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Human adaptation to biodiversity change: An adaptation process approach applied to a case study from southern India.

Thornton TF, Puri RK, Bhagwat S, Howard P.

Ambio. 2019 Sep 13. doi: 10.1007/s13280-019-01225-7. [Epub ahead of print]


'Antibiotic footprint' as a communication tool to aid reduction of antibiotic consumption-authors' response.

Limmathurotsakul D, Sandoe JAT, Barrett DC, Corley M, Hsu LY, Mendelson M, Collignon P, Laxminarayan R, Peacock SJ, Howard P.

J Antimicrob Chemother. 2019 Sep 3. pii: dkz372. doi: 10.1093/jac/dkz372. [Epub ahead of print] No abstract available.


Genome Sequences of Enteroinvasive Escherichia coli Sequence Type 6, 99, and 311 Strains Acquired in Asia Pacific.

Dhakal R, Wang Q, Howard P, Sintchenko V.

Microbiol Resour Announc. 2019 Sep 5;8(36). pii: e00944-19. doi: 10.1128/MRA.00944-19.


Optimizing impact through the Tiered Doctor of Nursing Practice Project Model.

Melander S, Howard PB, Williams TE, Tharp-Barrie K, El-Mallakh P, MacCallum T.

J Am Assoc Nurse Pract. 2019 Aug 22. doi: 10.1097/JXX.0000000000000283. [Epub ahead of print]


Emergency Care Policy and a Rare Condition: The Impact of Technology.

Howard PK.

J Emerg Nurs. 2019 Sep;45(5):479-480. doi: 10.1016/j.jen.2019.07.011. No abstract available.


Antimicrobial stewardship effectiveness on rationalizing the use of last line of antibiotics in a short period with limited human resources: a single centre cohort study.

Kuruc Poje D, Mađarić V, Janeš Poje V, Kifer D, Howard P, Marušić S.

BMC Res Notes. 2019 Aug 20;12(1):531. doi: 10.1186/s13104-019-4572-x.


Organization and training at national level of antimicrobial stewardship and infection control activities in Europe: an ESCMID cross-sectional survey.

Maraolo AE, Ong DSY, Cimen C, Howard P, Kofteridis DP, Schouten J, Mutters NT, Pulcini C; ESGAP-EUCIC-TAE Working Group on AMS/IPC mapping in Europe.

Eur J Clin Microbiol Infect Dis. 2019 Aug 8. doi: 10.1007/s10096-019-03648-2. [Epub ahead of print]


A Reactive Antibody Platform for One-Step Production of Antibody-Drug Conjugates through a Diels-Alder Reaction with Maleimide.

St Amant AH, Huang F, Lin J, Lemen D, Chakiath C, Mao S, Fazenbaker C, Zhong H, Harper J, Xu W, Patel N, Adams L, Vijayakrishnan B, Howard PW, Marelli M, Wu H, Gao C, Read de Alaniz J, Christie RJ.

Bioconjug Chem. 2019 Aug 19. doi: 10.1021/acs.bioconjchem.9b00436. [Epub ahead of print]


Adaptation of the WHO Essential Medicines List for national antibiotic stewardship policy in England: being AWaRe.

Budd E, Cramp E, Sharland M, Hand K, Howard P, Wilson P, Wilcox M, Muller-Pebody B, Hopkins S.

J Antimicrob Chemother. 2019 Jul 30. pii: dkz321. doi: 10.1093/jac/dkz321. [Epub ahead of print]


'Antibiotic footprint' as a communication tool to aid reduction of antibiotic consumption-authors' response.

Limmathurotsakul D, Sandoe JAT, Barrett DC, Corley M, Hsu LY, Mendelson M, Collignon P, Laxminarayan R, Peacock SJ, Howard P.

J Antimicrob Chemother. 2019 Sep 1;74(9):2823. doi: 10.1093/jac/dkz276. No abstract available.


Caring for our Past, Present, and Future.

Howard PK.

J Emerg Nurs. 2019 Jul;45(4):347-348. doi: 10.1016/j.jen.2019.05.007. No abstract available.


Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers.

Gregson SJ, Barrett AM, Patel NV, Kang GD, Schiavone D, Sult E, Barry CS, Vijayakrishnan B, Adams LR, Masterson LA, D'Hooge F, Snaith M, Harper J, Hartley JA, Howard PW.

Eur J Med Chem. 2019 Oct 1;179:591-607. doi: 10.1016/j.ejmech.2019.06.044. Epub 2019 Jun 18.


National mycology laboratory diagnostic capacity for invasive fungal diseases in 2017: Evidence of sub-optimal practice.

Schelenz S, Owens K, Guy R, Rautemaa-Richardson R, Manuel RJ, Richardson M, Moore C, Enoch DA, Micallef C, Howard P, Agrawal SG, Johnson EM, Muller-Pebody B; English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR).

J Infect. 2019 Aug;79(2):167-173. doi: 10.1016/j.jinf.2019.06.009. Epub 2019 Jun 21.


'Warning: allergic to penicillin': association between penicillin allergy status in 2.3 million NHS general practice electronic health records, antibiotic prescribing and health outcomes.

West RM, Smith CJ, Pavitt SH, Butler CC, Howard P, Bates C, Savic S, Wright JM, Hewison J, Sandoe JAT.

J Antimicrob Chemother. 2019 Jul 1;74(7):2075-2082. doi: 10.1093/jac/dkz127.


Orthopaedic registries - the UK view (National Joint Registry): impact on practice.

Porter M, Armstrong R, Howard P, Porteous M, Wilkinson JM.

EFORT Open Rev. 2019 Jun 3;4(6):377-390. doi: 10.1302/2058-5241.4.180084. eCollection 2019 Jun. Review.


Compositional space: A guide for environmental chemists on the identification of persistent and bioaccumulative organics using mass spectrometry.

Zhang X, Di Lorenzo RA, Helm PA, Reiner EJ, Howard PH, Muir DCG, Sled JG, Jobst KJ.

Environ Int. 2019 Jun 8:104808. doi: 10.1016/j.envint.2019.05.002. [Epub ahead of print]


A single dose of antibody-drug conjugate cures a stage 1 model of African trypanosomiasis.

MacGregor P, Gonzalez-Munoz AL, Jobe F, Taylor MC, Rust S, Sandercock AM, Macleod OJS, Van Bocxlaer K, Francisco AF, D'Hooge F, Tiberghien A, Barry CS, Howard P, Higgins MK, Vaughan TJ, Minter R, Carrington M.

PLoS Negl Trop Dis. 2019 May 23;13(5):e0007373. doi: 10.1371/journal.pntd.0007373. eCollection 2019 May.


'Antibiotic footprint' as a communication tool to aid reduction of antibiotic consumption.

Limmathurotsakul D, Sandoe JAT, Barrett DC, Corley M, Hsu LY, Mendelson M, Collignon P, Laxminarayan R, Peacock SJ, Howard P.

J Antimicrob Chemother. 2019 Aug 1;74(8):2122-2127. doi: 10.1093/jac/dkz185.


Making an Impact: Injury Prevention is a Priority.

Howard PK.

J Emerg Nurs. 2019 May;45(3):237-238. doi: 10.1016/j.jen.2019.03.002. No abstract available.


Measuring Appropriate Antibiotic Prescribing in Acute Hospitals: Development of a National Audit Tool Through a Delphi Consensus.

Hood G, Hand KS, Cramp E, Howard P, Hopkins S, Ashiru-Oredope D.

Antibiotics (Basel). 2019 Apr 29;8(2). pii: E49. doi: 10.3390/antibiotics8020049.


Antimicrobial use in UK long-term care facilities: results of a point prevalence survey.

Thornley T, Ashiru-Oredope D, Beech E, Howard P, Kirkdale CL, Elliott H, Harris C, Roberts A.

J Antimicrob Chemother. 2019 Jul 1;74(7):2083-2090. doi: 10.1093/jac/dkz135.


Discrimination of low- and high-grade appendiceal mucinous neoplasms by targeted sequencing of cancer-related variants.

LaFramboise WA, Pai RK, Petrosko P, Belsky MA, Dhir A, Howard PG, Becich MJ, Holtzman MP, Ahrendt SA, Pingpank JF, Zeh HJ, Dhir R, Bartlett DL, Choudry HA.

Mod Pathol. 2019 Jul;32(8):1197-1209. doi: 10.1038/s41379-019-0256-2. Epub 2019 Apr 8.


Erratum to: Degenerative Expansion of a Young Supergene.

Stolle E, Pracana R, Howard P, Paris CI, Brown SJ, Castillo-Carrillo C, Rossiter SJ, Wurm Y.

Mol Biol Evol. 2019 May 1;36(5):1111. doi: 10.1093/molbev/msz056. No abstract available.


Potentiation of PBD Dimers by Lipophilicity Manipulation.

Cailleau T, Adams LR, Arora N, Kang GD, Masterson L, Patel N, Hartley JA, Mao S, Harper J, Howard PW.

Curr Top Med Chem. 2019;19(9):741-752. doi: 10.2174/1568026619666190401112517.


Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension.

Li Q, Barrett A, Vijayakrishnan B, Tiberghien A, Beard R, Rickert KW, Allen KL, Christie RJ, Marelli M, Harper J, Howard P, Wu H, Dall'Acqua WF, Tsui P, Gao C, Borrok MJ.

Bioconjug Chem. 2019 Apr 17;30(4):1232-1243. doi: 10.1021/acs.bioconjchem.9b00170. Epub 2019 Apr 3.


A One Health investigation of Salmonella enterica serovar Wangata in north-eastern New South Wales, Australia, 2016-2017.

Collins J, Simpson KMJ, Bell G, Durrheim DN, Hill-Cawthorne GA, Hope K, Howard P, Kohlenberg T, Lawrence K, Lilly K, Porigneaux P, Sintchenko V, Wang Q, Ward MP, Wiethoelter A, Mor SM, Flint J.

Epidemiol Infect. 2019 Jan;147:e150. doi: 10.1017/S0950268819000475.


Neurointerventional Procedural Complications in a Growing Canadian Regional Stroke Center: Single Hospital Experience Analysis in the Context of Recommended Case Volumes.

Pasarikovski CR, Tanner BK, Marques AJP, da Costa L, Howard P, Dyer EE, Yang VXD.

World Neurosurg. 2019 Jul;127:e94-e100. doi: 10.1016/j.wneu.2019.02.137. Epub 2019 Mar 6.


Pipeline embolisation device with shield technology for the treatment of ruptured intracranial aneurysm.

Pasarikovski CR, Waggass G, Cardinell J, Howard P, da Costa L, Yang VX.

Neuroradiol J. 2019 Jun;32(3):189-192. doi: 10.1177/1971400919834692. Epub 2019 Mar 6.


Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer.

White JB, Fleming R, Masterson L, Ruddle BT, Zhong H, Fazenbaker C, Strout P, Rosenthal K, Reed M, Muniz-Medina V, Howard P, Dixit R, Wu H, Hinrichs MJ, Gao C, Dimasi N.

MAbs. 2019 Apr;11(3):500-515. doi: 10.1080/19420862.2019.1578611. Epub 2019 Mar 5.


Bisphosphonates: AHFS 92:24.

Toller CS, Charlesworth S, Mihalyo M, Howard P, Wilcock A.

J Pain Symptom Manage. 2019 May;57(5):1018-1030. doi: 10.1016/j.jpainsymman.2019.01.017. Epub 2019 Feb 7.


Antibiotic prescribing for residents in long-term-care facilities across the UK.

Thornley T, Ashiru-Oredope D, Normington A, Beech E, Howard P.

J Antimicrob Chemother. 2019 May 1;74(5):1447-1451. doi: 10.1093/jac/dkz008.


ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification 1.

O'Sullivan C, Nickerson PEB, Krupke O, Christie J, Chen LL, Mesa-Peres M, Zhu M, Ryan B, Chow RL, Howard PL.

Biochem Cell Biol. 2019 Jan 23:1-11. doi: 10.1139/bcb-2018-0250. [Epub ahead of print]


Much to Accomplish.

Howard PK.

J Emerg Nurs. 2019 Jan;45(1):1. doi: 10.1016/j.jen.2018.11.013. No abstract available.


An Alternative Focus for Route Design for the Synthesis of Antibody-Drug Conjugate Payloads.

Tiberghien AC, Howard PW, Goundry WRF, McCormick M, Parker JS.

J Org Chem. 2019 Apr 19;84(8):4830-4836. doi: 10.1021/acs.joc.8b02876. Epub 2019 Jan 11.


Finding the bad actor: Challenges in identifying toxic constituents in botanical dietary supplements.

Roberts GK, Gardner D, Foster PM, Howard PC, Lui E, Walker L, van Breemen RB, Auerbach SS, Rider C.

Food Chem Toxicol. 2019 Feb;124:431-438. doi: 10.1016/j.fct.2018.12.026. Epub 2018 Dec 21. Review.


Degenerative Expansion of a Young Supergene.

Stolle E, Pracana R, Howard P, Paris CI, Brown SJ, Castillo-Carrillo C, Rossiter SJ, Wurm Y.

Mol Biol Evol. 2019 Mar 1;36(3):553-561. doi: 10.1093/molbev/msy236. Erratum in: Mol Biol Evol. 2019 May 1;36(5):1111.


An evidence-based approach to understanding the competency development needs of the health service management workforce in Australia.

Liang Z, Blackstock FC, Howard PF, Briggs DS, Leggat SG, Wollersheim D, Edvardsson D, Rahman A.

BMC Health Serv Res. 2018 Dec 18;18(1):976. doi: 10.1186/s12913-018-3760-z.


Characterization and in vitro data of antibody drug conjugates (ADCs) derived from heterotrifunctional linker designed for the site-specific preparation of dual ADCs.

Kumar A, Kinneer K, Masterson L, Ezeadi E, Howard P, Wu H, Gao C, Dimasi N.

Data Brief. 2018 Nov 6;21:2208-2220. doi: 10.1016/j.dib.2018.11.005. eCollection 2018 Dec.


Evaluation of Pyrrolobenzodiazepine-Loaded Nanoparticles: A Targeted Drug Delivery Approach.

Tyagi P, Pechenov S, RiosDoria J, Masterson L, Dickinson NJ, Howard P, Mao S, Harper J, Wetzel L, Yo K, Subramony JA.

J Pharm Sci. 2019 Apr;108(4):1590-1597. doi: 10.1016/j.xphs.2018.11.023. Epub 2018 Nov 22.


Mapping the Pax6 3' untranslated region microRNA regulatory landscape.

Ryan BC, Lowe K, Hanson L, Gil T, Braun L, Howard PL, Chow RL.

BMC Genomics. 2018 Nov 15;19(1):820. doi: 10.1186/s12864-018-5212-x.


Synthesis of a heterotrifunctional linker for the site-specific preparation of antibody-drug conjugates with two distinct warheads.

Kumar A, Kinneer K, Masterson L, Ezeadi E, Howard P, Wu H, Gao C, Dimasi N.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3617-3621. doi: 10.1016/j.bmcl.2018.10.043. Epub 2018 Oct 26.


Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment.

Eustaquio T, Wang C, Dugard CK, George NI, Liu F, Slikker W Jr, Paule MG, Howard PC, Paredes AM.

Exp Cell Res. 2018 Dec 15;373(1-2):164-170. doi: 10.1016/j.yexcr.2018.10.009. Epub 2018 Oct 18.


Preclinical assessment of an antibody-PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells.

Kinneer K, Flynn M, Thomas SB, Meekin J, Varkey R, Xiao X, Zhong H, Breen S, Hynes PG, Fleming R, Bezabeh B, Chen CT, Wetzel L, Chen R, Dimasi N, Tai YT, Anderson KC, Herbst R, Howard PW, Hurt EM, Tice DA.

Leukemia. 2019 Mar;33(3):766-771. doi: 10.1038/s41375-018-0278-7. Epub 2018 Oct 12. No abstract available.


Using long term mortality to determine which perioperative risk factors of mortality following hip and knee replacement may be causal.

Hunt LP, Whitehouse MR, Howard PW, Ben-Shlomo Y, Blom AW.

Sci Rep. 2018 Oct 9;8(1):15026. doi: 10.1038/s41598-018-33314-0.


High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation.

Jakubovic R, Guha D, Gupta S, Lu M, Jivraj J, Standish BA, Leung MK, Mariampillai A, Lee K, Siegler P, Skowron P, Farooq H, Nguyen N, Alarcon J, Deorajh R, Ramjist J, Ford M, Howard P, Phan N, Costa LD, Heyn C, Tan G, George R, Cadotte DW, Mainprize T, Yee A, Yang VXD.

Sci Rep. 2018 Oct 5;8(1):14894. doi: 10.1038/s41598-018-32424-z.


Protecting Pax6 3' UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model.

Yongblah K, Alford SC, Ryan BC, Chow RL, Howard PL.

Mol Ther Nucleic Acids. 2018 Dec 7;13:144-153. doi: 10.1016/j.omtn.2018.08.018. Epub 2018 Sep 1.


Functional Neuroanatomy of Second Language Sentence Comprehension: An fMRI Study of Late Learners of American Sign Language.

Johnson L, Fitzhugh MC, Yi Y, Mickelsen S, Baxter LC, Howard P, Rogalsky C.

Front Psychol. 2018 Sep 6;9:1626. doi: 10.3389/fpsyg.2018.01626. eCollection 2018.


SLC46A3 as a Potential Predictive Biomarker for Antibody-Drug Conjugates Bearing Noncleavable Linked Maytansinoid and Pyrrolobenzodiazepine Warheads.

Kinneer K, Meekin J, Tiberghien AC, Tai YT, Phipps S, Kiefer CM, Rebelatto MC, Dimasi N, Moriarty A, Papadopoulos KP, Sridhar S, Gregson SJ, Wick MJ, Masterson L, Anderson KC, Herbst R, Howard PW, Tice DA.

Clin Cancer Res. 2018 Dec 15;24(24):6570-6582. doi: 10.1158/1078-0432.CCR-18-1300. Epub 2018 Aug 21.


Kinesin-1 Proteins KIF5A, -5B, and -5C Promote Anterograde Transport of Herpes Simplex Virus Enveloped Virions in Axons.

DuRaine G, Wisner TW, Howard P, Johnson DC.

J Virol. 2018 Sep 26;92(20). pii: e01269-18. doi: 10.1128/JVI.01269-18. Print 2018 Oct 15.


Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody-Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer.

Cho S, Zammarchi F, Williams DG, Havenith CEG, Monks NR, Tyrer P, D'Hooge F, Fleming R, Vashisht K, Dimasi N, Bertelli F, Corbett S, Adams L, Reinert HW, Dissanayake S, Britten CE, King W, Dacosta K, Tammali R, Schifferli K, Strout P, Korade M 3rd, Masson Hinrichs MJ, Chivers S, Corey E, Liu H, Kim S, Bander NH, Howard PW, Hartley JA, Coats S, Tice DA, Herbst R, van Berkel PH.

Mol Cancer Ther. 2018 Oct;17(10):2176-2186. doi: 10.1158/1535-7163.MCT-17-0982. Epub 2018 Jul 31.


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