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Items: 1 to 50 of 86

1.

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.

Anandagoda N, Willis JC, Hertweck A, Roberts LB, Jackson I, Gökmen MR, Jenner RG, Howard JK, Lord GM.

J Clin Invest. 2019 Mar 1;129(3):1257-1271. doi: 10.1172/JCI124725. Epub 2019 Feb 11.

2.

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function.

Garrido-Mesa N, Schroeder JH, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V, MacDonald TT, Howard JK, Grencis RK, Powell N, Lord GM.

Mucosal Immunol. 2019 Jan;12(1):51-63. doi: 10.1038/s41385-018-0092-6. Epub 2018 Oct 24.

3.

Comparison of the in vivo induction and transmission of α-synuclein pathology by mutant α-synuclein fibril seeds in transgenic mice.

Rutherford NJ, Dhillon JS, Riffe CJ, Howard JK, Brooks M, Giasson BI.

Hum Mol Genet. 2017 Dec 15;26(24):4906-4915. doi: 10.1093/hmg/ddx371.

4.

Prion-like transmission of α-synuclein pathology in the context of an NFL null background.

Rutherford NJ, Brooks M, Riffe CJ, Gorion KM, Howard JK, Dhillon JS, Giasson BI.

Neurosci Lett. 2017 Nov 20;661:114-120. doi: 10.1016/j.neulet.2017.09.054. Epub 2017 Sep 28.

5.

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety.

Brooks L, Viardot A, Tsakmaki A, Stolarczyk E, Howard JK, Cani PD, Everard A, Sleeth ML, Psichas A, Anastasovskaj J, Bell JD, Bell-Anderson K, Mackay CR, Ghatei MA, Bloom SR, Frost G, Bewick GA.

Mol Metab. 2016 Nov 4;6(1):48-60. doi: 10.1016/j.molmet.2016.10.011. eCollection 2017 Jan.

6.

Robust Central Nervous System Pathology in Transgenic Mice following Peripheral Injection of α-Synuclein Fibrils.

Ayers JI, Brooks MM, Rutherford NJ, Howard JK, Sorrentino ZA, Riffe CJ, Giasson BI.

J Virol. 2017 Jan 3;91(2). pii: e02095-16. doi: 10.1128/JVI.02095-16. Print 2017 Jan 15.

7.

Visible light dye-photosensitised oxidation of pyrroles using a simple LED photoreactor.

Howard JK, Rihak KJ, Hyland CJ, Bissember AC, Smith JA.

Org Biomol Chem. 2016 Sep 21;14(37):8873-8880.

PMID:
27722413
8.

Three new species of western California springsnails previously confused with Pyrgulopsis stearnsiana (Caenogastropoda, Hydrobiidae).

Hershler R, Liu HP, Babbitt C, Kellogg MG, Howard JK.

Zookeys. 2016 Jun 29;(601):1-19. doi: 10.3897/zookeys.601.9040. eCollection 2016.

9.

An Enantio- and Diastereoselective Chemoenzymatic Synthesis of α-Fluoro β-Hydroxy Carboxylic Esters.

Howard JK, Müller M, Berry A, Nelson A.

Angew Chem Int Ed Engl. 2016 Jun 1;55(23):6767-70. doi: 10.1002/anie.201602852. Epub 2016 Apr 19.

10.

High Time for Conservation: Adding the Environment to the Debate on Marijuana Liberalization.

Carah JK, Howard JK, Thompson SE, Short Gianotti AG, Bauer SD, Carlson SM, Dralle DN, Gabriel MW, Hulette LL, Johnson BJ, Knight CA, Kupferberg SJ, Martin SL, Naylor RL, Power ME.

Bioscience. 2015 Aug 1;65(8):822-829. Epub 2015 Jun 19.

11.

Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology.

Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ 3rd, Howard JK, Golde TE, Giasson BI, Borchelt DR.

Acta Neuropathol. 2016 Jan;131(1):151-4. doi: 10.1007/s00401-015-1505-1. Epub 2015 Nov 5. No abstract available.

12.

The Oxidation of Pyrrole.

Howard JK, Rihak KJ, Bissember AC, Smith JA.

Chem Asian J. 2016 Jan;11(2):155-67. doi: 10.1002/asia.201500659. Epub 2015 Sep 21. Review.

PMID:
26294175
13.

Recanalisation and ulcer recurrence rates following ultrasound-guided foam sclerotherapy.

Howard JK, Slim FJ, Wakely MC, Emerson LG, Davies CE, Kulkarni SR, Bulbulia RA, Whyman MR, Poskitt KR.

Phlebology. 2016 Aug;31(7):506-13. doi: 10.1177/0268355515598450. Epub 2015 Jul 29.

PMID:
26224059
14.

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice.

Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI.

Mol Neurodegener. 2015 Jul 30;10:32. doi: 10.1186/s13024-015-0029-4.

15.

Patterns of Freshwater Species Richness, Endemism, and Vulnerability in California.

Howard JK, Klausmeyer KR, Fesenmyer KA, Furnish J, Gardali T, Grantham T, Katz JV, Kupferberg S, McIntyre P, Moyle PB, Ode PR, Peek R, Quiñones RM, Rehn AC, Santos N, Schoenig S, Serpa L, Shedd JD, Slusark J, Viers JH, Wright A, Morrison SA.

PLoS One. 2015 Jul 6;10(7):e0130710. doi: 10.1371/journal.pone.0130710. eCollection 2015. Erratum in: PLoS One. 2016;11(7):e0158927.

16.

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Alhabbab R, Blair P, Elgueta R, Stolarczyk E, Marks E, Becker PD, Ratnasothy K, Smyth L, Safinia N, Sharif-Paghaleh E, O'Connell S, Noelle RJ, Lord GM, Howard JK, Spencer J, Lechler RI, Lombardi G.

Sci Rep. 2015 Jun 25;5:11554. doi: 10.1038/srep11554.

17.

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.

Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F, Goldberg R, Scott P, Canavan JB, Perucha E, Garrido-Mesa N, Irving PM, Sanderson JD, Hayee B, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Gastroenterology. 2015 Aug;149(2):456-67.e15. doi: 10.1053/j.gastro.2015.04.017. Epub 2015 Apr 25.

18.

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.

Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E, Lo JW, Powell N, Fazekasova H, Irving PM, Sanderson JD, Howard JK, Yagel S, Afzali B, MacDonald TT, Hernandez-Fuentes MP, Shpigel NY, Lombardi G, Lord GM.

Gut. 2016 Apr;65(4):584-94. doi: 10.1136/gutjnl-2014-306919. Epub 2015 Feb 24.

19.

Transitional-2 B cells acquire regulatory function during tolerance induction and contribute to allograft survival.

Moreau A, Blair PA, Chai JG, Ratnasothy K, Stolarczyk E, Alhabbab R, Rackham CL, Jones PM, Smyth L, Elgueta R, Howard JK, Lechler RI, Lombardi G.

Eur J Immunol. 2015 Mar;45(3):843-53. doi: 10.1002/eji.201445082. Epub 2014 Dec 16.

20.

Synthesis of nitrogen-substituted methylenecyclopropanes by strain-driven Overman rearrangement of cyclopropenylmethyl trichloroacetimidates.

Howard JK, Amin C, Lainhart B, Smith JA, Rimington J, Hyland CJ.

J Org Chem. 2014 Sep 5;79(17):8462-8. doi: 10.1021/jo501423u. Epub 2014 Aug 22.

PMID:
25101760
21.

The immune cell transcription factor T-bet: A novel metabolic regulator.

Stolarczyk E, Lord GM, Howard JK.

Adipocyte. 2014 Jan 1;3(1):58-62. doi: 10.4161/adip.26220. Epub 2013 Aug 28.

22.

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

Gökmen MR, Dong R, Kanhere A, Powell N, Perucha E, Jackson I, Howard JK, Hernandez-Fuentes M, Jenner RG, Lord GM.

J Immunol. 2013 Dec 15;191(12):5925-32. doi: 10.4049/jimmunol.1202254. Epub 2013 Nov 18.

23.

Comparison of population genetic patterns in two widespread freshwater mussels with contrasting life histories in western North America.

Mock KE, Brim Box JC, Chong JP, Furnish J, Howard JK.

Mol Ecol. 2013 Dec;22(24):6060-73. doi: 10.1111/mec.12557. Epub 2013 Nov 14.

PMID:
24118560
24.

Controlled oxidation of pyrroles: synthesis of highly functionalized γ-lactams.

Howard JK, Hyland CJ, Just J, Smith JA.

Org Lett. 2013 Apr 5;15(7):1714-7. doi: 10.1021/ol400491p. Epub 2013 Mar 25.

PMID:
23697385
25.

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.

Stolarczyk E, Vong CT, Perucha E, Jackson I, Cawthorne MA, Wargent ET, Powell N, Canavan JB, Lord GM, Howard JK.

Cell Metab. 2013 Apr 2;17(4):520-33. doi: 10.1016/j.cmet.2013.02.019.

26.

LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice.

Archer A, Stolarczyk E, Doria ML, Helguero L, Domingues R, Howard JK, Mode A, Korach-André M, Gustafsson JÅ.

J Lipid Res. 2013 May;54(5):1300-11. doi: 10.1194/jlr.M033977. Epub 2013 Feb 27.

27.

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A, Curtis MA, Jenner RG, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Immunity. 2012 Oct 19;37(4):674-84. doi: 10.1016/j.immuni.2012.09.008. Epub 2012 Oct 11.

28.

Chemoselective reduction of 2-acyl-N-sulfonylpyrroles: synthesis of 3-pyrrolines and 2-alkylpyrroles.

You HT, Grosse AC, Howard JK, Hyland CJ, Just J, Molesworth PP, Smith JA.

Org Biomol Chem. 2011 May 21;9(10):3948-53. doi: 10.1039/c1ob05111c. Epub 2011 Mar 29.

PMID:
21445438
29.

Genetic structuring in the freshwater mussel Anodonta corresponds with major hydrologic basins in the western United States.

Mock KE, Box JC, Chong JP, Howard JK, Nez DA, Wolf D, Gardner RS.

Mol Ecol. 2010 Feb;19(3):569-91. doi: 10.1111/j.1365-294X.2009.04468.x. Epub 2010 Jan 12.

PMID:
20070523
30.

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS.

Diabetes. 2007 Sep;56(9):2242-50. Epub 2007 May 1.

31.

Attenuation of leptin and insulin signaling by SOCS proteins.

Howard JK, Flier JS.

Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28. Review.

PMID:
17010638
32.

Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

Kievit P, Howard JK, Badman MK, Balthasar N, Coppari R, Mori H, Lee CE, Elmquist JK, Yoshimura A, Flier JS.

Cell Metab. 2006 Aug;4(2):123-32.

33.

Identification of SYT-SSX transcripts from synovial sarcomas using RT-multiplex PCR and capillary electrophoresis.

Thorson JA, Weigelin HC, Ruiz RE, Howard JK, Lucas DR.

Mod Pathol. 2006 May;19(5):641-7.

34.

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS.

Nat Med. 2004 Jul;10(7):734-8. Epub 2004 Jun 27.

PMID:
15220914
35.

Leptin prevents the fall in plasma osteocalcin during starvation in male mice.

Goldstone AP, Howard JK, Lord GM, Ghatei MA, Gardiner JV, Wang ZL, Wang RM, Girgis SI, Bailey CJ, Bloom SR.

Biochem Biophys Res Commun. 2002 Jul 12;295(2):475-81.

PMID:
12150974
36.

Leptin inhibits the anti-CD3-driven proliferation of peripheral blood T cells but enhances the production of proinflammatory cytokines.

Lord GM, Matarese G, Howard JK, Bloom SR, Lechler RI.

J Leukoc Biol. 2002 Aug;72(2):330-8.

PMID:
12149424
37.

Visceral adipose tissue and metabolic complications of obesity are reduced in Prader-Willi syndrome female adults: evidence for novel influences on body fat distribution.

Goldstone AP, Thomas EL, Brynes AE, Bell JD, Frost G, Saeed N, Hajnal JV, Howard JK, Holland A, Bloom SR.

J Clin Endocrinol Metab. 2001 Sep;86(9):4330-8.

PMID:
11549670
38.

Leptin potentiates experimental autoimmune encephalomyelitis in SJL female mice and confers susceptibility to males.

Matarese G, Sanna V, Di Giacomo A, Lord GM, Howard JK, Bloom SR, Lechler RI, Fontana S, Zappacosta S.

Eur J Immunol. 2001 May;31(5):1324-32.

39.

Requirement for leptin in the induction and progression of autoimmune encephalomyelitis.

Matarese G, Di Giacomo A, Sanna V, Lord GM, Howard JK, Di Tuoro A, Bloom SR, Lechler RI, Zappacosta S, Fontana S.

J Immunol. 2001 May 15;166(10):5909-16.

40.

The bioenergetics of the immune system.

Lord GM, Matarese G, Howard JK, Lechler RI.

Science. 2001 May 4;292(5518):855-6. No abstract available.

PMID:
11341277
41.

Increased leptin levels in serum and peritoneal fluid of patients with pelvic endometriosis.

Matarese G, Alviggi C, Sanna V, Howard JK, Lord GM, Carravetta C, Fontana S, Lechler RI, Bloom SR, De Placido G.

J Clin Endocrinol Metab. 2000 Jul;85(7):2483-7.

PMID:
10902797
42.

Starvation, leptin and epithelial cell proliferation in the gastrointestinal tract of the mouse.

Chaudhary M, Mandir N, FitzGerald AJ, Howard JK, Lord GM, Ghatei MA, Bloom SR, Goodlad RA.

Digestion. 2000;61(4):223-9.

PMID:
10878448
43.

Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice.

Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SR.

J Clin Invest. 1999 Oct;104(8):1051-9.

44.

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression.

Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI.

Nature. 1998 Aug 27;394(6696):897-901.

PMID:
9732873
45.

Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents.

Goldstone AP, Mercer JG, Gunn I, Moar KM, Edwards CM, Rossi M, Howard JK, Rasheed S, Turton MD, Small C, Heath MM, O'Shea D, Steere J, Meeran K, Ghatei MA, Hoggard N, Bloom SR.

FEBS Lett. 1997 Sep 29;415(2):134-8.

46.

Plasma immunoreactive leptin concentration in end-stage renal disease.

Howard JK, Lord GM, Clutterbuck EJ, Ghatei MA, Pusey CD, Bloom SR.

Clin Sci (Lond). 1997 Aug;93(2):119-26.

PMID:
9301426
47.

Neuropeptide Y induced feeding in the rat is mediated by a novel receptor.

O'Shea D, Morgan DG, Meeran K, Edwards CM, Turton MD, Choi SJ, Heath MM, Gunn I, Taylor GM, Howard JK, Bloom CI, Small CJ, Haddo O, Ma JJ, Callinan W, Smith DM, Ghatei MA, Bloom SR.

Endocrinology. 1997 Jan;138(1):196-202.

PMID:
8977404
48.

A cardiovascular risk reduction program for the classroom.

Howard JK, Bindler RM, Synoground G, van Gemert FC.

J Sch Nurs. 1996 Dec;12(4):4-11.

PMID:
9043262
49.

Antiferromagnetic interlayer correlations in annealed Ni80Fe20/Ag multilayers.

Borchers JA, Gehring PM, Erwin RW, Ankner JF, Majkrzak CF, Hylton TL, Coffey KR, Parker MA, Howard JK.

Phys Rev B Condens Matter. 1996 Oct 1;54(14):9870-9882. No abstract available.

PMID:
9984722
50.

"Success" in family nursing: experts describe phenomena.

Kirschling JM, Gilliss CL, Krentz L, Camburn CD, Clough RS, Duncan MT, Hendricks J, Howard JK, Roberts C, Smith-Young J, et al.

Nurs Health Care. 1994 Apr;15(4):186-9. No abstract available.

PMID:
7970250

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