5):311-321. doi: 10.1080/13546805.2019.1651708. Epub 2019 Aug 7.


An Improved Evans Blue Staining Method for Consistent, Accurate Assessment of Plasmodiophora brassicae Resting Spore Viability.

Harding MW, Hill TB, Yang Y, Daniels GC, Hwang SF, Strelkov SE, Howard RJ, Feng J.

Plant Dis. 2019 Sep;103(9):2330-2336. doi: 10.1094/PDIS-05-18-0855-RE. Epub 2019 Jul 12.


Optimising the acceptability and feasibility of acceptance and commitment therapy for treatment-resistant generalised anxiety disorder in older adults.

Lawrence V, Kimona K, Howard RJ, Serfaty MA, Wetherell JL, Livingston G, Wilkinson P, Walters K, Jones R, Wuthrich VM, Gould RL.

Age Ageing. 2019 Jul 12. pii: afz082. doi: 10.1093/ageing/afz082. [Epub ahead of print]


Clinical presentation and neuropsychological profiles of Functional Cognitive Disorder patients with and without co-morbid depression.

Bhome R, Huntley JD, Price G, Howard RJ.

Cogn Neuropsychiatry. 2019 Mar;24(2):152-164. doi: 10.1080/13546805.2019.1590190. Epub 2019 Mar 11.


Minimal physical therapy utilization compared with higher physical therapy utilization for patients with low back pain: a systematic review.

Ojha H, Masaracchio M, Johnston M, Howard RJ, Egan WE, Kirker K, Davenport TE.

Physiother Theory Pract. 2019 Feb 9:1-22. doi: 10.1080/09593985.2019.1571135. [Epub ahead of print]


Unsuccessful trials of therapies for Alzheimer's disease.

Schott JM, Aisen PS, Cummings JL, Howard RJ, Fox NC.

Lancet. 2019 Jan 5;393(10166):29. doi: 10.1016/S0140-6736(18)31896-8. No abstract available.


Multicomponent Frailty Assessment Tools for Older People with Psychiatric Disorders: A Systematic Review.

Sutton JL, Gould RL, Coulson MC, Ward EV, Butler AM, Smith M, Lavelle G, Rosa A, Langridge M, Howard RJ.

J Am Geriatr Soc. 2019 May;67(5):1085-1095. doi: 10.1111/jgs.15710. Epub 2018 Dec 27. Review.


Allosteric potentiation of a ligand-gated ion channel is mediated by access to a deep membrane-facing cavity.

Heusser SA, Lycksell M, Wang X, McComas SE, Howard RJ, Lindahl E.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10672-10677. doi: 10.1073/pnas.1809650115. Epub 2018 Oct 1.


Interventions for subjective cognitive decline: systematic review and meta-analysis.

Bhome R, Berry AJ, Huntley JD, Howard RJ.

BMJ Open. 2018 Jul 19;8(7):e021610. doi: 10.1136/bmjopen-2018-021610.


Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels.

Fourati Z, Howard RJ, Heusser SA, Hu H, Ruza RR, Sauguet L, Lindahl E, Delarue M.

Cell Rep. 2018 Apr 24;23(4):993-1004. doi: 10.1016/j.celrep.2018.03.108.


The neurochemistry of agitation in Alzheimer's disease: a systematic review.

Liu KY, Stringer AE, Reeves SJ, Howard RJ.

Ageing Res Rev. 2018 May;43:99-107. doi: 10.1016/j.arr.2018.03.003. Epub 2018 Mar 7.


TNF alpha inhibitors in Alzheimer's disease: A systematic review.

Ekert JO, Gould RL, Reynolds G, Howard RJ.

Int J Geriatr Psychiatry. 2018 May;33(5):688-694. doi: 10.1002/gps.4871. Epub 2018 Mar 7.


Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport.

Howard RJ, Carnevale V, Delemotte L, Hellmich UA, Rothberg BS.

Biochim Biophys Acta Biomembr. 2018 Apr;1860(4):927-942. doi: 10.1016/j.bbamem.2017.12.013. Epub 2017 Dec 16. Review.


Magnetic resonance imaging of the human locus coeruleus: A systematic review.

Liu KY, Marijatta F, Hämmerer D, Acosta-Cabronero J, Düzel E, Howard RJ.

Neurosci Biobehav Rev. 2017 Dec;83:325-355. doi: 10.1016/j.neubiorev.2017.10.023. Epub 2017 Oct 28. Review.


Predictors of treatment outcome in depression in later life: A systematic review and meta-analysis.

Tunvirachaisakul C, Gould RL, Coulson MC, Ward EV, Reynolds G, Gathercole RL, Grocott H, Supasitthumrong T, Tunvirachaisakul A, Kimona K, Howard RJ.

J Affect Disord. 2018 Feb;227:164-182. doi: 10.1016/j.jad.2017.10.008. Epub 2017 Oct 10. Review.


Assessing coastal wetland vulnerability to sea-level rise along the northern Gulf of Mexico coast: Gaps and opportunities for developing a coordinated regional sampling network.

Osland MJ, Griffith KT, Larriviere JC, Feher LC, Cahoon DR, Enwright NM, Oster DA, Tirpak JM, Woodrey MS, Collini RC, Baustian JJ, Breithaupt JL, Cherry JA, Conrad JR, Cormier N, Coronado-Molina CA, Donoghue JF, Graham SA, Harper JW, Hester MW, Howard RJ, Krauss KW, Kroes DE, Lane RR, McKee KL, Mendelssohn IA, Middleton BA, Moon JA, Piazza SC, Rankin NM, Sklar FH, Steyer GD, Swanson KM, Swarzenski CM, Vervaeke WC, Willis JM, Wilson KV.

PLoS One. 2017 Sep 13;12(9):e0183431. doi: 10.1371/journal.pone.0183431. eCollection 2017.


Adaptive working memory strategy training in early Alzheimer's disease: randomised controlled trial.

Huntley JD, Hampshire A, Bor D, Owen A, Howard RJ.

Br J Psychiatry. 2017 Jan;210(1):61-66. doi: 10.1192/bjp.bp.116.182048. Epub 2016 Oct 6.


Effects of electromagnetic fields emitted by GSM phones on working memory: a meta-analysis.

Zubko O, Gould RL, Gay HC, Cox HJ, Coulson MC, Howard RJ.

Int J Geriatr Psychiatry. 2017 Feb;32(2):125-135. doi: 10.1002/gps.4581. Epub 2016 Sep 20. Review.


Discovery of midgut genes for the RNA interference control of corn rootworm.

Hu X, Richtman NM, Zhao JZ, Duncan KE, Niu X, Procyk LA, Oneal MA, Kernodle BM, Steimel JP, Crane VC, Sandahl G, Ritland JL, Howard RJ, Presnail JK, Lu AL, Wu G.

Sci Rep. 2016 Jul 28;6:30542. doi: 10.1038/srep30542.


The importance of sustained attention in early Alzheimer's disease.

Huntley JD, Hampshire A, Bor D, Owen AM, Howard RJ.

Int J Geriatr Psychiatry. 2017 Aug;32(8):860-867. doi: 10.1002/gps.4537. Epub 2016 Jul 18.


Disentangling the Treatment of Agitation in Alzheimer's Disease.

Howard RJ.

Am J Psychiatry. 2016 May 1;173(5):441-3. doi: 10.1176/appi.ajp.2016.16010083. No abstract available.


Functional characterization of neurotransmitter activation and modulation in a nematode model ligand-gated ion channel.

Heusser SA, Yoluk Ö, Klement G, Riederer EA, Lindahl E, Howard RJ.

J Neurochem. 2016 Jul;138(2):243-53. doi: 10.1111/jnc.13644. Epub 2016 May 25.


Views of US Voters on Compensating Living Kidney Donors.

Peters TG, Fisher JS, Gish RG, Howard RJ.

JAMA Surg. 2016 Aug 1;151(8):710-6. doi: 10.1001/jamasurg.2016.0065.


Psychometric properties of multicomponent tools designed to assess frailty in older adults: A systematic review.

Sutton JL, Gould RL, Daley S, Coulson MC, Ward EV, Butler AM, Nunn SP, Howard RJ.

BMC Geriatr. 2016 Feb 29;16:55. doi: 10.1186/s12877-016-0225-2. Review.


Backscattered electron SEM imaging of resin sections from plant specimens: observation of histological to subcellular structure and CLEM.

Rizzo NW, Duncan KE, Bourett TM, Howard RJ.

J Microsc. 2016 Aug;263(2):142-7. doi: 10.1111/jmi.12373. Epub 2015 Dec 28.


Tests of pattern separation and pattern completion in humans-A systematic review.

Liu KY, Gould RL, Coulson MC, Ward EV, Howard RJ.

Hippocampus. 2016 Jun;26(6):705-17. doi: 10.1002/hipo.22561. Epub 2016 Jan 11. Review.


Psychotherapy and pharmacotherapy interventions to reduce distress or improve well-being in people with amyotrophic lateral sclerosis: A systematic review.

Gould RL, Coulson MC, Brown RG, Goldstein LH, Al-Chalabi A, Howard RJ.

Amyotroph Lateral Scler Frontotemporal Degener. 2015;16(5-6):293-302. doi: 10.3109/21678421.2015.1062515. Epub 2015 Aug 27. Review.


Organ Procurement Organizations and the Electronic Health Record.

Howard RJ, Cochran LD, Cornell DL.

Am J Transplant. 2015 Oct;15(10):2562-4. doi: 10.1111/ajt.13385. Epub 2015 Jul 2.


Ethanol Modulation is Quantitatively Determined by the Transmembrane Domain of Human α1 Glycine Receptors.

Horani S, Stater EP, Corringer PJ, Trudell JR, Harris RA, Howard RJ.

Alcohol Clin Exp Res. 2015 Jun;39(6):962-8. doi: 10.1111/acer.12735. Epub 2015 May 14.


Do cognitive interventions improve general cognition in dementia? A meta-analysis and meta-regression.

Huntley JD, Gould RL, Liu K, Smith M, Howard RJ.

BMJ Open. 2015 Apr 2;5(4):e005247. doi: 10.1136/bmjopen-2014-005247. Review. Erratum in: BMJ Open. 2017 Aug 30;7(8):e005247corr1.


Cognitive phenotype of psychotic symptoms in Alzheimer's disease: evidence for impaired visuoperceptual function in the misidentification subtype.

Reeves SJ, Clark-Papasavas C, Gould RL, Ffytche D, Howard RJ.

Int J Geriatr Psychiatry. 2015 Dec;30(12):1147-55. doi: 10.1002/gps.4265. Epub 2015 Mar 24.


Could pheromones have a place in the management of agitation in dementia?

Liu K, Howard RJ.

Int J Geriatr Psychiatry. 2015 Feb;30(2):219-20. doi: 10.1002/gps.4210. No abstract available.


Cognitive debt and Alzheimer's disease.

Marchant NL, Howard RJ.

J Alzheimers Dis. 2015;44(3):755-70. doi: 10.3233/JAD-141515.


Hippocampal abnormalities and age in chronic schizophrenia: morphometric study across the adult lifespan.

Pujol N, Penadés R, Junqué C, Dinov I, Fu CH, Catalán R, Ibarretxe-Bilbao N, Bargalló N, Bernardo M, Toga A, Howard RJ, Costafreda SG.

Br J Psychiatry. 2014 Nov;205(5):369-75. doi: 10.1192/bjp.bp.113.140384. Epub 2014 Sep 11.


Broad 4-hydroxyphenylpyruvate dioxygenase inhibitor herbicide tolerance in soybean with an optimized enzyme and expression cassette.

Siehl DL, Tao Y, Albert H, Dong Y, Heckert M, Madrigal A, Lincoln-Cabatu B, Lu J, Fenwick T, Bermudez E, Sandoval M, Horn C, Green JM, Hale T, Pagano P, Clark J, Udranszky IA, Rizzo N, Bourett T, Howard RJ, Johnson DH, Vogt M, Akinsola G, Castle LA.

Plant Physiol. 2014 Nov;166(3):1162-76. doi: 10.1104/pp.114.247205. Epub 2014 Sep 5.


Effects of disturbance associated with seismic exploration for oil and gas reserves in coastal marshes.

Howard RJ, Wells CJ, Michot TC, Johnson DJ.

Environ Manage. 2014 Jul;54(1):30-50. doi: 10.1007/s00267-014-0274-2. Epub 2014 May 1.


Seeking structural specificity: direct modulation of pentameric ligand-gated ion channels by alcohols and general anesthetics.

Howard RJ, Trudell JR, Harris RA.

Pharmacol Rev. 2014 Feb 10;66(2):396-412. doi: 10.1124/pr.113.007468. Print 2014. Review.


Interventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trials.

Gould RL, Coulson MC, Patel N, Highton-Williamson E, Howard RJ.

Br J Psychiatry. 2014 Feb;204(2):98-107. doi: 10.1192/bjp.bp.113.126003. Review. Erratum in: Br J Psychiatry. 2014 Oct;205(4):330.


Maize ARGOS1 (ZAR1) transgenic alleles increase hybrid maize yield.

Guo M, Rupe MA, Wei J, Winkler C, Goncalves-Butruille M, Weers BP, Cerwick SF, Dieter JA, Duncan KE, Howard RJ, Hou Z, Löffler CM, Cooper M, Simmons CR.

J Exp Bot. 2014 Jan;65(1):249-60. doi: 10.1093/jxb/ert370. Epub 2013 Nov 11.


Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA.

Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15.


Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E.

Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018. Epub 2013 Jul 25.


Behavioural and emotional symptoms of apathy are associated with distinct patterns of brain atrophy in neurodegenerative disorders.

Stanton BR, Leigh PN, Howard RJ, Barker GJ, Brown RG.

J Neurol. 2013 Oct;260(10):2481-90. doi: 10.1007/s00415-013-6989-9. Epub 2013 Jun 23.


Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.

Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M.

Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682.


Innovative solutions to novel drug development in mental health.

Insel TR, Voon V, Nye JS, Brown VJ, Altevogt BM, Bullmore ET, Goodwin GM, Howard RJ, Kupfer DJ, Malloch G, Marston HM, Nutt DJ, Robbins TW, Stahl SM, Tricklebank MD, Williams JH, Sahakian BJ.

Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 1):2438-44. doi: 10.1016/j.neubiorev.2013.03.022. Epub 2013 Apr 3. Review.


Could it be Quetiapine-induced Peripartum Cardiomyopathy?

Kaler M, Shakur R, Learner HI, Deaner A, Howard RJ.

Obstet Med. 2013 Mar;6(1):35-37. Epub 2013 Mar 1.


Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.


Genetic Composition of Phytophthora infestans in Canada Reveals Migration and Increased Diversity.

Kalischuk ML, Al-Mughrabi KI, Peters RD, Howard RJ, Platt HWB, Kawchuk LM.

Plant Dis. 2012 Dec;96(12):1729-1735. doi: 10.1094/PDIS-10-11-0859-RE.


Molecular mechanism for the dual alcohol modulation of Cys-loop receptors.

Murail S, Howard RJ, Broemstrup T, Bertaccini EJ, Harris RA, Trudell JR, Lindahl E.

PLoS Comput Biol. 2012;8(10):e1002710. doi: 10.1371/journal.pcbi.1002710. Epub 2012 Oct 4.

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