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Items: 1 to 50 of 116

1.

Dynamics and distribution of paxillin, vinculin, zyxin and VASP depend on focal adhesion location and orientation.

Legerstee K, Geverts B, Slotman JA, Houtsmuller AB.

Sci Rep. 2019 Jul 18;9(1):10460. doi: 10.1038/s41598-019-46905-2.

2.

Three-dimensional architecture of common benign and precancerous prostate epithelial lesions.

Verhoef EI, van Cappellen WA, Slotman JA, Kremers GJ, Ewing-Graham PC, Houtsmuller AB, van Royen ME, van Leenders GJLH.

Histopathology. 2019 Jun;74(7):1036-1044. doi: 10.1111/his.13848. Epub 2019 Apr 21.

PMID:
30815904
3.

ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer.

Cato L, de Tribolet-Hardy J, Lee I, Rottenberg JT, Coleman I, Melchers D, Houtman R, Xiao T, Li W, Uo T, Sun S, Kuznik NC, Göppert B, Ozgun F, van Royen ME, Houtsmuller AB, Vadhi R, Rao PK, Li L, Balk SP, Den RB, Trock BJ, Karnes RJ, Jenkins RB, Klein EA, Davicioni E, Gruhl FJ, Long HW, Liu XS, Cato ACB, Lack NA, Nelson PS, Plymate SR, Groner AC, Brown M.

Cancer Cell. 2019 Mar 18;35(3):401-413.e6. doi: 10.1016/j.ccell.2019.01.008. Epub 2019 Feb 14.

PMID:
30773341
4.

CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML.

J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14.

5.

Three-dimensional analysis reveals two major architectural subgroups of prostate cancer growth patterns.

Verhoef EI, van Cappellen WA, Slotman JA, Kremers GJ, Ewing-Graham PC, Houtsmuller AB, van Royen ME, van Leenders GJLH.

Mod Pathol. 2019 Jul;32(7):1032-1041. doi: 10.1038/s41379-019-0221-0. Epub 2019 Feb 8.

6.

Repetitive switching between DNA-binding modes enables target finding by the glucocorticoid receptor.

Keizer VIP, Coppola S, Houtsmuller AB, Geverts B, van Royen ME, Schmidt T, Schaaf MJM.

J Cell Sci. 2019 Feb 25;132(5). pii: jcs217455. doi: 10.1242/jcs.217455.

7.

SMoLR: visualization and analysis of single-molecule localization microscopy data in R.

Paul MW, de Gruiter HM, Lin Z, Baarends WM, van Cappellen WA, Houtsmuller AB, Slotman JA.

BMC Bioinformatics. 2019 Jan 15;20(1):30. doi: 10.1186/s12859-018-2578-3.

8.

Halogen-substituted anthranilic acid derivatives provide a novel chemical platform for androgen receptor antagonists.

Roell D, Rösler TW, Hessenkemper W, Kraft F, Hauschild M, Bartsch S, Abraham TE, Houtsmuller AB, Matusch R, van Royen ME, Baniahmad A.

J Steroid Biochem Mol Biol. 2019 Apr;188:59-70. doi: 10.1016/j.jsbmb.2018.12.005. Epub 2019 Jan 4.

PMID:
30615932
9.

Molecular underpinnings of enzalutamide resistance

Prekovic S, van den Broeck T, Linder S, van Royen ME, Houtsmuller AB, Handle F, Joniau S, Zwart W, Claessens F.

Endocr Relat Cancer. 2018 Nov 1;25(11):R545–R557. doi: 10.1530/ERC-17-0136.

PMID:
30306781
10.

Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.

Steurer B, Janssens RC, Geverts B, Geijer ME, Wienholz F, Theil AF, Chang J, Dealy S, Pothof J, van Cappellen WA, Houtsmuller AB, Marteijn JA.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4368-E4376. doi: 10.1073/pnas.1717920115. Epub 2018 Apr 9.

11.

Staphylococcal Protein A Is a Key Factor in Neutrophil Extracellular Traps Formation.

Hoppenbrouwers T, Sultan AR, Abraham TE, Lemmens-den Toom NA, Hansenová Maňásková S, van Cappellen WA, Houtsmuller AB, van Wamel WJB, de Maat MPM, van Neck JW.

Front Immunol. 2018 Feb 5;9:165. doi: 10.3389/fimmu.2018.00165. eCollection 2018.

12.

Alpha particle spectroscopy using FNTD and SIM super-resolution microscopy.

Kouwenberg JJM, Kremers GJ, Slotman JA, Wolterbeek HT, Houtsmuller AB, Denkova AG, Bos AJJ.

J Microsc. 2018 Jun;270(3):326-334. doi: 10.1111/jmi.12686. Epub 2018 Feb 2.

PMID:
29393521
13.

Correlation profiling of brain sub-cellular proteomes reveals co-assembly of synaptic proteins and subcellular distribution.

Pandya NJ, Koopmans F, Slotman JA, Paliukhovich I, Houtsmuller AB, Smit AB, Li KW.

Sci Rep. 2017 Sep 21;7(1):12107. doi: 10.1038/s41598-017-11690-3.

14.

Fast-spiking Parvalbumin Interneurons are Frequently Myelinated in the Cerebral Cortex of Mice and Humans.

Stedehouder J, Couey JJ, Brizee D, Hosseini B, Slotman JA, Dirven CMF, Shpak G, Houtsmuller AB, Kushner SA.

Cereb Cortex. 2017 Oct 1;27(10):5001-5013. doi: 10.1093/cercor/bhx203.

PMID:
28922832
15.

In vitro induction of NETosis: Comprehensive live imaging comparison and systematic review.

Hoppenbrouwers T, Autar ASA, Sultan AR, Abraham TE, van Cappellen WA, Houtsmuller AB, van Wamel WJB, van Beusekom HMM, van Neck JW, de Maat MPM.

PLoS One. 2017 May 9;12(5):e0176472. doi: 10.1371/journal.pone.0176472. eCollection 2017. Review.

16.

Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging.

Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ.

Cell. 2017 Mar 23;169(1):132-147.e16. doi: 10.1016/j.cell.2017.02.031.

17.

Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair.

Sánchez H, Paul MW, Grosbart M, van Rossum-Fikkert SE, Lebbink JHG, Kanaar R, Houtsmuller AB, Wyman C.

Nucleic Acids Res. 2017 May 5;45(8):4507-4518. doi: 10.1093/nar/gkx084.

18.

Structure of the homodimeric androgen receptor ligand-binding domain.

Nadal M, Prekovic S, Gallastegui N, Helsen C, Abella M, Zielinska K, Gay M, Vilaseca M, Taulès M, Houtsmuller AB, van Royen ME, Claessens F, Fuentes-Prior P, Estébanez-Perpiñá E.

Nat Commun. 2017 Feb 6;8:14388. doi: 10.1038/ncomms14388.

19.

Incorporation of a Valine-Leucine-Lysine-Containing Substrate in the Bacterial Cell Wall.

Hansenová Maňásková S, Bikker FJ, Nazmi K, van Zuidam R, Slotman JA, van Cappellen WA, Houtsmuller AB, Veerman EC, Kaman WE.

Bioconjug Chem. 2016 Oct 19;27(10):2418-2423. Epub 2016 Sep 22.

PMID:
27611478
20.

Actomyosin-dependent dynamic spatial patterns of cytoskeletal components drive mesoscale podosome organization.

Meddens MB, Pandzic E, Slotman JA, Guillet D, Joosten B, Mennens S, Paardekooper LM, Houtsmuller AB, van den Dries K, Wiseman PW, Cambi A.

Nat Commun. 2016 Oct 10;7:13127. doi: 10.1038/ncomms13127.

21.

Insulator speckles associated with long-distance chromatin contacts.

Buxa MK, Slotman JA, van Royen ME, Paul MW, Houtsmuller AB, Renkawitz R.

Biol Open. 2016 Sep 15;5(9):1266-74. doi: 10.1242/bio.019455.

22.

Three-dimensional microscopic analysis of clinical prostate specimens.

van Royen ME, Verhoef EI, Kweldam CF, van Cappellen WA, Kremers GJ, Houtsmuller AB, van Leenders GJ.

Histopathology. 2016 Dec;69(6):985-992. doi: 10.1111/his.13022. Epub 2016 Sep 21.

PMID:
27353346
23.

The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide.

Prekovic S, van Royen ME, Voet AR, Geverts B, Houtman R, Melchers D, Zhang KY, Van den Broeck T, Smeets E, Spans L, Houtsmuller AB, Joniau S, Claessens F, Helsen C.

Mol Cancer Ther. 2016 Jul;15(7):1702-12. doi: 10.1158/1535-7163.MCT-15-0892. Epub 2016 May 16.

24.

Synaptic vesicle dynamic changes in a model of fragile X.

Broek JAC, Lin Z, de Gruiter HM, van 't Spijker H, Haasdijk ED, Cox D, Ozcan S, van Cappellen GWA, Houtsmuller AB, Willemsen R, de Zeeuw CI, Bahn S.

Mol Autism. 2016 Mar 1;7:17. doi: 10.1186/s13229-016-0080-1. eCollection 2016.

25.

SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA.

Nat Commun. 2015 Jul 7;6:7499. doi: 10.1038/ncomms8499.

26.

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells.

Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C.

J Cell Biol. 2015 Mar 16;208(6):857. doi: 10.1083/jcb.20140501402182015c. No abstract available.

27.

Automated spherical aberration correction in scanning confocal microscopy.

Yoo HW, van Royen ME, van Cappellen WA, Houtsmuller AB, Verhaegen M, Schitter G.

Rev Sci Instrum. 2014 Dec;85(12):123706. doi: 10.1063/1.4904370.

PMID:
25554300
28.

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells.

Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C.

J Cell Biol. 2014 Dec 8;207(5):599-613. doi: 10.1083/jcb.201405014. Erratum in: J Cell Biol. 2015 Mar 16;208(6):857.

29.

Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair.

Gourdin AM, van Cuijk L, Tresini M, Luijsterburg MS, Nigg AL, Giglia-Mari G, Houtsmuller AB, Vermeulen W, Marteijn JA.

DNA Repair (Amst). 2014 Dec;24:46-56. doi: 10.1016/j.dnarep.2014.09.013. Epub 2014 Oct 16.

PMID:
25453469
30.

Analysis of biomolecular dynamics by FRAP and computer simulation.

Geverts B, van Royen ME, Houtsmuller AB.

Methods Mol Biol. 2015;1251:109-33. doi: 10.1007/978-1-4939-2080-8_7.

PMID:
25391797
31.

A natural androgen receptor antagonist induces cellular senescence in prostate cancer cells.

Hessenkemper W, Roediger J, Bartsch S, Houtsmuller AB, van Royen ME, Petersen I, Grimm MO, Baniahmad A.

Mol Endocrinol. 2014 Nov;28(11):1831-40. doi: 10.1210/me.2014-1170. Epub 2014 Sep 9.

32.

Novel Nor-Homo- and Spiro-Oxetan- Steroids Target the Human Androgen Receptor and Act as Antiandrogens.

Thiele M, Rabe S, Hessenkemper W, Roell D, Bartsch S, Kraft F, Abraham TE, Houtsmuller AB, van Royen ME, Giannis A, Baniahmad A.

Curr Med Chem. 2015;22(9):1156-1167. doi: 10.2174/0929867321666140601164240. Epub 2014 Jun 1.

PMID:
24934352
33.

Quantitation of glucocorticoid receptor DNA-binding dynamics by single-molecule microscopy and FRAP.

Groeneweg FL, van Royen ME, Fenz S, Keizer VI, Geverts B, Prins J, de Kloet ER, Houtsmuller AB, Schmidt TS, Schaaf MJ.

PLoS One. 2014 Mar 14;9(3):e90532. doi: 10.1371/journal.pone.0090532. eCollection 2014.

34.

Androgen receptor complexes probe DNA for recognition sequences by short random interactions.

Van Royen ME, van Cappellen WA, Geverts B, Schmidt T, Houtsmuller AB, Schaaf MJ.

J Cell Sci. 2014 Apr 1;127(Pt 7):1406-16. doi: 10.1242/jcs.135228. Epub 2014 Jan 30.

35.

Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA.

Mol Cell. 2013 Aug 22;51(4):469-79. doi: 10.1016/j.molcel.2013.08.007.

36.

Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome.

Elfferich P, van Royen ME, van de Wijngaart DJ, Trapman J, Drop SL, van den Akker EL, Lusher SJ, Bosch R, Bunch T, Hughes IA, Houtsmuller AB, Cools M, Faradz SM, Bisschop PH, Bunck MC, Oostdijk W, Brüggenwirth HT, Brinkmann AO.

Sex Dev. 2013;7(5):223-34. doi: 10.1159/000351820. Epub 2013 Jun 12.

37.

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.

Poulsen SL, Hansen RK, Wagner SA, van Cuijk L, van Belle GJ, Streicher W, Wikström M, Choudhary C, Houtsmuller AB, Marteijn JA, Bekker-Jensen S, Mailand N.

J Cell Biol. 2013 Jun 10;201(6):797-807. doi: 10.1083/jcb.201212075.

38.

A multi-parameter imaging assay identifies different stages of ligand-induced androgen receptor activation.

van Royen ME, van de Wijngaart DJ, Cunha SM, Trapman J, Houtsmuller AB.

Cytometry A. 2013 Sep;83(9):806-17. doi: 10.1002/cyto.a.22284. Epub 2013 Apr 12.

39.

The leukemia-associated fusion protein MN1-TEL blocks TEL-specific recognition sequences.

ter Haar WM, Meester-Smoor MA, van Wely KH, Schot CC, Janssen MJ, Geverts B, Bonten J, Grosveld GC, Houtsmuller AB, Zwarthoff EC.

PLoS One. 2012;7(9):e46085. doi: 10.1371/journal.pone.0046085. Epub 2012 Sep 26.

40.

The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status.

Le Dévédec SE, Geverts B, de Bont H, Yan K, Verbeek FJ, Houtsmuller AB, van de Water B.

J Cell Sci. 2012 Oct 1;125(Pt 19):4498-506. doi: 10.1242/jcs.104273. Epub 2012 Jul 5.

41.

Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex.

Bergink S, Toussaint W, Luijsterburg MS, Dinant C, Alekseev S, Hoeijmakers JH, Dantuma NP, Houtsmuller AB, Vermeulen W.

J Cell Biol. 2012 Mar 19;196(6):681-8. doi: 10.1083/jcb.201107050.

42.

Stepwise androgen receptor dimerization.

van Royen ME, van Cappellen WA, de Vos C, Houtsmuller AB, Trapman J.

J Cell Sci. 2012 Apr 15;125(Pt 8):1970-9. doi: 10.1242/jcs.096792. Epub 2012 Feb 10.

43.

Nuclear proteins: finding and binding target sites in chromatin.

van Royen ME, Zotter A, Ibrahim SM, Geverts B, Houtsmuller AB.

Chromosome Res. 2011 Jan;19(1):83-98. doi: 10.1007/s10577-010-9172-5.

PMID:
21181254
44.

Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment.

Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH, Vermeulen W.

Mol Cell Biol. 2010 Oct;30(20):4828-39. doi: 10.1128/MCB.00285-10. Epub 2010 Aug 16.

45.

Chromatin interaction of TATA-binding protein is dynamically regulated in human cells.

de Graaf P, Mousson F, Geverts B, Scheer E, Tora L, Houtsmuller AB, Timmers HT.

J Cell Sci. 2010 Aug 1;123(Pt 15):2663-71. doi: 10.1242/jcs.064097. Epub 2010 Jul 13.

46.

A 629RKLKK633 motif in the hinge region controls the androgen receptor at multiple levels.

Tanner TM, Denayer S, Geverts B, Van Tilborgh N, Kerkhofs S, Helsen C, Spans L, Dubois V, Houtsmuller AB, Claessens F, Haelens A.

Cell Mol Life Sci. 2010 Jun;67(11):1919-27. doi: 10.1007/s00018-010-0302-1. Epub 2010 Feb 26.

PMID:
20186458
47.

Functional analysis of novel androgen receptor mutations in a unique cohort of Indonesian patients with a disorder of sex development.

Elfferich P, Juniarto AZ, Dubbink HJ, van Royen ME, Molier M, Hoogerbrugge J, Houtsmuller AB, Trapman J, Santosa A, de Jong FH, Drop SL, Faradz SM, Bruggenwirth H, Brinkmann AO.

Sex Dev. 2009;3(5):237-44. doi: 10.1159/000252814. Epub 2009 Oct 23.

PMID:
19851057
48.

Heterochromatin protein 1 is recruited to various types of DNA damage.

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.

J Cell Biol. 2009 May 18;185(4):577-86. doi: 10.1083/jcb.200810035.

49.

Assembly of multiprotein complexes that control genome function.

Dinant C, Luijsterburg MS, Höfer T, von Bornstaedt G, Vermeulen W, Houtsmuller AB, van Driel R.

J Cell Biol. 2009 Apr 6;185(1):21-6. doi: 10.1083/jcb.200811080. Epub 2009 Mar 30. Review.

50.

UV-DDB-dependent regulation of nucleotide excision repair kinetics in living cells.

Nishi R, Alekseev S, Dinant C, Hoogstraten D, Houtsmuller AB, Hoeijmakers JH, Vermeulen W, Hanaoka F, Sugasawa K.

DNA Repair (Amst). 2009 Jun 4;8(6):767-76. doi: 10.1016/j.dnarep.2009.02.004. Epub 2009 Mar 21.

PMID:
19332393

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