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Methods for the Measurement of Early Events in Toxoplasma gondii Immunity in Mouse Cells.

Alvarez C, Campos AC, Howard JC, Loureiro J, Müller UB, Rodrigues AL.

Methods Mol Biol. 2020;2071:371-409. doi: 10.1007/978-1-4939-9857-9_20.


Soft Tissue Infection with Diaporthe phaseolorum in Heart Transplant Recipient with End-Stage Renal Failure.

Howard JC, Chen K, Werno A, Metcalf S.

Emerg Infect Dis. 2019 Sep;25(9):1748-1749. doi: 10.3201/eid2509.190768. Epub 2019 Sep 17.


Author Correction: Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.

Murillo-León M, Müller UB, Zimmermann I, Singh S, Widdershoven P, Campos C, Alvarez C, Könen-Waisman S, Lukes N, Ruzsics Z, Howard JC, Schwemmle M, Steinfeldt T.

Nat Commun. 2019 Apr 4;10(1):1645. doi: 10.1038/s41467-019-09648-2.


Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice.

Murillo-León M, Müller UB, Zimmermann I, Singh S, Widdershooven P, Campos C, Alvarez C, Könen-Waisman S, Lukes N, Ruzsics Z, Howard JC, Schwemmle M, Steinfeldt T.

Nat Commun. 2019 Mar 15;10(1):1233. doi: 10.1038/s41467-019-09200-2. Erratum in: Nat Commun. 2019 Apr 4;10(1):1645.


Calculating Optical Rotatory Dispersion Spectra in Solution Using a Smooth Dielectric Model.

Howard JC, Crawford TD.

J Phys Chem A. 2018 Nov 1;122(43):8557-8564. doi: 10.1021/acs.jpca.8b07803. Epub 2018 Oct 22.



Howard JC.

Educ Prim Care. 2018 Jul;29(4):199-200. doi: 10.1080/14739879.2018.1493953. Epub 2018 Aug 21. No abstract available.


Geographical and temporal clustering of OXA-48-producing Escherichia coli ST410 causing community-onset urinary tract infection in Christchurch, New Zealand.

Howard JC, Anderson T, Creighton J, Freeman JT.

J Antimicrob Chemother. 2018 Oct 1;73(10):2900-2901. doi: 10.1093/jac/dky269. No abstract available.


Performance of Property-Optimized Basis Sets for Optical Rotation with Coupled Cluster Theory.

Howard JC, Sowndarya S V S, Ansari IM, Mach TJ, Baranowska-Łączkowska A, Crawford TD.

J Phys Chem A. 2018 Jul 19;122(28):5962-5969. doi: 10.1021/acs.jpca.8b04183. Epub 2018 Jul 3.


Dissociation Energy of the H2O···HF Dimer.

Sexton TM, Howard JC, Tschumper GS.

J Phys Chem A. 2018 May 31;122(21):4902-4908. doi: 10.1021/acs.jpca.8b03397. Epub 2018 May 14.


Electronically Excited States in Solution via a Smooth Dielectric Model Combined with Equation-of-Motion Coupled Cluster Theory.

Howard JC, Womack JC, Dziedzic J, Skylaris CK, Pritchard BP, Crawford TD.

J Chem Theory Comput. 2017 Nov 14;13(11):5572-5581. doi: 10.1021/acs.jctc.7b00833. Epub 2017 Oct 17.


Drivers of excess costs of opioid abuse among a commercially insured population.

Scarpati LM, Kirson NY, Zichlin ML, Jia ZB, Birnbaum HG, Howard JC.

Am J Manag Care. 2017 May;23(5):276-282.


Evidence of transmission of an NDM-5-producing Klebsiella pneumoniae in a healthcare facility in New Zealand.

Howard JC, Creighton J, Heffernan H, Werno A.

J Antimicrob Chemother. 2017 Mar 1;72(3):949-951. doi: 10.1093/jac/dkw498. No abstract available.


OxLDL receptor chromatography from live human U937 cells identifies SYK(L) that regulates phagocytosis of oxLDL.

Howard JC, Florentinus-Mefailoski A, Bowden P, Trimble W, Grinstein S, Marshall JG.

Anal Biochem. 2016 Nov 15;513:7-20. doi: 10.1016/j.ab.2016.07.021. Epub 2016 Aug 7.


The impact of Toxoplasma gondii on the mammalian genome.

Müller UB, Howard JC.

Curr Opin Microbiol. 2016 Aug;32:19-25. doi: 10.1016/j.mib.2016.04.009. Epub 2016 Apr 26. Review.


Assessing the accuracy of some popular DFT methods for computing harmonic vibrational frequencies of water clusters.

Howard JC, Enyard JD, Tschumper GS.

J Chem Phys. 2015 Dec 7;143(21):214103. doi: 10.1063/1.4936654.


Getting down to the Fundamentals of Hydrogen Bonding: Anharmonic Vibrational Frequencies of (HF)2 and (H2O)2 from Ab Initio Electronic Structure Computations.

Howard JC, Gray JL, Hardwick AJ, Nguyen LT, Tschumper GS.

J Chem Theory Comput. 2014 Dec 9;10(12):5426-35. doi: 10.1021/ct500860v.


Benchmark Structures and Harmonic Vibrational Frequencies Near the CCSD(T) Complete Basis Set Limit for Small Water Clusters: (H2O)n = 2, 3, 4, 5, 6.

Howard JC, Tschumper GS.

J Chem Theory Comput. 2015 May 12;11(5):2126-36. doi: 10.1021/acs.jctc.5b00225. Epub 2015 Apr 27.


The Toxoplasma gondii rhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7.

Hermanns T, Müller UB, Könen-Waisman S, Howard JC, Steinfeldt T.

Cell Microbiol. 2016 Feb;18(2):244-59. doi: 10.1111/cmi.12499. Epub 2015 Oct 30.


RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.

Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4581-90. doi: 10.1073/pnas.1510031112. Epub 2015 Aug 3.


Correction: Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2015 Jul 9;13(7):e1002199. doi: 10.1371/journal.pbio.1002199. eCollection 2015 Jul. No abstract available.


Identification of the microsporidian Encephalitozoon cuniculi as a new target of the IFNγ-inducible IRG resistance system.

Ferreira-da-Silva Mda F, Springer-Frauenhoff HM, Bohne W, Howard JC.

PLoS Pathog. 2014 Oct 30;10(10):e1004449. doi: 10.1371/journal.ppat.1004449. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2014 Dec;10(12):. da Fonseca Ferreira-da-Silva, Marialice [corrected to Ferreira-da-Silva, Marialice da Fonseca].


Acantholysis: worth a second look?

Howard JC, Russell KJ, Vickers JL, Weiss E.

Dermatol Surg. 2014 Nov;40(11):1268-70. doi: 10.1097/DSS.0000000000000149. No abstract available.


N-body:Many-body QM:QM vibrational frequencies: application to small hydrogen-bonded clusters.

Howard JC, Tschumper GS.

J Chem Phys. 2013 Nov 14;139(18):184113. doi: 10.1063/1.4829463.


Reciprocal virulence and resistance polymorphism in the relationship between Toxoplasma gondii and the house mouse.

Lilue J, Müller UB, Steinfeldt T, Howard JC.

Elife. 2013 Oct 29;2:e01298. doi: 10.7554/eLife.01298.


Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.

Springer HM, Schramm M, Taylor GA, Howard JC.

J Immunol. 2013 Aug 15;191(4):1765-74. doi: 10.4049/jimmunol.1300641. Epub 2013 Jul 10.


Charge transfer and blue shifting of vibrational frequencies in a hydrogen bond acceptor.

Wright AM, Howard AA, Howard JC, Tschumper GS, Hammer NI.

J Phys Chem A. 2013 Jul 3;117(26):5435-46. doi: 10.1021/jp401642b. Epub 2013 May 24.


Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs).

Spekker K, Leineweber M, Degrandi D, Ince V, Brunder S, Schmidt SK, Stuhlsatz S, Howard JC, Schares G, Degistirici O, Meisel R, Sorg RV, Seissler J, Hemphill A, Pfeffer K, Däubener W.

Med Microbiol Immunol. 2013 Jun;202(3):197-206. doi: 10.1007/s00430-012-0281-y. Epub 2012 Dec 27.


The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence of Toxoplasma gondii.

Fentress SJ, Steinfeldt T, Howard JC, Sibley LD.

Cell Microbiol. 2012 Dec;14(12):1921-33. doi: 10.1111/cmi.12022. Epub 2012 Sep 20.


A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

Fleckenstein MC, Reese ML, Könen-Waisman S, Boothroyd JC, Howard JC, Steinfeldt T.

PLoS Biol. 2012;10(7):e1001358. doi: 10.1371/journal.pbio.1001358. Epub 2012 Jul 10.


Comparative genomics of the apicomplexan parasites Toxoplasma gondii and Neospora caninum: Coccidia differing in host range and transmission strategy.

Reid AJ, Vermont SJ, Cotton JA, Harris D, Hill-Cawthorne GA, Könen-Waisman S, Latham SM, Mourier T, Norton R, Quail MA, Sanders M, Shanmugam D, Sohal A, Wasmuth JD, Brunk B, Grigg ME, Howard JC, Parkinson J, Roos DS, Trees AJ, Berriman M, Pain A, Wastling JM.

PLoS Pathog. 2012;8(3):e1002567. doi: 10.1371/journal.ppat.1002567. Epub 2012 Mar 22.


Adolescents' perceptions of a mobile cell phone text messaging-enhanced intervention and development of a mobile cell phone-based HIV prevention intervention.

Cornelius JB, St Lawrence JS, Howard JC, Shah D, Poka A, McDonald D, White AC.

J Spec Pediatr Nurs. 2012 Jan;17(1):61-9. doi: 10.1111/j.1744-6155.2011.00308.x. Epub 2011 Nov 1.


Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography.

Walsh M, Thomas SG, Howard JC, Evans E, Guyer K, Medvecz A, Swearingen A, Navari RM, Ploplis V, Castellino FJ.

J Extra Corpor Technol. 2011 Sep;43(3):162-7. Review.


Structures, energetics and vibrational frequency shifts of hydrated pyrimidine.

Howard JC, Hammer NI, Tschumper GS.

Chemphyschem. 2011 Dec 9;12(17):3262-73. doi: 10.1002/cphc.201100457. Epub 2011 Oct 12.


The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii.

Howard JC, Hunn JP, Steinfeldt T.

Curr Opin Microbiol. 2011 Aug;14(4):414-21. doi: 10.1016/j.mib.2011.07.002. Epub 2011 Jul 23. Review.


Immunity-related GTPase M (IRGM) proteins influence the localization of guanylate-binding protein 2 (GBP2) by modulating macroautophagy.

Traver MK, Henry SC, Cantillana V, Oliver T, Hunn JP, Howard JC, Beer S, Pfeffer K, Coers J, Taylor GA.

J Biol Chem. 2011 Sep 2;286(35):30471-80. doi: 10.1074/jbc.M111.251967. Epub 2011 Jul 12. Erratum in: J Biol Chem. 2013 Apr 19;288(16):11504.


The IFN-γ-inducible GTPase, Irga6, protects mice against Toxoplasma gondii but not against Plasmodium berghei and some other intracellular pathogens.

Liesenfeld O, Parvanova I, Zerrahn J, Han SJ, Heinrich F, Muñoz M, Kaiser F, Aebischer T, Buch T, Waisman A, Reichmann G, Utermöhlen O, von Stebut E, von Loewenich FD, Bogdan C, Specht S, Saeftel M, Hoerauf A, Mota MM, Könen-Waisman S, Kaufmann SH, Howard JC.

PLoS One. 2011;6(6):e20568. doi: 10.1371/journal.pone.0020568. Epub 2011 Jun 17.


The activation mechanism of Irga6, an interferon-inducible GTPase contributing to mouse resistance against Toxoplasma gondii.

Pawlowski N, Khaminets A, Hunn JP, Papic N, Schmidt A, Uthaiah RC, Lange R, Vopper G, Martens S, Wolf E, Howard JC.

BMC Biol. 2011 Jan 28;9:7. doi: 10.1186/1741-7007-9-7.


Phosphorylation of mouse immunity-related GTPase (IRG) resistance proteins is an evasion strategy for virulent Toxoplasma gondii.

Steinfeldt T, Könen-Waisman S, Tong L, Pawlowski N, Lamkemeyer T, Sibley LD, Hunn JP, Howard JC.

PLoS Biol. 2010 Dec 21;8(12):e1000576. doi: 10.1371/journal.pbio.1000576. Erratum in: PLoS Biol. 2015 Jul;13(7):e1002199.


Spontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidney.

Zeng J, Howard JC.

BMC Biol. 2010 Nov 30;8:142. doi: 10.1186/1741-7007-8-142.


The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.

Hunn JP, Feng CG, Sher A, Howard JC.

Mamm Genome. 2011 Feb;22(1-2):43-54. doi: 10.1007/s00335-010-9293-3. Epub 2010 Oct 30. Review.


UNC93B1 mediates host resistance to infection with Toxoplasma gondii.

Melo MB, Kasperkovitz P, Cerny A, Könen-Waisman S, Kurt-Jones EA, Lien E, Beutler B, Howard JC, Golenbock DT, Gazzinelli RT.

PLoS Pathog. 2010 Aug 26;6(8):e1001071. doi: 10.1371/journal.ppat.1001071.


The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?

Hunn JP, Howard JC.

PLoS Pathog. 2010 Jul 15;6(7):e1001008. doi: 10.1371/journal.ppat.1001008. No abstract available.


The United Kingdom Conference of Educational Advisers (UKCEA) workforce surveys.

Howard JC.

Educ Prim Care. 2010 Jan;21(1):2-5. No abstract available.


Evidence from a UK teaching hospital that MRSA is primarily transmitted by the hands of healthcare workers.

Ludlam HA, Swayne RL, Kearns AM, Brown DF, Howard JC, Gunning K, Burnstein R, Nicholl CG, Brown NM.

J Hosp Infect. 2010 Mar;74(3):296-9. doi: 10.1016/j.jhin.2009.10.008. Epub 2010 Feb 11. No abstract available.


Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

Khaminets A, Hunn JP, Könen-Waisman S, Zhao YO, Preukschat D, Coers J, Boyle JP, Ong YC, Boothroyd JC, Reichmann G, Howard JC.

Cell Microbiol. 2010 Jul;12(7):939-61. doi: 10.1111/j.1462-5822.2010.01443.x. Epub 2010 Jan 26.


Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells.

Zhao YO, Könen-Waisman S, Taylor GA, Martens S, Howard JC.

PLoS One. 2010 Jan 13;5(1):e8648. doi: 10.1371/journal.pone.0008648.


Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemia.

Cooke FJ, Gkrania-Klotsas E, Howard JC, Stone M, Kearns AM, Ganner M, Carmichael AJ, Brown NM.

Clin Microbiol Infect. 2010 Jul;16(7):921-6. doi: 10.1111/j.1469-0691.2009.02969.x. Epub 2009 Nov 11.


Brucella abortus induces Irgm3 and Irga6 expression via type-I IFN by a MyD88-dependent pathway, without the requirement of TLR2, TLR4, TLR5 and TLR9.

Lapaque N, Muller A, Alexopoulou L, Howard JC, Gorvel JP.

Microb Pathog. 2009 Dec;47(6):299-304. doi: 10.1016/j.micpath.2009.09.005. Epub 2009 Sep 9.


Modeling infectious disease in mice: co-adaptation and the role of host-specific IFNgamma responses.

Coers J, Starnbach MN, Howard JC.

PLoS Pathog. 2009 May;5(5):e1000333. doi: 10.1371/journal.ppat.1000333. Epub 2009 May 29. No abstract available.

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