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Items: 21


IL-8 inhibits cAMP-stimulated alveolar epithelial fluid transport via a GRK2/PI3K-dependent mechanism.

Roux J, McNicholas CM, Carles M, Goolaerts A, Houseman BT, Dickinson DA, Iles KE, Ware LB, Matthay MA, Pittet JF.

FASEB J. 2013 Mar;27(3):1095-106. doi: 10.1096/fj.12-219295. Epub 2012 Dec 6.


Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.

Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12722-7. doi: 10.1073/pnas.1202492109. Epub 2012 Jul 16.


Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.

Nakamura JL, Phong C, Pinarbasi E, Kogan SC, Vandenberg S, Horvai AE, Faddegon BA, Fiedler D, Shokat K, Houseman BT, Chao R, Pieper RO, Shannon K.

Cancer Res. 2011 Jan 1;71(1):106-15. doi: 10.1158/0008-5472.CAN-10-2732.


Akt and autophagy cooperate to promote survival of drug-resistant glioma.

Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA.

Sci Signal. 2010 Nov 9;3(147):ra81. doi: 10.1126/scisignal.2001017.


Biocompatibility and reduced drug absorption of sol-gel-treated poly(dimethyl siloxane) for microfluidic cell culture applications.

Gomez-Sjoberg R, Leyrat AA, Houseman BT, Shokat K, Quake SR.

Anal Chem. 2010 Nov 1;82(21):8954-60. doi: 10.1021/ac101870s. Epub 2010 Oct 11.


Shaping development of autophagy inhibitors with the structure of the lipid kinase Vps34.

Miller S, Tavshanjian B, Oleksy A, Perisic O, Houseman BT, Shokat KM, Williams RL.

Science. 2010 Mar 26;327(5973):1638-42. doi: 10.1126/science.1184429.


Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs.

Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM.

Chem Biol. 2010 Feb 26;17(2):123-34. doi: 10.1016/j.chembiol.2010.01.010.


The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL.

Nat Chem Biol. 2010 Mar;6(3):244. No abstract available.


The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors.

Berndt A, Miller S, Williams O, Le DD, Houseman BT, Pacold JI, Gorrec F, Hon WC, Liu Y, Rommel C, Gaillard P, Rückle T, Schwarz MK, Shokat KM, Shaw JP, Williams RL.

Nat Chem Biol. 2010 Feb;6(2):117-24. doi: 10.1038/nchembio.293.


Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism.

Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF.

J Biol Chem. 2010 Feb 12;285(7):4278-90. doi: 10.1074/jbc.M109.036731. Epub 2009 Dec 8.


Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation.

Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY.

Science. 2009 Oct 9;326(5950):294-8. doi: 10.1126/science.1178577.


SHIP prevents lipopolysaccharide from triggering an antiviral response in mice.

Sly LM, Hamilton MJ, Kuroda E, Ho VW, Antignano FL, Omeis SL, van Netten-Thomas CJ, Wong D, Brugger HK, Williams O, Feldman ME, Houseman BT, Fiedler D, Shokat KM, Krystal G.

Blood. 2009 Mar 26;113(13):2945-54. doi: 10.1182/blood-2008-06-166082. Epub 2009 Jan 12.


Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha.

Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM.

Cancer Cell. 2008 Aug 12;14(2):180-92. doi: 10.1016/j.ccr.2008.06.014.


Towards quantitative assays with peptide chips: a surface engineering approach.

Houseman BT, Mrksich M.

Trends Biotechnol. 2002 Jul;20(7):279-81.


Peptide chips for the quantitative evaluation of protein kinase activity.

Houseman BT, Huh JH, Kron SJ, Mrksich M.

Nat Biotechnol. 2002 Mar;20(3):270-4.


Efficient Solid-Phase Synthesis of Peptide-Substituted Alkanethiols for the Preparation of Substrates That Support the Adhesion of Cells.

Houseman BT, Mrksich M.

J Org Chem. 1998 Oct 16;63(21):7552-7555. No abstract available.


Using electroactive substrates to pattern the attachment of two different cell populations.

Yousaf MN, Houseman BT, Mrksich M.

Proc Natl Acad Sci U S A. 2001 May 22;98(11):5992-6. Epub 2001 May 15.


The Role of Ligand Density in the Enzymatic Glycosylation of Carbohydrates Presented on Self-Assembled Monolayers of Alkanethiolates on Gold.

Houseman BT, Mrksich M.

Angew Chem Int Ed Engl. 1999 Mar 15;38(6):782-785. doi: 10.1002/(SICI)1521-3773(19990315)38:6<782::AID-ANIE782>3.0.CO;2-N.


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