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Computational Simulation Expands Understanding of Electrotransfer-Based Gene Augmentation for Enhancement of Neural Interfaces.

Al Abed A, Pinyon JL, Foster E, Crous F, Cowin GJ, Housley GD, Lovell NH.

Front Neurosci. 2019 Aug 6;13:691. doi: 10.3389/fnins.2019.00691. eCollection 2019.


Onset kinetics of noise-induced purinergic adaptation of the 'cochlear amplifier'.

Cederholm JME, Ryan AF, Housley GD.

Purinergic Signal. 2019 Sep;15(3):343-355. doi: 10.1007/s11302-019-09648-3. Epub 2019 Aug 3.


Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes.

Pinyon JL, von Jonquieres G, Crawford EN, Duxbury M, Al Abed A, Lovell NH, Klugmann M, Wise AK, Fallon JB, Shepherd RK, Birman CS, Lai W, McAlpine D, McMahon C, Carter PM, Enke YL, Patrick JF, Schilder AGM, Marie C, Scherman D, Housley GD.

Hear Res. 2019 Sep 1;380:137-149. doi: 10.1016/j.heares.2019.06.002. Epub 2019 Jun 21. Review.


Purinergic Signaling and Aminoglycoside Ototoxicity: The Opposing Roles of P1 (Adenosine) and P2 (ATP) Receptors on Cochlear Hair Cell Survival.

Lin SCY, Thorne PR, Housley GD, Vlajkovic SM.

Front Cell Neurosci. 2019 May 15;13:207. doi: 10.3389/fncel.2019.00207. eCollection 2019.


Human Brain Region-Specific Alternative Splicing of TRPC3, the Type 3 Canonical Transient Receptor Potential Non-Selective Cation Channel.

Cederholm JME, Kim Y, von Jonquieres G, Housley GD.

Cerebellum. 2019 Jun;18(3):536-543. doi: 10.1007/s12311-019-01026-4.


Computational Simulation of Array-based Electroporation in the Cochlea.

Abed AA, Foster E, Pinyon JL, Li CH, Cowin GJ, Housley GD, Lovell NH.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2462-2465. doi: 10.1109/EMBC.2018.8512808.


Dual-Plasmid Bionic Array-Directed Gene Electrotransfer in HEK293 Cells and Cochlear Mesenchymal Cells Probes Transgene Expression and Cell Fate.

Pinyon JL, Klugmann M, Lovell NH, Housley GD.

Hum Gene Ther. 2019 Feb;30(2):211-224. doi: 10.1089/hum.2018.062. Epub 2018 Oct 2.


Resistance to neomycin ototoxicity in the extreme basal (hook) region of the mouse cochlea.

Lin SCY, Thorne PR, Housley GD, Vlajkovic SM.

Histochem Cell Biol. 2018 Sep;150(3):281-289. doi: 10.1007/s00418-018-1683-8. Epub 2018 Jun 4.


Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.

Fröhlich D, Suchowerska AK, Voss C, He R, Wolvetang E, von Jonquieres G, Simons C, Fath T, Housley GD, Klugmann M.

Front Mol Neurosci. 2018 Mar 20;11:81. doi: 10.3389/fnmol.2018.00081. eCollection 2018.


Focal Ischaemic Infarcts Expand Faster in Cerebellar Cortex than Cerebral Cortex in a Mouse Photothrombotic Stroke Model.

Gorlamandala N, Parmar J, Craig AJ, Power JM, Moorhouse AJ, Krishnan AV, Housley GD.

Transl Stroke Res. 2018 Dec;9(6):643-653. doi: 10.1007/s12975-018-0615-1. Epub 2018 Feb 17.


Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.

von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M.

Acta Neuropathol. 2018 Jan;135(1):95-113. doi: 10.1007/s00401-017-1784-9. Epub 2017 Nov 7.


Comparing perilymph proteomes across species.

Palmer JC, Lord MS, Pinyon JL, Wise AK, Lovell NH, Carter PM, Enke YL, Housley GD, Green RA.

Laryngoscope. 2018 Jan;128(1):E47-E52. doi: 10.1002/lary.26885. Epub 2017 Nov 2.


Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.


β-Hydroxybutyrate Boosts Mitochondrial and Neuronal Metabolism but is not Preferred Over Glucose Under Activated Conditions.

Achanta LB, Rowlands BD, Thomas DS, Housley GD, Rae CD.

Neurochem Res. 2017 Jun;42(6):1710-1723. doi: 10.1007/s11064-017-2228-6. Epub 2017 Mar 18.


Understanding the cochlear implant environment by mapping perilymph proteomes from different species.

Palmer JC, Lord MS, Pinyon JL, Wise AK, Lovell NH, Carter PM, Enke YL, Housley GD, Green RA.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:5237-5240. doi: 10.1109/EMBC.2016.7591908.


Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss.

Vlajkovic SM, Ambepitiya K, Barclay M, Boison D, Housley GD, Thorne PR.

Hear Res. 2017 Mar;345:43-51. doi: 10.1016/j.heares.2016.12.015. Epub 2016 Dec 26.


Cellular mechanisms of noise-induced hearing loss.

Kurabi A, Keithley EM, Housley GD, Ryan AF, Wong AC.

Hear Res. 2017 Jun;349:129-137. doi: 10.1016/j.heares.2016.11.013. Epub 2016 Dec 2.


In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Fröhlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M.

Neurobiol Dis. 2017 Jan;97(Pt A):24-35. doi: 10.1016/j.nbd.2016.10.008. Epub 2016 Nov 2.


Scorpion toxin peptide action at the ion channel subunit level.

Housley DM, Housley GD, Liddell MJ, Jennings EA.

Neuropharmacology. 2017 Dec;127:46-78. doi: 10.1016/j.neuropharm.2016.10.004. Epub 2016 Oct 10. Review.


Disinhibition-like behavior in a P301S mutant tau transgenic mouse model of frontotemporal dementia.

Przybyla M, Stevens CH, van der Hoven J, Harasta A, Bi M, Ittner A, van Hummel A, Hodges JR, Piguet O, Karl T, Kassiou M, Housley GD, Ke YD, Ittner LM, Eersel Jv.

Neurosci Lett. 2016 Sep 19;631:24-9. doi: 10.1016/j.neulet.2016.08.007. Epub 2016 Aug 10.


Evaluation of Gene Therapy as an Intervention Strategy to Treat Brain Injury from Stroke.

Craig AJ, Housley GD.

Front Mol Neurosci. 2016 May 24;9:34. doi: 10.3389/fnmol.2016.00034. eCollection 2016. Review.


Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes.

von Jonquieres G, Fröhlich D, Klugmann CB, Wen X, Harasta AE, Ramkumar R, Spencer ZH, Housley GD, Klugmann M.

Front Mol Neurosci. 2016 Feb 23;9:13. doi: 10.3389/fnmol.2016.00013. eCollection 2016.


Mapping of bionic array electric field focusing in plasmid DNA-based gene electrotransfer.

Browne CJ, Pinyon JL, Housley DM, Crawford EN, Lovell NH, Klugmann M, Housley GD.

Gene Ther. 2016 Apr;23(4):369-79. doi: 10.1038/gt.2016.8. Epub 2016 Jan 30.


Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells.

Morton-Jones RT, Vlajkovic SM, Thorne PR, Cockayne DA, Ryan AF, Housley GD.

Purinergic Signal. 2015 Dec;11(4):551-60. doi: 10.1007/s11302-015-9473-4. Epub 2015 Oct 1.


Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier.

Froud KE, Wong AC, Cederholm JM, Klugmann M, Sandow SL, Julien JP, Ryan AF, Housley GD.

Nat Commun. 2015 May 12;6:7115. doi: 10.1038/ncomms8115.


Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior.

Harasta AE, Power JM, von Jonquieres G, Karl T, Drucker DJ, Housley GD, Schneider M, Klugmann M.

Neuropsychopharmacology. 2015 Jul;40(8):1969-78. doi: 10.1038/npp.2015.47. Epub 2015 Feb 11.


The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome.

Canales CP, Wong AC, Gunning PW, Housley GD, Hardeman EC, Palmer SJ.

Eur J Hum Genet. 2015 Jun;23(6):774-80. doi: 10.1038/ejhg.2014.188. Epub 2014 Sep 24.


Adenosine amine congener as a cochlear rescue agent.

Vlajkovic SM, Chang H, Paek SY, Chi HH, Sreebhavan S, Telang RS, Tingle M, Housley GD, Thorne PR.

Biomed Res Int. 2014;2014:841489. doi: 10.1155/2014/841489. Epub 2014 Aug 26.


Loss of central auditory processing in a mouse model of Canavan disease.

von Jonquieres G, Froud KE, Klugmann CB, Wong AC, Housley GD, Klugmann M.

PLoS One. 2014 May 14;9(5):e97374. doi: 10.1371/journal.pone.0097374. eCollection 2014.


Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear.

Pinyon JL, Tadros SF, Froud KE, Y Wong AC, Tompson IT, Crawford EN, Ko M, Morris R, Klugmann M, Housley GD.

Sci Transl Med. 2014 Apr 23;6(233):233ra54. doi: 10.1126/scitranslmed.3008177.


Glial promoter selectivity following AAV-delivery to the immature brain.

von Jonquieres G, Mersmann N, Klugmann CB, Harasta AE, Lutz B, Teahan O, Housley GD, Fröhlich D, Krämer-Albers EM, Klugmann M.

PLoS One. 2013 Jun 14;8(6):e65646. doi: 10.1371/journal.pone.0065646. Print 2013.


Neural cell adhesion molecule L1 modulates type I but not type II inner ear spiral ganglion neurite outgrowth in an in vitro alternate choice assay.

Brand Y, Sung M, Chavez E, Wei E, Pak KK, Housley GD, Bodmer D, Ryan AF.

J Mol Neurosci. 2013 Nov;51(3):663-70. doi: 10.1007/s12031-013-0040-6. Epub 2013 Jun 13.


ATP-gated ion channels mediate adaptation to elevated sound levels.

Housley GD, Morton-Jones R, Vlajkovic SM, Telang RS, Paramananthasivam V, Tadros SF, Wong AC, Froud KE, Cederholm JM, Sivakumaran Y, Snguanwongchai P, Khakh BS, Cockayne DA, Thorne PR, Ryan AF.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7494-9. doi: 10.1073/pnas.1222295110. Epub 2013 Apr 16.


Canonical transient receptor potential channel subtype 3-mediated hair cell Ca(2+) entry regulates sound transduction and auditory neurotransmission.

Wong AC, Birnbaumer L, Housley GD.

Eur J Neurosci. 2013 May;37(9):1478-86. doi: 10.1111/ejn.12158. Epub 2013 Feb 26.


Mutation of the ATP-gated P2X(2) receptor leads to progressive hearing loss and increased susceptibility to noise.

Yan D, Zhu Y, Walsh T, Xie D, Yuan H, Sirmaci A, Fujikawa T, Wong AC, Loh TL, Du L, Grati M, Vlajkovic SM, Blanton S, Ryan AF, Chen ZY, Thorne PR, Kachar B, Tekin M, Zhao HB, Housley GD, King MC, Liu XZ.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2228-33. doi: 10.1073/pnas.1222285110. Epub 2013 Jan 23.


Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction.

O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM.

J Vestib Res. 2012;22(5-6):213-9. doi: 10.3233/VES-2012-00461.


Synaptic profiles during neurite extension, refinement and retraction in the developing cochlea.

Huang LC, Barclay M, Lee K, Peter S, Housley GD, Thorne PR, Montgomery JM.

Neural Dev. 2012 Dec 7;7:38. doi: 10.1186/1749-8104-7-38.


Differential actions of isoflurane and ketamine-based anaesthetics on cochlear function in the mouse.

Cederholm JM, Froud KE, Wong AC, Ko M, Ryan AF, Housley GD.

Hear Res. 2012 Oct;292(1-2):71-9. doi: 10.1016/j.heares.2012.08.010. Epub 2012 Aug 28.


Alternative splicing of the TRPC3 ion channel calmodulin/IP3 receptor-binding domain in the hindbrain enhances cation flux.

Kim Y, Wong AC, Power JM, Tadros SF, Klugmann M, Moorhouse AJ, Bertrand PP, Housley GD.

J Neurosci. 2012 Aug 15;32(33):11414-23. doi: 10.1523/JNEUROSCI.6446-11.2012.


Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity.

Senadheera S, Kim Y, Grayson TH, Toemoe S, Kochukov MY, Abramowitz J, Housley GD, Bertrand RL, Chadha PS, Bertrand PP, Murphy TV, Tare M, Birnbaumer L, Marrelli SP, Sandow SL.

Cardiovasc Res. 2012 Sep 1;95(4):439-47. doi: 10.1093/cvr/cvs208. Epub 2012 Jun 21.


Type I vs type II spiral ganglion neurons exhibit differential survival and neuritogenesis during cochlear development.

Barclay M, Ryan AF, Housley GD.

Neural Dev. 2011 Oct 11;6:33. doi: 10.1186/1749-8104-6-33.


Recent insights into the regulation of breathing.

Housley GD.

Auton Neurosci. 2011 Oct 28;164(1-2):3-5. doi: 10.1016/j.autneu.2011.08.002. Epub 2011 Aug 17. Review.


Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss.

Vlajkovic SM, Guo CX, Telang R, Wong AC, Paramananthasivam V, Boison D, Housley GD, Thorne PR.

Exp Gerontol. 2011 Nov;46(11):905-14. doi: 10.1016/j.exger.2011.08.001. Epub 2011 Aug 7.


Adenosine amine congener mitigates noise-induced cochlear injury.

Vlajkovic SM, Lee KH, Wong AC, Guo CX, Gupta R, Housley GD, Thorne PR.

Purinergic Signal. 2010 Jun;6(2):273-81. doi: 10.1007/s11302-010-9188-5. Epub 2010 Jun 30.


Reduced P2x(2) receptor-mediated regulation of endocochlear potential in the ageing mouse cochlea.

Telang RS, Paramananthasivam V, Vlajkovic SM, Munoz DJ, Housley GD, Thorne PR.

Purinergic Signal. 2010 Jun;6(2):263-72. doi: 10.1007/s11302-010-9195-6. Epub 2010 Jul 13.


Distribution of NTPDase5 and NTPDase6 and the regulation of P2Y receptor signalling in the rat cochlea.

O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM.

Purinergic Signal. 2010 Jun;6(2):249-61. doi: 10.1007/s11302-010-9190-y. Epub 2010 Jun 19.


Differential expression of P2Y receptors in the rat cochlea during development.

Huang LC, Thorne PR, Vlajkovic SM, Housley GD.

Purinergic Signal. 2010 Jun;6(2):231-48. doi: 10.1007/s11302-010-9191-x. Epub 2010 Jun 11.


Role of adenosine kinase in cochlear development and response to noise.

Vlajkovic SM, Guo CX, Dharmawardana N, Wong AC, Boison D, Housley GD, Thorne PR.

J Neurosci Res. 2010 Sep;88(12):2598-609. doi: 10.1002/jnr.22421.


Developmental regulation of TRPC3 ion channel expression in the mouse cochlea.

Phan PA, Tadros SF, Kim Y, Birnbaumer L, Housley GD.

Histochem Cell Biol. 2010 Apr;133(4):437-48. doi: 10.1007/s00418-010-0686-x. Epub 2010 Mar 13.


Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea.

O'Keeffe MG, Thorne PR, Housley GD, Robson SC, Vlajkovic SM.

Histochem Cell Biol. 2010 Apr;133(4):425-36. doi: 10.1007/s00418-010-0682-1. Epub 2010 Mar 10.


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