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Items: 1 to 50 of 140

1.

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Monibas RM, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 4. pii: eaav3722. doi: 10.1126/science.aav3722. [Epub ahead of print]

PMID:
31273070
2.

Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.

Pio B, Chobanian HR, Guo Y, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Ashley E, Orr R, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Samuel K, Chen Q, Shang J, Lamca J, Ehrhart J, Nargund R, Howard AD, Colletti SL.

Bioorg Med Chem Lett. 2019 Jul 15;29(14):1842-1848. doi: 10.1016/j.bmcl.2019.04.050. Epub 2019 May 2.

PMID:
31109791
3.

Initial results from the New Horizons exploration of 2014 MU69, a small Kuiper Belt object.

Stern SA, Weaver HA, Spencer JR, Olkin CB, Gladstone GR, Grundy WM, Moore JM, Cruikshank DP, Elliott HA, McKinnon WB, Parker JW, Verbiscer AJ, Young LA, Aguilar DA, Albers JM, Andert T, Andrews JP, Bagenal F, Banks ME, Bauer BA, Bauman JA, Bechtold KE, Beddingfield CB, Behrooz N, Beisser KB, Benecchi SD, Bernardoni E, Beyer RA, Bhaskaran S, Bierson CJ, Binzel RP, Birath EM, Bird MK, Boone DR, Bowman AF, Bray VJ, Britt DT, Brown LE, Buckley MR, Buie MW, Buratti BJ, Burke LM, Bushman SS, Carcich B, Chaikin AL, Chavez CL, Cheng AF, Colwell EJ, Conard SJ, Conner MP, Conrad CA, Cook JC, Cooper SB, Custodio OS, Dalle Ore CM, Deboy CC, Dharmavaram P, Dhingra RD, Dunn GF, Earle AM, Egan AF, Eisig J, El-Maarry MR, Engelbrecht C, Enke BL, Ercol CJ, Fattig ED, Ferrell CL, Finley TJ, Firer J, Fischetti J, Folkner WM, Fosbury MN, Fountain GH, Freeze JM, Gabasova L, Glaze LS, Green JL, Griffith GA, Guo Y, Hahn M, Hals DW, Hamilton DP, Hamilton SA, Hanley JJ, Harch A, Harmon KA, Hart HM, Hayes J, Hersman CB, Hill ME, Hill TA, Hofgartner JD, Holdridge ME, Horányi M, Hosadurga A, Howard AD, Howett CJA, Jaskulek SE, Jennings DE, Jensen JR, Jones MR, Kang HK, Katz DJ, Kaufmann DE, Kavelaars JJ, Keane JT, Keleher GP, Kinczyk M, Kochte MC, Kollmann P, Krimigis SM, Kruizinga GL, Kusnierkiewicz DY, Lahr MS, Lauer TR, Lawrence GB, Lee JE, Lessac-Chenen EJ, Linscott IR, Lisse CM, Lunsford AW, Mages DM, Mallder VA, Martin NP, May BH, McComas DJ, McNutt RL Jr, Mehoke DS, Mehoke TS, Nelson DS, Nguyen HD, Núñez JI, Ocampo AC, Owen WM, Oxton GK, Parker AH, Pätzold M, Pelgrift JY, Pelletier FJ, Pineau JP, Piquette MR, Porter SB, Protopapa S, Quirico E, Redfern JA, Regiec AL, Reitsema HJ, Reuter DC, Richardson DC, Riedel JE, Ritterbush MA, Robbins SJ, Rodgers DJ, Rogers GD, Rose DM, Rosendall PE, Runyon KD, Ryschkewitsch MG, Saina MM, Salinas MJ, Schenk PM, Scherrer JR, Schlei WR, Schmitt B, Schultz DJ, Schurr DC, Scipioni F, Sepan RL, Shelton RG, Showalter MR, Simon M, Singer KN, Stahlheber EW, Stanbridge DR, Stansberry JA, Steffl AJ, Strobel DF, Stothoff MM, Stryk T, Stuart JR, Summers ME, Tapley MB, Taylor A, Taylor HW, Tedford RM, Throop HB, Turner LS, Umurhan OM, Van Eck J, Velez D, Versteeg MH, Vincent MA, Webbert RW, Weidner SE, Weigle GE 2nd, Wendel JR, White OL, Whittenburg KE, Williams BG, Williams KE, Williams SP, Winters HL, Zangari AM, Zurbuchen TH.

Science. 2019 May 17;364(6441). pii: eaaw9771. doi: 10.1126/science.aaw9771.

PMID:
31097641
4.

Allele-specific enhancers mediate associations between LCAT and ABCA1 polymorphisms and HDL metabolism.

Howard AD, Wang X, Prasad M, Sahu AD, Aniba R, Miller M, Hannenhalli S, Chang YC.

PLoS One. 2019 Apr 30;14(4):e0215911. doi: 10.1371/journal.pone.0215911. eCollection 2019.

5.

The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.

Rudenko O, Shang J, Munk A, Ekberg JP, Petersen N, Engelstoft MS, Egerod KL, Hjorth SA, Wu M, Feng Y, Zhou YP, Mokrosinski J, Thams P, Reimann F, Gribble F, Rehfeld JF, Holst JJ, Treebak JT, Howard AD, Schwartz TW.

Mol Metab. 2019 Jan;19:49-64. doi: 10.1016/j.molmet.2018.10.012. Epub 2018 Nov 5.

6.

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists.

Liu W, Hussain Z, Zang Y, Sweis RF, Romero FA, Finke PE, Moningka R, Bao J, Plotkin MA, Shang J, Dingley KH, Salituro G, Murphy BA, Howard AD, Ujjainwalla F, Wood HB, Duffy JL.

ACS Med Chem Lett. 2018 Oct 5;9(11):1088-1093. doi: 10.1021/acsmedchemlett.8b00306. eCollection 2018 Nov 8.

PMID:
30429950
7.

Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition.

Liu W, Shao PP, Liang GB, Bawiec J, He J, Aster SD, Wu M, Chicchi G, Wang J, Tsao KL, Shang J, Salituro G, Zhou YP, Li C, Akiyama TE, Metzger DE, Murphy BA, Howard AD, Weber AE, Duffy JL.

ACS Med Chem Lett. 2018 Sep 12;9(11):1082-1087. doi: 10.1021/acsmedchemlett.8b00305. eCollection 2018 Nov 8.

PMID:
30429949
8.

Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.

Chen HY, Plummer CW, Xiao D, Chobanian HR, DeMong D, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Di Salvo J, Thomas-Fowlkes B, Souza S, Tatosian DA, Chen Q, Hafey MJ, Houle R, Nolting AF, Orr R, Ehrhart J, Weinglass AB, Tschirret-Guth R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2018 Jun 14;9(7):685-690. doi: 10.1021/acsmedchemlett.8b00149. eCollection 2018 Jul 12.

9.

An APOO Pseudogene on Chromosome 5q Is Associated With Low-Density Lipoprotein Cholesterol Levels.

Montasser ME, O'Hare EA, Wang X, Howard AD, McFarland R, Perry JA, Ryan KA, Rice K, Jaquish CE, Shuldiner AR, Miller M, Mitchell BD, Zaghloul NA, Chang YC.

Circulation. 2018 Sep 25;138(13):1343-1355. doi: 10.1161/CIRCULATIONAHA.118.034016.

PMID:
29593015
10.

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.

Pachanski MJ, Kirkland ME, Kosinski DT, Mane J, Cheewatrakoolpong B, Xue J, Szeto D, Forrest G, Miller C, Bunzel M, Plummer CW, Chobanian HR, Miller MW, Souza S, Thomas-Fowlkes BS, Ogawa AM, Weinglass AB, Di Salvo J, Li X, Feng Y, Tatosian DA, Howard AD, Colletti SL, Trujillo ME.

PLoS One. 2017 Oct 20;12(10):e0186033. doi: 10.1371/journal.pone.0186033. eCollection 2017.

11.

GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.

Satapati S, Qian Y, Wu MS, Petrov A, Dai G, Wang SP, Zhu Y, Shen X, Muise ES, Chen Y, Zycband E, Weinglass A, Di Salvo J, Debenham JS, Cox JM, Lan P, Shah V, Previs SF, Erion M, Kelley DE, Wang L, Howard AD, Shang J.

J Lipid Res. 2017 Aug;58(8):1561-1578. doi: 10.1194/jlr.M075044. Epub 2017 Jun 5.

12.

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.

Lu J, Byrne N, Wang J, Bricogne G, Brown FK, Chobanian HR, Colletti SL, Di Salvo J, Thomas-Fowlkes B, Guo Y, Hall DL, Hadix J, Hastings NB, Hermes JD, Ho T, Howard AD, Josien H, Kornienko M, Lumb KJ, Miller MW, Patel SB, Pio B, Plummer CW, Sherborne BS, Sheth P, Souza S, Tummala S, Vonrhein C, Webb M, Allen SJ, Johnston JM, Weinglass AB, Sharma S, Soisson SM.

Nat Struct Mol Biol. 2017 Jul;24(7):570-577. doi: 10.1038/nsmb.3417. Epub 2017 Jun 5.

PMID:
28581512
13.

New Martian valley network volume estimate consistent with ancient ocean and warm and wet climate.

Luo W, Cang X, Howard AD.

Nat Commun. 2017 Jun 5;8:15766. doi: 10.1038/ncomms15766.

14.

GPR40 reduces food intake and body weight through GLP-1.

Gorski JN, Pachanski MJ, Mane J, Plummer CW, Souza S, Thomas-Fowlkes BS, Ogawa AM, Weinglass AB, Di Salvo J, Cheewatrakoolpong B, Howard AD, Colletti SL, Trujillo ME.

Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E37-E47. doi: 10.1152/ajpendo.00435.2016. Epub 2017 Mar 14.

15.

Design and Synthesis of Novel, Selective GPR40 AgoPAMs.

Plummer CW, Clements MJ, Chen H, Rajagopalan M, Josien H, Hagmann WK, Miller M, Trujillo ME, Kirkland M, Kosinski D, Mane J, Pachanski M, Cheewatrakoolpong B, Nolting AF, Orr R, Christensen M, Campeau LC, Wright MJ, Bugianesi R, Souza S, Zhang X, Di Salvo J, Weinglass AB, Tschirret-Guth R, Nargund R, Howard AD, Colletti SL.

ACS Med Chem Lett. 2017 Jan 23;8(2):221-226. doi: 10.1021/acsmedchemlett.6b00443. eCollection 2017 Feb 9.

16.

Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333. doi: 10.1016/j.bmcl.2017.01.082. Epub 2017 Feb 4. No abstract available.

PMID:
28169160
17.

The ESRD Quality Incentive Program: The Current Limitations of Evidence and Data to Develop Measures, Drive Improvement, and Incentivize Outcomes.

Diamond LH, Howard AD.

Adv Chronic Kidney Dis. 2016 Nov;23(6):377-384. doi: 10.1053/j.ackd.2016.11.007. Review.

PMID:
28115082
18.

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.

Guo L, Parker DL, Zang Y, Sweis RF, Liu W, Sherer EC, Buist N, Terebetski J, Kelly T, Bugianesi R, Priest BT, Dingley KH, Li X, Mitelman S, Salituro G, Trujillo ME, Pachanski M, Kirkland M, Powles MA, Eiermann GJ, Feng Y, Shang J, Howard AD, Ujjainwalla F, Sinz CJ, Debenham JS, Edmondson SD, Nargund RP, Hagmann WK, Li D.

ACS Med Chem Lett. 2016 Oct 12;7(12):1107-1111. eCollection 2016 Dec 8.

19.

Clues on the function of Manduca sexta perilipin 2 inferred from developmental and nutrition-dependent changes in its expression.

Chen X, Firdaus SJ, Howard AD, Soulages JL, Arrese EL.

Insect Biochem Mol Biol. 2017 Feb;81:19-31. doi: 10.1016/j.ibmb.2016.12.001. Epub 2016 Dec 7.

20.

Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. doi: 10.1016/j.bmcl.2016.10.054. Epub 2016 Oct 24. Erratum in: Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333.

PMID:
27815121
21.

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).

Ekberg JH, Hauge M, Kristensen LV, Madsen AN, Engelstoft MS, Husted AS, Sichlau R, Egerod KL, Timshel P, Kowalski TJ, Gribble FM, Reiman F, Hansen HS, Howard AD, Holst B, Schwartz TW.

Endocrinology. 2016 Dec;157(12):4561-4569. Epub 2016 Oct 25.

PMID:
27779915
22.

Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice.

Shang J, Castro-Perez JM, Shen X, Zhu Y, Liu H, Qian Y, Previs S, Howard AD, Erion M, Kelley DE, Wang L.

Obesity (Silver Spring). 2016 Sep;24(9):1938-45. doi: 10.1002/oby.21583. Epub 2016 Jul 26.

23.

Corrigendum: Convection in a volatile nitrogen-ice-rich layer drives Pluto's geological vigour.

McKinnon WB, Nimmo F, Wong T, Schenk PM, White OL, Roberts JH, Moore JM, Spencer JR, Howard AD, Umurhan OM, Stern SA, Weaver HA, Olkin CB, Young LA, Smith KE; New Horizons Geology, Geophysics and Imaging Theme Team.

Nature. 2016 Sep 1;537(7618):122. doi: 10.1038/nature18937. Epub 2016 Jul 6. No abstract available.

PMID:
27383784
24.

Convection in a volatile nitrogen-ice-rich layer drives Pluto's geological vigour.

McKinnon WB, Nimmo F, Wong T, Schenk PM, White OL, Roberts JH, Moore JM, Spencer JR, Howard AD, Umurhan OM, Stern SA, Weaver HA, Olkin CB, Young LA, Smith KE; New Horizons Geology, Geophysics and Imaging Theme Team.

Nature. 2016 Jun 2;534(7605):82-5. doi: 10.1038/nature18289. Erratum in: Nature. 2016 Sep 1;537(7618):122.

PMID:
27251279
25.

The geology of Pluto and Charon through the eyes of New Horizons.

Moore JM, McKinnon WB, Spencer JR, Howard AD, Schenk PM, Beyer RA, Nimmo F, Singer KN, Umurhan OM, White OL, Stern SA, Ennico K, Olkin CB, Weaver HA, Young LA, Binzel RP, Buie MW, Buratti BJ, Cheng AF, Cruikshank DP, Grundy WM, Linscott IR, Reitsema HJ, Reuter DC, Showalter MR, Bray VJ, Chavez CL, Howett CJ, Lauer TR, Lisse CM, Parker AH, Porter SB, Robbins SJ, Runyon K, Stryk T, Throop HB, Tsang CC, Verbiscer AJ, Zangari AM, Chaikin AL, Wilhelms DE; New Horizons Science Team.

Science. 2016 Mar 18;351(6279):1284-93. doi: 10.1126/science.aad7055.

26.

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.

He S, Dobbelaar PH, Guo L, Ye Z, Liu J, Jian T, Truong Q, Shah SK, Du W, Qi H, Bakshi RK, Hong Q, Dellureficio JD, Sherer E, Pasternak A, Feng Z, Reibarkh M, Lin M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

Bioorg Med Chem Lett. 2016 Mar 15;26(6):1529-1535. doi: 10.1016/j.bmcl.2016.02.022. Epub 2016 Feb 10.

PMID:
26898814
27.

The Pluto system: Initial results from its exploration by New Horizons.

Stern SA, Bagenal F, Ennico K, Gladstone GR, Grundy WM, McKinnon WB, Moore JM, Olkin CB, Spencer JR, Weaver HA, Young LA, Andert T, Andrews J, Banks M, Bauer B, Bauman J, Barnouin OS, Bedini P, Beisser K, Beyer RA, Bhaskaran S, Binzel RP, Birath E, Bird M, Bogan DJ, Bowman A, Bray VJ, Brozovic M, Bryan C, Buckley MR, Buie MW, Buratti BJ, Bushman SS, Calloway A, Carcich B, Cheng AF, Conard S, Conrad CA, Cook JC, Cruikshank DP, Custodio OS, Dalle Ore CM, Deboy C, Dischner ZJ, Dumont P, Earle AM, Elliott HA, Ercol J, Ernst CM, Finley T, Flanigan SH, Fountain G, Freeze MJ, Greathouse T, Green JL, Guo Y, Hahn M, Hamilton DP, Hamilton SA, Hanley J, Harch A, Hart HM, Hersman CB, Hill A, Hill ME, Hinson DP, Holdridge ME, Horanyi M, Howard AD, Howett CJ, Jackman C, Jacobson RA, Jennings DE, Kammer JA, Kang HK, Kaufmann DE, Kollmann P, Krimigis SM, Kusnierkiewicz D, Lauer TR, Lee JE, Lindstrom KL, Linscott IR, Lisse CM, Lunsford AW, Mallder VA, Martin N, McComas DJ, McNutt RL Jr, Mehoke D, Mehoke T, Melin ED, Mutchler M, Nelson D, Nimmo F, Nunez JI, Ocampo A, Owen WM, Paetzold M, Page B, Parker AH, Parker JW, Pelletier F, Peterson J, Pinkine N, Piquette M, Porter SB, Protopapa S, Redfern J, Reitsema HJ, Reuter DC, Roberts JH, Robbins SJ, Rogers G, Rose D, Runyon K, Retherford KD, Ryschkewitsch MG, Schenk P, Schindhelm E, Sepan B, Showalter MR, Singer KN, Soluri M, Stanbridge D, Steffl AJ, Strobel DF, Stryk T, Summers ME, Szalay JR, Tapley M, Taylor A, Taylor H, Throop HB, Tsang CC, Tyler GL, Umurhan OM, Verbiscer AJ, Versteeg MH, Vincent M, Webbert R, Weidner S, Weigle GE 2nd, White OL, Whittenburg K, Williams BG, Williams K, Williams S, Woods WW, Zangari AM, Zirnstein E.

Science. 2015 Oct 16;350(6258):aad1815. doi: 10.1126/science.aad1815.

28.

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.

Grunddal KV, Ratner CF, Svendsen B, Sommer F, Engelstoft MS, Madsen AN, Pedersen J, Nøhr MK, Egerod KL, Nawrocki AR, Kowalski T, Howard AD, Poulsen SS, Offermanns S, Bäckhed F, Holst JJ, Holst B, Schwartz TW.

Endocrinology. 2016 Jan;157(1):176-94. doi: 10.1210/en.2015-1600. Epub 2015 Oct 15.

PMID:
26469136
29.

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.

Mol Endocrinol. 2015 Sep;29(9):1243-53. doi: 10.1210/me.2014-1335. Epub 2015 Jul 28.

30.

Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists.

Lai Z, He S, Sherer EC, Wu Z, Yu Y, Ball R, Hong Q, Yang DX, Guo L, Li D, Tuang Q, Chicchi GG, Trusca D, Tsao KL, Zhou YP, Howard AD, Nargund RP, Hagmann WK.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3520-5. doi: 10.1016/j.bmcl.2015.06.087. Epub 2015 Jul 4.

PMID:
26199120
31.

Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS.

Watson JA, Bhattacharyya BJ, Vaden JH, Wilson JA, Icyuz M, Howard AD, Phillips E, DeSilva TM, Siegal GP, Bean AJ, King GD, Phillips SE, Miller RJ, Wilson SM.

PLoS Genet. 2015 Jun 26;11(6):e1005290. doi: 10.1371/journal.pgen.1005290. eCollection 2015 Jun.

32.

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.

Shah SK, He S, Guo L, Truong Q, Qi H, Du W, Lai Z, Liu J, Jian T, Hong Q, Dobbelaar P, Ye Z, Sherer E, Feng Z, Yu Y, Wong F, Samuel K, Madiera M, Karanam BV, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Feng Y, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Pachanski M, Fernandez G, Nelson D, Bunting P, Morissette P, Volksdorf S, Kerr J, Zhang BB, Howard AD, Zhou YP, Pasternak A, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2015 Mar 18;6(5):513-7. doi: 10.1021/ml500514w. eCollection 2015 May 14.

33.

Distinct effects of ubiquitin overexpression on NMJ structure and motor performance in mice expressing catalytically inactive USP14.

Vaden JH, Watson JA, Howard AD, Chen PC, Wilson JA, Wilson SM.

Front Mol Neurosci. 2015 Apr 23;8:11. doi: 10.3389/fnmol.2015.00011. eCollection 2015.

34.

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.

Hauge M, Vestmar MA, Husted AS, Ekberg JP, Wright MJ, Di Salvo J, Weinglass AB, Engelstoft MS, Madsen AN, Lückmann M, Miller MW, Trujillo ME, Frimurer TM, Holst B, Howard AD, Schwartz TW.

Mol Metab. 2014 Oct 24;4(1):3-14. doi: 10.1016/j.molmet.2014.10.002. eCollection 2015 Jan.

35.

Correlates of change in health care worker seasonal influenza vaccination rates among dialysis facilities.

Lynch JR, Armistead N, Vinson BB, Howard AD.

Am J Infect Control. 2015 Apr 1;43(4):409-11. doi: 10.1016/j.ajic.2014.12.011. Epub 2015 Feb 10.

PMID:
25681300
36.

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.

He S, Lai Z, Ye Z, Dobbelaar PH, Shah SK, Truong Q, Du W, Guo L, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Reibarkh M, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Fernandez G, Nelson D, Bunting P, Kerr J, Fitzgerald P, Morissette P, Volksdorf S, Eiermann GJ, Li C, Zhang B, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2014 Apr 21;5(7):748-53. doi: 10.1021/ml500028c. eCollection 2014 Jul 10.

37.

Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.

Li D, Wu Z, Yu Y, Ball RG, Guo L, Sherer E, He S, Hong Q, Lai Z, Qi H, Truong Q, Yang DX, Chicchi GG, Tsao KL, Trusca D, Trujillo M, Pachanski M, Eiermann GJ, Howard AD, Zhou YP, Zhang BB, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2014 Apr 24;5(6):690-5. doi: 10.1021/ml500079u. eCollection 2014 Jun 12.

38.

The Quality Incentive Program and how it will influence your practice.

Howard AD.

Nephrol News Issues. 2013 Jan;27(1):20-3. No abstract available.

PMID:
23427471
39.

The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.

Li XN, Herrington J, Petrov A, Ge L, Eiermann G, Xiong Y, Jensen MV, Hohmeier HE, Newgard CB, Garcia ML, Wagner M, Zhang BB, Thornberry NA, Howard AD, Kaczorowski GJ, Zhou YP.

J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. doi: 10.1124/jpet.112.199083. Epub 2012 Nov 16.

PMID:
23161216
40.

Fistula First Breakthrough Initiative (FFBI): lessons about arteriovenous fistula prevalence goals.

Howard AD, Howard RS, Goldstein SL, Meyer KB.

Am J Kidney Dis. 2013 Mar;61(3):523-5. doi: 10.1053/j.ajkd.2012.09.014. Epub 2012 Nov 14. No abstract available.

PMID:
23157938
41.

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.

He S, Ye Z, Truong Q, Shah S, Du W, Guo L, Dobbelaar PH, Lai Z, Liu J, Jian T, Qi H, Bakshi RK, Hong Q, Dellureficio J, Pasternak A, Feng Z, deJesus R, Yang L, Reibarkh M, Bradley SA, Holmes MA, Ball RG, Ruck RT, Huffman MA, Wong F, Samuel K, Reddy VB, Mitelman S, Tong SX, Chicchi GG, Tsao KL, Trusca D, Wu M, Shao Q, Trujillo ME, Eiermann GJ, Li C, Zhang BB, Howard AD, Zhou YP, Nargund RP, Hagmann WK.

ACS Med Chem Lett. 2012 May 7;3(6):484-9. doi: 10.1021/ml300063m. eCollection 2012 Jun 14.

42.

Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.

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