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Items: 1 to 50 of 245

1.

Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.

De Bruyn T, Ufuk A, Cantrill C, Kosa RE, Bi YA, Niosi M, Modi S, Rodrigues AD, Tremaine LM, Varma MVS, Galetin A, Houston JB.

Drug Metab Dispos. 2018 Jul;46(7):989-1000. doi: 10.1124/dmd.118.081315. Epub 2018 May 2.

PMID:
29720472
2.

In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.

Ufuk A, Kosa RE, Gao H, Bi YA, Modi S, Gates D, Rodrigues AD, Tremaine LM, Varma MVS, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2018 Jun;365(3):688-699. doi: 10.1124/jpet.118.247767. Epub 2018 Apr 11.

PMID:
29643253
3.

Simultaneous Assessment In Vitro of Transporter and Metabolic Processes in Hepatic Drug Clearance: Use of a Media Loss Approach.

Harrison J, De Bruyn T, Darwich AS, Houston JB.

Drug Metab Dispos. 2018 Apr;46(4):405-414. doi: 10.1124/dmd.117.079590. Epub 2018 Feb 8.

PMID:
29439129
4.

Importance of the Unstirred Water Layer and Hepatocyte Membrane Integrity In Vitro for Quantification of Intrinsic Metabolic Clearance.

Wood FL, Houston JB, Hallifax D.

Drug Metab Dispos. 2018 Mar;46(3):268-278. doi: 10.1124/dmd.117.078949. Epub 2017 Dec 12.

PMID:
29233818
5.

Clearance Prediction Methodology Needs Fundamental Improvement: Trends Common to Rat and Human Hepatocytes/Microsomes and Implications for Experimental Methodology.

Wood FL, Houston JB, Hallifax D.

Drug Metab Dispos. 2017 Nov;45(11):1178-1188. doi: 10.1124/dmd.117.077040. Epub 2017 Sep 8. Erratum in: Drug Metab Dispos. 2017 Dec;45(12 ):1239.

PMID:
28887366
6.

Incorporation of lysosomal sequestration in the mechanistic model for prediction of tissue distribution of basic drugs.

Assmus F, Houston JB, Galetin A.

Eur J Pharm Sci. 2017 Nov 15;109:419-430. doi: 10.1016/j.ejps.2017.08.014. Epub 2017 Aug 18.

PMID:
28823852
7.

Understanding the Interplay Between Uptake and Efflux Transporters Within In Vitro Systems in Defining Hepatocellular Drug Concentrations.

Cantrill C, Houston JB.

J Pharm Sci. 2017 Sep;106(9):2815-2825. doi: 10.1016/j.xphs.2017.04.056. Epub 2017 May 3.

PMID:
28478131
8.

In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages.

Ufuk A, Assmus F, Francis L, Plumb J, Damian V, Gertz M, Houston JB, Galetin A.

Mol Pharm. 2017 Apr 3;14(4):1033-1046. doi: 10.1021/acs.molpharmaceut.6b00908. Epub 2017 Mar 20.

PMID:
28252969
9.

Randomized controlled trial of the Resilience and Coping Intervention (RCI) with undergraduate university students.

Houston JB, First J, Spialek ML, Sorenson ME, Mills-Sandoval T, Lockett M, First NL, Nitiéma P, Allen SF, Pfefferbaum B.

J Am Coll Health. 2017 Jan;65(1):1-9. doi: 10.1080/07448481.2016.1227826. Epub 2016 Aug 25.

PMID:
27559857
10.

Effects of Displacement in Children Exposed to Disasters.

Pfefferbaum B, Jacobs AK, Van Horn RL, Houston JB.

Curr Psychiatry Rep. 2016 Aug;18(8):71. doi: 10.1007/s11920-016-0714-1. Review.

PMID:
27287465
11.

Public Disaster Communication and Child and Family Disaster Mental Health: a Review of Theoretical Frameworks and Empirical Evidence.

Houston JB, First J, Spialek ML, Sorenson ME, Koch M.

Curr Psychiatry Rep. 2016 Jun;18(6):54. doi: 10.1007/s11920-016-0690-5. Review.

PMID:
27086315
12.

Reactions of Oklahoma City bombing survivors to media coverage of the September 11, 2001, attacks.

Pfefferbaum B, Nitiéma P, Pfefferbaum RL, Houston JB, Tucker P, Jeon-Slaughter H, North CS.

Compr Psychiatry. 2016 Feb;65:70-8. doi: 10.1016/j.comppsych.2015.09.010. Epub 2015 Sep 25.

PMID:
26773993
13.

2011 Joplin, Missouri Tornado Experience, Mental Health Reactions, and Service Utilization: Cross-Sectional Assessments at Approximately 6 Months and 2.5 Years Post-Event.

Houston JB, Spialek ML, Stevens J, First J, Mieseler VL, Pfefferbaum B.

PLoS Curr. 2015 Oct 26;7. pii: ecurrents.dis.18ca227647291525ce3415bec1406aa5. doi: 10.1371/currents.dis.18ca227647291525ce3415bec1406aa5.

14.

In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.

Ufuk A, Somers G, Houston JB, Galetin A.

Pharm Res. 2015 Dec;32(12):3937-51. doi: 10.1007/s11095-015-1753-8. Epub 2015 Jul 30.

15.

Coverage of Posttraumatic Stress Disorder in the New York Times, 1950-2012.

Houston JB, Spialek ML, Perreault MF.

J Health Commun. 2016;21(2):240-8. doi: 10.1080/10810730.2015.1058441. Epub 2015 Dec 30.

PMID:
26166398
16.

Children's disaster reactions: the influence of exposure and personal characteristics.

Pfefferbaum B, Jacobs AK, Griffin N, Houston JB.

Curr Psychiatry Rep. 2015 Jul;17(7):56. doi: 10.1007/s11920-015-0598-5. Review.

PMID:
25980513
17.

Children's disaster reactions: the influence of family and social factors.

Pfefferbaum B, Jacobs AK, Houston JB, Griffin N.

Curr Psychiatry Rep. 2015 Jul;17(7):57. doi: 10.1007/s11920-015-0597-6. Review.

PMID:
25980512
18.

Social media and disasters: a functional framework for social media use in disaster planning, response, and research.

Houston JB, Hawthorne J, Perreault MF, Park EH, Goldstein Hode M, Halliwell MR, Turner McGowen SE, Davis R, Vaid S, McElderry JA, Griffith SA.

Disasters. 2015 Jan;39(1):1-22. doi: 10.1111/disa.12092. Epub 2014 Sep 22. Review.

PMID:
25243593
19.

Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs.

Nishimuta H, Houston JB, Galetin A.

Drug Metab Dispos. 2014 Sep;42(9):1522-31. doi: 10.1124/dmd.114.057372. Epub 2014 Jul 3.

20.

Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition.

Smith D, Artursson P, Avdeef A, Di L, Ecker GF, Faller B, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, van de Waterbeemd H, Sugano K, Testa B.

Mol Pharm. 2014 Jun 2;11(6):1727-38. doi: 10.1021/mp400713v. Epub 2014 May 6. Review.

PMID:
24724562
21.

Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.

Gertz M, Tsamandouras N, Säll C, Houston JB, Galetin A.

Pharm Res. 2014 Sep;31(9):2367-82. doi: 10.1007/s11095-014-1333-3. Epub 2014 Mar 13.

PMID:
24623479
22.

Children of National Guard troops: a pilot study of deployment, patriotism, and media coverage.

Pfefferbaum B, Jeon-Slaughter H, Jacobs AK, Houston JB.

Int J Emerg Ment Health. 2013;15(2):129-37.

PMID:
24558700
23.

Building community resilience to disasters through a community-based intervention: CART applications.

Pfefferbaum RL, Pfefferbaum B, Van Horn RL, Neas BR, Houston JB.

J Emerg Manag. 2013 Mar-Apr;11(2):151-9.

PMID:
24180095
24.

Prediction of human pharmacokinetics in 2013 and beyond.

Houston JB.

Drug Metab Dispos. 2013 Dec;41(12):1973-4. doi: 10.1124/dmd.113.055376. Epub 2013 Oct 15.

25.

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Godoy P, Hewitt NJ, Albrecht U, Andersen ME, Ansari N, Bhattacharya S, Bode JG, Bolleyn J, Borner C, Böttger J, Braeuning A, Budinsky RA, Burkhardt B, Cameron NR, Camussi G, Cho CS, Choi YJ, Craig Rowlands J, Dahmen U, Damm G, Dirsch O, Donato MT, Dong J, Dooley S, Drasdo D, Eakins R, Ferreira KS, Fonsato V, Fraczek J, Gebhardt R, Gibson A, Glanemann M, Goldring CE, Gómez-Lechón MJ, Groothuis GM, Gustavsson L, Guyot C, Hallifax D, Hammad S, Hayward A, Häussinger D, Hellerbrand C, Hewitt P, Hoehme S, Holzhütter HG, Houston JB, Hrach J, Ito K, Jaeschke H, Keitel V, Kelm JM, Kevin Park B, Kordes C, Kullak-Ublick GA, LeCluyse EL, Lu P, Luebke-Wheeler J, Lutz A, Maltman DJ, Matz-Soja M, McMullen P, Merfort I, Messner S, Meyer C, Mwinyi J, Naisbitt DJ, Nussler AK, Olinga P, Pampaloni F, Pi J, Pluta L, Przyborski SA, Ramachandran A, Rogiers V, Rowe C, Schelcher C, Schmich K, Schwarz M, Singh B, Stelzer EH, Stieger B, Stöber R, Sugiyama Y, Tetta C, Thasler WE, Vanhaecke T, Vinken M, Weiss TS, Widera A, Woods CG, Xu JJ, Yarborough KM, Hengstler JG.

Arch Toxicol. 2013 Aug;87(8):1315-530. doi: 10.1007/s00204-013-1078-5. Epub 2013 Aug 23. Review.

26.

Application of a physiologically based pharmacokinetic model to assess propofol hepatic and renal glucuronidation in isolation: utility of in vitro and in vivo data.

Gill KL, Gertz M, Houston JB, Galetin A.

Drug Metab Dispos. 2013 Apr;41(4):744-53. doi: 10.1124/dmd.112.050294. Epub 2013 Jan 9.

27.

Disaster Research Team Building: A Case Study of a Web-based Disaster Research Training Program.

Beaton RD, Johnson LC, Maida CA, Houston JB, Pfefferbaum B.

Traumatology (Tallahass Fla). 2012 Nov 19;18(4):86-91. Epub 2012 Jun 13.

28.

Cyclosporine inhibition of hepatic and intestinal CYP3A4, uptake and efflux transporters: application of PBPK modeling in the assessment of drug-drug interaction potential.

Gertz M, Cartwright CM, Hobbs MJ, Kenworthy KE, Rowland M, Houston JB, Galetin A.

Pharm Res. 2013 Mar;30(3):761-80. doi: 10.1007/s11095-012-0918-y. Epub 2012 Nov 22.

PMID:
23179780
29.

Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.

Hallifax D, Houston JB.

J Pharm Sci. 2012 Aug;101(8):2645-52. doi: 10.1002/jps.23202. Epub 2012 Jun 14.

PMID:
22700322
30.

Use of mechanistic modeling to assess interindividual variability and interspecies differences in active uptake in human and rat hepatocytes.

Ménochet K, Kenworthy KE, Houston JB, Galetin A.

Drug Metab Dispos. 2012 Sep;40(9):1744-56. doi: 10.1124/dmd.112.046193. Epub 2012 Jun 4.

31.

Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4.

Burt HJ, Pertinez H, Säll C, Collins C, Hyland R, Houston JB, Galetin A.

Drug Metab Dispos. 2012 Sep;40(9):1658-67. doi: 10.1124/dmd.112.046078. Epub 2012 May 23.

32.
33.

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.

Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, Sugano K.

Drug Discov Today. 2012 Aug;17(15-16):905-12. doi: 10.1016/j.drudis.2012.03.015. Epub 2012 Apr 4. Review.

PMID:
22507594
34.

A comprehensive assessment of repaglinide metabolic pathways: impact of choice of in vitro system and relative enzyme contribution to in vitro clearance.

Säll C, Houston JB, Galetin A.

Drug Metab Dispos. 2012 Jul;40(7):1279-89. doi: 10.1124/dmd.112.045286. Epub 2012 Mar 26.

35.

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS.

Drug Metab Dispos. 2012 May;40(5):1007-17. doi: 10.1124/dmd.111.042994. Epub 2012 Feb 16.

36.
37.

Evaluation of the novel in vitro systems for hepatic drug clearance and assessment of their predictive utility.

Houston JB, Rowland-Yeo K, Zanelli U.

Toxicol In Vitro. 2012 Dec;26(8):1265-71. doi: 10.1016/j.tiv.2011.12.016. Epub 2012 Jan 8.

PMID:
22244922
38.

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs.

Hallifax D, Turlizzi E, Zanelli U, Houston JB.

Eur J Pharm Sci. 2012 Apr 11;45(5):570-4. doi: 10.1016/j.ejps.2011.12.010. Epub 2011 Dec 24.

PMID:
22214813
39.

Incident-related television viewing and psychiatric disorders in Oklahoma City bombing survivors.

Pfefferbaum B, North CS, Pfefferbaum RL, Jeon-Slaughter H, Houston JB, Regens JL.

Int J Emerg Ment Health. 2012;14(4):247-55.

PMID:
23980489
40.

Perception of change and burden in children of national guard troops deployed as part of the global war on terror.

Pfefferbaum B, Houston JB, Allen SF.

Int J Emerg Ment Health. 2012;14(3):189-96.

PMID:
23894799
41.

Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model.

Ménochet K, Kenworthy KE, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2012 Apr;341(1):2-15. doi: 10.1124/jpet.111.187112. Epub 2011 Dec 21.

42.

Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.

Zanelli U, Caradonna NP, Hallifax D, Turlizzi E, Houston JB.

Drug Metab Dispos. 2012 Jan;40(1):104-10. doi: 10.1124/dmd.111.042309. Epub 2011 Oct 13.

43.

Predictive utility of in vitro rifampin induction data generated in fresh and cryopreserved human hepatocytes, Fa2N-4, and HepaRG cells.

Templeton IE, Houston JB, Galetin A.

Drug Metab Dispos. 2011 Oct;39(10):1921-9. doi: 10.1124/dmd.111.040824. Epub 2011 Jul 19.

44.

Kinetic characterization of rat hepatic uptake of 16 actively transported drugs.

Yabe Y, Galetin A, Houston JB.

Drug Metab Dispos. 2011 Oct;39(10):1808-14. doi: 10.1124/dmd.111.040477. Epub 2011 Jul 5.

45.

A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.

Newman WG, Payne K, Tricker K, Roberts SA, Fargher E, Pushpakom S, Alder JE, Sidgwick GP, Payne D, Elliott RA, Heise M, Elles R, Ramsden SC, Andrews J, Houston JB, Qasim F, Shaffer J, Griffiths CE, Ray DW, Bruce I, Ollier WE; TARGET study recruitment team.

Pharmacogenomics. 2011 Jun;12(6):815-26. doi: 10.2217/pgs.11.32. Epub 2011 May 3.

PMID:
21692613
46.

Physiologically based pharmacokinetic modeling of intestinal first-pass metabolism of CYP3A substrates with high intestinal extraction.

Gertz M, Houston JB, Galetin A.

Drug Metab Dispos. 2011 Sep;39(9):1633-42. doi: 10.1124/dmd.111.039248. Epub 2011 Jun 1.

47.

Prediction of human drug clearance by multiple metabolic pathways: integration of hepatic and intestinal microsomal and cytosolic data.

Cubitt HE, Houston JB, Galetin A.

Drug Metab Dispos. 2011 May;39(5):864-73. doi: 10.1124/dmd.110.036566. Epub 2011 Feb 8.

48.

Assessment of algorithms for predicting drug-drug interactions via inhibition mechanisms: comparison of dynamic and static models.

Guest EJ, Rowland-Yeo K, Rostami-Hodjegan A, Tucker GT, Houston JB, Galetin A.

Br J Clin Pharmacol. 2011 Jan;71(1):72-87. doi: 10.1111/j.1365-2125.2010.03799.x.

49.
50.

Critique of the two-fold measure of prediction success for ratios: application for the assessment of drug-drug interactions.

Guest EJ, Aarons L, Houston JB, Rostami-Hodjegan A, Galetin A.

Drug Metab Dispos. 2011 Feb;39(2):170-3. doi: 10.1124/dmd.110.036103. Epub 2010 Oct 29.

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