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Items: 1 to 50 of 89

1.

Cardiolipin-induced activation of pyruvate dehydrogenase links mitochondrial lipid biosynthesis to TCA cycle function.

Li Y, Lou W, Raja V, Denis S, Yu W, Schmidtke MW, Reynolds CA, Schlame M, Houtkooper RH, Greenberg ML.

J Biol Chem. 2019 Jun 11. pii: jbc.RA119.009037. doi: 10.1074/jbc.RA119.009037. [Epub ahead of print]

2.

HNRNPR Variants that Impair Homeobox Gene Expression Drive Developmental Disorders in Humans.

Duijkers FA, McDonald A, Janssens GE, Lezzerini M, Jongejan A, van Koningsbruggen S, Leeuwenburgh-Pronk WG, Wlodarski MW, Moutton S, Tran-Mau-Them F, Thauvin-Robinet C, Faivre L, Monaghan KG, Smol T, Boute-Benejean O, Ladda RL, Sell SL, Bruel AL, Houtkooper RH, MacInnes AW.

Am J Hum Genet. 2019 Jun 6;104(6):1040-1059. doi: 10.1016/j.ajhg.2019.03.024. Epub 2019 May 9.

PMID:
31079900
3.

Underpowered or negative? A crucial distinction. Reply to Dollerup OL, Treebak JT, Jessen N [letter].

Connell NJ, Houtkooper RH, Schrauwen P.

Diabetologia. 2019 Jun;62(6):1096. doi: 10.1007/s00125-019-4868-3. Epub 2019 Apr 13. No abstract available.

PMID:
30989254
4.

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion.

Liu YJ, Janssens GE, McIntyre RL, Molenaars M, Kamble R, Gao AW, Jongejan A, Weeghel MV, MacInnes AW, Houtkooper RH.

PLoS Genet. 2019 Mar 7;15(3):e1007633. doi: 10.1371/journal.pgen.1007633. eCollection 2019 Mar.

5.

NAD+ metabolism as a target for metabolic health: have we found the silver bullet?

Connell NJ, Houtkooper RH, Schrauwen P.

Diabetologia. 2019 Jun;62(6):888-899. doi: 10.1007/s00125-019-4831-3. Epub 2019 Feb 16. Review.

6.

Impact of newborn screening for very-long-chain acyl-CoA dehydrogenase deficiency on genetic, enzymatic, and clinical outcomes.

Bleeker JC, Kok IL, Ferdinandusse S, van der Pol WL, Cuppen I, Bosch AM, Langeveld M, Derks TGJ, Williams M, de Vries M, Mulder MF, Gozalbo ER, de Sain-van der Velden MGM, Rennings AJ, Schielen PJCI, Dekkers E, Houtkooper RH, Waterham HR, Pras-Raves ML, Wanders RJA, van Hasselt PM, Schoenmakers M, Wijburg FA, Visser G.

J Inherit Metab Dis. 2019 May;42(3):414-423. doi: 10.1002/jimd.12075. Epub 2019 Apr 8.

PMID:
30761551
7.

Translational Metabolism: A multidisciplinary approach towards precision diagnosis of inborn errors of metabolism in the omics era.

Wanders RJA, Vaz FM, Ferdinandusse S, van Kuilenburg ABP, Kemp S, van Karnebeek CD, Waterham HR, Houtkooper RH.

J Inherit Metab Dis. 2019 Mar;42(2):197-208. doi: 10.1002/jimd.12008. Epub 2019 Feb 5. Review.

PMID:
30723938
8.

COmplexome Profiling ALignment (COPAL) reveals remodeling of mitochondrial protein complexes in Barth syndrome.

Van Strien J, Guerrero-Castillo S, Chatzispyrou IA, Houtkooper RH, Brandt U, Huynen MA.

Bioinformatics. 2019 Jan 14. doi: 10.1093/bioinformatics/btz025. [Epub ahead of print]

PMID:
30649188
9.

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism Caenorhabditis elegans.

Witting M, Hastings J, Rodriguez N, Joshi CJ, Hattwell JPN, Ebert PR, van Weeghel M, Gao AW, Wakelam MJO, Houtkooper RH, Mains A, Le Novère N, Sadykoff S, Schroeder F, Lewis NE, Schirra HJ, Kaleta C, Casanueva O.

Front Mol Biosci. 2018 Nov 14;5:96. doi: 10.3389/fmolb.2018.00096. eCollection 2018.

10.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.

11.

Identification of key pathways and metabolic fingerprints of longevity in C. elegans.

Gao AW, Smith RL, van Weeghel M, Kamble R, Janssens GE, Houtkooper RH.

Exp Gerontol. 2018 Nov;113:128-140. doi: 10.1016/j.exger.2018.10.003. Epub 2018 Oct 6.

12.

Barth syndrome cells display widespread remodeling of mitochondrial complexes without affecting metabolic flux distribution.

Chatzispyrou IA, Guerrero-Castillo S, Held NM, Ruiter JPN, Denis SW, IJlst L, Wanders RJ, van Weeghel M, Ferdinandusse S, Vaz FM, Brandt U, Houtkooper RH.

Biochim Biophys Acta Mol Basis Dis. 2018 Nov;1864(11):3650-3658. doi: 10.1016/j.bbadis.2018.08.041. Epub 2018 Sep 1.

13.

Mitochondrial ubiquinone-mediated longevity is marked by reduced cytoplasmic mRNA translation.

Molenaars M, Janssens GE, Santermans T, Lezzerini M, Jelier R, MacInnes AW, Houtkooper RH.

Life Sci Alliance. 2018 Aug 31;1(5). doi: 10.26508/lsa.201800082.

14.

Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels.

Gao AW, Sterken MG, Uit de Bos J, van Creij J, Kamble R, Snoek BL, Kammenga JE, Houtkooper RH.

Genome Res. 2018 Sep;28(9):1296-1308. doi: 10.1101/gr.232322.117. Epub 2018 Aug 14.

15.

Preface - Animal models for aging.

Houtkooper RH.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2679. doi: 10.1016/j.bbadis.2018.06.015. Epub 2018 Jun 22. No abstract available.

PMID:
29940271
16.

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation.

Held NM, Kuipers EN, van Weeghel M, van Klinken JB, Denis SW, Lombès M, Wanders RJ, Vaz FM, Rensen PCN, Verhoeven AJ, Boon MR, Houtkooper RH.

Sci Rep. 2018 Jun 22;8(1):9562. doi: 10.1038/s41598-018-27875-3.

17.

Disorders of mitochondrial long-chain fatty acid oxidation and the carnitine shuttle.

Knottnerus SJG, Bleeker JC, Wüst RCI, Ferdinandusse S, IJlst L, Wijburg FA, Wanders RJA, Visser G, Houtkooper RH.

Rev Endocr Metab Disord. 2018 Mar;19(1):93-106. doi: 10.1007/s11154-018-9448-1. Review.

18.

Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice.

Kuipers EN, Dam ADV, Held NM, Mol IM, Houtkooper RH, Rensen PCN, Boon MR.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1786. doi: 10.3390/ijms19061786.

19.

Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease.

Smith RL, Soeters MR, Wüst RCI, Houtkooper RH.

Endocr Rev. 2018 Aug 1;39(4):489-517. doi: 10.1210/er.2017-00211. Review.

20.

Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM.

Cardiovasc Res. 2018 Aug 1;114(10):1324-1334. doi: 10.1093/cvr/cvy089.

PMID:
29635338
21.

Recurring mutations in RPL15 are linked to hydrops fetalis and treatment independence in Diamond-Blackfan anemia.

Wlodarski MW, Da Costa L, O'Donohue MF, Gastou M, Karboul N, Montel-Lehry N, Hainmann I, Danda D, Szvetnik A, Pastor V, Paolini N, di Summa FM, Tamary H, Quider AA, Aspesi A, Houtkooper RH, Leblanc T, Niemeyer CM, Gleizes PE, MacInnes AW.

Haematologica. 2018 Jun;103(6):949-958. doi: 10.3324/haematol.2017.177980. Epub 2018 Mar 29.

22.

Platelet Toll-like receptor expression and activation induced by lipopolysaccharide and sepsis.

Claushuis TAM, Van Der Veen AIP, Horn J, Schultz MJ, Houtkooper RH, Van 't Veer C, Van Der Poll T.

Platelets. 2019;30(3):296-304. doi: 10.1080/09537104.2018.1445841. Epub 2018 Mar 12.

PMID:
29528268
23.

Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome.

Kors L, Rampanelli E, Stokman G, Butter LM, Held NM, Claessen N, Larsen PWB, Verheij J, Zuurbier CJ, Liebisch G, Schmitz G, Girardin SE, Florquin S, Houtkooper RH, Leemans JC.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1883-1895. doi: 10.1016/j.bbadis.2018.03.003. Epub 2018 Mar 4.

24.

Csde1 binds transcripts involved in protein homeostasis and controls their expression in an erythroid cell line.

Moore KS, Yagci N, van Alphen F, Paolini NA, Horos R, Held NM, Houtkooper RH, van den Akker E, Meijer AB, 't Hoen PAC, von Lindern M.

Sci Rep. 2018 Feb 8;8(1):2628. doi: 10.1038/s41598-018-20518-7.

25.

Ethnic differences in metabolite signatures and type 2 diabetes: a nested case-control analysis among people of South Asian, African and European origin.

van Valkengoed IGM, Argmann C, Ghauharali-van der Vlugt K, Aerts JMFG, Brewster LM, Peters RJG, Vaz FM, Houtkooper RH.

Nutr Diabetes. 2017 Dec 19;7(12):300. doi: 10.1038/s41387-017-0003-z.

26.

Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity.

Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, García-Cáceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX.

Cell Rep. 2017 Sep 26;20(13):3034-3042. doi: 10.1016/j.celrep.2017.09.008.

27.

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans.

Gao AW, Uit de Bos J, Sterken MG, Kammenga JE, Smith RL, Houtkooper RH.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt A):2697-2706. doi: 10.1016/j.bbadis.2017.09.006. Epub 2017 Sep 15. Review.

28.

AMC-Bio-Artificial Liver culturing enhances mitochondrial biogenesis in human liver cell lines: The role of oxygen, medium perfusion and 3D configuration.

Adam AAA, van Wenum M, van der Mark VA, Jongejan A, Moerland PD, Houtkooper RH, Wanders RJA, Oude Elferink RP, Chamuleau RAFM, Hoekstra R.

Mitochondrion. 2018 Mar;39:30-42. doi: 10.1016/j.mito.2017.08.011. Epub 2017 Aug 24.

PMID:
28844938
29.

Acute detachment of hexokinase II from mitochondria modestly increases oxygen consumption of the intact mouse heart.

Nederlof R, Denis S, Lauzier B, Rosiers CD, Laakso M, Hagen J, Argmann C, Wanders R, Houtkooper RH, Hollmann MW, Houten SM, Zuurbier CJ.

Metabolism. 2017 Jul;72:66-74. doi: 10.1016/j.metabol.2017.04.008. Epub 2017 Apr 21.

30.

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans.

Gao AW, Chatzispyrou IA, Kamble R, Liu YJ, Herzog K, Smith RL, van Lenthe H, Vervaart MAT, van Cruchten A, Luyf AC, van Kampen A, Pras-Raves ML, Vaz FM, Houtkooper RH.

Sci Rep. 2017 May 25;7(1):2408. doi: 10.1038/s41598-017-02539-w.

31.

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.

Chatzispyrou IA, Alders M, Guerrero-Castillo S, Zapata Perez R, Haagmans MA, Mouchiroud L, Koster J, Ofman R, Baas F, Waterham HR, Spelbrink JN, Auwerx J, Mannens MM, Houtkooper RH, Plomp AS.

Hum Mol Genet. 2017 Jul 1;26(13):2541-2550. doi: 10.1093/hmg/ddx152.

32.

The gut microbiota as a modulator of innate immunity during melioidosis.

Lankelma JM, Birnie E, Weehuizen TAF, Scicluna BP, Belzer C, Houtkooper RH, Roelofs JJTH, de Vos AF, van der Poll T, Budding AE, Wiersinga WJ.

PLoS Negl Trop Dis. 2017 Apr 19;11(4):e0005548. doi: 10.1371/journal.pntd.0005548. eCollection 2017 Apr.

33.

Identification of enzymes involved in oxidation of phenylbutyrate.

Palir N, Ruiter JPN, Wanders RJA, Houtkooper RH.

J Lipid Res. 2017 May;58(5):955-961. doi: 10.1194/jlr.M075317. Epub 2017 Mar 9.

34.

A Ribosomopathy Reveals Decoding Defective Ribosomes Driving Human Dysmorphism.

Paolini NA, Attwood M, Sondalle SB, Vieira CMDS, van Adrichem AM, di Summa FM, O'Donohue MF, Gleizes PE, Rachuri S, Briggs JW, Fischer R, Ratcliffe PJ, Wlodarski MW, Houtkooper RH, von Lindern M, Kuijpers TW, Dinman JD, Baserga SJ, Cockman ME, MacInnes AW.

Am J Hum Genet. 2017 Mar 2;100(3):506-522. doi: 10.1016/j.ajhg.2017.01.034.

35.

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes.

Lachmandas E, Boutens L, Ratter JM, Hijmans A, Hooiveld GJ, Joosten LA, Rodenburg RJ, Fransen JA, Houtkooper RH, van Crevel R, Netea MG, Stienstra R.

Nat Microbiol. 2016 Dec 19;2:16246. doi: 10.1038/nmicrobiol.2016.246.

PMID:
27991883
36.

Ketones and inborn errors of metabolism: old friends revisited.

Wüst RC, Visser G, Wanders RJ, Houtkooper RH.

J Inherit Metab Dis. 2017 Jan;40(1):3-4. doi: 10.1007/s10545-016-9997-y. No abstract available.

PMID:
27830424
37.

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin.

Kulkarni SS, Joffraud M, Boutant M, Ratajczak J, Gao AW, Maclachlan C, Hernandez-Alvarez MI, Raymond F, Metairon S, Descombes P, Houtkooper RH, Zorzano A, Cantó C.

Diabetes. 2016 Dec;65(12):3552-3560. Epub 2016 Sep 9.

38.

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Koopman M, Michels H, Dancy BM, Kamble R, Mouchiroud L, Auwerx J, Nollen EA, Houtkooper RH.

Nat Protoc. 2016 Oct;11(10):1798-816. doi: 10.1038/nprot.2016.106. Epub 2016 Sep 1.

39.

Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough.

Hornberger TA, Carter HN, Hood DA, Figueiredo VC, Dupont-Versteegden EE, Peterson CA, McCarthy JJ, Camera DM, Hawley JA, Chaillou T, Cheng AJ, Nader GA, Wüst RC, Houtkooper RH.

J Appl Physiol (1985). 2016 Aug 1;121(2):597-600. doi: 10.1152/japplphysiol.00509.2016. No abstract available.

40.

Sirtuin activation as a therapeutic approach against inborn errors of metabolism.

Bleeker JC, Houtkooper RH.

J Inherit Metab Dis. 2016 Jul;39(4):565-72. doi: 10.1007/s10545-016-9939-8. Epub 2016 May 4. Review.

41.

The impact of altered carnitine availability on acylcarnitine metabolism, energy expenditure and glucose tolerance in diet-induced obese mice.

Schooneman MG, Houtkooper RH, Hollak CE, Wanders RJ, Vaz FM, Soeters MR, Houten SM.

Biochim Biophys Acta. 2016 Aug;1862(8):1375-82. doi: 10.1016/j.bbadis.2016.04.012. Epub 2016 Apr 22.

42.

Atypical Clinical Presentations of TAZ Mutations: An Underdiagnosed Cause of Growth Retardation?

Thiels C, Fleger M, Huemer M, Rodenburg RJ, Vaz FM, Houtkooper RH, Haack TB, Prokisch H, Feichtinger RG, Lücke T, Mayr JA, Wortmann SB.

JIMD Rep. 2016;29:89-93. Epub 2016 Jan 3.

43.

Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.

Chatzispyrou IA, Held NM, Mouchiroud L, Auwerx J, Houtkooper RH.

Cancer Res. 2015 Nov 1;75(21):4446-9. doi: 10.1158/0008-5472.CAN-15-1626. Epub 2015 Oct 16. Review.

44.

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance.

Vatner DE, Yan L, Lai L, Yuan C, Mouchiroud L, Pachon RE, Zhang J, Dillinger JG, Houtkooper RH, Auwerx J, Vatner SF.

Aging Cell. 2015 Dec;14(6):1075-84. doi: 10.1111/acel.12401. Epub 2015 Oct 1.

45.

Antibiotic use and abuse: a threat to mitochondria and chloroplasts with impact on research, health, and environment.

Wang X, Ryu D, Houtkooper RH, Auwerx J.

Bioessays. 2015 Oct;37(10):1045-53. doi: 10.1002/bies.201500071. Epub 2015 Sep 8.

46.

Mitochondrial quality control pathways as determinants of metabolic health.

Held NM, Houtkooper RH.

Bioessays. 2015 Aug;37(8):867-76. doi: 10.1002/bies.201500013. Epub 2015 May 26. Review.

47.

Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity.

Kooijman S, van den Berg R, Ramkisoensing A, Boon MR, Kuipers EN, Loef M, Zonneveld TC, Lucassen EA, Sips HC, Chatzispyrou IA, Houtkooper RH, Meijer JH, Coomans CP, Biermasz NR, Rensen PC.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6748-53. doi: 10.1073/pnas.1504239112. Epub 2015 May 11.

48.

Fatty acid oxidation flux predicts the clinical severity of VLCAD deficiency.

Diekman EF, Ferdinandusse S, van der Pol L, Waterham HR, Ruiter JP, Ijlst L, Wanders RJ, Houten SM, Wijburg FA, Blank AC, Asselbergs FW, Houtkooper RH, Visser G.

Genet Med. 2015 Dec;17(12):989-94. doi: 10.1038/gim.2015.22. Epub 2015 Apr 2.

PMID:
25834949
49.

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J.

Cell Rep. 2015 Mar 17;10(10):1681-1691. doi: 10.1016/j.celrep.2015.02.034. Epub 2015 Mar 12.

50.

Laminar shear stress inhibits endothelial cell metabolism via KLF2-mediated repression of PFKFB3.

Doddaballapur A, Michalik KM, Manavski Y, Lucas T, Houtkooper RH, You X, Chen W, Zeiher AM, Potente M, Dimmeler S, Boon RA.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):137-45. doi: 10.1161/ATVBAHA.114.304277. Epub 2014 Oct 30.

PMID:
25359860

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