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Items: 1 to 50 of 130


Guidelines for cell-type heterogeneity quantification based on a comparative analysis of reference-free DNA methylation deconvolution software.

Decamps C, Privé F, Bacher R, Jost D, Waguet A; HADACA consortium, Houseman EA, Lurie E, Lutsik P, Milosavljevic A, Scherer M, Blum MGB, Richard M.

BMC Bioinformatics. 2020 Jan 13;21(1):16. doi: 10.1186/s12859-019-3307-2.


Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue.

Wilkins OM, Johnson KC, Houseman EA, King JE, Marsit CJ, Christensen BC.

Epigenetics. 2019 Dec 16:1-21. doi: 10.1080/15592294.2019.1695332. [Epub ahead of print]


Corrigendum to: Peaks, Means, and Determinants of Real-Time TVOC Exposures Associated with Cleaning and Disinfecting Tasks in Healthcare Settings.

Virji MA, Liang X, Su FC, Lebouf RF, Stefaniak AB, Stanton ML, Henneberger PK, Houseman EA.

Ann Work Expo Health. 2019 Oct 28. pii: wxz059. doi: 10.1093/annweh/wxz059. [Epub ahead of print] No abstract available.


Serum dioxin and DNA methylation in the sperm of operation ranch hand veterans exposed to Agent Orange.

Kelsey KT, Rytel M, Dere E, Butler R, Eliot M, Huse SM, Houseman EA, Koestler DC, Boekelheide K.

Environ Health. 2019 Oct 29;18(1):91. doi: 10.1186/s12940-019-0533-z.


Peaks, Means, and Determinants of Real-Time TVOC Exposures Associated with Cleaning and Disinfecting Tasks in Healthcare Settings.

Virji MA, Liang X, Su FC, LeBouf RF, Stefaniak AB, Stanton ML, Henneberger PK, Houseman EA.

Ann Work Expo Health. 2019 Aug 7;63(7):759-772. doi: 10.1093/annweh/wxz043.


A Bayesian Approach for Summarizing and Modeling Time-Series Exposure Data with Left Censoring.

Houseman EA, Virji MA.

Ann Work Expo Health. 2017 Aug 1;61(7):773-783. doi: 10.1093/annweh/wxx046.


Normal breast tissue DNA methylation differences at regulatory elements are associated with the cancer risk factor age.

Johnson KC, Houseman EA, King JE, Christensen BC.

Breast Cancer Res. 2017 Jul 10;19(1):81. doi: 10.1186/s13058-017-0873-y.


A path analysis of multiple neurotoxic chemicals and cognitive functioning in older US adults (NHANES 1999-2002).

Przybyla J, Houseman EA, Smit E, Kile ML.

Environ Health. 2017 Mar 7;16(1):19. doi: 10.1186/s12940-017-0227-3.


5-Hydroxymethylcytosine localizes to enhancer elements and is associated with survival in glioblastoma patients.

Johnson KC, Houseman EA, King JE, von Herrmann KM, Fadul CE, Christensen BC.

Nat Commun. 2016 Nov 25;7:13177. doi: 10.1038/ncomms13177.


Validation of a DNA methylation reference panel for the estimation of nucleated cells types in cord blood.

Cardenas A, Allard C, Doyon M, Houseman EA, Bakulski KM, Perron P, Bouchard L, Hivert MF.

Epigenetics. 2016 Nov;11(11):773-779. Epub 2016 Sep 26.


Enlarged leukocyte referent libraries can explain additional variance in blood-based epigenome-wide association studies.

Kim S, Eliot M, Koestler DC, Houseman EA, Wetmur JG, Wiencke JK, Kelsey KT.

Epigenomics. 2016 Sep;8(9):1185-92. doi: 10.2217/epi-2016-0037. Epub 2016 Aug 16.


Cross-Sectional Study of Polybrominated Flame Retardants and Self-Reported Attention Deficit Hyperactivity Disorder in US Youth Aged 12-15 (NHANES 2003-2004).

Przybyla J, Kile ML, Smit E, Houseman EA.

J Environ Public Health. 2016;2016:2392045. doi: 10.1155/2016/2392045. Epub 2016 Jul 4.


Regions of variable DNA methylation in human placenta associated with newborn neurobehavior.

Paquette AG, Houseman EA, Green BB, Lesseur C, Armstrong DA, Lester B, Marsit CJ.

Epigenetics. 2016 Aug 2;11(8):603-13. doi: 10.1080/15592294.2016.1195534. Epub 2016 Jul 1.


Reference-free deconvolution of DNA methylation data and mediation by cell composition effects.

Houseman EA, Kile ML, Christiani DC, Ince TA, Kelsey KT, Marsit CJ.

BMC Bioinformatics. 2016 Jun 29;17:259. doi: 10.1186/s12859-016-1140-4.


methyLiftover: cross-platform DNA methylation data integration.

Titus AJ, Houseman EA, Johnson KC, Christensen BC.

Bioinformatics. 2016 Aug 15;32(16):2517-9. doi: 10.1093/bioinformatics/btw180. Epub 2016 Apr 8.


OxyBS: estimation of 5-methylcytosine and 5-hydroxymethylcytosine from tandem-treated oxidative bisulfite and bisulfite DNA.

Houseman EA, Johnson KC, Christensen BC.

Bioinformatics. 2016 Aug 15;32(16):2505-7. doi: 10.1093/bioinformatics/btw158. Epub 2016 Apr 19.


Hydroxymethylation is uniquely distributed within term placenta, and is associated with gene expression.

Green BB, Houseman EA, Johnson KC, Guerin DJ, Armstrong DA, Christensen BC, Marsit CJ.

FASEB J. 2016 Aug;30(8):2874-84. doi: 10.1096/fj.201600310R. Epub 2016 Apr 26.


The DNA methylation profile of activated human natural killer cells.

Wiencke JK, Butler R, Hsuang G, Eliot M, Kim S, Sepulveda MA, Siegel D, Houseman EA, Kelsey KT.

Epigenetics. 2016 May 3;11(5):363-80. doi: 10.1080/15592294.2016.1163454. Epub 2016 Mar 11.


Epigenome-Wide Assessment of DNA Methylation in the Placenta and Arsenic Exposure in the New Hampshire Birth Cohort Study (USA).

Green BB, Karagas MR, Punshon T, Jackson BP, Robbins DJ, Houseman EA, Marsit CJ.

Environ Health Perspect. 2016 Aug;124(8):1253-60. doi: 10.1289/ehp.1510437. Epub 2016 Jan 15.


Arsenic exposure and the seroprevalence of total hepatitis A antibodies in the US population: NHANES, 2003-2012.

Cardenas A, Smit E, Bethel JW, Houseman EA, Kile ML.

Epidemiol Infect. 2016 Jun;144(8):1641-51. doi: 10.1017/S0950268815003088. Epub 2016 Jan 7.


In utero arsenic exposure and epigenome-wide associations in placenta, umbilical artery, and human umbilical vein endothelial cells.

Cardenas A, Houseman EA, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Wright RO, Christiani DC, Kile ML.

Epigenetics. 2015;10(11):1054-63. doi: 10.1080/15592294.2015.1105424.


Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes.

Gonseth S, Roy R, Houseman EA, de Smith AJ, Zhou M, Lee ST, Nusslé S, Singer AW, Wrensch MR, Metayer C, Wiemels JL.

Epigenetics. 2015;10(12):1166-76. doi: 10.1080/15592294.2015.1117889.


Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research.

Michaud DS, Houseman EA, Marsit CJ, Nelson HH, Wiencke JK, Kelsey KT.

Cancer Epidemiol Biomarkers Prev. 2015 Dec;24(12):1811-9. doi: 10.1158/1055-9965.EPI-15-0681. Epub 2015 Sep 22. Review.


DNA Methylation in Whole Blood: Uses and Challenges.

Houseman EA, Kim S, Kelsey KT, Wiencke JK.

Curr Environ Health Rep. 2015 Jun;2(2):145-54. doi: 10.1007/s40572-015-0050-3. Review.


DNA methylation changes in the placenta are associated with fetal manganese exposure.

Maccani JZ, Koestler DC, Houseman EA, Armstrong DA, Marsit CJ, Kelsey KT.

Reprod Toxicol. 2015 Nov;57:43-9. doi: 10.1016/j.reprotox.2015.05.002. Epub 2015 May 15.


Response to "Civil time ≠ biological time: Recent options for empirically testing possible effects of chronodisruption".

Bhatti P, Adams C, Zhang Y, Song X, Makar KW, Sather CL, Kelsey KT, Houseman EA, Wang P.

Chronobiol Int. 2015 Jun;32(5):699-700. doi: 10.3109/07420528.2015.1039887. Epub 2015 May 18. No abstract available.


Differential DNA methylation in umbilical cord blood of infants exposed to mercury and arsenic in utero.

Cardenas A, Koestler DC, Houseman EA, Jackson BP, Kile ML, Karagas MR, Marsit CJ.

Epigenetics. 2015;10(6):508-15. doi: 10.1080/15592294.2015.1046026. Epub 2015 Apr 29.


Cell-composition effects in the analysis of DNA methylation array data: a mathematical perspective.

Houseman EA, Kelsey KT, Wiencke JK, Marsit CJ.

BMC Bioinformatics. 2015 Mar 21;16:95. doi: 10.1186/s12859-015-0527-y.


Placental DNA Methylation Related to Both Infant Toenail Mercury and Adverse Neurobehavioral Outcomes.

Maccani JZ, Koestler DC, Lester B, Houseman EA, Armstrong DA, Kelsey KT, Marsit CJ.

Environ Health Perspect. 2015 Jul;123(7):723-9. doi: 10.1289/ehp.1408561. Epub 2015 Mar 6.


Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.

Lee ST, Muench MO, Fomin ME, Xiao J, Zhou M, de Smith A, Martín-Subero JI, Heath S, Houseman EA, Roy R, Wrensch M, Wiencke J, Metayer C, Wiemels JL.

Nucleic Acids Res. 2015 Mar 11;43(5):2590-602. doi: 10.1093/nar/gkv103. Epub 2015 Feb 17.


Arsenic exposure and prevalence of the varicella zoster virus in the United States: NHANES (2003-2004 and 2009-2010).

Cardenas A, Smit E, Houseman EA, Kerkvliet NI, Bethel JW, Kile ML.

Environ Health Perspect. 2015 Jun;123(6):590-6. doi: 10.1289/ehp.1408731. Epub 2015 Jan 30.


Normal cell-type epigenetics and breast cancer classification: a case study of cell mixture-adjusted analysis of DNA methylation data from tumors.

Houseman EA, Ince TA.

Cancer Inform. 2014 Dec 9;13(Suppl 4):53-64. doi: 10.4137/CIN.S13980. eCollection 2014.


Adiposity is associated with DNA methylation profile in adipose tissue.

Agha G, Houseman EA, Kelsey KT, Eaton CB, Buka SL, Loucks EB.

Int J Epidemiol. 2015 Aug;44(4):1277-87. doi: 10.1093/ije/dyu236. Epub 2014 Dec 25.


A recursively partitioned mixture model for clustering time-course gene expression data.

Koestler DC, Marsit CJ, Christensen BC, Kelsey KT, Houseman EA.

Transl Cancer Res. 2014;3(3):217-232.


Nightshift work and genome-wide DNA methylation.

Bhatti P, Zhang Y, Song X, Makar KW, Sather CL, Kelsey KT, Houseman EA, Wang P.

Chronobiol Int. 2015 Feb;32(1):103-12. doi: 10.3109/07420528.2014.956362. Epub 2014 Sep 4.


Leukocyte-adjusted epigenome-wide association studies of blood from solid tumor patients.

Langevin SM, Houseman EA, Accomando WP, Koestler DC, Christensen BC, Nelson HH, Karagas MR, Marsit CJ, Wiencke JK, Kelsey KT.

Epigenetics. 2014 Jun;9(6):884-95. doi: 10.4161/epi.28575. Epub 2014 Mar 26.


A novel approach to the discovery of survival biomarkers in glioblastoma using a joint analysis of DNA methylation and gene expression.

Smith AA, Huang YT, Eliot M, Houseman EA, Marsit CJ, Wiencke JK, Kelsey KT.

Epigenetics. 2014 Jun;9(6):873-83. doi: 10.4161/epi.28571. Epub 2014 Mar 26.


Quantitative reconstruction of leukocyte subsets using DNA methylation.

Accomando WP, Wiencke JK, Houseman EA, Nelson HH, Kelsey KT.

Genome Biol. 2014 Mar 5;15(3):R50. doi: 10.1186/gb-2014-15-3-r50.


Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood.

Kile ML, Houseman EA, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Cardenas A, Wright RO, Christiani DC.

Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.


Influence of GSTT1 Genetic Polymorphisms on Arsenic Metabolism.

Kile ML, Houseman EA, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Hsueh YM, Christiani DC.

J Indian Soc Agric Stat. 2013 Aug 1;67(2):197-207.


PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia.

Xiao J, Lee ST, Xiao Y, Ma X, Houseman EA, Hsu LI, Roy R, Wrensch M, de Smith AJ, Chokkalingam A, Buffler P, Wiencke JK, Wiemels JL.

Int J Cancer. 2014 Sep 1;135(5):1101-9. doi: 10.1002/ijc.28759. Epub 2014 Feb 19.


Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E.

PLoS One. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014.


Reference-free cell mixture adjustments in analysis of DNA methylation data.

Houseman EA, Molitor J, Marsit CJ.

Bioinformatics. 2014 May 15;30(10):1431-9. doi: 10.1093/bioinformatics/btu029. Epub 2014 Jan 21.


Placental DNA methylation alterations associated with maternal tobacco smoking at the RUNX3 gene are also associated with gestational age.

Maccani JZ, Koestler DC, Houseman EA, Marsit CJ, Kelsey KT.

Epigenomics. 2013 Dec;5(6):619-30. doi: 10.2217/epi.13.63.


Variants of asthma and chronic obstructive pulmonary disease genes and lung function decline in aging.

Poon AH, Houseman EA, Ryan L, Sparrow D, Vokonas PS, Litonjua AA.

J Gerontol A Biol Sci Med Sci. 2014 Jul;69(7):907-13. doi: 10.1093/gerona/glt179. Epub 2013 Nov 19.


Recommendations for the design and analysis of epigenome-wide association studies.

Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C, Irizarry RA.

Nat Methods. 2013 Oct;10(10):949-55. doi: 10.1038/nmeth.2632. Review.


Review of processing and analysis methods for DNA methylation array data.

Wilhelm-Benartzi CS, Koestler DC, Karagas MR, Flanagan JM, Christensen BC, Kelsey KT, Marsit CJ, Houseman EA, Brown R.

Br J Cancer. 2013 Sep 17;109(6):1394-402. doi: 10.1038/bjc.2013.496. Epub 2013 Aug 27. Review.


Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis.

Koestler DC, Christensen B, Karagas MR, Marsit CJ, Langevin SM, Kelsey KT, Wiencke JK, Houseman EA.

Epigenetics. 2013 Aug;8(8):816-26. doi: 10.4161/epi.25430. Epub 2013 Jun 25.


Differential DNA methylation in umbilical cord blood of infants exposed to low levels of arsenic in utero.

Koestler DC, Avissar-Whiting M, Houseman EA, Karagas MR, Marsit CJ.

Environ Health Perspect. 2013 Aug;121(8):971-7. doi: 10.1289/ehp.1205925. Epub 2013 Jun 11.


Recursively partitioned mixture model clustering of DNA methylation data using biologically informed correlation structures.

Koestler DC, Christensen BC, Marsit CJ, Kelsey KT, Houseman EA.

Stat Appl Genet Mol Biol. 2013 Mar 5;12(2):225-40. doi: 10.1515/sagmb-2012-0068.

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