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Items: 1 to 50 of 79

1.

Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3.

Houtman J, Freitag K, Gimber N, Schmoranzer J, Heppner FL, Jendrach M.

EMBO J. 2019 Jan 7. pii: e99430. doi: 10.15252/embj.201899430. [Epub ahead of print]

PMID:
30617086
2.

Transmission of T Cell Receptor-Mediated Signaling via the GRB2 Family of Adaptor Proteins.

Bilal MY, Houtman JCD.

In: Soboloff J, Kappes DJ, editors. Signaling Mechanisms Regulating T Cell Diversity and Function. Boca Raton (FL): CRC Press/Taylor & Francis; 2018. Chapter 9.

3.

Polymicrobial sepsis influences NK-cell-mediated immunity by diminishing NK-cell-intrinsic receptor-mediated effector responses to viral ligands or infections.

Jensen IJ, Winborn CS, Fosdick MG, Shao P, Tremblay MM, Shan Q, Tripathy SK, Snyder CM, Xue HH, Griffith TS, Houtman JC, Badovinac VP.

PLoS Pathog. 2018 Oct 31;14(10):e1007405. doi: 10.1371/journal.ppat.1007405. eCollection 2018 Oct.

4.

Glycerol monolaurate induces filopodia formation by disrupting the association between LAT and SLP-76 microclusters.

Zhang MS, Tran PM, Wolff AJ, Tremblay MM, Fosdick MG, Houtman JCD.

Sci Signal. 2018 May 1;11(528). pii: eaam9095. doi: 10.1126/scisignal.aam9095.

5.

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site.

Zhang L, Martini GD, Rube HT, Kribelbauer JF, Rastogi C, FitzPatrick VD, Houtman JC, Bussemaker HJ, Pufall MA.

Genome Res. 2018 Jan;28(1):111-121. doi: 10.1101/gr.222844.117. Epub 2017 Dec 1.

6.

Yellow Fever Virus, but Not Zika Virus or Dengue Virus, Inhibits T-Cell Receptor-Mediated T-Cell Function by an RNA-Based Mechanism.

McLinden JH, Bhattarai N, Stapleton JT, Chang Q, Kaufman TM, Cassel SL, Sutterwala FS, Haim H, Houtman JC, Xiang J.

J Infect Dis. 2017 Nov 27;216(9):1164-1175. doi: 10.1093/infdis/jix462.

7.

Natural Products Discovered in a High-Throughput Screen Identified as Inhibitors of RGS17 and as Cytostatic and Cytotoxic Agents for Lung and Prostate Cancer Cell Lines.

Bodle CR, Mackie DI, Hayes MP, Schamp JH, Miller MR, Henry MD, Doorn JA, Houtman JCD, James MA, Roman DL.

J Nat Prod. 2017 Jul 28;80(7):1992-2000. doi: 10.1021/acs.jnatprod.7b00112. Epub 2017 Jun 16.

8.

TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22.

Wallis AM, Wallace EC, Hostager BS, Yi Z, Houtman JCD, Bishop GA.

Sci Rep. 2017 May 18;7(1):2081. doi: 10.1038/s41598-017-02280-4.

9.

Pretreatment of activated human CD8 T cells with IL-12 leads to enhanced TCR-induced signaling and cytokine production.

Vacaflores A, Freedman SN, Chapman NM, Houtman JC.

Mol Immunol. 2017 Jan;81:1-15. doi: 10.1016/j.molimm.2016.11.008. Epub 2016 Nov 22.

10.

Human Serum Albumin (HSA) Suppresses the Effects of Glycerol Monolaurate (GML) on Human T Cell Activation and Function.

Zhang MS, Houtman JC.

PLoS One. 2016 Oct 20;11(10):e0165083. doi: 10.1371/journal.pone.0165083. eCollection 2016.

11.

The Anti-sigma Factor RsiV Is a Bacterial Receptor for Lysozyme: Co-crystal Structure Determination and Demonstration That Binding of Lysozyme to RsiV Is Required for σV Activation.

Hastie JL, Williams KB, Bohr LL, Houtman JC, Gakhar L, Ellermeier CD.

PLoS Genet. 2016 Sep 7;12(9):e1006287. doi: 10.1371/journal.pgen.1006287. eCollection 2016 Sep.

12.

Glycerol Monolaurate (GML) inhibits human T cell signaling and function by disrupting lipid dynamics.

Zhang MS, Sandouk A, Houtman JC.

Sci Rep. 2016 Jul 26;6:30225. doi: 10.1038/srep30225.

13.

Acridine Orange Indicates Early Oxidation of Wood Cell Walls by Fungi.

Houtman CJ, Kitin P, Houtman JC, Hammel KE, Hunt CG.

PLoS One. 2016 Jul 25;11(7):e0159715. doi: 10.1371/journal.pone.0159715. eCollection 2016.

14.

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism.

Vacaflores A, Chapman NM, Harty JT, Richer MJ, Houtman JC.

PLoS One. 2016 Jun 9;11(6):e0157175. doi: 10.1371/journal.pone.0157175. eCollection 2016.

15.

The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1.

Boehm EM, Powers KT, Kondratick CM, Spies M, Houtman JC, Washington MT.

J Biol Chem. 2016 Apr 15;291(16):8735-44. doi: 10.1074/jbc.M115.697938. Epub 2016 Feb 22.

16.

Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands.

Bartelt RR, Light J, Vacaflores A, Butcher A, Pandian M, Nash P, Houtman JC.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2560-9. doi: 10.1016/j.bbamcr.2015.06.002. Epub 2015 Jun 12.

17.

Optimization of methods for the genetic modification of human T cells.

Bilal MY, Vacaflores A, Houtman JC.

Immunol Cell Biol. 2015 Nov;93(10):896-908. doi: 10.1038/icb.2015.59. Epub 2015 Jun 1.

18.

GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That Control PLC-γ1 Activation and Cytokine Production.

Bilal MY, Houtman JC.

Front Immunol. 2015 Mar 30;6:141. doi: 10.3389/fimmu.2015.00141. eCollection 2015.

19.

ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing zeta associated protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells.

Cadra S, Gucciardi A, Valignat MP, Theodoly O, Vacaflores A, Houtman JC, Lellouch AC.

Biochem Biophys Res Commun. 2015 Apr 10;459(3):405-10. doi: 10.1016/j.bbrc.2015.02.117. Epub 2015 Feb 28.

PMID:
25735979
20.

GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

Bilal MY, Zhang EY, Dinkel B, Hardy D, Yankee TM, Houtman JC.

Cell Signal. 2015 Apr;27(4):841-50. doi: 10.1016/j.cellsig.2015.01.012. Epub 2015 Jan 28.

21.

TCR-mediated functions are enhanced in activated peripheral blood T cells isolated from leucocyte reduction systems.

Tremblay MM, Houtman JC.

J Immunol Methods. 2015 Jan;416:137-45. doi: 10.1016/j.jim.2014.11.009. Epub 2014 Nov 25.

22.

Proline-rich tyrosine kinase 2 controls PI3-kinase activation downstream of the T cell antigen receptor in human T cells.

Chapman NM, Yoder AN, Barbón KM, Bilal MY, Connolly SF, Houtman JC.

J Leukoc Biol. 2015 Feb;97(2):285-96. doi: 10.1189/jlb.2A1013-568RRR. Epub 2014 Nov 11.

23.

Evidence of a bacterial receptor for lysozyme: binding of lysozyme to the anti-σ factor RsiV controls activation of the ecf σ factor σV.

Hastie JL, Williams KB, Sepúlveda C, Houtman JC, Forest KT, Ellermeier CD.

PLoS Genet. 2014 Oct 2;10(10):e1004643. doi: 10.1371/journal.pgen.1004643. eCollection 2014 Oct.

24.

Phosphorylation of Nox1 regulates association with NoxA1 activation domain.

Streeter J, Schickling BM, Jiang S, Stanic B, Thiel WH, Gakhar L, Houtman JC, Miller FJ Jr.

Circ Res. 2014 Nov 7;115(11):911-8. doi: 10.1161/CIRCRESAHA.115.304267. Epub 2014 Sep 16.

25.

Functions of the FAK family kinases in T cells: beyond actin cytoskeletal rearrangement.

Chapman NM, Houtman JC.

Immunol Res. 2014 Aug;59(1-3):23-34. doi: 10.1007/s12026-014-8527-y. Review.

26.

Activated PLC-γ1 is catalytically induced at LAT but activated PLC-γ1 is localized at both LAT- and TCR-containing complexes.

Cruz-Orcutt N, Vacaflores A, Connolly SF, Bunnell SC, Houtman JC.

Cell Signal. 2014 Apr;26(4):797-805. doi: 10.1016/j.cellsig.2013.12.022. Epub 2014 Jan 8.

27.

Use of nanoclay platelets in food packaging materials: technical and cytotoxicity approach.

Jorda-Beneyto M, Ortuño N, Devis A, Aucejo S, Puerto M, Gutiérrez-Praena D, Houtman J, Pichardo S, Maisanaba S, Jos A.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(3):354-63. doi: 10.1080/19440049.2013.874045. Epub 2014 Feb 19.

PMID:
24328862
28.

Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.

Chapman NM, Connolly SF, Reinl EL, Houtman JC.

J Immunol. 2013 Dec 15;191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13.

29.

Specificity residues determine binding affinity for two-component signal transduction systems.

Willett JW, Tiwari N, Müller S, Hummels KR, Houtman JC, Fuentes EJ, Kirby JR.

MBio. 2013 Nov 5;4(6):e00420-13. doi: 10.1128/mBio.00420-13.

30.

Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production.

Tremblay MM, Bilal MY, Houtman JC.

Mol Immunol. 2014 Feb;57(2):161-70. doi: 10.1016/j.molimm.2013.09.002. Epub 2013 Oct 12.

31.

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.

32.

A calcineurin docking motif (LXVP) in dynamin-related protein 1 contributes to mitochondrial fragmentation and ischemic neuronal injury.

Slupe AM, Merrill RA, Flippo KH, Lobas MA, Houtman JC, Strack S.

J Biol Chem. 2013 Apr 26;288(17):12353-65. doi: 10.1074/jbc.M113.459677. Epub 2013 Mar 13.

33.

Non-catalytic functions of Pyk2 and Fyn regulate late stage adhesion in human T cells.

Chapman NM, Yoder AN, Houtman JC.

PLoS One. 2012;7(12):e53011. doi: 10.1371/journal.pone.0053011. Epub 2012 Dec 27.

34.

Distinct signaling pathways regulate TLR2 co-stimulatory function in human T cells.

Chapman NM, Bilal MY, Cruz-Orcutt N, Knudson C, Madinaveitia S, Light J, Houtman JC.

Cell Signal. 2013 Mar;25(3):639-50. doi: 10.1016/j.cellsig.2012.11.026. Epub 2012 Dec 5.

35.

The adaptor protein LAT serves as an integration node for signaling pathways that drive T cell activation.

Bartelt RR, Houtman JC.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb;5(1):101-10. doi: 10.1002/wsbm.1194. Epub 2012 Nov 13. Review.

36.

3-picolyl azide adenine dinucleotide as a probe of femtosecond to picosecond enzyme dynamics.

Dutta S, Li YL, Rock W, Houtman JC, Kohen A, Cheatum CM.

J Phys Chem B. 2012 Jan 12;116(1):542-8. doi: 10.1021/jp208677u. Epub 2011 Dec 15.

37.

Characterization of azido-NAD+ to assess its potential as a two-dimensional infrared probe of enzyme dynamics.

Dutta S, Cook RJ, Houtman JC, Kohen A, Cheatum CM.

Anal Biochem. 2010 Dec 15;407(2):241-6. doi: 10.1016/j.ab.2010.08.008. Epub 2010 Aug 10.

38.

Glycosylation contributes to variability in expression of murine cytomegalovirus m157 and enhances stability of interaction with the NK-cell receptor Ly49H.

Guseva NV, Fullenkamp CA, Naumann PW, Shey MR, Ballas ZK, Houtman JC, Forbes CA, Scalzo AA, Heusel JW.

Eur J Immunol. 2010 Sep;40(9):2618-31. doi: 10.1002/eji.200940134.

39.

Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.

EMBO J. 2010 Jul 21;29(14):2315-28. doi: 10.1038/emboj.2010.133. Epub 2010 Jun 18.

40.

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.

Collins M, Bartelt RR, Houtman JC.

Mol Immunol. 2010 May;47(9):1665-74. doi: 10.1016/j.molimm.2010.03.009. Epub 2010 Apr 9.

PMID:
20381867
41.

NetPath: a public resource of curated signal transduction pathways.

Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A.

Genome Biol. 2010 Jan 12;11(1):R3. doi: 10.1186/gb-2010-11-1-r3.

42.

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems.

Collins M, Tremblay M, Chapman N, Curtiss M, Rothman PB, Houtman JC.

J Leukoc Biol. 2010 Apr;87(4):691-701. doi: 10.1189/jlb.0409227. Epub 2009 Dec 22.

PMID:
20028775
43.

14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia.

Agassandian M, Chen BB, Schuster CC, Houtman JC, Mallampalli RK.

FASEB J. 2010 Apr;24(4):1271-83. doi: 10.1096/fj.09-136044. Epub 2009 Dec 9.

44.

Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters.

Picollo A, Malvezzi M, Houtman JC, Accardi A.

Nat Struct Mol Biol. 2009 Dec;16(12):1294-301. doi: 10.1038/nsmb.1704. Epub 2009 Nov 8.

45.

PI3 kinase function is vital for the function but not formation of LAT-mediated signaling complexes.

Cruz-Orcutt N, Houtman JC.

Mol Immunol. 2009 Jul;46(11-12):2274-83. doi: 10.1016/j.molimm.2009.04.006. Epub 2009 May 8.

PMID:
19427038
46.

Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells.

Bartelt RR, Cruz-Orcutt N, Collins M, Houtman JC.

PLoS One. 2009;4(5):e5430. doi: 10.1371/journal.pone.0005430. Epub 2009 May 4.

47.

Error analysis of metabolic-rate measurements in mammalian-cell culture by carbon and nitrogen balances.

Bonarius HP, Houtman JH, Schmid G, de Gooijer CD, Tramper J.

Cytotechnology. 1999 May;29(3):167-76. doi: 10.1023/A:1008063324292.

48.

Metabolic-flux analysis of hybridoma cells under oxidative and reductive stress using mass balances.

Bonarius HP, Houtman JH, Schmid G, de Gooijer CD, Tramper J.

Cytotechnology. 2000 Feb;32(2):97-107. doi: 10.1023/A:1008142218103.

49.

Mono-, bis-, and tris(crown ether)s assembled around 1,3,5-triaroylbenzene scaffolds.

Pigge FC, Dighe MK, Houtman JC.

J Org Chem. 2008 Apr 4;73(7):2760-7. doi: 10.1021/jo7026867. Epub 2008 Mar 11.

PMID:
18331059
50.

Control of the ability of profilin to bind and facilitate nucleotide exchange from G-actin.

Wen KK, McKane M, Houtman JC, Rubenstein PA.

J Biol Chem. 2008 Apr 4;283(14):9444-53. doi: 10.1074/jbc.M709806200. Epub 2008 Jan 27.

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