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Items: 22


Istaroxime, a positive inotropic agent devoid of proarrhythmic properties in sensitive chronic atrioventricular block dogs.

Bossu A, Kostense A, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.

Pharmacol Res. 2018 Jul;133:132-140. doi: 10.1016/j.phrs.2018.05.001. Epub 2018 May 16.


Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.

Bossu A, Houtman MJC, Meijborg VMF, Varkevisser R, Beekman HDM, Dunnink A, de Bakker JMT, Mollova N, Rajamani S, Belardinelli L, van der Heyden MAG, Vos MA.

Br J Pharmacol. 2018 Jun;175(12):2470-2482. doi: 10.1111/bph.14217. Epub 2018 May 6.


PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.

Ji Y, Veldhuis MG, Zandvoort J, Romunde FL, Houtman MJC, Duran K, van Haaften G, Zangerl-Plessl EM, Takanari H, Stary-Weinzinger A, van der Heyden MAG.

J Biomed Sci. 2017 Jul 15;24(1):44. doi: 10.1186/s12929-017-0352-x.


Short-term Variability of Repolarization Is Superior to Other Repolarization Parameters in the Evaluation of Diverse Antiarrhythmic Interventions in the Chronic Atrioventricular Block Dog.

Bossu A, Varkevisser R, Beekman HDM, Houtman MJC, van der Heyden MAG, Vos MA.

J Cardiovasc Pharmacol. 2017 Jun;69(6):398-407. doi: 10.1097/FJC.0000000000000488. Review.


Class III antiarrhythmic drugs amiodarone and dronedarone impair KIR 2.1 backward trafficking.

Ji Y, Takanari H, Qile M, Nalos L, Houtman MJC, Romunde FL, Heukers R, van Bergen En Henegouwen PMP, Vos MA, van der Heyden MAG.

J Cell Mol Med. 2017 Oct;21(10):2514-2523. doi: 10.1111/jcmm.13172. Epub 2017 Apr 19.


Calcium release near L-type calcium channels promotes beat-to-beat variability in ventricular myocytes from the chronic AV block dog.

Antoons G, Johnson DM, Dries E, Santiago DJ, Ozdemir S, Lenaerts I, Beekman JD, Houtman MJ, Sipido KR, Vos MA.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):326-34. doi: 10.1016/j.yjmcc.2015.10.008. Epub 2015 Oct 8.


Insights in KIR2.1 channel structure and function by an evolutionary approach; cloning and functional characterization of the first reptilian inward rectifier channel KIR2.1, derived from the California kingsnake (Lampropeltis getula californiae).

Houtman MJ, Korte SM, Ji Y, Kok B, Vos MA, Stary-Weinzinger A, van der Heyden MA.

Biochem Biophys Res Commun. 2014 Oct 3;452(4):992-7. doi: 10.1016/j.bbrc.2014.09.031. Epub 2014 Sep 16.


Increased sarcolemmal Na(+)/H(+) exchange activity in hypertrophied myocytes from dogs with chronic atrioventricular block.

van Borren MM, Vos MA, Houtman MJ, Antoons G, Ravesloot JH.

Front Physiol. 2013 Nov 26;4:322. doi: 10.3389/fphys.2013.00322. eCollection 2013.


Efficient and specific cardiac IK₁ inhibition by a new pentamidine analogue.

Takanari H, Nalos L, Stary-Weinzinger A, de Git KC, Varkevisser R, Linder T, Houtman MJ, Peschar M, de Boer TP, Tidwell RR, Rook MB, Vos MA, van der Heyden MA.

Cardiovasc Res. 2013 Jul 1;99(1):203-14. doi: 10.1093/cvr/cvt103. Epub 2013 Apr 25.


Structure-activity relationships of pentamidine-affected ion channel trafficking and dofetilide mediated rescue.

Varkevisser R, Houtman MJ, Linder T, de Git KC, Beekman HD, Tidwell RR, Ijzerman AP, Stary-Weinzinger A, Vos MA, van der Heyden MA.

Br J Pharmacol. 2013 Jul;169(6):1322-34. doi: 10.1111/bph.12208.


Inhibiting the clathrin-mediated endocytosis pathway rescues K(IR)2.1 downregulation by pentamidine.

Varkevisser R, Houtman MJ, Waasdorp M, Man JC, Heukers R, Takanari H, Tieland RG, van Bergen En Henegouwen PM, Vos MA, van der Heyden MA.

Pflugers Arch. 2013 Feb;465(2):247-59. doi: 10.1007/s00424-012-1189-5. Epub 2012 Nov 29.


Relevance of calmodulin/CaMKII activation for arrhythmogenesis in the AV block dog.

Bourgonje VJ, Schoenmakers M, Beekman JD, van der Nagel R, Houtman MJ, Miedema LF, Antoons G, Sipido K, de Windt LJ, van Veen TA, Vos MA.

Heart Rhythm. 2012 Nov;9(11):1875-83. doi: 10.1016/j.hrthm.2012.07.023. Epub 2012 Jul 27.


Experimental Mapping of the Canine KCNJ2 and KCNJ12 Gene Structures and Functional Analysis of the Canine K(IR)2.2 ion Channel.

Houtman MJ, Takanari H, Kok BG, van Eck M, Montagne DR, Vos MA, de Boer TP, van der Heyden MA.

Front Physiol. 2012 Jan 30;3:9. doi: 10.3389/fphys.2012.00009. eCollection 2012.


Comparison of the IKr blockers moxifloxacin, dofetilide and E-4031 in five screening models of pro-arrhythmia reveals lack of specificity of isolated cardiomyocytes.

Nalos L, Varkevisser R, Jonsson MK, Houtman MJ, Beekman JD, van der Nagel R, Thomsen MB, Duker G, Sartipy P, de Boer TP, Peschar M, Rook MB, van Veen TA, van der Heyden MA, Vos MA.

Br J Pharmacol. 2012 Jan;165(2):467-78. doi: 10.1111/j.1476-5381.2011.01558.x.


Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.

Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA.

Circ Arrhythm Electrophysiol. 2011 Aug;4(4):566-76. doi: 10.1161/CIRCEP.110.958991. Epub 2011 May 27.


Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1.

Nalos L, de Boer TP, Houtman MJ, Rook MB, Vos MA, van der Heyden MA.

Eur J Pharmacol. 2011 Feb 10;652(1-3):96-103. doi: 10.1016/j.ejphar.2010.10.093. Epub 2010 Nov 27.


Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

Oros A, Houtman MJ, Neco P, Gomez AM, Rajamani S, Oosterhoff P, Attevelt NJ, Beekman JD, van der Heyden MA, Ver Donck L, Belardinelli L, Richard S, Antoons G, Vos MA; CONTICA investigators.

Br J Pharmacol. 2010 Sep;161(1):162-75. doi: 10.1111/j.1476-5381.2010.00883.x.


Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.

Stein M, Boulaksil M, Jansen JA, Herold E, Noorman M, Joles JA, van Veen TA, Houtman MJ, Engelen MA, Hauer RN, de Bakker JM, van Rijen HV.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H310-21. doi: 10.1152/ajpheart.01137.2009. Epub 2010 Apr 30.


The mammalian K(IR)2.x inward rectifier ion channel family: expression pattern and pathophysiology.

de Boer TP, Houtman MJ, Compier M, van der Heyden MA.

Acta Physiol (Oxf). 2010 Jul 1;199(3):243-56. doi: 10.1111/j.1748-1716.2010.02108.x. Epub 2010 Mar 13. Review.


The anti-protozoal drug pentamidine blocks KIR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel.

de Boer TP, Nalos L, Stary A, Kok B, Houtman MJ, Antoons G, van Veen TA, Beekman JD, de Groot BL, Opthof T, Rook MB, Vos MA, van der Heyden MA.

Br J Pharmacol. 2010 Apr;159(7):1532-41. doi: 10.1111/j.1476-5381.2010.00658.x. Epub 2010 Feb 24.


Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.

Antoons G, Oros A, Beekman JD, Engelen MA, Houtman MJ, Belardinelli L, Stengl M, Vos MA.

J Am Coll Cardiol. 2010 Feb 23;55(8):801-9. doi: 10.1016/j.jacc.2009.10.033.


Inhibition of cardiomyocyte automaticity by electrotonic application of inward rectifier current from Kir2.1 expressing cells.

de Boer TP, van Veen TA, Houtman MJ, Jansen JA, van Amersfoorth SC, Doevendans PA, Vos MA, van der Heyden MA.

Med Biol Eng Comput. 2006 Jul;44(7):537-42. Epub 2006 Apr 20.


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