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Items: 1 to 50 of 122

1.

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomašević Z, Denduluri N, Šeparović R, Gokmen E, Bashford A, Ruiz Borrego M, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M, Chan A; ExteNET Study Group.

Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13.

PMID:
29146401
2.

US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer.

Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji T, White JD.

J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx007.

3.

Enhanced immunostimulatory effects of DNA-encapsulated peptide hydrogels.

Medina SH, Li S, Howard OM, Dunlap M, Trivett A, Schneider JP, Oppenheim JJ.

Biomaterials. 2015;53:545-53. doi: 10.1016/j.biomaterials.2015.02.125. Epub 2015 Mar 23.

PMID:
25890750
4.

IKKα is required for the homeostasis of regulatory T cells and for the expansion of both regulatory and effector CD4 T cells.

Chen X, Willette-Brown J, Wu X, Hu Y, Howard OM, Hu Y, Oppenheim JJ.

FASEB J. 2015 Feb;29(2):443-54. doi: 10.1096/fj.14-259564. Epub 2014 Nov 5.

5.

Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways.

Zhao Z, Fan H, Higgins T, Qi J, Haines D, Trivett A, Oppenheim JJ, Wei H, Li J, Lin H, Howard OM.

Cancer Lett. 2014 Dec 28;355(2):232-41. doi: 10.1016/j.canlet.2014.08.037. Epub 2014 Sep 19.

6.

The Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.

Wei F, Yang D, Tewary P, Li Y, Li S, Chen X, Howard OM, Bustin M, Oppenheim JJ.

Cancer Res. 2014 Nov 1;74(21):5989-98. doi: 10.1158/0008-5472.CAN-13-2042. Epub 2014 Sep 9.

7.

In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo.

Zhou Q, Hu Y, Howard OM, Oppenheim JJ, Chen X.

Cytokine. 2014 Jan;65(1):56-64. doi: 10.1016/j.cyto.2013.09.008. Epub 2013 Sep 27.

8.

β-Defensin 2 and 3 promote the uptake of self or CpG DNA, enhance IFN-α production by human plasmacytoid dendritic cells, and promote inflammation.

Tewary P, de la Rosa G, Sharma N, Rodriguez LG, Tarasov SG, Howard OM, Shirota H, Steinhagen F, Klinman DM, Yang D, Oppenheim JJ.

J Immunol. 2013 Jul 15;191(2):865-74. doi: 10.4049/jimmunol.1201648. Epub 2013 Jun 17.

9.

Alarmin-induced cell migration.

Yang D, Wei F, Tewary P, Howard OM, Oppenheim JJ.

Eur J Immunol. 2013 Jun;43(6):1412-8. doi: 10.1002/eji.201243138. Epub 2013 May 18.

10.

Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells.

Yoshimura T, Howard OM, Ito T, Kuwabara M, Matsukawa A, Chen K, Liu Y, Liu M, Oppenheim JJ, Wang JM.

PLoS One. 2013;8(3):e58791. doi: 10.1371/journal.pone.0058791. Epub 2013 Mar 18.

11.

TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment.

Chen X, Wu X, Zhou Q, Howard OM, Netea MG, Oppenheim JJ.

J Immunol. 2013 Feb 1;190(3):1076-84. doi: 10.4049/jimmunol.1202659. Epub 2012 Dec 31.

12.

Melanoma cell-derived exosomes alter macrophage and dendritic cell functions in vitro.

Marton A, Vizler C, Kusz E, Temesfoi V, Szathmary Z, Nagy K, Szegletes Z, Varo G, Siklos L, Katona RL, Tubak V, Howard OM, Duda E, Minarovits J, Nagy K, Buzas K.

Immunol Lett. 2012 Nov-Dec;148(1):34-8. doi: 10.1016/j.imlet.2012.07.006. Epub 2012 Aug 8.

PMID:
22898052
13.

Interleukin-8-like activity in a filarial asparaginyl-tRNA synthetase.

Kron MA, Wang C, Vodanovic-Jankovic S, Howard OM, Kuhn LA.

Mol Biochem Parasitol. 2012 Sep;185(1):66-9. doi: 10.1016/j.molbiopara.2012.06.003. Epub 2012 Jun 16.

PMID:
22710390
14.

Inducible NOS-induced chloride intracellular channel 4 (CLIC4) nuclear translocation regulates macrophage deactivation.

Malik M, Jividen K, Padmakumar VC, Cataisson C, Li L, Lee J, Howard OM, Yuspa SH.

Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6130-5. doi: 10.1073/pnas.1201351109. Epub 2012 Apr 2.

15.

Structural plasticity of a transmembrane peptide allows self-assembly into biologically active nanoparticles.

Tarasov SG, Gaponenko V, Howard OM, Chen Y, Oppenheim JJ, Dyba MA, Subramaniam S, Lee Y, Michejda C, Tarasova NI.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9798-803. doi: 10.1073/pnas.1014598108. Epub 2011 May 31.

16.

Painful pathways induced by TLR stimulation of dorsal root ganglion neurons.

Qi J, Buzas K, Fan H, Cohen JI, Wang K, Mont E, Klinman D, Oppenheim JJ, Howard OM.

J Immunol. 2011 Jun 1;186(11):6417-26. doi: 10.4049/jimmunol.1001241. Epub 2011 Apr 22.

17.

Gene from a psoriasis susceptibility locus primes the skin for inflammation.

Wolf R, Mascia F, Dharamsi A, Howard OM, Cataisson C, Bliskovski V, Winston J, Feigenbaum L, Lichti U, Ruzicka T, Chavakis T, Yuspa SH.

Sci Transl Med. 2010 Dec 8;2(61):61ra90. doi: 10.1126/scitranslmed.3001108.

18.

Expression of costimulatory TNFR2 induces resistance of CD4+FoxP3- conventional T cells to suppression by CD4+FoxP3+ regulatory T cells.

Chen X, Hamano R, Subleski JJ, Hurwitz AA, Howard OM, Oppenheim JJ.

J Immunol. 2010 Jul 1;185(1):174-82. doi: 10.4049/jimmunol.0903548. Epub 2010 Jun 4.

19.

The G-protein-coupled formylpeptide receptor FPR confers a more invasive phenotype on human glioblastoma cells.

Huang J, Chen K, Chen J, Gong W, Dunlop NM, Howard OM, Gao Y, Bian XW, Wang JM.

Br J Cancer. 2010 Mar 16;102(6):1052-60. doi: 10.1038/sj.bjc.6605591. Epub 2010 Mar 2.

20.

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.

Chen X, Subleski JJ, Hamano R, Howard OM, Wiltrout RH, Oppenheim JJ.

Eur J Immunol. 2010 Apr;40(4):1099-106. doi: 10.1002/eji.200940022.

21.

An inhibitor of CCL2-induced chemotaxis from the fungus Leptoxyphium sp.

Klausmeyer P, Howard OM, Shipley SM, McCloud TG.

J Nat Prod. 2009 Aug;72(8):1369-72. doi: 10.1021/np800745r.

PMID:
19637889
22.

Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.

Huang J, Chen K, Huang J, Gong W, Dunlop NM, Howard OM, Bian X, Gao Y, Wang JM.

Carcinogenesis. 2009 Feb;30(2):348-55. doi: 10.1093/carcin/bgn266. Epub 2008 Nov 26.

23.

Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15.

Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH.

J Immunol. 2008 Jul 15;181(2):1499-506.

24.
25.

Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells.

Kopf H, de la Rosa GM, Howard OM, Chen X.

Int Immunopharmacol. 2007 Dec 15;7(13):1819-24. Epub 2007 Sep 20.

26.

Functional and genomic analyses of FOXP3-transduced Jurkat-T cells as regulatory T (Treg)-like cells.

Kim JY, Kim HJ, Hurt EM, Chen X, Howard OMZ, Farrar WL.

Biochem Biophys Res Commun. 2007 Oct 12;362(1):44-50. doi: 10.1016/j.bbrc.2007.07.187. Epub 2007 Aug 10.

PMID:
17706604
27.

Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells.

Chen X, Bäumel M, Männel DN, Howard OM, Oppenheim JJ.

J Immunol. 2007 Jul 1;179(1):154-61.

28.

Transactivation of the epidermal growth factor receptor by formylpeptide receptor exacerbates the malignant behavior of human glioblastoma cells.

Huang J, Hu J, Bian X, Chen K, Gong W, Dunlop NM, Howard OM, Wang JM.

Cancer Res. 2007 Jun 15;67(12):5906-13.

29.

Pertussis toxin by inducing IL-6 promotes the generation of IL-17-producing CD4 cells.

Chen X, Howard OM, Oppenheim JJ.

J Immunol. 2007 May 15;178(10):6123-9.

30.

Dendritic cells as a pharmacological target of traditional Chinese medicine.

Chen X, Yang L, Howard OM, Oppenheim JJ.

Cell Mol Immunol. 2006 Dec;3(6):401-10. Review.

31.

Autoantigen signalling through chemokine receptors.

Howard OZ.

Curr Opin Rheumatol. 2006 Nov;18(6):642-6. Review.

PMID:
17053513
32.
33.

The scaffold protein Cybr is required for cytokine-modulated trafficking of leukocytes in vivo.

Coppola V, Barrick CA, Bobisse S, Rodriguez-Galan MC, Pivetta M, Reynolds D, Howard OM, Palko ME, Esteban PF, Young HA, Rosato A, Tessarollo L.

Mol Cell Biol. 2006 Jul;26(14):5249-58.

34.

Brugia malayi asparaginyl-transfer RNA synthetase induces chemotaxis of human leukocytes and activates G-protein-coupled receptors CXCR1 and CXCR2.

Ramirez BL, Howard OM, Dong HF, Edamatsu T, Gao P, Hartlein M, Kron M.

J Infect Dis. 2006 Apr 15;193(8):1164-71. Epub 2006 Mar 6.

PMID:
16544258
35.

Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.

Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM.

Eur J Immunol. 2006 Mar;36(3):671-80.

37.

Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.

Carlos CA, Dong HF, Howard OM, Oppenheim JJ, Hanisch FG, Finn OJ.

J Immunol. 2005 Aug 1;175(3):1628-35.

38.

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.

Dong HF, Wigmore K, Carrington MN, Dean M, Turpin JA, Howard OM.

Genes Immun. 2005 Oct;6(7):609-19.

39.

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.

Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM.

Blood. 2005 Oct 15;106(8):2619-26. Epub 2005 Jun 30.

40.
41.

Formylpeptide receptor FPR and the rapid growth of malignant human gliomas.

Zhou Y, Bian X, Le Y, Gong W, Hu J, Zhang X, Wang L, Iribarren P, Salcedo R, Howard OM, Farrar W, Wang JM.

J Natl Cancer Inst. 2005 Jun 1;97(11):823-35.

PMID:
15928303
42.

Effects of IL-7 and dexamethasone: induction of CD25, the high affinity IL-2 receptor, on human CD4+ cells.

Chung IY, Dong HF, Zhang X, Hassanein NM, Howard OM, Oppenheim JJ, Chen X.

Cell Immunol. 2004 Nov-Dec;232(1-2):57-63.

PMID:
15922716
43.

Autoantigens act as tissue-specific chemoattractants.

Oppenheim JJ, Dong HF, Plotz P, Caspi RR, Dykstra M, Pierce S, Martin R, Carlos C, Finn O, Koul O, Howard OM.

J Leukoc Biol. 2005 Jun;77(6):854-61. Review.

PMID:
15917448
44.
45.

Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.

Krakauer T, Chen X, Howard OM, Young HA.

Immunopharmacol Immunotoxicol. 2005;27(1):53-66.

PMID:
15803859
46.

Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate.

Howard OM, Dong HF, Su SB, Caspi RR, Chen X, Plotz P, Oppenheim JJ.

Blood. 2005 Jun 1;105(11):4207-14. Epub 2005 Feb 15.

47.

Human ribonuclease A superfamily members, eosinophil-derived neurotoxin and pancreatic ribonuclease, induce dendritic cell maturation and activation.

Yang D, Chen Q, Rosenberg HF, Rybak SM, Newton DL, Wang ZY, Fu Q, Tchernev VT, Wang M, Schweitzer B, Kingsmore SF, Patel DD, Oppenheim JJ, Howard OM.

J Immunol. 2004 Nov 15;173(10):6134-42.

48.

An expanding appreciation of the role chemokine receptors play in cancer progression.

Howard OM, Galligan CL.

Curr Pharm Des. 2004;10(19):2377-89. Review.

PMID:
15279615
49.

Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation.

Chen X, Krakauer T, Oppenheim JJ, Howard OM.

J Altern Complement Med. 2004 Jun;10(3):519-26.

PMID:
15253857
50.

Functional redundancy of the human CCL4 and CCL4L1 chemokine genes.

Howard OM, Turpin JA, Goldman R, Modi WS.

Biochem Biophys Res Commun. 2004 Jul 30;320(3):927-31.

PMID:
15240137

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