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Items: 1 to 50 of 388

1.

IKKβ slows Huntington's disease progression in R6/1 mice.

Ochaba J, Fote G, Kachemov M, Thein S, Yeung SY, Lau AL, Hernandez S, Lim RG, Casale M, Neel MJ, Monuki ES, Reidling J, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2019 May 28;116(22):10952-10961. doi: 10.1073/pnas.1814246116. Epub 2019 May 14.

2.

Transcriptome alterations in myotonic dystrophy skeletal muscle and heart.

Wang ET, Treacy D, Eichinger K, Struck A, Estabrook J, Olafson H, Wang TT, Bhatt K, Westbrook T, Sedehizadeh S, Ward A, Day J, Brook D, Berglund JA, Cooper T, Housman D, Thornton C, Burge C.

Hum Mol Genet. 2019 Apr 15;28(8):1312-1321. doi: 10.1093/hmg/ddy432.

PMID:
30561649
3.

Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction.

Nath SR, Yu Z, Gipson TA, Marsh GB, Yoshidome E, Robins DM, Todi SV, Housman DE, Lieberman AP.

J Clin Invest. 2018 Aug 1;128(8):3630-3641. doi: 10.1172/JCI99042. Epub 2018 Jul 23.

4.

Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.

Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chiò A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A.

EMBO J. 2018 Jun 1;37(11). pii: e98684. doi: 10.15252/embj.201798684. Epub 2018 May 15.

5.

Could antiretrovirals be treating EBV in MS? A case report.

Drosu NC, Edelman ER, Housman DE.

Mult Scler Relat Disord. 2018 May;22:19-21. doi: 10.1016/j.msard.2018.02.029. Epub 2018 Feb 27.

6.

HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.

Neueder A, Gipson TA, Batterton S, Lazell HJ, Farshim PP, Paganetti P, Housman DE, Bates GP.

Sci Rep. 2017 Oct 2;7(1):12556. doi: 10.1038/s41598-017-12897-0.

7.

Detection of long repeat expansions from PCR-free whole-genome sequence data.

Dolzhenko E, van Vugt JJFA, Shaw RJ, Bekritsky MA, van Blitterswijk M, Narzisi G, Ajay SS, Rajan V, Lajoie BR, Johnson NH, Kingsbury Z, Humphray SJ, Schellevis RD, Brands WJ, Baker M, Rademakers R, Kooyman M, Tazelaar GHP, van Es MA, McLaughlin R, Sproviero W, Shatunov A, Jones A, Al Khleifat A, Pittman A, Morgan S, Hardiman O, Al-Chalabi A, Shaw C, Smith B, Neo EJ, Morrison K, Shaw PJ, Reeves C, Winterkorn L, Wexler NS; US–Venezuela Collaborative Research Group, Housman DE, Ng CW, Li AL, Taft RJ, van den Berg LH, Bentley DR, Veldink JH, Eberle MA.

Genome Res. 2017 Nov;27(11):1895-1903. doi: 10.1101/gr.225672.117. Epub 2017 Sep 8.

8.

A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich's Ataxia.

McGinty RJ, Puleo F, Aksenova AY, Hisey JA, Shishkin AA, Pearson EL, Wang ET, Housman DE, Moore C, Mirkin SM.

Cell Rep. 2017 Sep 5;20(10):2490-2500. doi: 10.1016/j.celrep.2017.08.051.

9.

Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits.

Lim RG, Quan C, Reyes-Ortiz AM, Lutz SE, Kedaigle AJ, Gipson TA, Wu J, Vatine GD, Stocksdale J, Casale MS, Svendsen CN, Fraenkel E, Housman DE, Agalliu D, Thompson LM.

Cell Rep. 2017 May 16;19(7):1365-1377. doi: 10.1016/j.celrep.2017.04.021.

10.

Genome Sequencing Technologies and Nursing: What Are the Roles of Nurses and Nurse Scientists?

Taylor JY, Wright ML, Hickey KT, Housman DE.

Nurs Res. 2017 Mar/Apr;66(2):198-205. doi: 10.1097/NNR.0000000000000211.

11.

Striosome-dendron bouquets highlight a unique striatonigral circuit targeting dopamine-containing neurons.

Crittenden JR, Tillberg PW, Riad MH, Shima Y, Gerfen CR, Curry J, Housman DE, Nelson SB, Boyden ES, Graybiel AM.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11318-11323. Epub 2016 Sep 19.

12.

Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Ouyang Q, Nakayama T, Baytas O, Davidson SM, Yang C, Schmidt M, Lizarraga SB, Mishra S, Ei-Quessny M, Niaz S, Gul Butt M, Imran Murtaza S, Javed A, Chaudhry HR, Vaughan DJ, Hill RS, Partlow JN, Yoo SY, Lam AT, Nasir R, Al-Saffar M, Barkovich AJ, Schwede M, Nagpal S, Rajab A, DeBerardinis RJ, Housman DE, Mochida GH, Morrow EM.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5598-607. doi: 10.1073/pnas.1609221113. Epub 2016 Sep 6.

13.

Lead toxicity and genetics in Flint, MI.

Taylor JY, Wright ML, Housman D.

NPJ Genom Med. 2016;1. pii: 16018. Epub 2016 Jun 22. No abstract available.

14.

A perspective for sequencing familial hypercholesterolaemia in African Americans.

Wright ML, Housman D, Taylor JY.

NPJ Genom Med. 2016 May 11;1:16012. doi: 10.1038/npjgenmed.2016.12. eCollection 2016.

15.

tranSMART: An Open Source Knowledge Management and High Content Data Analytics Platform.

Scheufele E, Aronzon D, Coopersmith R, McDuffie MT, Kapoor M, Uhrich CA, Avitabile JE, Liu J, Housman D, Palchuk MB.

AMIA Jt Summits Transl Sci Proc. 2014 Apr 7;2014:96-101. eCollection 2014.

16.

Potential function for the Huntingtin protein as a scaffold for selective autophagy.

Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, Housman DE, Thompson LM, Steffan JS.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16889-94. doi: 10.1073/pnas.1420103111. Epub 2014 Nov 10.

17.

Aberrantly spliced HTT, a new player in Huntington's disease pathogenesis.

Gipson TA, Neueder A, Wexler NS, Bates GP, Housman D.

RNA Biol. 2013 Nov;10(11):1647-52. doi: 10.4161/rna.26706. Epub 2013 Oct 11.

18.

Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries.

Boissonneault KR, Henningsen BM, Bates SS, Robertson DL, Milton S, Pelletier J, Hogan DA, Housman DE.

BMC Mol Biol. 2013 Nov 1;14:25. doi: 10.1186/1471-2199-14-25.

19.

Targeting H3K4 trimethylation in Huntington disease.

Vashishtha M, Ng CW, Yildirim F, Gipson TA, Kratter IH, Bodai L, Song W, Lau A, Labadorf A, Vogel-Ciernia A, Troncosco J, Ross CA, Bates GP, Krainc D, Sadri-Vakili G, Finkbeiner S, Marsh JL, Housman DE, Fraenkel E, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):E3027-36. doi: 10.1073/pnas.1311323110. Epub 2013 Jul 19.

20.

Temporary organ displacement coupled with image-guided, intensity-modulated radiotherapy for paraspinal tumors.

Katsoulakis E, Solomon SB, Maybody M, Housman D, Niyazov G, Riaz N, Lovelock M, Spratt DE, Erinjeri JP, Thornton RH, Yamada Y.

Radiat Oncol. 2013 Jun 24;8:150. doi: 10.1186/1748-717X-8-150.

21.

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq.

van Blitterswijk M, Wang ET, Friedman BA, Keagle PJ, Lowe P, Leclerc AL, van den Berg LH, Housman DE, Veldink JH, Landers JE.

PLoS One. 2013;8(4):e60788. doi: 10.1371/journal.pone.0060788. Epub 2013 Apr 8.

22.

Systematic identification of combinatorial drivers and targets in cancer cell lines.

Tabchy A, Eltonsy N, Housman DE, Mills GB.

PLoS One. 2013;8(4):e60339. doi: 10.1371/journal.pone.0060339. Epub 2013 Apr 5. Erratum in: PLoS One. 2013;8(5). doi:10.1371/annotation/85d86c29-4ba6-4bf0-94f6-2977b3e1c792.

23.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3077-82. doi: 10.1073/pnas.1222663110. Epub 2013 Jan 30.

24.

Extensive changes in DNA methylation are associated with expression of mutant huntingtin.

Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2354-9. doi: 10.1073/pnas.1221292110. Epub 2013 Jan 22.

25.

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease.

Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2366-70. doi: 10.1073/pnas.1221891110. Epub 2013 Jan 22.

26.

In vivo identification of therapeutic constructs from pooled candidates in HD model mice.

Crook ZR, Housman DE.

J Huntingtons Dis. 2013;2(4):437-41. doi: 10.3233/JHD-130073.

PMID:
25062730
27.

Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines.

Crook ZR, Housman DE.

J Huntingtons Dis. 2013;2(4):405-36. doi: 10.3233/JHD-130072. Review.

PMID:
25062729
28.

Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins.

Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB.

Cell. 2012 Aug 17;150(4):710-24. doi: 10.1016/j.cell.2012.06.041.

29.

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD.

Mol Cell. 2012 Apr 27;46(2):171-86. doi: 10.1016/j.molcel.2012.04.008.

30.

Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice.

Crook ZR, Housman DE.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7487-92. doi: 10.1073/pnas.1204542109. Epub 2012 Apr 23.

31.

Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching.

Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD.

J Am Chem Soc. 2012 Mar 14;134(10):4731-42. doi: 10.1021/ja210088v. Epub 2012 Mar 5.

32.

Incidence of secondary cancer development after high-dose intensity-modulated radiotherapy and image-guided brachytherapy for the treatment of localized prostate cancer.

Zelefsky MJ, Housman DM, Pei X, Alicikus Z, Magsanoc JM, Dauer LT, St Germain J, Yamada Y, Kollmeier M, Cox B, Zhang Z.

Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):953-9. doi: 10.1016/j.ijrobp.2011.08.034. Epub 2011 Dec 13.

PMID:
22172904
33.

Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme.

Jun HJ, Acquaviva J, Chi D, Lessard J, Zhu H, Woolfenden S, Bronson RT, Pfannl R, White F, Housman DE, Iyer L, Whittaker CA, Boskovitz A, Raval A, Charest A.

Oncogene. 2012 Jun 21;31(25):3039-50. doi: 10.1038/onc.2011.474. Epub 2011 Oct 24.

34.

Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation.

Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A.

Cancer Res. 2011 Dec 1;71(23):7198-206. doi: 10.1158/0008-5472.CAN-11-1514. Epub 2011 Oct 10.

35.

Huntington's disease: can mice lead the way to treatment?

Crook ZR, Housman D.

Neuron. 2011 Feb 10;69(3):423-35. doi: 10.1016/j.neuron.2010.12.035. Review. Erratum in: Neuron. 2011 Mar 10;69(5):1038.

36.

Rapid haplotype inference for nuclear families.

Williams AL, Housman DE, Rinard MC, Gifford DK.

Genome Biol. 2010;11(10):R108. doi: 10.1186/gb-2010-11-10-r108. Epub 2010 Oct 29.

37.

CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease.

Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM.

Hum Mol Genet. 2010 May 1;19(9):1756-65. doi: 10.1093/hmg/ddq055. Epub 2010 Feb 10.

38.

Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve.

Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS.

PLoS One. 2010 Jan 21;5(1):e8830. doi: 10.1371/journal.pone.0008830.

39.

Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease.

Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, Zeitlin S, Bilbe G, Paganetti P.

Anal Biochem. 2009 Dec 1;395(1):8-15. doi: 10.1016/j.ab.2009.08.001. Epub 2009 Aug 6.

PMID:
19664996
40.

Development of a method for the high-throughput quantification of cellular proteins.

Paganetti P, Weiss A, Trapp M, Hammerl I, Bleckmann D, Bodner RA, Coven-Easter S, Housman DE, Parker CN.

Chembiochem. 2009 Jul 6;10(10):1678-88. doi: 10.1002/cbic.200900131.

PMID:
19492395
41.

Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas.

Jun HJ, Woolfenden S, Coven S, Lane K, Bronson R, Housman D, Charest A.

Cancer Res. 2009 Mar 15;69(6):2180-4. doi: 10.1158/0008-5472.CAN-08-3351. Epub 2009 Mar 10.

42.

Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.

Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2712-6. doi: 10.1073/pnas.0813314106. Epub 2009 Feb 5.

43.

Association between arterial stiffness and variations in oestrogen-related genes.

Peter I, Kelley-Hedgepeth A, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GF.

J Hum Hypertens. 2009 Oct;23(10):636-44. doi: 10.1038/jhh.2009.1. Epub 2009 Feb 5.

44.

Integrating Clinical Data into the i2b2 Repository.

Abend A, Housman D, Johnson B.

Summit Transl Bioinform. 2009 Mar 1;2009:1-5. No abstract available.

45.

The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort.

Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF.

J Hypertens. 2009 Jan;27(1):55-60. doi: 10.1097/HJH.0b013e328317c8ae.

46.

Linking test ordering with order tracking: closing the loop in ambulatory care.

Siegel LC, Housman D, Newmark L, Ungar J, Einbinder JS, Gandhi TK.

AMIA Annu Symp Proc. 2008 Nov 6:1131.

PMID:
18999233
47.

Improving physician note entry rates through an incentive program.

Greim J, Housman D, Lenz S, Mort E, Ferris TG, Meyer GS, Einbinder JS.

AMIA Annu Symp Proc. 2008 Nov 6:939.

PMID:
18999141
48.

Modeling pediatric vaccination guidelines in a data warehouse.

Housman D, Greim J, Morgan SJ, Nelson SM, Flanagan T, Martin K, Eskin M, Einbinder JS.

AMIA Annu Symp Proc. 2008 Nov 6:976.

PMID:
18999017
49.

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells.

Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A.

Science. 2008 Oct 31;322(5902):703-9. doi: 10.1126/science.1160058.

50.

Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.

Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR; International-Venezuela Collaborative Research Group.

Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):425-9. doi: 10.1002/ajmg.b.30826.

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