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Items: 1 to 50 of 223

1.

IKKβ slows Huntington's disease progression in R6/1 mice.

Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10952-10961. doi: 10.1073/pnas.1814246116. Epub 2019 May 14.

2.

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.

Nath SR, Yu Z, Gipson TA, Marsh GB, Yoshidome E, Robins DM, Todi SV, Housman DE, Lieberman AP.

J Clin Invest. 2018 Aug 1;128(8):3630-3641. doi: 10.1172/JCI99042. Epub 2018 Jul 23.

3.

Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.

Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chiò A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A.

EMBO J. 2018 Jun 1;37(11). pii: e98684. doi: 10.15252/embj.201798684. Epub 2018 May 15.

4.

Could antiretrovirals be treating EBV in MS? A case report.

Drosu NC, Edelman ER, Housman DE.

Mult Scler Relat Disord. 2018 May;22:19-21. doi: 10.1016/j.msard.2018.02.029. Epub 2018 Feb 27.

5.

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.

Neueder A, Gipson TA, Batterton S, Lazell HJ, Farshim PP, Paganetti P, Housman DE, Bates GP.

Sci Rep. 2017 Oct 2;7(1):12556. doi: 10.1038/s41598-017-12897-0.

6.

Detection of long repeat expansions from PCR-free whole-genome sequence data.

Dolzhenko E, van Vugt JJFA, Shaw RJ, Bekritsky MA, van Blitterswijk M, Narzisi G, Ajay SS, Rajan V, Lajoie BR, Johnson NH, Kingsbury Z, Humphray SJ, Schellevis RD, Brands WJ, Baker M, Rademakers R, Kooyman M, Tazelaar GHP, van Es MA, McLaughlin R, Sproviero W, Shatunov A, Jones A, Al Khleifat A, Pittman A, Morgan S, Hardiman O, Al-Chalabi A, Shaw C, Smith B, Neo EJ, Morrison K, Shaw PJ, Reeves C, Winterkorn L, Wexler NS; US–Venezuela Collaborative Research Group, Housman DE, Ng CW, Li AL, Taft RJ, van den Berg LH, Bentley DR, Veldink JH, Eberle MA.

Genome Res. 2017 Nov;27(11):1895-1903. doi: 10.1101/gr.225672.117. Epub 2017 Sep 8.

7.

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia.

McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM.

Cell Rep. 2017 Sep 5;20(10):2490-2500. doi: 10.1016/j.celrep.2017.08.051.

8.

Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.

Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM.

Cell Rep. 2017 May 16;19(7):1365-1377. doi: 10.1016/j.celrep.2017.04.021.

9.

Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists?

Taylor JY, Wright ML, Hickey KT, Housman DE.

Nurs Res. 2017 Mar/Apr;66(2):198-205. doi: 10.1097/NNR.0000000000000211.

10.

Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.

Crittenden JR, Tillberg PW, Riad MH, Shima Y, Gerfen CR, Curry J, Housman DE, Nelson SB, Boyden ES, Graybiel AM.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11318-11323. Epub 2016 Sep 19.

11.

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Ouyang Q, Nakayama T, Baytas O, Davidson SM, Yang C, Schmidt M, Lizarraga SB, Mishra S, Ei-Quessny M, Niaz S, Gul Butt M, Imran Murtaza S, Javed A, Chaudhry HR, Vaughan DJ, Hill RS, Partlow JN, Yoo SY, Lam AT, Nasir R, Al-Saffar M, Barkovich AJ, Schwede M, Nagpal S, Rajab A, DeBerardinis RJ, Housman DE, Mochida GH, Morrow EM.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5598-607. doi: 10.1073/pnas.1609221113. Epub 2016 Sep 6.

12.

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94. doi: 10.1073/pnas.1420103111. Epub 2014 Nov 10.

13.

Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries.

Boissonneault KR, Henningsen BM, Bates SS, Robertson DL, Milton S, Pelletier J, Hogan DA, Housman DE.

BMC Mol Biol. 2013 Nov 1;14:25. doi: 10.1186/1471-2199-14-25.

14.

Targeting H3K4 trimethylation in Huntington disease.

Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3027-36. doi: 10.1073/pnas.1311323110. Epub 2013 Jul 19.

15.

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.

van Blitterswijk M, Wang ET, Friedman BA, Keagle PJ, Lowe P, Leclerc AL, van den Berg LH, Housman DE, Veldink JH, Landers JE.

PLoS One. 2013;8(4):e60788. doi: 10.1371/journal.pone.0060788. Epub 2013 Apr 8.

16.

Systematic identification of combinatorial drivers and targets in cancer cell lines.

Tabchy A, Eltonsy N, Housman DE, Mills GB.

PLoS One. 2013;8(4):e60339. doi: 10.1371/journal.pone.0060339. Epub 2013 Apr 5. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/85d86c29-4ba6-4bf0-94f6-2977b3e1c792.

17.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3077-82. doi: 10.1073/pnas.1222663110. Epub 2013 Jan 30.

18.

Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.

19.

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22.

20.

In vivo identification of therapeutic constructs from pooled candidates in HD model mice.

Crook ZR, Housman DE.

J Huntingtons Dis. 2013;2(4):437-41. doi: 10.3233/JHD-130073.

PMID:
25062730
21.

Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines.

Crook ZR, Housman DE.

J Huntingtons Dis. 2013;2(4):405-36. doi: 10.3233/JHD-130072. Review.

PMID:
25062729
22.

Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB.

Cell. 2012 Aug 17;150(4):710-24. doi: 10.1016/j.cell.2012.06.041.

23.

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD.

Mol Cell. 2012 Apr 27;46(2):171-86. doi: 10.1016/j.molcel.2012.04.008.

24.

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice.

Crook ZR, Housman DE.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7487-92. doi: 10.1073/pnas.1204542109. Epub 2012 Apr 23.

25.

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.

Jun HJ, Acquaviva J, Chi D, Lessard J, Zhu H, Woolfenden S, Bronson RT, Pfannl R, White F, Housman DE, Iyer L, Whittaker CA, Boskovitz A, Raval A, Charest A.

Oncogene. 2012 Jun 21;31(25):3039-50. doi: 10.1038/onc.2011.474. Epub 2011 Oct 24.

26.

Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.

Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A.

Cancer Res. 2011 Dec 1;71(23):7198-206. doi: 10.1158/0008-5472.CAN-11-1514. Epub 2011 Oct 10.

27.

Rapid haplotype inference for nuclear families.

Williams AL, Housman DE, Rinard MC, Gifford DK.

Genome Biol. 2010;11(10):R108. doi: 10.1186/gb-2010-11-10-r108. Epub 2010 Oct 29.

28.

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM.

Hum Mol Genet. 2010 May 1;19(9):1756-65. doi: 10.1093/hmg/ddq055. Epub 2010 Feb 10.

29.

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS.

PLoS One. 2010 Jan 21;5(1):e8830. doi: 10.1371/journal.pone.0008830.

30.

Development of a method for the high-throughput quantification of cellular proteins.

Paganetti P, Weiss A, Trapp M, Hammerl I, Bleckmann D, Bodner RA, Coven-Easter S, Housman DE, Parker CN.

Chembiochem. 2009 Jul 6;10(10):1678-88. doi: 10.1002/cbic.200900131.

PMID:
19492395
31.

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6. doi: 10.1073/pnas.0813314106. Epub 2009 Feb 5.

32.

Association between arterial stiffness and variations in oestrogen-related genes.

Peter I, Kelley-Hedgepeth A, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GF.

J Hum Hypertens. 2009 Oct;23(10):636-44. doi: 10.1038/jhh.2009.1. Epub 2009 Feb 5.

33.

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A.

Science. 2008 Oct 31;322(5902):703-9. doi: 10.1126/science.1160058.

34.

Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.

Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR; International-Venezuela Collaborative Research Group.

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):425-9. doi: 10.1002/ajmg.b.30826.

35.

mTORC1 promotes survival through translational control of Mcl-1.

Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10853-8. doi: 10.1073/pnas.0804821105. Epub 2008 Jul 29.

36.

Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.

Gayán J, Brocklebank D, Andresen JM, Alkorta-Aranburu G; US-Venezuela Collaborative Research Group, Zameel Cader M, Roberts SA, Cherny SS, Wexler NS, Cardon LR, Housman DE.

Genet Epidemiol. 2008 Jul;32(5):445-53. doi: 10.1002/gepi.20317.

PMID:
18481795
37.

Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels.

Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM.

J Clin Endocrinol Metab. 2008 Jul;93(7):2779-85. doi: 10.1210/jc.2008-0106. Epub 2008 Apr 29.

38.

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse.

Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16685-9. Epub 2007 Oct 9.

39.

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD.

J Clin Invest. 2007 Jun;117(6):1699-707. Epub 2007 May 10.

40.

Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments.

Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG.

J Biomol Screen. 2007 Apr;12(3):351-60. Epub 2007 Mar 22.

PMID:
17379859
41.

Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene.

Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples LA, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ.

Hypertension. 2007 May;49(5):1000-6. Epub 2007 Mar 19.

PMID:
17372038
42.

The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset.

Andresen JM, Gayán J, Djoussé L, Roberts S, Brocklebank D, Cherny SS; US-Venezuela Collaborative Research Group; HD MAPS Collaborative Research Group, Cardon LR, Gusella JF, MacDonald ME, Myers RH, Housman DE, Wexler NS.

Ann Hum Genet. 2007 May;71(Pt 3):295-301. Epub 2006 Dec 19.

43.

Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.

Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17278-83. Epub 2006 Nov 6.

44.

Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds.

Andresen JM, Gayán J, Cherny SS, Brocklebank D, Alkorta-Aranburu G, Addis EA; US-Venezuela Collaborative Research Group, Cardon LR, Housman DE, Wexler NS.

J Med Genet. 2007 Jan;44(1):44-50. Epub 2006 Oct 3.

45.

New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions.

Bodner RA, Housman DE, Kazantsev AG.

Cell Cycle. 2006 Jul;5(14):1477-80. Epub 2006 Jul 17. Review.

PMID:
16861893
46.

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.

Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4246-51. Epub 2006 Mar 6.

47.

Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts.

Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SC, Uitterlinden AG, Pols HA, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE.

Circ Res. 2006 Mar 17;98(5):590-2. Epub 2006 Feb 16.

PMID:
16484614
48.

Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women.

Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ.

Am J Hypertens. 2005 Nov;18(11):1388-95.

PMID:
16280269
49.

Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study.

Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D.

J Hypertens. 2005 Dec;23(12):2193-200.

PMID:
16269961
50.

Estrogen receptor alpha gene variation and the risk of stroke.

Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ.

Stroke. 2005 Oct;36(10):2281-2. Epub 2005 Sep 22.

PMID:
16179580

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